X-ray dose received by patients in a population survey for colonic diverticular disease.
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Pelvic phleboliths are familiar structures to radiologists although their pathogenesis is not fully understood. The literature suggests a relationship between the prevalence of phleboliths and diverticular disease, and with a low-fibre diet. Phleboliths are said to be seen more frequently in women and on the left side in the pelvis. Their number seems to increase with advancing age. We have attempted to establish relations of phleboliths with diverticulitis, diverticulosis, sex, age and pelvic location. In this study the only statistically significant relation was an increase of the number of phleboliths with advancing age.
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Diverticular disease of the colon is very common in developed countries with its prevalence increasing with age, varying from < 10% in those < 40 years of age, to an estimated 50-66% of patients > 80 years of age. Diverticulitis, defined as inflammation and/or infection associated with diverticula, is the most common clinical complication of this disorder, affecting an estimated 10-25% of patients with colonic diverticula. The therapeutic measures aim at putting the intestine 'at rest', thus resolving the infection, the consequences of the inflammation and preventing or limiting complications. For patients with severe and complicated diverticulitis, ampicillin, gentamicin, metronidazole, piperacillin and tazobactam are the antibiotics successfully used in clinical practice, whereas ciprofloxacin, metronidazole and more recently, rifaximin, have been successfully used in the treatment of uncomplicated diverticular disease. Mesalazine (alone or in association with antibiotics) and probiotics are the two latest therapies for the treatment of diverticulitis which have been developed in the last few years. In fact, the combination of mesalazine and an antibiotic showed significant superiority in improving the severity of symptoms, bowel habits and in preventing symptomatic recurrence of diverticulitis than antibiotics alone, but probiotics also seem to be effective in preventing recurrence of the disease. In light of the excellent results obtained in the treatment of inflammatory bowel disease and irritable bowel syndrome, it is probable that probiotics may be the future best treatment also for mild-to-moderate uncomplicated attacks of acute diverticulitis, especially if used with salycilates.
Diverticular disease is worldwide in distribution, but the incidence is highest in industrialised countries. It is associated with aging and low intake of dietary fibre. There is a broad range of clinical manifestations--from asymptomatic diverticula to life-threatening complications. Elderly patients often present with complicated diverticular disease, and may lack typical symptoms and signs. Treatment includes fibre supplementation, drugs or antibiotics for complications, and surgery for refractory disease. Proper diagnosis and treatment requires knowledge of the full range of presentations and careful selection and timing of medical versus surgical intervention.
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The correlation between the haustral pattern in the sigmoid colon, on the one hand, and the pressure activity and presence of diverticula, on the other, was examined in 184 patients, subjected to both X-ray examination and sigmoid pressure measurement. No correlation was found between an increased haustral pattern and a high pressure activity. Only a special S-shaped haustral pattern showed a slight correlation to an increased pressure activity. An interpretation of colonic haustral pattern in terms of muscular activity, therefore, seems unwarranted. A significant correlation was found between an increased haustral pattern and the presence of sigmoid diverticula.
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Diverticulosis is one of the most common diseases of the colon. Its importance arises from complications. In countries of the Western hemisphere the incidence is 10-20% beyond the age of 50. Among the natives of Africa and South-Eastern Asia it is practically unknown. It is suggested that the disease is caused by low residue diet, modern living conditions. and constitutional disorders. 500 barium enemas revealed 13,4% patients with diverticula including a 5-year-old child and a 32-year-old woman. The incidence of diverticulosis among patients over 40 years of age is 19,6%. The sex distribution is 1 : 1,9 male to female. The complications are demonstrated by case histories: Diverticulitis with ileus, foreign body trap, sub-acute perforation, sigmoid-vaginal fistula, sigmoid-bladder fistula, sigmoid-uterus fistula in a 5-year-old girl.
Diverticulosis from surgical point of view means treatment of complications. Treatment of primarily acute and chronic diverticulitis without complications should be conservative in the beginning. Primarily or secondarily complicated cases should undergo proper surgical resection. In these cases a step-by-step procedure has to be considered. Suspicion of simultaneous diverticulosis with carcinoma demands operative clarification.
The sigmoid colon differs from the remaining colon anatomically, functionally and by increased incidence of disease. Occasionally it may be very difficult to differentiate diverticulitis of the sigma from a malignant tumor. It is felt that hypotonic sigmoidography improves the diagnostic accuracy. Selective angiography of the inferior mesenteric artery may be of further diagnostic help. Pharmaco-angiographic examinations with Eupaverin yielded no better results.
There is an increasing number of cases of colonic diverticular disease among hospital admissions to AUBMC being more prevalent in patients > 50 years old (76.5%). Colonic diverticular disease were more prevalent in urban population admitted to AUBMC (95.6%). Diverticulitis is the most common complication of colonic diverticular disease among admitted cases with colonic diverticular disease (51%). All patients with diverticulitis who presented without abdominal pain had fever. This finding made diverticulitis part of the differential diagnosis in cases of FUO in patients over 50 years old.
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