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PubMed1986

Effects of imposed delay of response and item complexity on auditory comprehension by aphasics.

Ten aphasic and five control subjects were administered an auditory comprehension task similar to Levels I-IV of the Revised Token Test under conditions of 0, 5, 10, and 20 sec of imposed response delay. Responses were evaluated in terms of performance accuracy and response time. Aphasic subjects' response accuracy was significantly effected by an interaction between the length of delay imposed and the complexity of the stimulus. The aphasic group also demonstrated a significant main effect for item complexity. Control subjects' accuracy was not influenced by the treatment conditions. Latency measures indicated the aphasic subjects were slower to respond across all treatment conditions. Both groups' latency scores were significantly effected by item complexity. A comparison of mean latencies by condition did, however, suggest different patterns of response for the two groups. Results are discussed in terms of theoretical and clinical implications for the auditory comprehension deficits of aphasia.

Adult↗
PubMed1985

Speech processing ability in alcoholics: a transient impairment and its relation to field dependence.

Alcoholic and non-alcoholic subjects received a test of the ability to identify speech presented against competing speech (Synthetic Sentence Identification) and a test of field dependence (Embedded-Figures Test (EFT). Performance on the speech task (which involved auditory figure-ground differentiation) bore no special relationship to performance on the field-dependence test. However, cross-sectional and longitudinal data suggested that recently-drinking alcoholics are temporarily impaired in their speech-processing ability, recovering this ability after several months of alcohol-abstinence. A relationship between chronicity of alcoholism and field dependence was also observed. The latter relationship, along with findings on auditory tests, were discussed in terms of their relevance to the issue of whether field dependence is an antecedent to or a consequence of alcoholism.

Adult↗
PubMed1995

The development and reliability of the Mental Health Research Institute Unusual Perceptions Schedule (MUPS): an instrument to record auditory hallucinatory experience.

The Mental Health Research Institute Unusual Perceptions Schedule (MUPS) is a comprehensive instrument developed to record subjects' experiences of auditory hallucinations as completely as possible. The Schedule comprises a semi-structured interview and documents the physical characteristics of auditory hallucinations such as their onset and course, number, volume, tone, location, as well as other phenomena associated with them such as delusions. In addition, other aspects of hallucinations, such as coping strategies, contributing factors and subjects' personal views and reactions are also explored. In a sample of 100 subjects drawn primarily from the in-patient wards at Royal Park Hospital the MUPS was found to be an acceptable instrument to subjects in the field. Interrater reliability assessed in a subsample of 30 subjects was found to be high at the level of the individual items. Whether used in whole or part, the MUPS provides a reliable and acceptable method of assessing patients' experience of auditory hallucinations.

Adaptation, Psychological↗
PubMed2005

Poor hand-pointing to sounds in right brain-damaged patients: not just a problem of spatial-hearing.

We asked 22 right brain-damaged (RBD) patients and 11 elderly healthy controls to perform hand-pointing movements to free-field unseen sounds, while modulating two non-auditory variables: the initial position of the responding hand (left, centre or right) and the presence or absence of task-irrelevant ambient vision. RBD patients suffering from visual neglect, unlike RBD patients without neglect and healthy controls, showed a systematic rightward error in sound localisation, which was modulated by the non-auditory variables. Localisation errors were exacerbated by initial hand-position to the right of the body-midline, and reduced by the leftwards initial hand-position. Moreover, for the visual neglect patients, mere presence of ambient vision worsened localisation errors. These results demonstrate that although hand-pointing to sounds has often been considered a straightforward approach to investigate sound-localisation abilities in brain-damaged patients, in some patients it may actually reveal localisation deficits that reflect a combination of impaired spatial-hearing and spatial biases from other sensory modalities (i.e., vision and proprioception).

Aged↗
PubMed2006

Corpus callosum size is linked to dichotic deafness and hemisphericity, not sex or handedness.

Individuals differ in the number of corpus callosum (CC) nerve fibers interconnecting their cerebral hemispheres by about threefold. Early reports suggested that males had smaller CCs than females. This was often interpreted to support the concept that the male brain is more "lateralized" or "specialized," thus accounting for presumed male predominance in mathematics, as well as for aggressive behavior. Ultimately, meta-analyses of these many reports found no significant overall sex differences in inter-cerebral information carrying capacity. Here, using quantitative MRI, we found the midline CC area of 113 subjects was significantly correlated, not with handedness or sex, but with dichotic deafness, and even more so with redefined hemisphericity, the latter accounting for over 19% of CC variability. That is, both dichotic hearing and right brain-oriented individuals of either sex had significantly larger CCs than dichotically deaf or left brain-oriented persons. Thus, current traditions of brain laterality and gender may benefit from revisions that include redefined hemisphericity.

