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Results for “ERYTHROCYTE AGGREGATION, INTRAVASCULAR”

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PubMed1980

[Blood rheological and coagulation properties in abdominal aortic aneurysm].

From the analysis of information on 158 patients who underwent operation for aneurysm of the abdominal aorta and on the basis of complications associated with impaired hemostasis, considerable disorders were revealed in the blood rheologic and coagulative properties. These disorders intensify during the operation and in the first 3 postoperative days and may lead to the development of microcirculatory and thrombotic complications. The syndrome of generalized intravascular coagulation may develop in patients with large aneurysms of the abdominal aorta, in which operations are most traumatizing. A scheme for correcting disturbances in the blood rheologic and coagulative properties in the pathological condition is given.

Adolescent↗

PubMed2006

[Venous malformations and coagulopathy].

Activation of the coagulation process is frequently encountered in patients with venous vascular malformations and results in the local formation of clots and the consumption of components of the coagulation process (platelets, clotting factors). This activation accounts for multiple biological abnormalities such as the elevation of the D-dimers, reduction of fibrinogen and platelets count and less frequently a local intravascular coagulation (LIC). This process seems to be responsible for the local painful symptoms. In case of LIC, bleeding complications may be observed. Therapeutically, antithrombotic treatment with low-molecular weight heparin can improve the local coagulopathy with beneficial effects on blood tests disturbances, pain and bleeding tendency.

Blood Coagulation Disorders↗

PubMed1984

[Role of intravascular coagulation in the pathophysiology of the hemolytic-uremic syndrome].

Endothelial cell injury of capillaries and arterioles is considered to be the primary event in the hemolytic uremic syndrome. Intravascular coagulation increases the damaging processes. This intravascular coagulation can still be active after admission to the clinic. Several new data are available: prostacyclin deficiency can be present possibly due to the absence of a stimulating factor in plasma; the platelets are exhausted; an inhibitor of glomerular fibrinolysis has been demonstrated. A generally accepted therapy for HUS is still lacking.

Antithrombin III↗

PubMedDate not supplied

[The aggregation indices in the bulbar vessels of persons of different ages].

Computer-aided analysis of television images of the eye (CAATIE) helps objectively assess the intravascular aggregation in the bulbar vessels by determining the values of aggregation gradients of intravascular bloodflow. Standards gradients of intravascular bloodflow aggregation have been determined for three age groups. CAATIE permits the assessment of parietal bloodflow in large veins. No disorders of parietal bloodflow were detected in subjects without vascular abnormalities. The derived aggregation values for CAATIE in subjects of different age help assess the severity of microcirculatory disorders in vascular diseases on the basis of deviations of the above parameters from age-specific norm.

Adolescent↗

PubMed1996

Rheological properties of commonly used plasma substitutes during preoperative normovolaemic acute haemodilution.

Preoperative normovolaemic acute haemodilution (PNAH) is used to reduce major blood loss during elective surgery. Considerable attention has been paid to colloid osmotic pressure, index of diffusibility and intravascular half-life of the currently available substitutes, but there is little information on their rheological properties from in vivo studies. Forty patients undergoing elective aortic reconstruction were given 4% human albumin (HA), 3.5% dextran 40 (Dxt 40), 6% dextran 60 (Dxt 60), 6% hydroxyethylstarch 200 (HES) or modified fluid gelatin (Gel) during PNAH to produce a packed cell volume (PCV) of approximately 30%. Mean volumes of more than 1000 ml were infused. Blood samples were obtained before infusion, immediately after, and 1.5 h after the end of haemodilution. The following variables were measured: PCV, plasma viscosity, whole blood viscosity at measured and corrected PCV (0.45), and erythrocyte aggregation. Haemodynamic and metabolic variables were determined at the same time. The five substitutes had very different effects on red blood cell aggregation and low shear rate viscosity at corrected PCV. Red blood cell aggregation was reduced in the presence of HA, Dxt 40, but was increased moderately to markedly in the presence of the other substitutes in the following order: HES < Dxt 60 < Gel. The influence of the rheological conditions on tissue oxygenation was assessed by measuring the concentration of lactic acid; this was unchanged after PNAH with HA or Dxt 40, but was increased in the presence of HES, Dxt 60 or Gel.

Adult↗

PubMed1990

Inhibition of intravascular platelet aggregation by endothelium-derived relaxing factor: reversal by red blood cells.

