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At least 307 records · Page 17Linked to original sources
PubMed1986

Improved programs for DNA and protein sequence analysis on the IBM personal computer and other standard computer systems.

We have previously described programs for a variety of types of sequence analysis (1-4). These programs have now been integrated into a single package. They are written in the standard C programming language and run on virtually any computer system with a C compiler, such as the IBM/PC and other computers running under the MS/DOS and UNIX operating systems. The programs are widely distributed and may be obtained from the authors as described below.

Amino Acid Sequence↗
PubMed1992

The hardware components of a computer system.

The two goals of this article are to give you a very brief overview of the evolution of computing and an introduction to the elements of a computer. The birth of the modern computer can be traced to John von Neumann. The model he proposed consisted of four major parts: the control unit, the arithmetic unit, the memory, and the input/output unit. His concept for a "stored program" computer provided the foundation for five decades of computer designs.

Computer Systems↗
PubMedDate not supplied

[Experience in introducing monitoring computer systems in anesthesiology and intensive care units].

The paper describes the author's experience in practically using a monitoring computer system at the Anesthesiology, Resuscitation and Intensive Care Unit, Republican Clinical Hospital No.1, in Izhevsky Udmurtia. The system enables physicians, primarily anesthesiologists-reanimatologists to automate their work. It also allows the problem of routine accounting and report documentation to be solved.

Anesthesiology↗
PubMed2000

[Computer system for simulating population dynamic patterns of polygenes and mobile genetic elements upon truncation selection for a quantitative trait].

A computer system was developed for simulation of population dynamics of interacting polygene patterns and mobile genetic elements (MGEs) under selection for a quantitative trait. The system is stochastic (Monte Carlo) and takes into account the main sources of random change in the patterns (recombinations, transpositions, excisions), genetic drift, and determined trends of selection and other genetic processes in a finite population. Using this model, it is possible to analyze the dynamics of many population parameters that cannot be experimentally estimated: frequencies of polygenic alleles, proportions of adaptive and random fixations, average heterozygosities of polygenes and MGEs, coefficient of inbreeding, heritability, etc. In addition, the model can be used to test various hypotheses on polygene-MGE interaction.

Adaptation, Physiological↗
PubMed1992

Whole words and decoding for short-term learning: comparisons on a "talking-computer" system.

Low-and average-ability readers in first and second grade studied a list of 36 words using a "talking-computer" system. The system highlighted and simultaneously pronounced orthographic units in the words when the children touched the words with a light pen. During two training sessions, the computer presented four groups of 9 words each, one group as whole words, one in syllabic units, one in subsyllabic units, and one as single grapheme-phoneme units. All children learned the least words with single grapheme-phoneme units, having had the greatest difficulty blending the units into words during training. The other presentation units did not differ significantly from each other for most students on post-testing. However, the low first-grade readers learned fewer words segmented and presented by subsyllables than by syllable or word units, but only for multisyllabic words. Monosyllabic words were blended and learned as easily with onset-rime segmentation as with whole word units, for all children.

Achievement↗
PubMed2001

Impaired absorption and omission of insulin: a novel method of detection using the diabetes advisory system computer model.

The Diabetes Advisory System (DIAS) is a decision-support program developed to assist insulin dose adjustment in type 1 diabetes. In this paper, we show how it might be used to identify impaired absorption or omission of insulin in patients with poorly controlled blood glucose. An evaluation of glucose results from four outpatients with persistent hyperglycemia is presented (age 19-48 years with type 1 diabetes for 13-18 years of duration, HbA1c 9.4-13.6%). Each had completed a 4-day record of blood glucose (BG, pre-meal and bedtime), dietary (carbohydrate) intake, and insulin doses (with injection sites). From these data, DIAS modeled a glucose profile (simulated glucose, SG) for the same period. Qualitative assessments were made of differences between BG and SG, and selective reduction or complete removal of insulin doses where BG >> SG. Large improvements in modeling were attributed to either impaired absorption or omission of insulin. Confirmation of these problems was sought from the patients by detailed consultation and physical examination. Impaired insulin absorption was suspected in two patients, both having significant injection site abnormalities. Insulin omission was suspected in the other two subjects. Both had normal injection sites, and one admitted to missing doses. Following retraining, data from three patients showed noticeable improvements in overall modeling as well as glucose control. Using DIAS in the evaluation of patients with type 1 diabetes may highlight previously unrecognized injection site abnormalities or insulin dose omission. This could assist rational optimization of insulin therapy in cases of persistently poor glucose control.

