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PubMed1991

Genetic, phenotypic, and environmental parameter estimates of calving difficulty, weight, and measures of pelvic size in beef heifers.

The heritabilities for and the genetic, phenotypic, and environmental correlations among calving difficulty scores (CDS) and measures of size of the pelvic inlet were estimated using 547 records of 2-yr-old heifers from three synthetic breed groups. Calving difficulty score was treated first as a trait of the dam and then as a trait of the calf and was analyzed on three scales: raw scores from 0 to 3 (0 = normal birth, 3 = most difficult delivery requiring a hard pull, veterinary assistance, or surgical intervention), Snell-transformed scores, and a binary (0, 1) scale. Estimates of heritability for CDS as a trait of the dam were similar to those when it was considered a trait of the calf. Heritability estimates for CDS on the raw and transformed scales were similar and moderate in magnitude (.36 +/- .15 to .47 +/- .18) but were higher than most reported estimates. However, on the binary scale the estimates were lower (.26 +/- .17, .28 +/- .14). Estimates of heritability for the horizontal and vertical pelvic diameters and the pelvic area were high, implying that pelvic size in heifers might be readily modified by selection. The genetic and phenotypic correlations between CDS as a dam trait and pelvic dimensions were low, whereas the correlations between CDS and dam weight at calving were moderate. As a calf trait, CDS was highly correlated genetically with calf birth weight, but the phenotypic correlations were moderate.

Analysis of Variance↗
PubMed2000

Relation of weight gain and weight loss on subsequent diabetes risk in overweight adults.

STUDY OBJECTIVE: To determine whether long term weight gain and weight loss are associated with subsequent risk of type 2 diabetes in overweight, non-diabetic adults. DESIGN: Prospective cohort. Baseline overweight was defined as BMI>/=27.3 for women and BMI>/=27. 8 for men. Annual weight change (kg/year) over 10 years was calculated using measured weight at subjects' baseline and first follow up examinations. In the 10 years after measurement of weight change, incident cases of diabetes were ascertained by self report, hospital discharge records, and death certificates. SETTING: Community. PARTICIPANTS: 1929 overweight, non-diabetic adults. MAIN RESULTS: Incident diabetes was ascertained in 251 subjects. Age adjusted cumulative incidence increased from 9.6% for BMI<29 to 26. 2% for BMI>/=37. Annual weight change over 10 years was higher in subjects who become diabetic compared with those who did not for all BMI<35. Relative to overweight people with stable weight, each kg of weight gained annually over 10 years was associated with a 49% increase in risk of developing diabetes in the subsequent 10 years. Each kg of weight lost annually over 10 years was associated with a 33% lower risk of diabetes in the subsequent 10 years. CONCLUSIONS: Weight gain was associated with substantially increased risk of diabetes among overweight adults, and even modest weight loss was associated with significantly reduced diabetes risk. Minor weight reductions may have major beneficial effects on subsequent diabetes risk in overweight adults at high risk of developing diabetes.

Adult↗
PubMed2002

Reinnervation of denervated muscle in a split-nerve transfer model.

This study was performed to quantify the reinnervation of denervated muscle in a split-nerve transfer model and to determine any possible downgrading effects on the donor nerve and its end organ. Fifty-four adult Wistar rats weighing 200 to 250 g were used. The experimental design consisted of two groups. The motor nerve branch to the anterior tibial muscle and gastrocnemius muscle of the right hind limb were dissected in all rats. In the experimental group (N = 36), the motor nerve branch of the tibial nerve to the gastrocnemius muscle was exposed, cut, and ligated. The motor nerve branch to the anterior tibial muscle was split and transected longitudinally, and the medial half was routed posteriorly. End-to-end neural anastomosis was performed between this medial half of the split nerve and the distal stump of the gastrocnemius nerve. In the control group (N = 18), while the same surgical preparation was performed, the motor nerve branch to the anterior tibial muscle and gastrocnemius nerve were exposed and transected, and the nerve endings were ligated, but neural anastomosis was not performed between these nerves. The left hind limb of all rats served as a normal comparison side without any surgical intervention. Both of the groups were divided into three subgroups (12 rats each for the experimental groups and 6 rats each for the control group) to evaluate the results after periods of 1, 3, and 6 months. Electromyography, light microscopic and morphometric examination, and muscle weight measurements were used to document the results. Although stimulation of the peroneal and tibial nerves did not produce any compound muscle action potential (CMAP) recordings from either the anterior tibial or the gastrocnemius muscle in the control group, the normalized CMAP areas of the tibial nerve were (mean +/- standard deviation) 16.2 +/- 30.8% in the 1-month group, 63.4 +/- 34.7% in the 3-month group, and 72.4 +/- 16.3% in the 6-month group. For the peroneal nerve, the normalized CMAP areas were 17.0 +/- 32.2%, 53.4 +/- 29.4%, and 54.4 +/- 14.5% for the 1-, 3-, and 6-month groups in the experimental groups respectively. A high number of regenerating myelinated nerve fibers was identified in the distal part of the coapted motor nerve branch to the gastrocnemius muscle. The average number of myelinated fibers in the lateral half of the split nerve in the experimental group was 15,108 fibers per square millimeter, 14,167 fibers per square millimeter, and 19,830 fibers per square millimeter at months 1, 3, and 6 respectively. The average number of fibers proximal to the nerve anastomotic site was 15,423 fibers per square millimeter, 19,200 fibers per square millimeter, and 20,774 fibers per square millimeter. Distal to the nerve anastomotic site, the number of myelinated fibers was 17,941 fibers per square millimeter, 18,885 fibers per square millimeter, and 18,895 fibers per square millimeter at 1, 3, and 6 months respectively. There were no myelinated fibers in the control group sections. There were significant differences in muscle weight between the experimental and control groups at the end of month 6. The difference between the experimental side and the untouched normal healthy side was not significant in the weight measurements of both muscles. The results show acceptable reinnervation by split-nerve transfer with minimal functional impairment of the donor muscle. This study confirms that split-nerve transfer is a reliable method of reconstruction for paralyzed muscle with minimal donor area morbidity.