Adolescent↗
PubMed2004

When only the right hemisphere is left: studies in language and communication.

An adult of above normal intelligence, BL, underwent left hemispherectomy at age five, and subsequently graduated from college and has been regularly employed. Using standardized neuropsychological instruments, previous extensive testing had revealed optimal performance for a hemispherectomized subject. To probe communicative abilities in greater detail, and to examine current questions about linguistic superiority of the left hemisphere and "crowding" of right hemisphere functions, 12 additional protocols were administered. BL performed at normal or above on nearly all protocols. However, performance on production of phonemically complex words was effortful, and deficits were seen on two tests requiring comprehension of linguistic contrasts in prosody (Linguistic Prosody Test) and syntax (the Active-Passive Test). These findings support previous claims of reduced ability in specific, circumscribed linguistic functions in the left hemispherectomized person, and lead to suggestions for further testing of communicative competence in individuals with a single intact hemisphere.

Anomia↗
PubMed2005

Auditory backward masking deficits in children with reading disabilities.

Studies evaluating temporal auditory processing among individuals with reading and other language deficits have yielded inconsistent findings due to methodological problems () and sample differences. In the current study, seven auditory masking thresholds were measured in fifty-two 7- to 10-year-old children (26 diagnosed with reading disability [RD], 26 without reading disability). Hierarchic multiple regression analyses indicated that RD status predicted performance only in the backward-bandpass noise (p<.05) and backward notched-noise conditions (p<.05), suggesting both temporal and spectral auditory processing deficits. These results suggest that any auditory deficit associated with RD may be more complex than previously hypothesized.

Attention↗
PubMed2006

An acquired deficit of audiovisual speech processing.

We report a 53-year-old patient (AWF) who has an acquired deficit of audiovisual speech integration, characterized by a perceived temporal mismatch between speech sounds and the sight of moving lips. AWF was less accurate on an auditory digit span task with vision of a speaker's face as compared to a condition in which no visual information from the lower face was available. He was slower in matching words to pictures when he saw congruent lip movements compared to no lip movements or non-speech lip movements. Unlike normal controls, he showed no McGurk effect. We propose that multisensory binding of audiovisual language cues can be selectively disrupted.

Acoustic Stimulation↗
PubMed2006

Developmental timeframes for induction of microgyria and rapid auditory processing deficits in the rat.

Induction of a focal freeze lesion to the skullcap of a 1-day-old rat pup leads to the formation of microgyria similar to those identified postmortem in human dyslexics. Rats with microgyria exhibit rapid auditory processing deficits similar to those seen in language-impaired (LI) children, and infants at risk for LI and these effects are particularly marked in juvenile as compared to adult subjects. In the current study, a startle response paradigm was used to investigate gap detection in juvenile and adult rats that received bilateral freezing lesions or sham surgery on postnatal day (P) 1, 3 or 5. Microgyria were confirmed in P1 and 3 lesion rats, but not in the P5 lesion group. We found a significant reduction in brain weight and neocortical volume in P1 and 3 lesioned brains relative to shams. Juvenile (P27-39) behavioral data indicated significant rapid auditory processing deficits in all three lesion groups as compared to sham subjects, while adult (P60+) data revealed a persistent disparity only between P1-lesioned rats and shams. Combined results suggest that generalized pathology affecting neocortical development is responsible for the presence of rapid auditory processing deficits, rather than factors specific to the formation of microgyria per se. Finally, results show that the window for the induction of rapid auditory processing deficits through disruption of neurodevelopment appears to extend beyond the endpoint for cortical neuronal migration, although, the persistent deficits exhibited by P1 lesion subjects suggest a secondary neurodevelopmental window at the time of cortical neuromigration representing a peak period of vulnerability.

Acoustic Stimulation↗
PubMed2006

Evaluation of multi-attribute auditory discrimination in dyslexia with the mismatch negativity.

