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Long-term memory for elementary visual percepts: memory psychophysics of context and acquisition effects.

In the first phase of each of two experiments, participants learned to associate a set of labels (i.e., consonant-vowel-consonant [CVC]) with a set of line lengths by using a paired-associate learning procedure. In the second phase of each experiment, these learned labels were used as memorial standards in the method of constant stimuli. Psychometric functions and the associated indices of discriminative performance (i.e., Weber fractions [WFs], just noticeable difference, and point of subjective equality) were then obtained for the remembered standards. In Experiment 1, WFs (i.e., the indices of memory precision) obtained with remembered standards were found to be higher (i.e., had poorer discriminability) than were WFs obtained with perceptual standards. In addition, WFs obtained with the remembered standards exhibited serial position effects (i.e., poorer discriminability for central items in the memory ensemble) and systematically varied with set size (i.e., the number of standards in the memory set), but WFs obtained with perceptual standards did not depend on serial position or set size. In Experiment 2, increasing the number of acquisition trials reduced WFs and diminished serial position effects. In addition, WFs did not vary systematically with the "physical" spacing between the standards in memory, but they did with the ordinal spacing. The results are consistent with a noisy analogue representation of remembered magnitudes, whereby central items in a memory ensemble are subject to lateral inhibition and thus reduced discriminability. Finally, presentation order effects, as defined by the classic time-order error, were observed with purely perceptual comparisons but not with comparisons involving a remembered standard. This latter finding is inconsistent with a strong form of the functional equivalence view of perception and memory.

Humans↗

Support for a continuous (single-process) model of recognition memory and source memory.

Does memory retrieval occur in a continuous or an all-or-none manner? The shape of the receiver operating characteristic (ROC) has been used to answer this question, with curvilinear and linear memory ROCs indicating continuous and all-or-none retrieval processes, respectively. Signal detection models (e.g., the unequal variance model) correspond to a continuous retrieval process, whereas threshold models (including the multinomial model and the recollection component of the dual-process model) correspond to an all-or-none process. In studies of source memory, Slotnick et al. (2000) and others have observed curvilinear ROCs (supporting the unequal variance model), whereas Yonelinas (1999) observed linear ROCs (supporting the dual-process model). We resolve these seemingly inconsistent results, showing that source memory ROCs are naturally curvilinear but can appear linear when nondiagnostic source information is included in the analysis. Furthermore, the unequal variance model accounted for both recognition memory and source memory ROCs, supporting a continuous process of memory retrieval.

Humans↗

A pool of central memory-like CD4 T cells contains effector memory precursors.

The L51S mutation in the D10.G4.1 TCR alpha-chain reduces the affinity of the TCR to its ligand by affecting the interactions among the TCR, the beta-chain of I-A(k), and the bound peptide. We show that this mutation drives the generation of a pool of memory CD44(high)CD62L(neg)CD45RB(neg) CD4 TCR transgenic T cells. Their activation threshold is low, such that they proliferate in response to lower concentrations of agonist peptides than naive L51S CD4 T cells. Unlike effector memory CD4 T cells, however, they lack immediate effector function in response to TCR stimulation. These cells express IL-2R alpha only after culture with specific peptide. Although they can be recovered from lymph nodes, the majority lack the expression of the lymph node homing receptor CCR7. When these cells receive a second TCR stimulation in vitro, they differentiate into potent Th2-like effector cells, producing high levels of IL-4 at doses of agonist peptide too low to stimulate cytokine release from similarly differentiated naive L51S CD4 T cells. Having these properties, the L51S TCR transgenic memory CD4 T cells cannot be classified as either strict central memory or effector memory, but, rather, as a pool of memory T cells containing effector memory precursors.

Amino Acid Substitution↗

Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance.

