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PubMed1976

Thrombophlebitis and pulmonary embolism with surgical intervention in the third trimester.

A case of acute deep vein thrombophlebitis and pulmonary embolism in late gestation has been presented with a discussion of diagnostic modalities, therapeutic regimens, and theoretical considerations. It is our belief that aggressive medical management is best accomplished by giving heparin intravenously as the primary anticoagulant. When medical management is best accomplished by giving heparin intravenously as the primary anticoagulant. When medical management is not effective or if embolism occurs, surgical intervention, consisting of vena caval clipping and ovarian vein ligation with scrupulous attention to detail, is indicated. Further, support to prophylaxis of abruptio placenta secondary to the mechanism espoused by Mengert et al is added by the course of this patient.

Adult↗
PubMed1984

Gastrocnemius musculotendinous rupture: a condition confused with thrombophlebitis.

Over a 24-year interval I have seen 22 cases of rupture of the medial head of the gastrocnemius muscle where it inserts into the soleus aponeurosis. The rupture may result in a swelling that is easily confused with thrombophlebitis and result in unnecessary hospitalization and anticoagulant therapy with its attendant expense and possible complications. The process is self-limiting and heals without sequelae in three to six weeks.

Aged↗
PubMed1988

Suppurative thrombophlebitis: a new look at a continuing problem.

Despite knowledge of its existence and despite precautionary measures, suppurative thrombophlebitis remains a significant problem in critical care, with a reported incidence of approximately 4% and associated mortality as high as 83%. In a retrospective study, we identified additional risk factors such as emergency department or field placement of catheters and administration of potassium boluses. New guidelines for surveillance and prevention have proved successful.

Catheters, Indwelling↗
PubMed1989

Deep vein thrombophlebitis and pulmonary embolism in patients with malignant gliomas.

Patients with malignant gliomas are at increased risk for deep vein thrombophlebitis (DVT) and pulmonary embolism (PE). Difficult anticoagulation in cancer patients undergoing surgery, chemotherapy, or radiotherapy limit the choices of therapy for DVT. Interruption of the inferior vena cava with a Greenfield filter is a safe method of treating patients who have malignant gliomas and DVT with PE. We studied 23 patients treated for malignant gliomas; 16 were men and seven were women, with a mean age of 51 years (range, 26 to 78). Five patients had DVT shown by noninvasive blood flow studies, and four subsequently had PE, as demonstrated by ventilation perfusion lung scan; in one patient PE was diagnosed at autopsy. Of the 23 patients, four with postoperative craniotomy had DVT and all four had PE. Two of the five patients who received preoperative chemotherapy had DVT and three had PE. All patients with PE had a Greenfield filter placed in the inferior vena cava via the internal jugular vein without adverse sequelae.

Adult↗
PubMed1990

Conn's syndrome with rhabdomyolysis mimicking deep vein thrombophlebitis.

We have reported a case of Conn's syndrome, with pain, tenderness, and swelling of the calf mimicking deep vein thrombophlebitis. The symptoms were associated with sever hypokalemia and rhabdomyolysis, and these findings subsequently explained by primary aldosteronism, which was cured by adrenalectomy.

Adenoma↗
PubMed1978

Pain and clinical thrombophlebitis following intravenous diazepam and lorazepam.

Eighty-seven per cent of surgical patients receiving undiluted diazepam experienced pain on injection while 6-16%, depending on the dose, manifested evidence of clinical thrombophlebitis. This was improved when diazepam, 10 mg, was diluted to 20-40 ml with intravenous solution. In contrast, lorazepam appeared to have minimal irritative or injurious effects on veins whether undiluted or diluted. In view of these results and clinical studies reporting a higher patient acceptance of lorazepam than diazepam, lorazepam may be a superior drug for use in anaesthesia.

Adolescent↗
PubMed1990

Superficial migratory thrombophlebitis and the lupus anticoagulant.

The lupus anticoagulant is an antiphospholipid antibody found in association with systemic lupus erythematosus and in a variety of other diseases, as well as in healthy individuals. In the laboratory, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis, mainly of the larger veins and arteries. The case of a young woman who developed superficial migratory thrombophlebitis in association with a high titer lupus anticoagulant is presented. Her diagnosis was initially missed because the partial thromboplastin time was not elevated. This appears to have resulted from the use of a specific thromboplastin relatively insensitive to the presence of the antibody. Retesting with a more sensitive reagent showed a markedly prolonged partial thromboplastin time.

Adult↗
PubMed1999

Crohn's disease presenting as septic thrombophlebitis of the portal vein (pylephlebitis): case report and review of the literature.

Septic thrombophlebitis of the portal vein, or pylephlebitis, is an extremely rare complication of intraabdominal infection, most commonly caused by diverticulitis (1). The following case report describes a patient without previous significant medical history presenting with painless jaundice and presumed malignancy. Workup revealed pylephlebitis due to an ileal abscess secondary to Crohn's disease. The patient was successfully treated with broad spectrum antibiotics and terminal small bowel and right colon resection. To our knowledge, this is the first reported case of Crohn's disease diagnosed after presentation with pylephlebitis.

Abdominal Abscess↗
PubMed2005

Are erythema nodosum-like lesions and superficial thrombophlebitis prodromal in terms of visceral involvement in Behcet's disease?

