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At least 307 records · Page 17Linked to original sources
PubMed1985

The impact of antitumor therapy on nutrition.

The treatment of the cancer patient by surgery, chemotherapy or radiation therapy can impose significant nutritional disabilities on the host. The nutritional disabilities seen in the tumor-bearing host from antitumor therapy are produced by factors which either limit oral intake or cause malabsorption of nutrients. The host malnutrition caused as a consequence of surgery, chemotherapy or radiation therapy assumes even more importance when one realizes that many cancer patients are already debilitated from their disease.

Antineoplastic Agents↗
PubMed2001

Patients with local adverse effects from dental alloys: frequency, complaints, symptoms, allergy.

Data on the prevalence of adverse effects from dental cast alloys and on the characteristics of the related patient groups are scarce. Therefore, the aim of the present study was to investigate patients in a defined part of Germany attributing oral complaints or symptoms to dental cast alloys. All dentists in the area of Eastern Bavaria (with 1 million inhabitants) were asked to send corresponding patients to our department during a 3-year period. Out of this collection, patients with complaints or symptoms in the oral cavity were recruited and characterized with regard to number, age and sex distribution, type of subjective complaints and objective intraoral symptoms, and allergy status based on an alloy analysis. Patients reporting to our department with suspected local adverse effects from dental cast alloys represented 0.01% of the population. Thirty-four percent of the patients were 50-59 years old, with females prevailing (76%). A great variety of subjective complaints was reported, which mainly resembles those reported by patients with adverse effects attributed to other dental materials like amalgam or denture base materials. The main objective intraoral symptoms were gingivitis, anomalies of the tongue (lingua plicata, lingua geographica), discoloration of the gingiva, redness of the palate or tongue and lichenoid reactions of the oral mucosa. In not more than 10% of the patients, allergy was diagnosed as contributing to the complaints or symptoms.

Adult↗
PubMed1999

Pharmacokinetic profile of alniditan nasal spray during and outside migraine attacks.

AIMS: To compare the pharmacokinetic profile of intranasal alniditan during and outside migraine attacks, and to investigate the relationship between initial rise of alniditan plasma concentration, and headache improvement. METHODS: Twenty-seven migraine patients (age: 18-65 years) were randomized to receive alniditan 2 mg or 4 mg, and investigated both during and outside a migraine attack. Maximal plasma concentrations (Cmax), time to Cmax (tmax), and the area under the curve over 2 h (AUC(0,2 h)), were calculated from the individual plasma concentration-time profile, obtained from 10 blood samples in each patient, during each of the two administrations. RESULTS: Alniditan was rapidly absorbed into the systemic circulation (tmax=11 min). All investigated pharmacokinetic parameters (Cmax, tmax, AUC(0,2 h)) were similar during and outside migraine attacks, both in the 2 mg (n = 13) and the 4 mg group (n = 14). In the 4 mg group, during attacks, mean plasma alniditan concentration at 5 min after administration (Ct=5) in responders (21+/-16 ng ml(-1); n=10) was significantly higher than the Ct=5 in nonresponders (3+/-3 ng ml(-1); P=0.01; n=4). However, the Cmax and AUC(0,2 h) in responders (33+/-18 ng ml(-1) and 12+/-6 ng ml(-1) h) were also significantly higher than the Cmax and AUC(0,2 h) in nonresponders (13+/-9 ng ml(-1); P=0.048 and 5+/-3 ng ml(-1) h; P=0.03). CONCLUSIONS: Absorption of alniditan nasal spray was not affected by migraine attacks, although 95% confidence intervals were wide. Early rise of plasma concentrations and the amount of drug in the circulation were related to headache improvement in the higher dose group.

Administration, Intranasal↗
PubMed2000

Symptoms and their impact on nutrition.

OBJECTIVES: To provide assessment guidelines and management strategies for symptoms affecting nutritional status in patients with cancer. DATA SOURCES: Published articles, book chapters, and research reports. CONCLUSIONS: Patients with cancer experience a variety of symptoms that affect their nutritional status. It is possible to reduce the impact of these symptoms on the nutritional status of the patient through effective symptom management strategies, nutritional assessments, and interventions. IMPLICATIONS FOR NURSING PRACTICE: The nutritional status of cancer patients can be supported by anticipating and managing disease- and treatment-related symptoms. Nurses contribute actively to the achievement of positive patient outcomes when they manage symptoms in a manner that enhances nutrition.

Anorexia↗
PubMed1993

Gustatory and olfactory considerations: examination and treatment in general practice.

Gustatory and olfactory problems have deleterious consequences to systemic health, nutritional status and quality of life. Since patients with these problems are initially seen by dentists, they should be identified, treated and referred to other health care providers when appropriate. Care of these patients should be included in the general dental practice.

General Practice, Dental↗
PubMed2000

A prospective, quantitative study on the clinical outcome of lingual nerve repair.

We previously showed in laboratory studies that the most effective method for repair of damaged lingual nerves was by excision of the neuroma, mobilization of the stumps, and direct reapposition with epineurial sutures. We have now undertaken a prospective study in a series of 53 patients treated by this method and have evaluated the outcome by quantifying and comparing the results of tests of sensation before and after operation. The outcome in individual patients was variable. However, pooled data from all patients showed a highly significant improvement in sensation at the final assessment 12 months or more after the repair. The proportion of patients who responded to most or all light touch stimuli increased from 0% to 51% after repair, and the proportion who responded to pin-prick stimuli increased from 34% to 77%. There was no correlation between the final results of any of the tests and the delay before repair. None of the patients regained completely normal sensation and there was no reduction in the number with spontaneous paraesthesia or pain. However, fewer patients tended to bite the tongue by accident and most of them considered the operation worthwhile. These data show that lingual nerve repair is effective in most patients and we suggest that it should be offered to all those who show few signs of spontaneous recovery after injury.

Adolescent↗