BDNF plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. A frequent single nucleotide polymorphism in the targeting region of the human BDNF gene (val66met) has been associated with abnormal intracellular trafficking and regulated secretion of BDNF in cultured hippocampal neurons transfected with the met allele. In addition, the met allele has been associated with abnormal hippocampal neuronal function as well as impaired episodic memory in human subjects, but a direct effect of BDNF alleles on hippocampal processing of memory has not been demonstrated. We studied the relationship of the BDNF val66met genotype and hippocampal activity during episodic memory processing using blood oxygenation level-dependent functional magnetic resonance imaging and a declarative memory task in healthy individuals. Met carriers exhibited relatively diminished hippocampal engagement in comparison with val homozygotes during both encoding and retrieval processes. Remarkably, the interaction between the BDNF val66met genotype and the hippocampal response during encoding accounted for 25% of the total variation in recognition memory performance. These data implicate a specific genetic mechanism for substantial normal variation in human declarative memory and suggest that the basic effects of BDNF signaling on hippocampal function in experimental animals are important in humans.

Adult↗

Studies on B-cell memory. III. T-dependent aspect of B memory generation in mice immunized with T-independent type-2(TI-2) antigen.

The time course of B-cell memory development to a dinitrophenyl (DNP) T-independent type-2 (TI-2) antigen was investigated by adoptive cell transfer. Strong IgM and IgG memory developed in BALB/c mice after immunization with DNP-dextran, to be recalled by challenge with either T-dependent (TD) antigen or TI-2 antigen. However, only weak IgM memory and very feeble IgG memory were detected in athymic nude mice receiving the same immunization as euthymic mice. Once memory was established under probable T cell influence, its recall by TI-2 antigen challenge seemed independent of T cell help and did not require sharing of carriers between priming and challenge antigens. The following may be concluded. (i) Long-term IgM and IgG memory is induced by TI-2 antigen priming in the presence of functional T cells. (ii) The class switch from IgM to IgG in the memory B cell pool is driven effectively by TI-2 antigen and is probably T cell-dependent.

Animals↗

Immunological memory to Listeria monocytogenes in rodents. IV. Studies on origin and fate of tissue-positioned T memory cells.

In this report on memory T cells mediating anti-microbial resistance to Listeria monocytogenes (LM) it was analysed whether memory cells found in tissue during late-phase (e.g. 10-60 days after infection) are long-lived progeny of cells which settled in tissues during early phase (e.g. 4-10 days after infection), or whether they are short lived but constantly replaced from other sources of memory cells. The study provides evidence for both mechanisms. Transfer and parabiosis experiments as well as radiometric and autoradiographic studies suggested that early-phase cells give rise to late-phase memory cells in the extravascular compartment. These memory cells were shown to mediate resistance and respond to antigen in vitro. Mediators of resistance in the unstimulated peritoneal cavity during late-phase are long-lived. On the other hand, parabiosis studies suggested that late-phase resident peritoneal cells which mediate resistance and respond to antigen in vitro have in part arrived after the end of early phase. Such cells are found in low numbers in central lymph during late-phase. The simplest interpretation of these data is that LM-specific lymphoblasts spontaneously extravasate and settle in tissues as long-lived memory cells. Since the numbers of LM-specific lymphoblasts released from lymphoid tissue is highest during early phase, the majority of resident memory cells are progeny of early-phase lymphoblasts.

Animals↗

Enhanced hippocampal corticotropin-releasing factor gene expression associated with memory consolidation and memory storage in rats.

Corticotropin-releasing factor (CRF) has been found to play an important role in modulating the learning and memory processes in rats. In the present study, we examined the alteration of CRF mRNA level in rat hippocampus at different stages of the memory process. Results indicated that CRF mRNA is quite homogenously distributed within subdivisions of the hippocampus, with the dentate gyrus (DG) has a relatively lower expression level. By using the one-way inhibitory avoidance learning paradigm, we have selected the good memory (GM) rats (with a retention score of 600) and the poor memory (PM) rats (with retention scores < 80). Results indicated that CRF mRNA level in the hippocampus was significantly increased in GM rats when compared with that in the PM rats at 1 hr, 3 hr and 6 hr after training. It was not markedly altered at 24 hr and 72 hr post-training. However, it was again increased at 21 days post-training in both the hippocampus and the frontal cortex. Further, this effect was demonstrated not to be associated with the acute footshock stress. These results together suggest that enhanced hippocampal CRF gene expression is probably associated with both memory consolidation and memory storage, but is not associated with maintenance of formed memory in rats.

Animals↗

[Japanese version of the Short-Memory Questionnaire: memory evaluation in Alzheimer's disease].

