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At least 307 records · Page 17Linked to original sources
PubMed2006

Transmembrane helix heterodimerization in lipid bilayers: probing the energetics behind autosomal dominant growth disorders.

Here, we show that the energetics of transmembrane helix heterodimer formation can be characterized in liposomes using Förster resonance energy transfer (FRET). We present the theory and the protocol for measuring the free energy of heterodimerization, and the total (hetero and homo-dimeric) dimer fraction. We use the presented methodology to determine the propensity for heterodimer formation between wild-type fibroblast growth factor receptor 3 (FGFR3) transmembrane domain and the Ala391Glu mutant, linked to Crouzon syndrome with acanthosis nigricans.

Acanthosis Nigricans↗
PubMed1980

[Vitamin D in the prevention of growth disorders].

A recent therapeutic development consists in the utilization of vitamins as pharmacological agents in the treatment of a variety of diseases. The growth defect accompanying deficiency rickets and other forms of refractory rickets can be prevented or corrected, at least partially, by the use of high doses of its metabolites, 25 OH D3, 1,25 (OH)2 D3, 1 OH D3. On the basis of many published studies and of a few patients personally observed it is possible to delineate the form and the dosage of these drugs for the treatment of vitamin D dependent rickets and of the bone lesions in renal insufficiency, in familial hypophosphatemic rickets and in complex tubulopaties. In some of these a dietetic treatment in association with vitamin D or its metabolites may be essential.

Adolescent↗
PubMed1987

[Changes in the mast cell content of the lamina propria mucosa of the small intestine in enteral-induced growth disorders in childhood].

Duodenal jejeunal biopsy material from children with growth retardation due to enteric disease was investigated. The disease dependent mucosa types were classified into three groups according to Shmerling (1970). Mucosa types and established histological alterations can be correlated. Toluidine blue staining sections were analyzed morphometrically by light microscopy to study changes in the mucosal mast cells. The mast cell content in specimens with subtotal villal atrophy (type III) was reduced significantly compared to normal mucosa (type I).

Antigen-Presenting Cells↗
PubMed1990

The phakomatoses as paracrine growth disorders (paracinopathies).

A microcomputer database management system retrieved all 170 probands with phakomatoses evaluated through the genetic clinics at the University of South Florida between January 2, 1982 and December 31, 1987. Neurofibromatosis (NF) was the diagnosis of 118 of them; 42 had other phakomatoses and 10 had transitional phenotypes difficult to classify. The analysis of the hamartomas of all probands indicated disorganized differentiation and overgrowth of cell species characteristic for the involved tissue and location. Abundance of extracellular fibrillary components was also evident in most hamartomas. Adequate blood supply was a conditio sine qua non. This was seen in monogenic, sporadic, transitional and combined phakomatoses alike and implied a common pathogenesis. The paracrine growth factors and their regulation emerged as the most plausible common denominator for the pathogenesis. A unitary pathogenetic hypothesis is proposed that the phakomatoses represent paracrine growth regulation disorders (paracrinopathies). Conditions such as fibromatoses, lipomatoses, lipodystrophies, hemihyper/hypotrophies, including Russell-Silver and Beckwith-Wiedemann syndromes may be proven to be paracrinopathies as well.

Dysplastic Nevus Syndrome↗