[Geographical distribution of cancer in Japan--mortality of cancer in prefectures in Japan during 1978-1982].
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A clinical study in a group of patients with digestive cancers was done with a radioimmunoassay technique employing a carcinoembryonic antigen (CEA) fraction. Among 45 patients with colorectal carcinomas, 51% showed CEA levels in the pathologic range before therapy, those with metastatic disease from well differentiated adenocarcinomas showed the higher values. Measurement of the circulating levels of this CEA fraction proved to be more useful in the monitoring of the course of disease during and after antineoplastic treatment. Sensitivity of the radioimmunoassay technique for the remaining digestive cancers was over 50%, but pathologic CEA values are not exclusive for malignant digestive disease, since 22% of patients with benign diseases also showed raised serum levels of CEA.
Incidence rates of the cancer registry of the department of Calvados were compared, by site and by age group, with those obtained from the cancer registry of the comprehensive cancer center in Caen, concerning the population of the department of Calvados. In males, these rates are approximately similar for head and neck sites; for the hospital registry they are 50% of those recorded by the population registry for lung cancer, and 30% for prostatic cancer. In females, the all-sites rates are nearly identical for the youngest age groups and 50% for the older. They are not significantly different for digestive cancer, and 75% for cervix and breast cancer. The incidence rates of both registries were compared with mortality rates. They indicate mortality rates which appear relatively high for the pancreas, and they show imprecisions for the uterus and head and neck (pharynx-larynx) sites.
A systematic registration of mortality and morbidity from digestive cancers was started in January 1976 in the French department of COTE-D'Or (population 455,727). In the course of two years 913 new cases of digestive cancers were recorded. Nearly half of these cancers were colorectal cancers. The survey gives informations on histology, stage of the disease and survival. The morbidity survey allows comparison with the incidence rate of digestive cancers in other countries.
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The labelling index (LI) of 96 breast adenocarcinomas and of 43 upper respiratory and digestive tract cancers has been measured. For the two histological groups, the distribution of individual values is found to be log-normal, with a mean value depending on the tumour type. Our data have been compared with other authors results. The dispersion of individual values within a same histological type suggests that the LI is interesting as an individual value depending on the patient and his own cancer. For breast adenocarcinomas the LI values obtained have been separated in two groups depending upon the patient age, the age of 53 has been chosen to separate premenopausal from post-menopausal patients. A test of significance showed that the two corresponding log-normal distributions were different, even at the 0.01 level of significance, a mean LI value thus characterizing each distribution.
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In addition to presentation of five personal observations of lipomas of the digestive tract (1 esophageal, 3 gastric, 1 jejunal), the authors review over 1 400 cases published in the literature. No cases of degeneration were found. Esophageal lipomas are extremely rare (1.5 p. cent of digestive tract lipomas) and are often confused, prior to anatomical proof, with leiomyomas, which are much more frequent. Lipomas represent 3 to 5 p. cent of all benign tumors of the stomach; the most frequent site is the antrum and the average diameter is 5 cm. From a clinical standpoint, such tumors are asymptomatic unless they are of large size or peri-orificial. The radiologic diagnosis is usually a benign tumor, lipomas being diagnosed only rarely. Lipomas of the small intestine represent 13 to 15 p. cent of all benign tumors there; the preferential site is the ileum (49.6 p. cent), followed by the duodenum (23.4 p. cent). Clinical latency was associated with 43 p. cent of the cases reviewed. Barium examinations generally led to the diagnosis of a benign tumor but provided no etiological information. Lipomas constitute the most frequent benign tumor of the colon and rectum after adenomas. When compared with all other locations, the colon accounts for 51.1 p. cent of cases. No preferential site was observed within the colon itself, and multiple forms were seen in 14 p. cent of cases. Clinical latency was associated with 30.3 p. cent of the colo-rectal cases reviewed, and radiological exams were generally unable to diagnose lipomas.(ABSTRACT TRUNCATED AT 250 WORDS)
Two hundred cancer patients with bone metastases were studied by gammagraphy employing 555 MBq of 99mTc-MDP. The results were compared with those obtained by radiology and alkaline phosphatase determination, showing that gammagraphy is positive in 93 per 100 of the cases and is more useful than the other procedures to make a pre-radiologic diagnosis of bone metastases (27 per 100).
We studied the pattern of metastasis at autopsy in 158 patients with carcinoma of the pancreas and in 29 patients with carcinoma of the periampullary structures. The three most commonly involved organs were the abdominal lymph nodes, liver, and lung. Other organs and sites were involved in less than 25% of the cases. For pancreatic carcinoma, whether the diagnosis was made antemortem or at autopsy, the incidence of metastatic involvement of various sites was similar. Comparing patients with carcinoma of the pancreatic head only with those with tumor of the body or tail, the latter group had a higher incidence of involvement of abdominal nodes, liver, stomach, small bowel, spleen, peritoneum, lung, and other intrathoracic organs. Carcinoma of the duodenum or ampulla had the highest incidence (67%) of involving only one abdominal lymph nodal region, whereas 14% to 50% of carcinomas of the pancreas had such nodal metastasis.
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