Studies were performed to determine whether endothelium-derived relaxing factor (EDRF) can inhibit platelet aggregation within the vascular lumen, and if so, whether the inhibition persists in the presence of red blood cells (RBCs). Canine femoral arteries mounted in an organ bath were perfused with physiologic saline solution to which acetylsalicylic acid was added to block prostacyclin formation. During contraction with phenylephrine, addition of acetylcholine to the perfusing solution to evoke EDRF release relaxed the vessel wall. Washed human platelets labeled with 14C-5-hydroxytryptamine were added to the perfusing solution, and activated by thrombin infused via a branch vessel. The perfusate was collected downstream and centrifuged; the fraction of 14C-5-hydroxytryptamine appearing in the supernatant reflected the degree of platelet activation. Stimulation of EDRF release with acetylcholine inhibited 14C-5-hydroxytryptamine release. Hemoglobin (Hb) (10(-5) mol/L) blocked vascular relaxation and platelet-inhibition. RBCs at a hematocrit of 10% (treated with echothiophate to block erythrocyte cholinesterase) did not prevent relaxation but reversed the platelet inhibition. Lower hematocrits did not completely block the inhibition. Thus, erythrocyte Hb may modulate the inhibition of intraluminal platelet aggregation by EDRF.

Animals↗

PubMed1985

Pathological and adaptive vascular changes in the microcirculatory bed according to morphological and biomicroscopic findings.

Using non-injection methods (membrane silvering, their staining with Sudan black B or Schiff's reagent) and using conjunctival microscopy, the state of microcirculation in various diseases was investigated on autopsy material (162 observations) and in vivo (78 patients). On the basis of the results the authors deduce general principles of the description and functional evaluation of pathological changes in the microcirculatory system, and divide them into vascular, intravascular and extravascular (stromal) ones. They stress that besides pathological changes proper it is necessary to differentiate also adaptive changes in the microvascular structure, changes in rheological properties of blood and in the interstitium. It is recommended to apply the same principles in description and functional evaluation of the findings of biomicroscopic examination of microcirculation in clinical practice.

Adolescent↗

PubMed2000

Acute intravascular hemolysis secondaryto out-of-group platelet transfusion.

BACKGROUND: Acute intravascular hemolysis is rarely associated with platelet transfusion. Out-of-group single-donor platelets may cause hemolysis if the donor has high-titer ABO hemagglutinins. CASE REPORT: A 44-year-old woman, blood group A, was recently diagnosed with acute myeloid leukemia and was receiving chemotherapy. After the transfusion of apheresis platelets from a group O donor, back pain, hemoglobinuria, and hemoglobinemia developed, and her Hb dropped by 2.3 g per dL, despite the transfusion of 2 units of RBCs. RESULTS: Investigation revealed acute intravascular hemolysis with a positive DAT due to anti-A(1) on her RBCs. The donor's titer of anti-A(1) was greater than 16,000. CONCLUSION: Review of published cases raises the possibility that hemolytic reactions to out-of-group platelets may be more frequent since the use of apheresis platelets has increased.

Adult↗

PubMed1981

[Microcirculation in alcoholics].

Conjunctival biomicroscopy was used to examine microcirculation in 221 males suffering from alcoholism. The control group consisted of 73 practically healthy males. Marked perivascular, vascular, and intravascular changes were revealed in the terminal blood flow system in all the alcoholics; these changes were found to progress, as the disease became graver. After 1.5- to 2-month antialcoholic treatment a distinct improvement of only perivascular disturbances was noted. Quantitative assessment of the microcirculation using the conjunctival indices can be taken for an additional criterion of diagnosis and specification of the alcoholism stage.

Adult↗

PubMed1992

Decreased platelet aggregation after reperfusion in orthotopic liver transplantation.

Increased blood loss is a major contributory factor to postoperative short- and longterm outcome in orthotopic liver transplantation (OLT). Hyperfibrinolysis, occurring mainly in the anhepatic phase, and disseminated intravascular coagulation (DIC), starting immediately after reperfusion, have been observed to parallel increased bleeding tendency. However, other factors may also contribute. For the first time we investigated platelet aggregation during the course of 10 OLTs and found a marked reduction of adenosine diphosphate-, collagen-, and ristocetin-induced platelet aggregation immediately after reperfusion. Since this is the point at which increased bleeding tendency is known to occur, it would seem that, apart from DIC and hyperfibrinolysis, an intermediate dysfunction of platelet aggregation may be a major cause of intraoperative bleeding.