BACKGROUND AND PURPOSE: Memory deficit is a common sign of Alzheimer's disease (AD), which appeared generally in the early stage of the disease. Therefore, evaluation of memory is important for management of patients and for clinical research of AD. The Short-Memory Questionnaire (SMQ), an easily administered, informant-based scale, which was developed by Koss et al. (1993), is a standardized, validated, and reliable tool to assess everyday memory problems. In the present study, we prepared a Japanese version of the SMQ and examined its reliability and validity in assessing AD patients. SUBJECTS AND METHODS: The subjects consisted of 42 patients with NINCDS-ADRDA probable AD whose diagnosis was made on the basis of the results of comprehensive examinations including cranial CT/MRI and SPECT and age- and education-matched 53 healthy controls. Patients had no history of stroke, head injury, or any other prior neurological events. Patients and controls were between the ages of 51 and 90 years, and they had from 6 to 16 years education. The Japanese version of the SMQ was given to a family member by either neuropsychiatrist, public nurse or case worker. To evaluate test-retest reliability of the test, interview was repeated in 16 randomly selected patients by two different examiners (neuropsychiatrist and another) in two weeks interval. The Mini-Mental State Examination (MMSE) was used to assess the severity of cognitive impairment. RESULT: The test-retest reliability was acceptably high with intraclass correlation coefficients. There was a high correlation between scores of SMQ and MMSE. The SMQ had excellent specificity and sensitivity in discriminating patients from controls. Caregiver appraisals of memory deficits significantly correlated with generalized cognitive dysfunction. CONCLUSIONS: Similarly to the original version, the present Japanese version of the SMQ is a reliable and valid tool in assessing memory function in AD, which can be effectively used in clinical settings and epidemiologic studies to screen out persons with memory problems.

Aged↗

Short-term memory impairments in Alzheimer-type dementia: evidence for separable impairments of articulatory rehearsal and long-term memory.

Two experiments are described which investigate the short-term memory deficits found in Alzheimer-type dementia. In the first experiment memory span for words of differing spoken duration is related to speech rate. Memory span was lower in subjects suffering from Alzheimer-type dementia than for normal elderly controls but in both cases a linear function related recall to speech rate for items of differing spoken durations. The function for Alzheimer subjects had an equivalent slope (interpreted as reflecting a contribution from a sub-vocal rehearsal process) but a lower intercept (interpreted as reflecting a contribution from a long-term memory component). The second experiment investigated the effects of repeating supra-span lists of items in a serial recall task. As predicted the control subjects showed substantial increases in recall across trials associated with elevations of the speech rate/recall functions while the Alzheimer subjects showed very little benefit from repetition of the lists. We conclude that the verbal short-term memory deficit found in Alzheimer-type dementia has two components: a deficit in the rate of rehearsal and an impairment in the long-term memory component of short-term recall.

Aged↗

Are rape memories different? A comparison of rape, other unpleasant, and pleasant memories among employed women.

The study examined empirically-measured memory characteristics, compared pleasant and unpleasant intense memories as well as rape and other unpleasant memories, and determined whether rape memories exhibited significantly more "flashbulb" characteristics. Data consisted of responses to a mailed survey of women employees of a medical center (N = 1,037) and a university (N = 2,142). Pleasant and unpleasant memories were differentiated by feelings, consequences, and level of unexpectedness. The most powerful discriminator of rape from other unpleasant memories was the degree to which they were less clear and vivid, contained a less meaningful order, were less well-remembered, and were less thought and talked about. Few "flashbulb" characteristics discriminated among memory types. Implications for clinical work with rape survivors were discussed.

Adolescent↗

Distinct patterns of regeneration of central memory, effector memory and effector TCD8+ cell subsets after different hematopoietic cell transplant types: possible influence in the recovery of anti-cytomegalovirus immune response and risk for its reactivation.

