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[The effect of quercetin on the metabolic processes in combined body exposure to hypoxia and hyperthermia].

Quercetin given in a dose of 100 mg/kg 3 hours before acute systemic hypoxia (10 ob%) combined with hyperthermia (43 degrees C) has been demonstrated to prevent a drastic activation of lipid peroxidation and arachidonic acid metabolism parallel to a marked decrease the activity of the body's antioxidative and detoxifying systems under the conditions studied. The pronounced pharmacotherapeutical effects was due to its antioxidative and antilipooxygenase activities and its ability to induce the hepatic monooxygenase system.

Acute Disease↗
PubMed1977

[Contractile function of the heart and its reactivity to noradrenaline in the process of the bodies adaptation to moderate altitudes].

In acute experiments on rats adapted for 4 weeks to the altitude of 2100 m it was found that at the early period of altitude adaptation the left ventricular systolic pressure and the maximal rates of pressure rise and fall considerably exceeded the values of control tests conducted in Moscow. Later on the parameters of the cardiac contractile function stabilized gradually. In 4 weeks the heart of adapted animals showed a greater increment of the contractility parameters in response to noradrenaline injection and a higher stability of the contractile function at very high heart rates.

Adaptation, Physiological↗
PubMed1980

[Significance of multivesicular bodies in synthetic cell processes].

Phosphatase-positive and -negative multivesicular bodies (mvb) are discernable by ultrastructural and ultracytochemical findings. The phosphatase-negative mvb are actually not considered to belong to the group of lysosomes. Because, they are obviously involved in synthesizing the cell-specific lamellated bodies (i.e. multilamellated bodies of type II alveolarepithelium cells, keratinosomes, praemelanosomes). By studying the literature about ultrastructural findings in tumors we found that mvb are generally increased in number in tumor cells. The changes in structure of the tumor cell membrane might be interpreted in a way that the synthesizing ability of mvb would generally provide phospholipoproteins to adjust a structural steady state of cell membranes. Our findings suggest that the synthetical activities of the mvb are coupled with multi-enzyme complexes of the vesicle membranes. Obviously, these membranes originate fro the Golgi-apparatus being closely related to the smooth endoplasmic reticulum.

Animals↗
PubMed1983

Pericentriolar processes of photoreceptor cell basal bodies in the mammalian retina.

Pericentriolar processes (arm-like fibers) of the migrating centrioles (diplosome) in differentiating retinal photoreceptor cells were examined in six mammalian species (hamster, vole, rat, rabbit, ferret, cat). These processes emanate in a radial fashion from one end of the centrioles comprising the photoreceptor diplosome. The pericentriolar processes of the basal body are first observed as the diplosome migrates toward the apical plasmalemma, suggesting that centrioles are committed early-on to developing such processes. One pericentriolar process arises from each set of microtubular triplets comprising the centriole and are apicoexternally oriented at an angle of between 30 and 60 degrees with the centriolar axis. Prior to the arrival of one of the centrioles at the apical plasmalemma these processes connect with an electron-dense portion of a centriole-associated vacuole. The diplosome migrates to the apical plasmalemma where one centriole (the presumptive basal body) orients perpendicularly to the apical plasmalemma. The centriole-associated vacuole appears to fuse with the plasmalemma. The pericentriolar processes appear to attach to this fusion site on the plasmalemma which is a region of the membrane characterized by increased electron density (the basilar plate). Invagination of the apical membrane, which occurs at this same site, is accompanied by a lengthening of the microtubules forming a cilium and is observed as an outpouching of the plasmalemma within the aforementioned invagination. The associated vacuole apparently becomes continuous with the apical plasmalemma. These pericentriolar processes appear to be functionally involved in ciliogenesis and offer structural stability between the basal body, the plasmalemma and indirectly the cilium.

Animals↗
PubMed2004

Endoscopic assistance in the removal of a foreign body in the condylar process.