OBJECTIVE: Dyslexia is associated with impairments in the phonological system or with more general auditory dysfunctions. We determined the discrimination of 5 sound contrasts (pitch, duration, intensity, location, and the presence of a gap) in dyslexia with the mismatch negativity (MMN). METHODS: We compared MMNs of 9 adult dyslexic and 11 control subjects with a new 5-deviant paradigm which enables one to assess the discrimination of each of these features in 15 min. Also, a control oddball condition with pitch and duration deviants was included. In the new paradigm, all deviant stimuli are presented in the same stimulus block so that the standard stimuli, of which there are 50%, alternate with the deviant stimuli. RESULTS: In the 5-deviant paradigm, a diminished pitch-MMN and an enhanced location-MMN were found in dyslexic individuals. Furthermore, pitch and duration MMNs in this and in the oddball paradigms suggested that smaller MMNs are elicited in the new than oddball paradigm in dyslexic subjects. CONCLUSIONS: Pitch discrimination is impaired in dyslexia. However, location discrimination, not addressed previously with MMN, is enhanced. Furthermore, dyslexic subjects are more impaired in detecting changes in sound streams with than without variation. SIGNIFICANCE: In dyslexia research, the new 5-deviant MMN paradigm is feasible and even more sensitive than the traditional oddball paradigm.

Acoustic Stimulation↗
PubMed2006

Congenital amusia.

Explore the source record for details and available documents.

Auditory Perceptual Disorders↗
PubMed2005

Auditory processing deficits in rats with neonatal hypoxic-ischemic injury.

Hypoxia-ischemia (HI) refers to reduced blood oxygenation and/or a diminished amount of blood perfusing the brain, and is associated with premature birth/very low birth weight (VLBW). HI represents a common cause of injury to the perinatal brain. Indeed, a significant number of premature/VLBW infants go on to demonstrate cognitive/behavioral deficits, with particularly high incidence of disruptions in language development. Auditory processing deficits, in turn, have been suggested to play a causal role in the development of language impairments. Specifically, the inability to identify fast elements in speech is purported to exert cascading detrimental effects on phonological discrimination, processing, and identification. Based on this convergent evidence, the current studies address auditory processing evaluation in a rodent model of HI injury induced on postnatal days 1, 7, or 10 (which in turn is well accepted as modeling HI-related injury to the perinatal human). Induced injuries were followed by a battery of auditory testing, and a spatial maze assessment, performed both during juvenile and adult periods. Results indicate that rats suffering from these early HI insults performed significantly worse than shams on tasks requiring rapid auditory processing, and on a test of spatial learning (Morris water maze (MWM)), although these effects were not seen on simpler versions of auditory tasks or on a water escape assessment (thus ruling out hearing/motor impairments). Correlations were found between performance on rapid auditory and spatial behavioral tasks and neuroanatomical measures for HI animals such as: the volume of the hippocampus, cerebral cortex, ventricles, and/or the area of the corpus callosum. Cumulative findings suggest that perinatal HI injury in the rat may lead to neurodevelopmental damage associated, in turn, with auditory processing and/or learning and memory impairments. As such, the current model may have critical implications for the study of neurophysiological underpinnings of cognitive deficits in premature/VLBW infants.

Aging↗
PubMed2007

Abnormal frequency discrimination in children with SLI as indexed by mismatch negativity (MMN).

For several decades, the aetiology of specific language impairment (SLI) has been associated with a central auditory processing deficit disrupting the normal language development of affected children. One important aspect for language acquisition is the discrimination of different acoustic features, such as frequency information. Concerning SLI, studies to date that examined frequency discrimination abilities have been contradictory. We hypothesized that an auditory processing deficit in children with SLI depends on the frequency range and the difference between the tones used. Using a passive mismatch negativity (MMN)-design, 13 boys with SLI and 13 age- and IQ-matched controls (7-11 years) were tested with two sine tones of different frequency (700Hz versus 750Hz). Reversed hemispheric activity between groups indicated abnormal processing in SLI. In a second time window, MMN2 was absent for the children with SLI. It can therefore be assumed that a frequency discrimination deficit in children with SLI becomes particularly apparent for tones below 750Hz and for a frequency difference of 50Hz. This finding may have important implications for future research and integration of various research approaches.

Acoustic Stimulation↗
PubMed2004

Receptive amusia: temporal auditory processing deficit in a professional musician following a left temporo-parietal lesion.