TCD8+ cells may be divided into subsets with different phenotypes and functions: naive, central memory, effector memory and effector. Aiming to better understand the differences in early reconstitution of these TCD8+ cell subsets and their relationship with post-transplant anti-cytomegalovirus (CMV) immune responses recovery, we prospectively analyzed the transfer and expansion of these subsets in different transplant types. We found that graft cells from donor's peripheral blood, either allogeneic or autologous, were enriched for central memory, effector memory and effector phenotypes compared to allogeneic bone marrow grafts, as assessed by surface markers phenotyping and granzyme B expression. However, post-transplant, these subsets expanded in autologous recipients only, reaching numbers much greater than in allo-recipients at days +29 and +96. At the same time, autologous recipients presented less CMV reactivation and more vigorous CMV-induced interferon-gamma and lymphoproliferative responses. The marked loss of allo-transferred memory TCD8+ cells was probably due to the fact that they were more activated and more prone to apoptosis than auto-transferred TCD8+ cells as assessed by CD69 and active caspase 3 expression. Thus, transfer of peripheral blood stem cells in the allogeneic but not autologous setting is associated with poor expansion of memory TCD8+ cells, probably delaying antiviral immune reconstitution. These data may have important implications for the design of better strategies to immunoprotect this population against infectious challenges since different transplant types have different potentials for memory TCD8+ cells transfer and expansion.

Adult↗

Memory and memory confidence in obsessive-compulsive disorder.

Pathological doubt, often found in individuals with obsessive-compulsive disorder (OCD), has been theoretically linked to memory deficits, but empirical evidence for such deficits has been mixed. In contrast, many studies suggest that individuals with OCD have low confidence in their memories. The present study aimed to build upon previous research by measuring memory accuracy and confidence in OCD using ecologically valid, idiographically-selected stimuli. Individuals with OCD (OCs), anxious controls (ACs), and nonanxious controls (NACs) were exposed to a set of objects that the OCs had identified as safe, unsafe, or neutral. Participants were then asked to recall as many objects as possible and to rate their confidence in each memory. This process was repeated 6 times, using the same stimuli for each trial. Contrary to hypothesis, no group differences emerged in memory accuracy. However, OCs' memory confidence for unsafe objects showed a progressive decline over repeated trials. This pattern was not observed among NACs or ACs. Furthermore, OCs with primary checking reported lower confidence in long-term memory than did OCs without primary checking. These results suggest that when OCs are repeatedly exposed to threat-related stimuli (such as repeated checking), their level of confidence in remembering these stimuli paradoxically decreases.

Adult↗

Lateralization of spatial-memory processes: evidence on spatial span, maze learning, and memory for object locations.

Spatial memory is one of the most important cognitive functions in daily life, enabling us to locate objects in our environment or to learn a route or a path. In the present study, we elaborated on the hypothesis that human spatial memory consists of multiple sub-processes, relying on different brain structures. Therefore, 50 patients with an ischemic stroke and 40 healthy participants underwent tests measuring spatial span and maze learning. By means of a computer paradigm the following aspects of memory for object locations were assessed: (1) object location binding; (2) positional memory; (3) a combination of these two aspects. The results clearly showed a double dissociation: the group of patients with an infarct in the left hemisphere (LH) was impaired on object location binding, whereas the group with an infarct in the right hemisphere (RH) was impaired on positional memory. Lesions in the RH resulted also in impairments on maze learning. Moreover, patients with lesions in the posterior part of the parietal or the occipital lobe performed especially worse on spatial-memory tasks. These findings extend the theoretical framework of categorical versus coordinate spatial processing in the human brain and corroborate previous findings on selective aspects of memory for object locations.

Adult↗

Vasopressin and memory. II. Lesions to the hippocampus block the memory enhancing effects of AVP4-9 in the radial maze.

Previous work has shown that the arginine vasopressin fragment AVP4-9 enhanced overall performance in the radial arm maze. This enhancement effect was due to improved working memory as well as to improved reference memory. The present study uses a behavioral approach to investigate whether these effects of vasopressin on memory are mediated by the hippocampus. Animals received either NMDA lesions to the hippocampus or sham operations and were then treated with AVP4-9 or saline. The testing was performed in an eight-arm radial maze for 60 sessions, and all injections were given s.c. 30 min prior to testing. The hippocampal lesioned animals showed a marked deficit in working memory that was not ameliorated by AVP4-9; however, the improvement in reference memory produced by the compound was as large as in healthy animals. Since the AVP treatment did not differentiate between the two hippocampal groups, the memory enhancing effects of AVP4-9 were blocked by hippocampal lesions. It is concluded that vasopressin has a more general effect on memory and that its site of action includes but is not limited to the hippocampus.

