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Results for “Contingent Negative Variation”

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PubMed2005

An independent components analysis (ICA) approach to the study of developmental differences in the saccadic contingent negative variation.

This study investigated the development of the saccadic CNV in 74 subjects aged 7-18 years, using pro- and anti-saccade tasks, and independent components analysis (ICA) for data analysis. Within the 2-stimulus paradigm, a central fixation point (S1) was followed 2.5s later by a peripheral cue (S2) presented at 4 degrees to the left or right of S1 in random order. The EEG was recorded from 40 electrodes applied over both hemispheres using a DC amplifier. With increasing age, pro- and anti-saccadic reaction times became faster, this effect being slightly more pronounced during childhood for the anti-saccade task. ICA revealed a lateral-posterior sCNV in younger children, and the known anterior-central sCNV in late adolescents. By contrast, the gaze maintenance negativity (GMNb), an anterior-central negativity accompanying the excursion of the eye, was present in all age groups. Our results underline the importance of topographical approaches in developmental ERP research and the usefulness of ICA. They suggest major task-dependent developmental differences in the spatial modulation of frontal-lobe sensitive ERP components.

Adolescent↗
PubMed1988

[Modifications of contingent negative variation (CNV) induced by oxytocin infusion].

The central effects of an intravenous infusion of oxytocin (OT), 3,680 mIU in 45 min, were investigated in 20 male volunteers in a double-blind study combining an electrophysiological and a psychometrical approach. The electrophysiological approach consisted in the simultaneous recording of the CNV (Fz-A1 and Cz-A1) and the spontaneous EEG (bipolar P3-P4) recording on which was carried out an FFT analysis. On the other hand, various psychometric tests allowed to assess memory (Rey's tests), attention (K-T test) processes and mood changes (visual analogue scales). Within the hour following the infusion, OT induced a significant decrease of CNV amplitude and an increase of the post-imperative positive component at Cz-A1. A similar effect was still observed one week later, but was more marked at Fz-A1. Neither mood nor attention tests evidenced any significant effect of OT. Only one item of the memory test PRM (item 4) revealed a significant impairment after OT infusion. There were no subjective effects reported. These observations provide new electrophysiological arguments supporting a central action of peripheral OT administration in man. This action, which may be characterized as an acceleration of CNV "habituation" is the opposite of the one described with vasopressin.

Brain↗