Adenosine Diphosphate↗

PubMed2005

Graft-versus-host disease in severe combined immunodeficiency/beige mice administered canine leukocytes.

This report describes the development and lesions of graft-versus-host disease (GVHD) in severe combined immunodeficiency/ beige (SCID/BG) mice after the administration of canine leukocytes. Intraperitoneal injections of 0.87 x 10(7) canine lymphocytes were given to each of 9 mice; 5 mice received no canine lymphocytes. Morphologic evidence of successful engraftment included peritoneal aggregates of lymphocytes and repopulation of spleen and lymph nodes by lymphocytes. Canine CD45R was expressed by 2.25% of peripheral blood leukocytes in the 1 mouse tested 65 d after engraftment but by none of the cells of a control mouse. Canine immunoglobulin G was detected in serum samples from 5 of the 6 tested mice given canine lymphocytes but none of the control mice. By 13 to 65 d after receiving canine lymphocytes, 5 of the 9 mice had died of GVHD or had been euthanized because of it; all the control mice remained healthy. Lesions of GVHD included hemolytic anemia, cholangiohepatitis, alveolitis, and disseminated intravascular coagulation. Serum from the donor dog and from all 15 randomly selected dogs caused agglutination of normal mouse erythrocytes, supporting a diagnosis of immune-mediated hemolytic anemia in the dog-mouse chimeras. All of the mouse serum tested contained murine immunoglobulin, and this "leakiness" may have contributed to the development of GVHD.

Animals↗

PubMed1983

[Livedo reticularis: dermatologic alarm signal in cold agglutinin disease].

A hitherto healthy adult man developed paroxysmal cold agglutinin disease following an infection of the upper respiratory tract with mycoplasma pneumoniae. Despite continuous blood exchange he died of massive intravascular hemolysis and uremia after 5 days. A presenting striking symptom of this rapidly fatal disease was the acute onset of generalized livedo reticularis. The disease was caused by the rare anti Pr-cold agglutinins which are capable of eliciting hemolysis even in low titers and, in the present case, at body temperature.

Adult↗

PubMedDate not supplied

[A comparative evaluation of the effect of glurenorm and sulfonylurea preparations on the intravascular microcirculatory indices in type-II diabetes mellitus].

Analysis of the effects of glurenorm and some sulfonylurea drugs, such as maninil, minidiab, chlorpropamide, on some parameters of intravascular microcirculation has demonstrated the specific features of this drug. Though all these hypoglycemic agents favorably influence the microcirculation when carbohydrate metabolism compensation is attained, glurenorm improved the status of formed elements of the blood (red cell and platelet aggregation) more noticeably than the rest drugs, which fact recommends it as a drug of choice for patients with type II medium-severe diabetes with the predominant involvement of the cellular component of the microcirculation.

Adult↗

PubMedDate not supplied

[The clinical characteristics of the course of hypertension in patients with disorders of the rheological properties of the blood].

As many as 185 patients with stage I-III hypertensive disease were examined, their age ranging between 30 and 70 years. Investigation of rheologic properties of blood involved determination of hematocrit value, blood viscosity, aggregation of erythrocytes, platelets, content of fibrinogen, products of fibrin cleavage. It has been ascertained that in patients with stage I hypertensive disease, disorders of rheologic properties of blood are characterised by disturbances in the platelet link of the bloodflow, with the degree being dependent on the cerebral symptomatology; those in patients with stage II hypertensive disease were evidenced by high values for blood viscosity; as to stage III disease complicated by disordered cerebral bloodflow, the degree of rheologic abnormalities may characterize the course and outcome of the disease.

Adult↗

PubMed1981

Acute immune intravascular hemolysis due to hydrochlorothiazide.

Acute near-fatal intravascular hemolysis and renal failure developed in a patient after he had ingested 15 to 20 tablets of both methyldopa (Aldomet) nd hydrochlorothiazide (HydroDiuril). Serologic test results were inconsistent with those associated with methyldopa-induced hemolytic anemia and suggested that hemolysis was caused by hydrochlorothiazide antibodies reacting by an immune complex mechanism.

Acute Kidney Injury↗

PubMed1987

Acute inflammation and a Shwartzman-like reaction induced by interleukin-1 and tumor necrosis factor. Synergistic action of the cytokines in the induction of inflammation and microvascular injury.

