On the paw oedema resulting from subcutaneous injection of histamine liberators in the rat.
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After rapid gelatin infusion in many cases a release of relatively small amounts of histamine was observed. Clinical symptoms occured in 5 cases in correspondence to the increased histamine levels, but were relatively harmless. The application of dextran 60 induced anaphylactoid reactions in 2 persons, with death in one case. Plasma histamine level were normal in both cases. Histamine release probably is not the cause of dextrn induced anaphylactoid reactions.
The ulcer-protective effect of cimetidine has been compared with that of an antacid (Solugastril) containing aluminium hydroxide and calcium carbonate. Ulcers have been produced by using dialysis sacks containing histamine. This model corresponds to stress ulcers observed in risk patients. Both cimetidine and the antacid were capable of inhibiting the ulcer development in corresponding doses and applications: The present results show that an antacid might be qualified for the treatment of stress ulcers in the human therapy.
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