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At least 307 records · Page 17Linked to original sources
PubMed1984

Corticotropin-releasing factor (CRF)-like immunoreactivity in the gastro-entero-pancreatic endocrine system.

CRF has been detected in the endocrine pancreas by immunocytochemistry with an antiserum that recognizes mainly the C-terminal portion of CRF-41. CRF-containing cells have been shown to be present in the pancreas of representative species of fishes, amphibians, reptiles, birds, and mammals including man. Light and electron microscopic observations indicate that the CRF-containing cells in the endocrine pancreas are similar to glucagon (A) cells both in their morphology and distribution. Individual CRF-containing cells are also found scattered in the exocrine pancreas in all species studied. In addition, CRF-containing cells have been identified in the human, monkey, cat, and rat stomach and small intestine. Recent reports also indicate that CRF-like immunoreactivity is present in the circulating blood, the adrenal medulla, and the placenta. Finally, several peripheral (pancreas, stomach, colon, lung and thyroid) tumors which produced corticotropin-releasing substances have been described by others. Although the peripheral actions of CRF are not yet known, these observations indicate that it is widely distributed in peripheral tissues and it may also represent a new tumor marker.

Animals↗
PubMed1987

[Value of morphometry in the endocrine system of the kidneys].

Basing on the comparison of literature and own data on the morphofunctional analysis of the endocrine renal system (juxtaglomerular apparatus and interstitial medullary cells taken as an example) the necessity was shown to characterize first of all the changes occurring in the structures studied and to determine the stages of the pathologic process involved. Such an approach enables one to select the adequate method of quantitative analysis and to obtain reliable results. The significance of quantification is emphasized as an integral part of any morphologic study providing the performance of correction analysis with the identification of morphofunctional parallels.

Humans↗
PubMed1994

The pulmonary neuroepithelial endocrine system in the quail, Coturnix coturnix. Light- and electron-microscopical immunocytochemistry and morphology.

Despite extensive knowledge of the neuroepithelial endocrine (NEE) system in the lungs of species of various vertebrate classes, data on avians are limited. The present investigation deals with the light- and electron-microscopical immunocytochemistry and morphology of pulmonary NEE cells in the quail, Coturnix coturnix. Light-microscopically, serotonin immunoreactivity was detected in numerous solitary and clustered NEE cells located in the cilio-mucous epithelium of primary and secondary bronchi in adult as well as in newly hatched quails. Only in newly hatched quails could a small number of bombesin- and somatostatin-like immunoreactive NEE cells be demonstrated. Electron-microscopical morphology revealed that NEE cells contained dense-cored vesicles of a wide range of diameters and electron densities. Nearly all of the NEE cells were seen to rest on the basement membrane of the cilio-mucous epithelium, lacking direct contact with the luminal surface. Nerve varicosities or nerve endings, of both afferent and efferent morphological appearance, were found directly apposed to the basal portion of NEE cells, invaginating between NEE cells or between NEE cells and adjacent epithelial cells. Often, synaptic specializations could be recognized between NEE cells and nerve terminals. Electron-microscopical immunocytochemistry confirmed that the intraepithelial serotonin-containing cells correspond to the cells with NEE characteristics. Moreover, two types of NEE cells could be distinguished in newly hatched quail lungs. Both types showed serotonin immunoreactivity selectively distributed over the dense-cored vesicles, but somatostatin- and bombesin-like immunoreactivities were only noted in one of the NEE cell types and were never seen colocalized. Thus, the avian NEE system too, harbors at least three different bioactive substances and has a morphology comparable to that of mammals, reptiles and amphibians.

Animals↗