A Shwartzman-like reaction was elicited in rabbits by preparing the skin with intradermal injections of recombinant human tumor necrosis factor alpha (TNF alpha) and recombinant human interleukin-1 (IL-1 alpha or beta). The animals were challenged intravenously with endotoxin or by intravascular activation of complement with immune complexes or zymosan 18 hours later and were sacrificed after another 2 hours. Animals challenged with saline did not develop Shwartzman-like reactions. The sites prepared with endotoxin or with either form of IL-1 plus TNF alpha developed visible hemorrhage, whereas sites injected with either IL-1 or TNF alpha alone did not. Hemorrhage and microthrombosis were quantitated with 59Fe-labeled erythrocytes and 111In-platelets for 2 hours after the intravenous challenge, and the findings confirmed the observations made on gross inspection. Dermal sites prepared with the cytokines and challenged intravenously with endotoxin, immune complexes, or zymosan exhibited some diffuse hemorrhage and an intense erythrocyte extravasation around distended vessels, along skin appendages, and the panniculus carnosus muscle. The lumens of many large and postcapillary venules contained aggregates of platelets and leukocytes. These changes were superimposed on those seen at prepared sites (leukocyte infiltration). By electron microscopy fibrin was demonstrable in association with the formed elements of the blood. Histologic examination of the 18-hour-old preparative lesions or 20-hour-old lesions of saline-"challenged" animals revealed accumulation of leukocytes in the dermis, predominantly neutrophils. This accumulation was sparse at sites treated with only IL-1 or TNF alpha, but very intense at sites treated with both IL-1 and TNF alpha or with endotoxin. These observations were confirmed quantitatively by measuring the accumulation of 51Cr-labeled neutrophils for 2 hours after injection. The potency of IL-1 alpha was comparable to that in our earlier report, and TNF alpha was about three log times less potent. Sites treated with both IL-1 alpha and TNF alpha resulted in 69% greater neutrophil emigration than the additive response elicited by each cytokine. The reported findings implicate a synergism between IL-1 and TNF alpha in the induction of both the inflammatory reaction (preceding the Shwartzman reaction) and the thrombohemorrhagic component of the Shwartzman reaction proper.

Acute Disease↗

PubMed1976

[Intravascular disorders of microcirculation and microthrombus formation in patients with chronic ischemic disease of the heart].

Most of the 104 patients with ischaemic heart disease had distinct functional and structural microcirculation disorders. The slugging syndrome was revealed in 98% of the cases. In 56% of the patients microthrombus formation was noted in the microcirculatory bed, as well as a reduction of the perfusion capillary blood flow and an increase of the shunting flow, the half-resorption of sodium-131I from the skin and muscle depot being decreased. A clear relationship is noticed between the intravascular microcirculatory disorders, the functional state of the erythrocytes and platelets, the increased coagulation potential of the blood, the appearance of components that indicate the possibility of a diffuse intravascular blood coagulation (fibrinogen B, products of fibrinogen and fibrin decomposition), the changes in lipid metabolism. Stasis of the blood flow with distinct signs of the slugging syndrome, microthrombosis, activation of the kallikrein-kinin system and increasing shunting flow were revealed in patient with a severe course of the disease. Criteria for a quantitative assessment of the noted changes were developed.

Adult↗

PubMed1992

The relationship between intracardiovascular smoke-like echo and erythrocyte rouleaux formation.

Intravascular smoke-like echo always appears in regions of stasis, but the exact mechanism of its production is unclear. We investigated its appearance in relation to erythrocyte rouleaux formation. To study this relationship we performed a series of in vitro and animal experiments. In the in vitro study, we observed an erythrocyte suspension by ultrasonography and found it to be echo-free. Under the microscope, red blood cells were observed in a dispersed state. If an equal amount of lymphocyte separation solution was added to the suspension, smoke-like echo appeared, and red blood cells were seen in a rouleaux pattern. In animal (mongrel dogs) experiments, under physiologic conditions with normal blood flow velocity, all cardiac cavities and the inferior vena cava were echo-free. When stasis was induced experimentally in the inferior vena cava, red blood cells aggregated to form rouleaux and smoke-like echo appeared. On resumption of normal blood flow, the rouleaux dispersed to form erythrocytes again. The mechanism of production of intracardiovascular smoke-like echo is closely related to the formation of erythrocyte rouleaux. When rouleaux are formed, they become larger and appear nearer or larger than the ultrasonic wavelength. Thus reflections are produced and smoke-like echo appears.

Animals↗