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Numbers of metrial gland cells in the placental labyrinth of congenic resistant and inbred strains of mice, with observations on the size of the labyrinth.

The size of the placental labyrinth and the number of metrial gland cells in it were investigated, from the eleventh to the sixteenth day of gestation, in C57BL/10Sn, B10.A/SgSn, SWR/J and DBA/2J isogenic matings and C57BL/10Sn X B10.A/SgSn and B10.A/SgSn X C57BL/10Sn congenic matings. It was found that both H-2 disparity between mother and conceptus and some other strain-specific trait under genetic control influence the size of the placental labyrinth, while the number of labyrinthine metrial gland cells is affected only by the strain-specific trait.

Animal Husbandry↗

Uterine and cytoplasmic effects on pup eyelid opening in two inbred strains of mice.

Age at Eyelid Opening (AEO) differs in two inbred strains of laboratory mice: NZB and CBA/H. Ovarian transplantation and fostering methods were employed to test for variation of genotypic expression in different environments. (1) A global maternal effect was demonstrated for AEO in parental and F1 pups. (2) AEO of H and N pups is not affected by the parental vs. F1 modification of post-natal maternal environment. (3) The genotype of the mother, via uterine environment, interacts with pup genotype: only the CBA/H strain reacts to the parental vs. F1 modification in uterine environment. (4) A cytoplasmic effect for AEO was successfully replicated. Additional analyses demonstrate that AEO is not cytoplasmically inherited but rather modulated by the cytoplasmic environment.

Aging↗