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At least 325 records · Page 18Linked to original sources
PubMed1984

[Post-traumatic growth disorders and corrective measures on the growing skeleton].

In order to develop efficient therapies in paediatric traumatology we investigated 1500 patients in all age groups with bony lesions of the growing skeleton. In particular we wanted to evaluate the limits and reliability of the correction mechanisms. Having done this evaluation we found some completely new correction mechanisms, and also we defined the reliability of the known mechanisms of repair. Also we wanted to determine the frequencies of the various disturbances of growth and how far these could be influenced by primary therapy. The rare disturbance of partial stimulation of growth, resulting in consecutive deformity was the only one which could be primarily influenced by therapy.

Child↗
PubMed1982

[Growth disorders of the upper end of the femur following treatment of congenital hip luxation].

From approximately 2,500 cases of treated congenital dislocation of the hip, the authors have selected 82 cases with 100 hips showing disturbance of the superior epiphysis and metaphysis of the femur. These have been observed after several types of treatment - napkins in abduction, abduction harnesses, abduction splintage, closed reduction by Lorenz technique, progressive reduction by Somerville technique or open reduction. The risk factors have been analysed in 22 hips treated by progressive reduction. It is concluded that changes in the metaphysis and in the growth plate are the main cause of late abnormality. A classification of these abnormalities is proposed to aid diagnosis and for the institution of earlier treatment. In severe cases, combined pelvic and femoral osteotomy give the most satisfactory results.

Adolescent↗
PubMed1985

[Epiphyseal points of the fetal knee. The impact of growth disorders on bone maturation].

The radiological appearance of bone maturity can be used as a criterion for fetal maturity. This examination with limited irradiation to the fetus is an alternative to amniocentesis. The practice of the latter is not without risk. The authors carried out 194 examinations of the contents of the uterus to look at the epiphyses of the knee between the 34th and 40th week of amenorrhoea. The found three groups: 1) those with normal development; 2) those with delayed development and 3) those with more advanced development. They did not find significant correlation between small-for-dates growth and bony maturity. On the other hand, where there was increased growth of the fetus in cases where maternal diabetes was excluded there was demonstrated that bony maturity accelerated with the presence of Béclard's point from the 34th week onwards. With such great variation in the dates of the appearance of points of ossification the presence of epiphyseal points in the knee cannot be taken as a criterion to establish fetal maturity nor the minimum duration of the pregnancy.

Birth Weight↗
PubMed2006

Growth disorders in children with type 1 diabetes mellitus.

The aim of the research was to analyze anthropometric variables in children with type 1 diabetes mellitus (DM) in relation with the stage of pubertal development at onset of disease and quality of metabolic control over five-year long observation. Diagnosed children were taller than their peers. This especially referred to age group between 4 and 9.5 years. On the whole, weight of the patients and healthy controls did not differ. However, the diagnosed children had substantially lower weight in puberty than healthy controls. Body mass index was significantly lower in the group of diagnosed children on the whole and in puberty. During a five-year long observation patients have had a significant retardation of growth. However, that retardation referred primarily to patients in prepuberty. Growth retardation was more pronounced with bad metabolic control. Growth was satisfactory if onset of disease had been in puberty. A significant weight gain was observed in patients in puberty whereas in those in prepuberty there was no significant change of body weight at the end of five-year long observation. Metabolic control did not affect observed changes. There were significant differences of anthropometric variables between those suffering from type 1 DM and their peers. The differences depended on the age at onset. The disease had a negative effect on growth with onset in prepuberty, whereas in puberty growth was satisfactory. However, puberty was a period in which patients increased their weight excessively. Prepuberty was a period in which growth had been significantly affected by metabolic control.

Age of Onset↗
PubMed1990

[Dynamic balance in the prevention of growth disorders].

The authors examine the characteristic of the standing position and the successive developmental phases of proprioceptive afferent stimuli which lead to the coordination of muscles responsible for the control of static and dynamic balance. Subsequently, they analyze pathological changes due to intrinsic factors which are likely to be involved in dysmorphisms of the spine, and to extrinsic factors such as those brought about by orthotic or surgical intervention on the spine. The authors conclude stressing the clinical and prognostic importance of global evaluation of kinetic alterations resulting from zonal changes in the entire complex of the locomotor system.

Growth Disorders↗
PubMed1990

[Use of arginine hydrochloride in non-endocrine growth disorders].