Adult↗
PubMed1990

A classification of health computer systems and how it could help in deciding investment requirements.

Investment in information technology by the NHS is reaching unprecedented levels. This is true throughout the service, from the highly publicized district information systems and hospital information support systems to the investment of GPs in microcomputers. To place all these system developments in context, Peter Cross considers the changes in the structure of health computing in the 1980s and sets out a methodology for assessing both the need for computer systems and their success.

Decision Making↗
PubMed1981

Application of a gas chromatography mass spectrometry computer system for clinical diagnosis.

Currently, one of the major clinical problems is diagnosis of inherited metabolic disorders in neonates which are caused by a defect of specific enzymes. In order to diagnose such diseases at an earlier stage, we have developed a new mass screening method, consisting of a gas chromatography mass spectrometry computer system with a newly developed 'Diagnosis Computer Program'. In this program, the chromatographic pattern of the urine of a patient with an inherited metabolic disorder is compared with that of a normal person. Internal standards are applied to simplify the comparison. The total ion current chromatogram is drawn with the relative retention times plotted on the horizontal axis and the relative intensities on the vertical axis. Diseases are diagnosed by characteristics and quantity of abnormal compounds in the urine. Reference to the stored mass spectra of abnormal compounds by a library search enables the diagnosis to be more precise. Using this program, twenty-six inherited metabolic disorders are routinely diagnosed. The diagnosis of tyrosinosis is used here as an example.

Alkaptonuria↗
PubMed1995

Analysis of a Bacillus subtilis genome fragment using a co-operative computer system prototype.

Analysis of the huge volume of data generated by large scale sequencing projects requires the construction of new, sophisticated computer systems. These systems should be able to manage the biological data as well as the results of their analysis. They should also help the user to choose the most appropriate methods, and to string them together in order to solve a global analysis task. In this paper we present the prototype of a software system providing an environment for the analysis of large-scale sequence data. As a first step toward this end, this environment has been put to the test within the Bacillus subtilis genome sequencing project. This system integrates both the descriptive knowledge of the entities involved (genes, regulatory signals and the like) and the methodological knowledge comprising an extensible set of analytical methods. A knowledge representation based on two existing object-oriented models is used to implement this integrated system. In addition, the present prototype provides a suitable user interface both for displaying simultaneously the results generated by several methods and for interacting with the objects. We present in this paper the analysis of a B. subtilis genome fragment, present in data libraries but not annotated. Annotation of the genes present in the fragment allowed us to combine the results of several methods used for predicting coding sequences, and to characterize it as comprising a cryptic phage, the skin element. Comparison between the annotation of the skin element and a standard region of the chromosome indicated that local features of the nucleotide sequence could discriminate between phage and non-phage DNA sequence.

Bacillus subtilis↗
PubMed1981

An on-line computer system for hospital bacteriology: description of its development and comments after five years' use.

The development over several years of a computer system for hospital bacteriology reporting is described. The system was developed from a manual method to a punch-card batch processing system and finally to a real-time on-line system. The value of the system to the clinical departments and laboratory is discussed. Apart from minor defects the system has been of immense advantage to all who make use of its facilities.

Bacteriology↗
PubMed1980

Interactive computer system for monitoring multiphasic health screening.

In an on-going population screening investigation at the Department of Preventive Medicine in Malmö, an interactive computer system has been developed for monitoring: (i) the electron and invitation of the health screening population; (ii) on-line registration and representation of demographic informations, test results and questionnaires; (iii) generation of the patient files and other listings; (iv) systems for diagnostic and statistical processing and representation. Ten thousand health screening investigations have now been monitored by the system, which is described in this report.