Animals↗

Two weeks of transdermal estradiol treatment in postmenopausal elderly women and its effect on memory and mood: verbal memory changes are associated with the treatment induced estradiol levels.

The present randomized double blind study investigated the effects of a 2 week transdermal estradiol treatment on memory performance in 38 healthy elderly women. Cognitive performance was tested at baseline and after 2 weeks of estradiol or placebo treatment using verbal, semantic, and spatial memory tests as well as a mental rotation task and the Stroop. Initial results showed no differences after treatment between placebo or estradiol treated subjects. However, within treatment group analysis revealed that estradiol treated subjects who reached higher estradiol levels (larger than 29 pg/ml) performed significantly better after treatment in the delayed recall of the paired associate test (verbal memory) than subjects who reached lower estradiol levels (P < 0.05). A nonsignificant trend was observed for the immediate recall condition (P < 0.10). These findings were strengthened by correlations between treatment-induced estradiol levels and changes in verbal memory performance. In addition, there was an association between estradiol levels and mood changes. However mood changes were not significantly associated with changes in verbal memory performance (P > 0.20). The present study supports the idea that estradiol replacement has specific effects on verbal memory in healthy postmenopausal women, with delayed recall being more affected. It suggests that these effects can occur relatively rapidly, and that there may be a dose response relationship of estradiol to memory enhancement. Furthermore, the fact that these results were obtained in women who had been menopausal for an average of 17 years before entering the study indicates that the brain maintains a sensitivity for estrogens even after years of low estradiol plasma concentrations.

Administration, Cutaneous↗

Effects of memory training on the subjective memory functioning and mental health of older adults: a meta-analysis.

The effectiveness of memory training on the subjective memory functioning and mental health of older adults was examined in a meta-analysis. Effect sizes indicated that memory training led to improved subjective memory functioning (d+2 = .19), but the magnitude of the improvement was less than that obtained on objective memory measures (d+2 = .66) in the meta-analysis of P. Verhaeghen, A. Marcoen, and L. Goossens (1992). However, no differences in effectiveness were found among mnemonic training, expectancy modification, or placebo procedures such as unstructured practice. Improvement of subjective memory functioning was enhanced by including pretraining in skills such as the use of imagery and by including interventions to improve participants' attitudes toward the effects of aging on memory functioning.

Adaptation, Psychological↗

Correlates of memory decline: a 4-year longitudinal study of older adults with memory complaints.

Change in memory performance and its correspondence to change in speed of performance and self-reported memory functioning were investigated longitudinally in 30 older adults with memory complaints. Subjects were assessed by self-report questionnaires and cognitive tests 3 times, at near 2-year intervals. A significant decline in word-recall scores was found, which was accompanied at the group level by significant self-reported decline in everyday memory functioning and nonsignificant decline in Wechsler Adult Intelligence Scale Digit Symbol scores (alpha = .05). The oldest subjects showed the most substantial declines in memory performance. At the individual level, however, memory change did not significantly correlate with either change in self-reports or change in Digit Symbol scores. Although these results do not support a cognitive slowing model of decline at the intraindividual level, they do have implications for intervention of age-related memory decline.

Aged↗

Memory independence and memory interference in cognitive development.

Recent experiments have established the surprising fact that age improvements in reasoning are often dissociated from improvements in memory for determinative informational inputs. Fuzzy-trace theory explains this memory-independence effect on the grounds that reasoning operations do not directly access verbatim traces of critical background information but, rather, process gist that was retrieved and edited in parallel with the encoding of such information. This explanation also envisions 2 ways in which children's memory and reasoning might be mutually interfering: (a) memory-to-reasoning interference, a tendency to process verbatim traces of background inputs on both memory probes and reasoning problems that simultaneously improves memory performance and impairs reasoning, and (b) reasoning-to-memory interference, a tendency for reasoning activities that produce problem solutions to erase or reduce the distinctiveness of verbatim traces of background inputs. Both forms of interference were detected in studies of children's story inferences.

Attention↗