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[Testing, estimating, "significance"--concept and language of medical biometry].

The justification for the application of medical treatments and diagnostic methods has gained importance during the last decades. Together with scientific argumentations also the concepts of medical statistics have found a widespread use and are nowadays indispensible tools for clinical research. In publications of clinical trials, epidemiological investigations and animal experiments p-values, statistical tests and confidence intervals help the reader to evaluate the significance and relevance of the provided results. A prerequisite is a clear understanding of the concepts underlying these methodological terms. This paper presents the basic concepts of medical statistics and demonstrates the conclusions that can be drawn with the aid of these concepts.

Biometry↗

[Ultrasound fetal biometry and birth weight prognosis with the use of Aoki method and classical regression analysis].

We have attempted to estimate prognostic value of neonatal birth weight prediction with the use of fetal sonographic data: biparietal diameter, femur length, transverse and longitudinal abdominal diameter. Clinical and ultrasound data from 265 pregnant women with singleton gestation who delivered within 7 days from the last ultrasound scan were analyzed. For the fetal weight estimation we have calculated fetal abdominal area in the equation proposed by Aoki in 1990. Predicted and observed neonatal birth weight centiles and coefficients of determination were calculated with the use of regression analysis. Prediction method of neonatal weight with Aoki method explained 70% of variability in our population. In contrast, regression analysis on ultrasound data explained 99% of observer variability in neonatal birth weight. We conclude that own method of birth weight prediction could be of value, however it should be tested in a new prospectively examined population.

Adult↗

[Biometry of the malignant glaucoma (author's transl)].

The survey of a population of 7 patients with malignant glaucoma, whose 3 were bilateral, showed that the total length of these eyes was weaker, the corneal radius shorter, the anterior chamber more shallow and the insertion of the lens more anterior than that of eyeballs with angle-closure glaucoma on the whole. These latter, we must remind, are already smaller than normal eyes. But this lessening of size does not affect the corneal diameter which remains always normal. And the lens, which is greater than normally in the angle-closure glaucoma, in the contrary is normal or smaller in the malignant glaucoma. The authors think that this little size of the lens allows it to be dislocated anteriorly through the limbal ring after the operation, and so is the cause of the post-surgical malignant glaucoma.

Biometry↗