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At least 325 records · Page 18Linked to original sources
PubMed1981

A source of error in mutagen testing of foods.

Mutagenic compounds reported to be present in foods may be forming during the extraction process rather than during cooking or baking. In this study, the formation of mutagenic substances in biscuits was examined using in the extraction procedure either ammonium sulfate and ammonium hydroxide or sodium sulfate and sodium hydroxide. Compounds producing high mutagenic activity in Salmonella strains 1538 and TA 98 obtained from aqueous biscuit extracts containing ammonium ions. No mutagenic activity was observed in extracts from aqueous biscuit extracts containing sodium ions until some ammonium ions (NH4OH) were added. We suggest that ammonium sulfate and ammonium hydroxide not be used in the extraction procedure of food when studying mutagen formation.

Bread↗
PubMed1993

Electrical field stimulation causes oxidation of exogenous histamine in Krebs-Henseleit buffer: a potential source of error in studies of isolated airways.

Electric field stimulation (EFS) relaxes human histamine-precontracted airways in vitro. This relaxation is only partly neurally mediated. Nonneural relaxation has been also shown in blood vessels and is due to the generation of oxygen radicals by EFS. In isolated airways the origin of the nonneural component of the relaxation is not clear. Because exogenous catecholamines are oxidized during EFS of carbogenated Krebs-Henseleit (K-H) buffer, we questioned whether this is also the case for exogenous histamine. Human airways precontracted with histamine or methacholine were exposed to either EFS-stimulated carbogenated K-H buffer that also contained histamine or methacholine or unstimulated buffer. Airways exposed to EFS-stimulated buffer that contained histamine relaxed, whereas airways exposed to buffer containing methacholine or exposed to unstimulated buffer did not. It appeared that the histamine concentrations in the organ baths decreased during 30 min of EFS. This decrease was significantly reduced in the presence of ascorbic acid. We conclude that EFS causes oxidation of histamine in carbogenated K-H buffer, and this may at least partly explain the nonneural component of EFS-induced relaxations of precontracted human isolated airways. Therefore, histamine should not be used to induce precontraction in EFS experiments.

Aged↗
PubMed2004

Sources of error in road safety scheme evaluation: a method to deal with outdated accident prediction models.

This paper considers the errors that arise in using outdated accident prediction models in road safety scheme evaluation. Methods to correct for regression-to-mean (RTM) effects in scheme evaluation normally rely on the use of accident prediction models. However, because accident risk tends to decline over time, such models tend to become outdated and the estimated treatment effect is then exaggerated. A new correction procedure is described which can effectively eliminate such errors.

Accidents, Traffic↗
PubMed2006

Sources of error in computerized neuropsychological assessment.

Computerized neuropsychological assessment has integrated slowly into research and practice since the introduction of the personal computer. Though initial integration of technology to the laboratory and clinical setting utilized specialized hardware and software, newer generation assessment tools are integrated with "off-the-shelf" operating systems. Further, neuropsychological assessment is beginning to find Internet-based application for remote assessment. As these applications are more broadly applied, it is essential to understand potential errors that can be created both in test administration and in reaction time measurement due to hardware and software interactions. In this article, user considerations are specifically addressed for resident and Internet-enabled assessment software. Potential hardware and software conflicts are defined and potential remediation is suggested. Computerized assessment is a valuable tool for neuropsychologists as long as it is used responsibly with an understanding of the potential technical complications.

Diagnosis, Computer-Assisted↗
PubMed2006

Sources of error and interpretation of plaque morphology by optical coherence tomography.