Animals↗
PubMed2001

Secular trends in body mass index by birth cohort in eastern Finland from 1972 to 1997.

OBJECTIVE: To describe changes in body mass index (BMI) with age over a 25 y period, and to investigate whether those changes differed by birth cohort, gender or education. DESIGN: Six cross-sectional population surveys repeated in eastern Finland every fifth year between 1972 and 1997. Synthetic birth cohorts were created by dividing subjects into twelve 5 y groups according to birth year. SUBJECTS: Independent random samples from the national population register including men and women aged 25-64 y, the final sample comprising 18 439 men and 19 501 women. The oldest birth cohort included subjects born in 1913-1917 and the youngest were born in 1968-1972. MEASUREMENTS: Weight and height were measured, and data on educational level were collected by a self-administered questionnaire. RESULTS: A BMI increase with age was more prominent in women (4.2 kg/m(2) in 25 y) than in men (3.3 kg/m(2) in 25 y), and was very similar in all birth cohorts. In men, the BMI increase with age varied across cohorts. Among birth cohorts participating in each survey, the BMI increase over the 25 y period was most prominent (3.9 kg/m(2) in 25 y) in men born between 1943 and 1947. Among all birth cohorts, the strongest upward trend (0.2 kg/m(2) per year) was observed in men born between 1953 and 1957. CONCLUSIONS: Weight gain with age has remained unchanged in women over the 25 y period, whereas in men, the younger the birth cohort, the more prominent was the BMI increase with age.

Adult↗
PubMed2005

Retrospective review of megestrol use for weight loss in an elderly veteran population.

OBJECTIVE: Evaluate the efficacy of megestrol acetate therapy for nonmalignancy and/or non-AIDS-related weight loss in the elderly. DESIGN: Retrospective chart review. SETTING: Inpatients or outpatients at the West Palm Beach Veterans Affairs Medical Center. PATIENTS: Two inclusion criteria were applied: patients older than 65 years and patients initiated on megestrol therapy from January 1 to December 31, 2002. All eligible patients meeting the above criteria were eligible for inclusion in the study. Patients who had a diagnosis of malignancy and/or AIDS, no baseline weight, no follow-up weights, no record of laboratory values, and/or were receiving enteral or parenteral nutrition available at the West Palm Beach Veterans Affairs Medical Center, were excluded. Patients who received megestrol therapy for less than one week also were excluded. MEASUREMENTS: Weight loss in the previous six months, baseline weight, follow-up weights at 3, 6, 9, and 12 months after megestrol initiation, baseline and follow-up albumin for 12 months after megestrol initiation, and any adverse effects from megestrol. RESULTS: Fifty-seven patients (males 56, females 1) were included. The average age was 78.5 years old. The average duration of therapy was 3.2 months, and the average starting dose of megestrol was 436 mg per day. At baseline, patients were, on average, 102% of their ideal body weight. Baseline measurement of albumin was obtained in 89% (N = 23) of patients. Six out of 23 (26%) patients had a baseline albumin less than 3 g/dL. The average baseline albumin was 3.6. Weight loss in the six months prior to megestrol initiation occurred in 63% of patients. Over the 12-month follow-up period, the percentage of patients who gained weight was 40%, lost weight was 49%, and had no change in weight was 11%. There were no differences in baseline characteristics between the patients who did or did not gain weight during the 12-month period after megestrol initiation. No documented adverse side effects were attributed to megestrol. CONCLUSION: Patients both gained and lost weight when receiving megestrol therapy. There was no difference between the patients who did or did not gain weight using objective measures of weight loss.