This case report describes the application of the endoscopic technique in the removal of a metallic foreign body in the condylar process in an 81-year-old man. The patient's history indicated 60 years of pain in the left preauricular region as well as complaints of localized headaches. Physical examination revealed multiple scars on the patient's left preauricular region. No limitation of mandibular movement and no joint clicking were detected. Maximal mouth opening was 45 mm. According to the patient, masticatory function was normal. Digital palpation of the temporomandibular joint did not produce pain. Radiographic diagnosis was performed, which showed a pointed metallic foreign body lodged in the left condylar process. The removal of the foreign body was performed under endoscopic visualization via an intraoral approach. A 30 degrees-angled 4-mm diameter endoscope (Karl Storz, Tuttlingen, Germany) with a xenon light source was used.

Aged↗
PubMed2001

Fractures of the posterior part of the body and unilateral spinous process of the axis: a case report.

STUDY DESIGN: A case report and review of the literature. OBJECTIVES: To present a case of the fractures of the posterior part of the body and unilateral spinous process of the axis. SUMMARY OF BACKGROUND DATA: A few authors have described fractures involving the body of the axis. Fractures of the posterior part of the body and unilateral spinous process of the axis are extremely rare. METHODS: A fracture of the posterior part of the body and unilateral spinous process was treated nonsurgically by a halo and a Philadelphia brace. The relevant literature was reviewed. RESULTS: Solid bony union was shown by plain radiographs and computed tomography. The patient was free of pain and obtained a full range of motion. CONCLUSION: The presumed mechanism of injury in the fracture described here was flexion and axial rotation.

Aged↗
PubMed2005

Insights into the preparation of supported catalysts: a spatially resolved Raman and UV-Vis spectroscopic study into the drying process of CoMo/gamma-Al2O3 catalyst bodies.

Spatially resolved Raman and UV-vis-NIR microspectroscopy have been used as tools to study the preparation process of supported catalyst bodies. Detailed spectroscopic information on the local coordination geometry of two different metallic species along with their macro-distribution over the catalyst body has been obtained, enabling a good understanding of the physicochemical processes occurring during the drying process of impregnated gamma-Al(2)O(3) bodies. The formation and decomposition of the Keggin-type complex H(x)PMo(11)CoO(40)((7-)(x)-), which is considered to be a potential precursor for CoMoS(2)/gamma-Al(2)O(3) HDS catalysts, inside gamma-Al(2)O(3) bodies is shown to be a function of the composition of the impregnation solutions, the aging time, and the drying conditions applied. This knowledge has been successfully applied to prepare samples with a well-defined distribution of the bimetallic complex, that is, either egg-shell, egg-yolk, or homogeneous distributions. The Raman results are presented in a semiquantitative way by subtraction of a reference spectrum of a sample containing a known amount of H(x)PMo(11)CoO(40)((7-)(x)-) from the spectra recorded along the cross-section of the catalyst bodies.

Journal Article↗
PubMed1984

Plasma responses of pancreatic polypeptide, glucagon and insulin in normal and alloxan diabetic dogs, and their regional levels in the pancreas.

The plasma responses of pancreatic polypeptide (PP), glucagon (IRG) and insulin (IRI) after administration of beef soup were studied in normal and alloxan diabetic dogs kept in a poor metabolic state for 4 weeks, and their regional levels in the pancreas were determined and compared at the uncinate process, head, body and tail. The plasma PP levels of the diabetic dogs were significantly higher than those of the normal dogs and they increased after beef soup administration in both groups. The plasma IRG levels did not change significantly after beef soup administration in either group, but significantly high levels were found in the diabetic dogs. The IRI content in the normal dog pancreas was highest at the tail, followed in order by the body, head and uncinate process, and was decreased to about one-tenth to one-fortieth in the alloxan diabetic dogs. On the other hand, the amounts of PP in the pancreas of both normal and diabetic dogs were greatest at the uncinate process, followed in order by the head, body and tail. In an inverse relationship with the PP findings, the IRG content in the pancreas was highest at the tail and lowest at the uncinate process in both kinds of dogs. The differences in both PP and IRG between diabetic and normal dogs were generally not significant. These results show that irrespective of the high plasma levels of PP and IRG in the diabetic dogs, their levels in the pancreas did not change significantly.

Animals↗