Computers↗
PubMedDate not supplied

Expert system computer program for troubleshooting the gel-clot Limulus amebocyte lysate (LAL) assay.

This article describes a knowledge-based or expert system computer program that can assist in troubleshooting the gel-clot Limulus Amebocyte Lysate (LAL) method for the assay of endotoxin in parenteral products and in-process materials. The program may also be used to train new personnel and/or to assist in the development of an LAL method for a new product or material. The program includes LAL assay information for 31 parenteral products and materials. The program uses rules-of-thumb and intuition to diagnose 155 possible LAL assay problems and logically reduce them to 37 recommended problem solving processes. The program also provides references to support its recommendation.

Endotoxins↗
PubMed1981

Assessment of renal transplantation using a gamma camera computer system.

Five hundred eleven isotope studies were performed following renal transplantation in 130 patients, using a standard technique and a gamma camera computer system in a nuclear medicine department situated half a mile away from the renal transplant unit. A comprehensive picture of renal function is obtained from perfusion studies, renography, effective renal plasma flow, I-131-Hippuran uptake, and excretion measurements.

Acute Kidney Injury↗
PubMed1992

Computer system RFPs: long form vs. short form.

Requests for proposal, the thousand-page tomes hospitals write when shopping for a new computer system, evoke an array of emotions. Some hate them, saying they're too long, too expensive to answer and leave too many false impressions. Others like them, saying RFPs are valuable, especially as an organizational tool. Some hospitals say they have the answer--a more focused approach.

Competitive Bidding↗
PubMedDate not supplied

Measurement of the effects of an integrated, point-of-care computer system on quality of nursing documentation and patient satisfaction.

This quasi-experimental, modified time series study measured the effects of the nursing module of a point of care clinical information system on nursing documentation and patient satisfaction. Measurements were taken before implementation of the module and at 6-, 12-, and 18-month intervals postimplementation. Quality of nursing documentation was measured by compliance to items applicable to nursing documentation selected from the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) Closed Medical Review Tool. Patient satisfaction was measured by using the Risser Patient Satisfaction Scale. The study data showed a statistically significant increase in the quality of nursing documentation after implementation of the computerized nursing documentation system, as well as a decrease in variability in charting, as evidenced by a decrease in standard deviations. A significant increase in charting compliance was still occurring between the 12- and the 18-month time points after initiation of automated documentation. The point of care computer system did not seem to affect patient satisfaction with the nurse-patient relationship.

Humans↗
PubMed1982

A community hospital laboratory computer system: an eight-year longitudinal study of economic impact.

An analysis of the intralaboratory economic effects of installation of a dedicated laboratory computer system in a 450-bed acute care general hospital laboratory is presented using data accumulated during an eight-year period. Data collection and analytic conventions used included: (1) an inflation factor derived from the CPI to adjust costs; (2) semilogarithmic plotting; (3) patient procedure counts tallied as the raw count for patient specimens according to the CAP Workload Recording Method; and (4) total workload (including patient standard and control items) recorded according to the CAP WRM. The authors conclude that computerization has produced: (1) a decrease in inflation adjusted labor costs per unit of work; (2) a decrease in inflation adjusted direct cost per unit of work; (3) A decline in the ratio of clerical to technical labor force; and (4) An increase in overall productivity of approximately 7%.

Computers↗
PubMed1995

Selecting a pharmacy computer system for the future.

Major advances are occurring in the field of computer science that have placed us at the threshold of a significant revolution in the management and application of clinical data. These advances will have a profound effect on the practice of pharmacy and are occurring at a time when many hospital pharmacies are deciding whether to enhance or replace their current systems. To best position your department for the future, it is essential that you are knowledgeable of the advances being made, have a vision for how they will affect your practice, and undergo a well-organized and thorough selection process.

Clinical Pharmacy Information Systems↗