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Results for “Containment of Biohazards”

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At least 325 records · Page 18Linked to original sources
PubMed2006

Laboratory containment practices for arthropod vectors of human and animal pathogens.

Arthropod-borne pathogens have an impact on the health and well-being of humans and animals throughout the world. Research involving arthropod vectors of disease is often dependent on the ability to maintain the specific arthropod species in laboratory colonies. The author reviews current arthropod containment practices and discusses their importance from public health and ecological perspectives.

Animals↗
PubMed2004

Moving on up: upgrading from an ABSL2 to ABSL3 facility.

Renewed interest in bioterrorism-related research has resulted in the need for more ABSL3/4 facilities. In some cases, money has been available to build new facilities, but more often institutions are faced with retrofitting existing facilities to meet the higher containment standards. The author discusses several factors that must be addressed before beginning this type of renovation project.

Animal Husbandry↗
PubMed1996

Restricting the dispersal of recombinant DNA: design of a contained biological catalyst.

To restrict horizontal gene spread and, thus, create organisms whose behavior in the field is more predictable, we have combined a mini-Tn5 cloning system that allows stable insertion of foreign genes into the chromosomes of a variety of Gram-negative bacteria with a gene-containment circuit based on the universal lethal-function colicin E3. Use of the system is exemplified by the construction of a micro-organism designed to degrade polychlorinated biphenyls, important environmental pollutants. The relevant genotype of the microorganism is subject to a stringent gene-containment mechanism that provides neither an advantage nor a disadvantage to the host cell for survival, but decreases frequencies of productive chromosomal transfer frequencies by at least four orders of magnitude.

Catalysis↗