Erythema nodosum (EN)-like lesions and superficial thrombophlebitis (ST) are skin symptoms that are frequently observed in Behcet's disease. In most of the patients, skin symptoms precede serious visceral involvement. The study included 78 patients whose mean age was 33.48 +/- 6.16 (21-48). Of the cases, 37 were females and 41 were males. Forty-two patients (53.8%) had EN-like lesion and 12 (15.3%) had ST. Six of 54 patients, who had EN-like lesion and ST, were found to have no visceral involvement. In six of the remaining 48 patients, it was established that visceral involvement developed before lesions. It was found in 42 patients that these two lesions preceded visceral involvement. In addition, 18 of 24 patients who did not have these two lesions, do not still have visceral involvement. Therefore, we think that EN-like lesion and ST can be guiding in predicting serious visceral involvement and complications that can develop in advanced stages of Behcet's disease.

Adult↗
PubMed1975

Treatment of superficial thrombophlebitis: a randomized, bouble-blind trial of heparinoid cream.

In a prospective, double-blind, randomized trial the efficacy of a heparinoid in ointment form was assessed in treating superficial thrombophlebitis developing after continuous intravenous infusion. One hundred surgical patients were studied, and clinical examination and the iodine-125-labelled fibrinogen test used to assess the results. The mean time required for the relief of local symptoms and signs and the rate of local decline in radioactivity differed significantly between patients receiving the heparinoid cream and those recieving the placebo.

Administration, Topical↗
PubMed1977

Thrombophlebitis migrans in ulcerative colitis.

A case of thrombophlebitis migrans in ulcerative colitis in a Maltese housewife is reported. The association of thrombo-embolic disease and ulcerative colitis is reviewed.

Colitis, Ulcerative↗
PubMed1989

Thrombophlebitis migrans following co-trimoxazole therapy.

We report an unusual and severe vasculitic disorder following co-trimoxazole, given orally for a urinary tract infection. The vasculitis was manifest solely as thrombophlebitis migrans and involving only veins without evidence of polyarteritis nodosa, or underlying malignancy.

Anti-Infective Agents, Urinary↗
PubMed1977

Assessment of conventional criteria for the early diagnosis of thrombophlebitis with the 125I-fibrinogen uptake test.

Analysis of 55 positive tests of a total of 300 tests by conventional criteria revealed that 125I-fibrinogen provides useful information early enough for clinical management. Of the tests which were ultimately interpreted as positive by conventional criteria, at least one was positive at 3-4 hours in 67% of the tests and 98% of the tests were positive at 24 hours after the administration of 125I-fibrinogen. A 20% difference between contralateral identical locations of the legs and a 20% difference between adjacent locations of the ipsilateral leg were found with almost equal frequency in the positive tests, whereas a 20% increase at the same location was less sensitive. The 125I-fibrogen uptake test is a simple and accurate technique for early diagnosis of active thrombophlebitis.

Fibrinogen↗
PubMed1985

Calf hematoma mimicking thrombophlebitis: sonographic and computed tomographic appearance.

Five patients with calf hematomas presented with signs and symptoms suggesting thrombophlebitis, obscuring the correct diagnosis. Venography showed no venous thrombosis; further diagnostic studies using ultrasound and/or computed tomography provided the correct diagnosis in all patients. Ultrasound showed a hypoechoic mass clearly demarcated from surrounding soft tissue, while computed tomography showed a well-defined mass whose density depended on the age of the hematoma.

Adolescent↗
PubMed1987

Deep venous thrombophlebitis: detection with 4-hour versus 24-hour platelet scintigraphy.

Thirty-one nonheparinized patients with suspected deep venous thrombophlebitis (DVT) underwent contrast venography and indium-111 platelet scintigraphy (In-111 PS). Venography permitted identification of acute DVT in 12 of 31 cases (39%). One additional patient was considered to have acute DVT despite nonconclusive venography results. In-111 PS results were positive at 4 hours in nine of 13 cases (69%) and at 24 hours in 12 of 13 cases (92%). Two of four patients with false-negative 4-hour In-111 PS studies had received warfarin. Thus, the sensitivity of 4-hour In-111 PS in patients not receiving anticoagulants was 82%. Venography results were negative for acute DVT in 18 cases, and 4-hour In-111 PS studies were negative or equivocal in each. In-111 PS is an alternative to contrast venography for detecting acute DVT. If 4-hour In-111 PS results are positive, anticoagulation can be initiated. Delayed images are necessary if the 4-hour images are negative or equivocal.

Aged↗
PubMed1989

Recurrent thrombophlebitis due to protein C deficiency after splenectomy for immune thrombocytopenic purpura.

A young woman with recurrent thrombophlebitis following splenectomy for immune thrombocytopenic purpura and two cesarian sections was found to carry a protein C deficiency. This pathology should be considered in any patient with recurrent thromboembolism even when predisposing factors such as pregnancy and postoperative state may by themselves be responsible for such manifestations.

Adult↗
PubMed1984

In vivo platelet activation in lower limbs thrombophlebitis. A longitudinal study.

Platelet activation in vivo was studied in patients with thrombophlebitis of the lower limbs. The parameters considered were the platelet aggregate ratio (PAR) and the beta-thromboglobulin (beta-tg) level, which were repeatedly evaluated from the disease onset up to 3 months later, during anticoagulating and antiaggregating therapy. A significant decrease of PAR was found, along with a significant rise of the beta-tg level at the onset of the disease, and these values slowly returned to normal on therapy course. The same parameters exceeded the normal range again when the patients arbitrarily suspended any drug assumption. The possible significance and implications of these findings are discussed.

Adult↗