Journal Article↗
PubMed1995

Changes in body weight in relation to mortality in 6441 European middle-aged men: the Seven Countries Study.

OBJECTIVES: To study the relation between changes in body weight and subsequent mortality. DESIGN: Prospective follow-up study. SETTING: Population study. SUBJECTS: 6441 men aged 40-59 y at baseline participating in the European cohorts of the Seven Countries Study. The men were divided into groups depending on their weight pattern ascertained from three weight measurements with intervals of 5 years. They were also divided in quartiles according to the degree of weight variability. MAIN OUTCOME MEASURES: All-cause and cause-specific mortality during 15 years following the last weight measurement. Deaths occurring during the first 5 years of follow-up were excluded. RESULTS: Significantly elevated hazard ratios (RR) for death from all causes (RR = 1.3; 95% confidence interval (CI): 1.2-1.5), all cardiovascular diseases (RR = 1.2; 95% CI: 1.0-1.5) and other causes (RR = 1.6; 95% CI: 1.2-2.2) were found for men with a decreasing weight compared with men with a constant weight. A fluctuating weight was associated with an increased risk of all cause mortality (RR = 1.2; 95% CI: 1.0-1.4), coronary heart disease (RR = 1.5; 95% CI: 1.0-1.9) and myocardial infarction (RR = 1.5; 95% CI: 1.0-2.2). The group of men with an increasing body weight also had elevated hazard ratios for dying from coronary heart disease and myocardial infarction, but these were only significant when the total 15-year follow-up was analyzed. The risks of dying from all-causes, cardiovascular disease, cancer and other causes were increased in the upper quartile versus the lower quartile of weight variability. CONCLUSIONS: The results of the present study show that a decreasing and a fluctuating body weight are associated with increased mortality. An average increase of 7 kg body weight was associated with an elevated risk of dying from coronary heart disease and myocardial infarction. Lowest mortality in these middle-aged men was found in those who maintained a constant body weight.

Aging↗
PubMed2000

Age, education and occupation as determinants of trends in body mass index in Finland from 1982 to 1997.

OBJECTIVE: To investigate trends in body mass index (BMI) and prevalence of obesity among adults in Finland from 1982 to 1997, and to identify population groups with increasing obesity. SUBJECTS: Random samples from the national population register including men and women aged 25-64 y (n = 24604, total). DESIGN: Four cross-sectional surveys carried out in three areas in Finland every fifth year since 1982. MEASUREMENTS: Weight and height were measured, and data on occupation and education level were collected by a self-administered questionnaire. RESULTS: The mean BMI increased in both genders. In men, the upward trend was greatest (the increase of 1.3 kg/m2 in 15 y) in the oldest age group (55-64 y), and was found also (the increase of 0.6 kg/m2) in the youngest age group (25-34 y), whereas in women, the upward trend was most prominent (the increase of 0.9 kg/m2) in the youngest age group. BMI increased in all educational groups in men, but in women the upward trend seemed to be greatest in the lowest educational group. The upward trends were most prominent among retired and unemployed men, while in women changes in BMI were similar in all occupational groups. CONCLUSION: The strongest upward trend in BMI was found in the oldest men, in the youngest age group in both genders and, in particular, among men who were outside the labor force. Education is still a strong determinant of obesity, especially in women, although the social gradient in BMI has not widened in the 1990s.

Adult↗
PubMed1991

Direct molecular weight determination of resin-bound oligopeptides using 252Cf plasma-desorption mass spectrometry.

Plasma-desorption mass spectrometry is proved to be capable of the direct molecular weight determination of totally protected resin-bound oligopeptides. The molecular weight measured is the molecular weight of the fully protected oligopeptide including the molecular weight of the linker, which connects the oligopeptide and the polystyrene resin. This method makes it possible to check the success of (a step in) the synthesis of a peptide before its deprotection or cleaving from the resin. This can make it a strong tool in the analysis of resin-bound oligopeptides.

Amino Acid Sequence↗
PubMed1979

Effect of intralesional and systemic BCG-application or a combined cyclophosphamide/BCG treatment on experimental bladder cancer.

Infiltrating transitional cell carcinomas of the urinary bladder were induced by ingestion of 0.188% N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT) in 145 female Wistar rats. After 8 months of carcinogen exposure, the animals were divided into different treatment groups. They received cyclophosphamide intraperitoneally as a single injection or BCG either once intralesionally or weekly subcutaneously or a combination of cyclophosphamide followed by subcutaneous BCG. The treatment effect was determined by body weight measurements and bladder tumour weight after 12 months. Compared with a control group statistically significant differences of bladder tumour weights were found after treatment with BCG alone or in combination with cyclophosphamide. Intralesional BCG resulted in an insignificant increase of tumour weights.