This study examined the musical processing in a professional musician who suffered from amusia after a left temporo-parietal stroke. The patient showed preserved metric judgement and normal performance in all aspects of melodic processing. By contrast, he lost the ability to discriminate or reproduce rhythms. Arrhythmia was only observed in the auditory modality: discrimination of auditorily presented rhythms was severely impaired, whereas performance was normal in the visual modality. Moreover, a length effect was observed in discrimination of rhythm, while this was not the case for melody discrimination. The arrhythmia could not be explained by low-level auditory processing impairments such as interval and length discrimination and the impairment was limited to auditory input, since the patient produced correct rhythmic patterns from a musical score. Since rhythm processing was selectively disturbed in the auditory modality, the arrhythmia cannot be attributed to a impairment of supra-modal temporal processing. Rather, our findings suggest modality-specific encoding of musical temporal information. Besides, it is proposed that the processing of auditory rhythmic sequences involves a specific left hemispheric temporal buffer.

Acoustic Stimulation↗
PubMed2005

Visual localization of sounds.

Circumscribed hemispheric lesions in the right hemisphere have been shown to impair auditory spatial functions. Due to a strong crossmodal links that exist between vision and audition, in the present study, we have hypothesized that multisensory integration can play a specific role in recovery from spatial representational deficits. To this aim, a patient with severe auditory localization defect was asked to indicate verbally the spatial position where the sound was presented. The auditory targets were presented at different spatial locations, at 8 degrees, 24 degrees, 40 degrees, 56 degrees to either sides of the central fixation point. The task was performed either in a unimodal condition (i.e., only sounds were presented) or in crossmodal conditions (i.e., a visual stimulus was presented simultaneously to the auditory target). In the crossmodal conditions, the visual cue was presented either at the same spatial position as the sound or at 16 degrees or 32 degrees, nasal or temporal, of spatial disparity from the auditory target. The results showed that a visual stimulus strongly improves the patient's ability to localize the sounds, but only when it was presented in the same spatial position of the auditory target.

Acoustic Stimulation↗
PubMed2005

Vocal amusia in a professional tango singer due to a right superior temporal cortex infarction.

We describe the psychophysical features of vocal amusia in a professional tango singer caused by an infarction mainly involving the superior temporal cortex of the right hemisphere. The lesion also extended to the supramarginal gyrus, the posterior aspect of the postcentral gyrus and the posterior insula. She presented with impairment of musical perception that was especially pronounced in discriminating timbre and loudness but also in discriminating pitch, and a severely impaired ability to reproduce the pitch just presented. In contrast, language and motor disturbances were almost entirely absent. By comparing her pre- and post-stroke singing, we were able to show that her singing after the stroke lacked the fine control of the subtle stress and pitch changes that characterized her pre-stroke singing. Such impairment could not be explained by the impairment of pitch perception. The findings suggest that damage to the right temporoparietal cortex is enough to produce both perceptive and expressive deficits in music.

Aged↗
PubMed2005

Audio-visual matching of speech and non-speech oral gestures in patients with aphasia and apraxia of speech.

BACKGROUND: Audio-visual speech perception mechanisms provide evidence for a supra-modal nature of phonological representations, and a link of these mechanisms to motor representations of speech has been postulated. This leads to the question if aphasic patients and patients with apraxia of speech are able to exploit the visual signal in speech perception and if implicit knowledge of audio-visual relationships is preserved in these patients. Moreover, it is unknown if the audio-visual processing of mouth movements has a specific organisation in the speech as compared to the non-speech domain. METHODS: A discrimination task with speech and non-speech stimuli was applied in four presentation modes: auditory, visual, bimodal and cross-modal. We investigated 14 healthy persons and 14 patients with aphasia and/or apraxia of speech. RESULTS: Patients made substantially more errors than normal subjects on both the speech and the non-speech stimuli, in all presentation modalities. Normal controls made only few errors on the speech stimuli, regardless of the presentation mode, but had a high between-subject variability in the cross-modal matching of non-speech stimuli. The patients' cross-modal processing of non-speech stimuli was mainly predicted by lower face apraxia scores, while their audio-visual matching of syllables was predicted by word repetition abilities and the presence of apraxia of speech. CONCLUSIONS: (1) Impaired speech perception in aphasia is located at a supra-modal representational level. (2) Audio-visual processing is different for speech and non-speech oral gestures. (3) Audio-visual matching abilities in patients with left-hemisphere lesions depend on their speech and non-speech motor abilities.

Adult↗