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At least 307 records · Page 17Linked to original sources
PubMed1983

[Treatments and diagnosis of lung cancer--field study results: report from japan lung cancer TNM classification committee].

The results of 4,931 lung cancer cases treated during 1970-72 were examined to evaluate the factors (especially N factors) influencing the prognosis of lung cancer. The background factors examined included T-factor, N-factor, M-factor, clinical stage, histological type, age and sex. The prognosis was also examined according to treatment method. The 5-year survival rate in the curative resection only group was 42.6%, in curative resection + chemotherapy 52.1%, and in curative resection + chemotherapy 52.1%, and 54.8%. The results suggest improved 5-year survival by multimodality treatment.

Adenocarcinoma↗
PubMed1971

Magnetic anisotropy and the orientation of retinal rods in a homogeneous magnetic field.

The reported orientation of retinal rods in a homogeneous magnetic field can be explained by the magnetic anisotropy of oriented molecules in the disc membranes of the rods. The energy of a single rod as a function of orientation in the magnetic field, the time required for alingment of the rod in a viscous medium, and the fluctuations of orientation are calculated. Arguments that rhodopsin is the constituent responsible for the effect are given. The possibility of orientation due to inhomogeneity of the magnetic field is ruled out. The application of magnetic anisotropy as an experimental tool in biology is indicated.

Animals↗
PubMed2006

Increased levels of inducible HSP70 in cells exposed to electromagnetic fields.

Because reports in the literature on the effects of electromagnetic fields (EMFs) on expression of the 70-kDa heat-shock protein (HSP70) are somewhat contradictory, we studied the influence of low-frequency EMFs on the accumulation of inducible HSP70 in several cell models. Some of the cell types tested showed increased levels of HSP70 protein when exposed for 24 h to 50 Hz, 680 microT EMFs. In endothelial cells, EMFs alone induced only a poor and transient activation of the heat-shock transcription factor 1 (HSF1); however, neither the level of HSP70 mRNA nor the synthesis of HSP70 appeared to be altered significantly. Accordingly, transfection experiments involving HSP70 promoter showed that gene transcription was not affected. We also noted a marked reduction in proteasome activities in cell extracts exposed to EMFs. Interestingly, the heat-shock-induced levels of HSP70 mRNA and protein were increased by a concomitant weak stressor like EMFs. Taken together, our results indicate that in EMF-exposed endothelial cells, HSP70 gene transcription and translation are unaffected; however, EMFs alone promoted accumulation of the inducible HSP70 protein, probably by increasing its stability, and it enhanced accumulation and translation of the heat-induced HSP70 mRNA when applied in concert with heat shock.

Animals↗
PubMed2005

Harmonic response of cellular membrane pumps to low frequency electric fields.

We report on harmonic generation by budding yeast cells in response to a sinusoidal electric field, which is seen to be minimal when the field amplitude is less than a threshold value. Surprisingly, sodium metavanadate, an inhibitor of P-type ATPases reportedly responsible for nonlinear response in yeast, reduces the threshold field amplitude, increasing harmonic generation at low amplitudes while reducing it at large amplitudes, whereas the addition of glucose dramatically increases the production of even harmonics. Finally, a simple model is proposed to interpret the observed behavior.

Adenosine Triphosphatases↗
PubMed2004

Pupillary anomaly masquerading as a glaucomatous visual field defect: a case report.

BACKGROUND: Patients are often referred to ophthalmologists with focal visual field defects on routine testing, possibly related to a potential diagnosis of glaucoma. However, examination of the individual patient's ocular characteristics as well as facial characteristics may often reveal a cause of the visual field defect. CASE PRESENTATION: We describe a patient who was found to have a superior visual field defect on routine testing by the optician. Repeat perimetry with pharmacological dilatation of the pupil revealed that the cause of the field defect was related to an eccentric inferiorly displaced pupil, secondary to trauma some years previously. DISCUSSION: Individual patient characteristics, including both ocular, as well as facial, need to be considered, when interpreting any visual field defect.

Aged↗
PubMed2002

Optical measurement of ultrasonic Poynting and velocity vector fields.

This report describes a method for estimating several wide bandwidth ultrasonic field parameters from optical measurements of the local, acoustically induced, refractive index perturbation in water. These parameters include Poynting and particle velocity vector fields as well as pressure and density fields at any temporal delay under mild (forward-propagating) assumptions on the angular plane-wave spectrum of the ultrasound field. A sampling theorem is derived stating that two complete measurements of the three-dimensional pressure field separated in time by delta t allow release of the forward-propagating assumption for every acoustic wave number k satisfying k not = n pi/(c delta t), where c is the acoustic wave speed in the medium and n an integer greater than zero. The approach provides detailed measurements of very general ultrasound fields. Two optical measurement methods that acquire the Radon transform of the three-dimensional refractive index perturbation are briefly reviewed. It is shown that the Radon transform of the field itself satisfies a two-dimensional wave equation and may be propagated independently forward or backward in time under a source-free model. Conversely, the Radon transform of the ultrasound field measurement at several known time delays provides a means of applying a filter to the data based on known ultrasound propagation models. Each two-dimensional distribution may be propagated to a common time point and the ensemble averaged, thus incorporating the propagation model into the measurement. We support the presented theory with several experiments.

Journal Article↗
PubMed1999

Backus and Gilbert method for vector fields.

This report describes the theory of Backus and Gilbert with special emphasis for the case of vector fields as required for the solution of the electromagnetic inverse problem. A description of the method is presented with the detailed mathematical derivation of the coefficients that determine the solution for the retrieval of vector fields. Such derivation, to our knowledge, has never been reported in the literature. We also identify some crucial points that can (and had) lead to misuse of this solution and describe some disadvantages of this theory for the case of vector fields suggesting some alternatives to deal with them.

Brain Mapping↗
PubMed2004

Unified univariate and multivariate random field theory.

We report new random field theory P values for peaks of canonical correlation SPMs for detecting multiple contrasts in a linear model for multivariate image data. This completes results for all types of univariate and multivariate image data analysis. All other known univariate and multivariate random field theory results are now special cases, so these new results present a true unification of all currently known results. As an illustration, we use these results in a deformation-based morphometry (DBM) analysis to look for regions of the brain where vector deformations of nonmissile trauma patients are related to several verbal memory scores, to detect regions of changes in anatomical effective connectivity between the trauma patients and a group of age- and sex-matched controls, and to look for anatomical connectivity in cortical thickness.

Adult↗
PubMed1977

The macrophage electrophoretic mobility (MEM) test for the diagnosis of hydatidiform mole and choriocarcinoma. Preliminary report.

In 1970, Field and Caspary reported that lymphocytes from patients with malignant disease can be stimulated by a basic protein from human brain (human encephalitogenic protein--HEP). The stimulated lymphocytes are capable of releasing the macrophage-slowing factor, which reduces the electrophoretic mobility of guinea-pig macrophages. In general, this effect was not found with lymphocytes from patients without malignant disease. This paper deals with the application of the MEM test using HEP and HCG as antigen in the diagnosis of trophoblastic disease. We have found cellular sensitization against HCG in all patients with gestational trophoblastic tumours and against HEP in patients with hydatidiform moles of the group II or III as well as choriocarcinoma. Patients with malignant tumours of different localization showed a cellular sensitization against HEP, but only some against HCG. In pregnant women no cellular sensitization against HEP as well as HCG was detected. The results of the MEM test using HEP as antigen in patients with gestational trophoblastic tumours are compared with the clinical findings and the histological diagnosis. By means of this combination a more exact evaluation of the biological activity of the trophoblastic disease was obtained.

Adult↗