This study was performed to assess the strengths and weaknesses of optical coherence tomography (OCT) intravascular imaging in identifying plaque morphology. Seventy-nine postmortem human coronary arterial sections classified as fibrous-cap atheromas, calcific plaques, fibrous plaques, and complicated lesions were studied. OCT was able to identify 45% of fibrous-cap atheromas (kappa=0.27, p<0.01), 68% of fibrocalcific plaques (kappa=0.40, p<0.001), 83% of fibrous plaques (kappa=0.37, p<0.001), and 100% of complicated lesions (all thrombi; kappa=1, p<0.001). Misinterpretation was caused mainly by the low OCT signal penetration, which could not detect lipid pools or calcium behind thick fibrous caps, and by an inability to distinguish calcium deposits from lipid pools or the opposite. Lesions with thick (>150 microm) caps were histologically identified as 25 thick fibrous-cap atheromas, 8 fibrocalcific plaques, and 5 fibrous plaques; all these lesions were relatively "stable." In contrast, lesions with fibrous caps<150 microm were either vulnerable or stable lesions (11 thin-fibrous-cap atheromas and 11 fibrocalcific plaques). In conclusion, although OCT images may give an indication of the overall composition of large homogenous signal-poor regions, such as lipids or calcified areas, they could be unreliable in differentiating areas with heterogenous compositions. OCT may easily recognize relatively stable lesions.

Artifacts↗
PubMed2005

Sources of errors in assessing ozone visible symptoms on native vegetation.

This paper aims to identify the problems regarding the evaluation of ozone (and ozone-like) symptoms, by examining the results of the 4th UN/ECE ICP-Forests Intercalibration Course for the assessment of ozone-induced visible symptoms. Trees, shrubs and herbaceous species were evaluated in a tree nursery, at Lattecaldo (Switzerland) and under open field conditions at Moggio (Italy). The main findings were: (i) the most expert surveyors tended to be grouped in the same cluster and, during the field exercises, they tended to assess in a more conservative manner compared to the less trained participants; (ii) the agreement was greater in assessing the absence rather than the presence of symptoms; (iii) typical interveinal stippling on the upper leaf surface was more accurately evaluated than discoloration; (iv) uncertainties resulted mainly for species which showed greater variability in their symptom manifestation, and for certain herbaceous species.

Ecosystem↗
PubMed2004

Ultrasound probe pressure as a source of error in prostate localization for external beam radiotherapy.

PURPOSE: A pelvic phantom was constructed to evaluate the effect of ultrasound probe pressure during performance of bipolar acquisition technique (BAT) for prostate localization for radiotherapy. METHODS AND MATERIALS: A pelvic phantom of a gelatin mold with a water-filled balloon representing the bladder and rectum and a central encapsulated clay sphere representing the prostate was constructed. This phantom was then scanned using planning computed tomography (CT). The geometric information of the phantom was outlined in two planes. The phantom was then scanned using the BAT system with mild and moderate ultrasound probe pressure. Differences in prostate depth between the CT and BAT systems were displayed. RESULTS: A difference of 1 cm between the phantom surface and the prostate could be produced with moderate ultrasound probe pressure. The differences were similar between the CT- and BAT-generated contours and were dependent on the ultrasound probe pressure. CONCLUSION: Care must be taken not to cause any alteration in prostate localization with increasing ultrasound probe pressure when using BAT localization. Increased probe pressure may introduce errors in prostate localization and under dose the target.

Diagnostic Errors↗
PubMed1987

Solvent-induced photodegradation as a source of error in the analysis of polycyclic aromatic hydrocarbons.

The photodegradation of seven common polycyclic aromatic hydrocarbons (PAHs) has been examined in a range of organic solvents. Reactions followed a first order equation with benzo[a]pyrene and benzo[a]anthracene being the most rapidly photodegraded. Generally, the more polar the solvent the faster is the degradation process. A number of photodegradation products were identified by gas chromatography-mass spectrometry. The identification of compounds such as 4-amino-1-naphthalenecarbonitrile and 1H,3H-naphtho[1,8-cd]pyran-1-one clearly indicated that the solvent molecules have taken part in the formation of these compounds. Solvent-induced photodegradation is shown to be an important consideration in choosing the optimum solvent for the best analytical recoveries of PAHs from various matrices.

Chromatography, High Pressure Liquid↗