Animals↗
PubMed2006

Overweight and basal metabolic rate in boys with attention-deficit/hyperactivity disorder.

We investigated a possible association between attention-deficit/hyperactivity disorder (ADHD) and overweight by measuring weight status and energy expenditure (basal metabolic rate, BMR) in 39 ADHD-boys with hyperactivity (mixed hyperactive/impulsive and inattentive or predominantly hyperactive/impulsive) and 30 healthy boys. The age range for the total group was 8-14 years. Weight and height were measured by a calibrated scales and stadiometer. Body mass index standard deviation scores (BMI-SDS) were calculated. BMR was determined by indirect calorimetry. Significant differences were obtained between the ADHD- and the control-group, but not between ADHD-subgroups. Both BMI-SDS and BMR were higher in the group of ADHD-boys, whereby the differences were more marked when they were older. More overweight and obese subjects were found in the ADHD-sample. Impulsive behavior in ADHD-boys with hyperactivity may lead to an increased food intake, which is then likely to overcompensate the heightened energy expenditure.

Adolescent↗
PubMed1998

Resting metabolic rate in preadolescent girls at high risk of obesity.

OBJECTIVE: To investigate whether children at high risk of obesity have a reduced resting metabolic rate (RMR). DESIGN: Cross-sectional study. SUBJECTS: 93 healthy girls (age: 8-12 y) were allocated to one of four groups, according to the subjects' and their parents' weight status: group 1, overweight children with both parents overweight (OB/OB2; n = 17); group 2, normal weight children with both parents overweight (N/OB2; n = 28); group 3, overweight children of discordant parents (OB/OB1; n = 21) and group 4, normal weight children with both parents normal weight (N/OB0; n = 27). MEASUREMENTS: Weight, height, fat-free mass (FFM) and fat mass (FM) by bioelectrical impedance analysis (BIA), RMR (indirect calorimetry) for the duration of 25 min. RESULTS: Controlling for disparities in body composition, age and physical maturity, significant differences were found in adjusted group means of RMR (OB/OB2 1181 kcal/d; N/OB2 1276 kcal/d; OB/OB1 1234 kcal/d; N/OB0 1199 kcal/d; P < 0.02) with the OB/OB2 girls showing the lowest energy expenditure. CONCLUSION: We found evidence that preadolescent girls at risk of obesity, are not generally predisposed to a higher body weight, because of a greater metabolic efficiency. In fact, our data show that more emphasis should be laid on defining different subgroups of both overweight and normal weight subjects in studies investigating metabolic rate.

Aging↗
PubMedDate not supplied

[Measuring plantar weight distribution of shoes with forefoot support].

PURPOSE: Differences in weight bearing using forefoot relief ortheses available on the German market. METHODS: Six different forefoot relief shoes were tested. All ten probands wearing the same shoe-size, had a physiological foot anatomy and a normal gait. Contact time, contact area, maximum pressure and the pressure-time integral were assessed in six different areas of the sole. We used the dynamic device Fast SCAN by MEGASCAN placing the sensor inside the orthesis. RESULTS: A reduction of the pressure underneath the forefoot was seen with all sample shoes. In particular 3 types showed favourable parameters. The Metasan walking aid keeping the forefoot hanging free, reduced the pressure to almost zero compared to barefoot walking. The Forefoot relief orthesis with protective shield--also not supporting the forefoot--permitted a reduction down to 20% of the barefoot pressure. The Forefoot relief orthesis Dr. L. S. Barouk is reducing the pressure to 20% as well, allows a safer gait by lifting the front parts of the foot. Concerning the gait line remarkable differences between the shoe-types are seen. In all samples the front tipping edge of the shoe was free of peak loading. CONCLUSIONS: The shoes tested do reduce the pressure under the toes and under the metatarsals. They are not suitable for the postoperative care of proximal metatarsal or tarsometatarsal osteotomies.

Adult↗
PubMed1990

A new measure of weight locus of control: the Dieting Beliefs Scale.

This article describes the construction and preliminary validation of a new scale of weight locus of control, the Dieting Beliefs Scale. The 156-item scale demonstrated moderate internal consistency and high test-retest reliability in a sample of undergraduate women. Principal-components analysis suggested three factors. The three factors were interpretable and had distinct relations with a variety of weight-related and psychological variables. The results suggest that weight locus of control is a multidimensional construct, and they provide a possible explanation for the inconsistent findings concerning the relation between weight locus of control and dieting success. Implications for the study of dieting relapse and for the construction of treatment programs are discussed.

Adult↗