We have examined a group composed of 60 short prepubertal children (height less than 3 degrees centile; 31 M, 29 F, age from 4.17-10.5 years) with a decreased height velocity (less than 10 degrees centile) and in which endocrine, systemic or specific causes of short stature have been ruled out by the performance of several instrumental or laboratory analyses. Auxological features of a 12-month period (from time -12 to time 0) without any treatment ("off" period) have been compared with an immediately following 12-month period (from time 0 to time +12), during which hydrochloride arginine was administered ("on" period); 2 phials per day in subjects older than 6 years and 1 phial per day in those less old than 6 years. In the absence of the pubertal development, height changed from -1.95 +/- 0.29 (m +/- 1 SD) standard deviation scores (SDS) at time -12 to -2.17 +/- 0.28 SDS at time 0 and -2.24 +/- 0.29 SDS at time +12 with a variation of -0.22 +/- 0.09 SDS in "off" period and of -0.07 +/- 0.14 SDS in "on" period (p less than 0.001) and therefore a difference between the two periods of 0.16 +/- 0.13 SDS. Height age (HA)/chronological age (CA) ratio was 0.74 +/- 0.05, 0.73 +/- 0.04 e 0.73 +/- 0.04, at time -12, 0 and +12, respectively. Height velocity changed from 4.18 +/- 0.47 cm/yr, -1.84 +/- 0.45 SDS for CA and -2.07 +/- 0.41 SDS for bone age (BA) during "off" period to 4.72 +/- 0.74 cm/yr, -1.05 +/- 0.83 SDS for CA and -1.31 +/- 0.77 SDS for BA during "on" period (p less than 0.001) with a variation of 0.53 +/- 0.56 cm/yr, 0.78 +/- 0.65 SDS for CA and 0.77 +/- 0.69 SDS for BA. BA resulted 6.57 +/- 1.55 years at time 0 and 7.34 +/- 1.54 years at time +12; HA/BA ratio changed from 0.86 +/- 0.07 at time 0 to 0.88 +/- 0.07 at time +12 (p less than 0.01) with a ratio between the two values of 1.01 +/- 0.02. Height and height velocity did not result statistically different between males and females or between subjects with delayed BA and those with non-delayed BA, while HA/BA ratio resulted significantly higher in the subjects with non-delayed BA than in those with delayed BA.(ABSTRACT TRUNCATED AT 400 WORDS)

Age Determination by Skeleton↗
PubMed1981

[Normal growth and disorders of growth in children and adolescents (author's transl)].

Normal growth and its variability are discussed on the basis of the new Zürich standard percentile charts. In the perinatal period boys grow faster than girls, presumably because of higher concentration of plasma testosterone. At the age of 6-7 years there is a modest midgrowth spurt, presumably caused by the increasing secretion of adrenal androgens (adrenarche). Just before puberty growth velocity reaches its lowest point. This is followed by the pubertal growth spurt with its peak at a mean age of 12 years in girls and 14 years in boys. This growth spurt is more marked in boys and is caused by the increasing secretion of gonadal steroids (gonadarche). Three or four years later growth ceases. Growth and bone maturation are closely related. In both the pubertal growth spurt and bone maturation girls are two years advanced compared to boys. From height and bone age a quite accurate estimation of the timing of puberty and of adult height can be made. Height and growth velocity are independent multifactorial variables. The majority of growth problems are caused by constitutional (familial) variants of height (familial short or tall stature) and of velocity of growth and maturation (familial acceleration or delay of growth and adolescence). The causes of growth disturbances of organic origin are chromosomal aberrations (e.g., Down syndrome), dysmorphology syndromes (e.g., Russell-Silver syndrome), endocrinopathies (e.g., hypopituitary dwarfism), chronic diseases (e.g., celiac disease), and bone dysplasias (e.g., achondroplasia).

Adolescent↗
PubMed1968

[Growth disorders].

Explore the source record for details and available documents.

Body Constitution↗
PubMed1978

[Carbadox in combination with furazolidone in the prevention of enteral and growth disorders in weaned piglets].

Two feed mixtures were produced, each containing the antimicrobial preparation Carbadox and different amounts of furazolidone. Their fortnightly administration in starters to piglets weaned at the age of 25--31 days prevented mortality and stimulated somatic growth and feed utilization. Premix with a higher content of furazolidone markedly depressed the clinical symptoms of gastro-enteritis and reduced the number of the haemolytic germs of E. coli in the contents of the duodenum and jejunum. The presence of furazolidone in the feed completely eliminated enteral disorders and delayed the onset of the disease, or alleviated its course, in cases of severe diarrhoea, which killed, in the control group, the piglets of the same litter. Weight gains were significantly increased, particularly in the first post-weaning week, the difference from the control being up to 520%. Almost 0.5 kg of the COS 2 starter was saved per 1 kg of piglet live weight gain. Under the current farming conditions of five agricultural enterprises the weight gains during the ten days of the administration of the medicated feed were increased, on an average by 0.84-1.32 kg. In herds where the untreated piglets put on less than 1 kg the gains were increased by 96--124%. It is recommended to administer the new-developed medicated premix to prevent losses due to alteration of the intestinal microflora in early-weaned piglets.

Animal Feed↗
PubMed1997

Dopamine function in obsessive-compulsive disorder: growth hormone response to apomorphine stimulation.

Indirect observations suggest that the dopaminergic system may be involved in the pathophysiology of obsessive-compulsive disorder (OCD). The dopaminergic function of 15 patients with OCD and 15 age/sex-matched controls was evaluated by measuring the growth hormone (GH) responses to stimulation with the dopaminergic agonist apomorphine (APO), which increases growth hormone-releasing hormone (GHRH), GH, and somatomedine C (SMD-C) secretions. Therefore, we measured basal plasma GH and SMD-C concentrations and GH responses to GHRH stimulation to exclude that a downstream pathology of the somatotropic axis could obscure the significance of the results of the APO test. The response of prolactin (PRL) to APO inhibition were also measured. Basal plasma levels of GH, SMD-C, and PRL, GH responses to GHRH stimulation, and PRL responses to APO inhibition did not differ in the two groups of subjects. GH responses to APO stimulation were blunted in obsessive-compulsive (OC) patients. The emetic response to the same stimulation was stronger in patients than in controls. These responses suggest that in our OC patients there is a dysregulation of the dopaminergic system, which is possibly expressed in different ways in the various areas of the central nervous system.

Adolescent↗
PubMed2000

[Spontaneous corrections, growth disorders and post-traumatic deformities after fractures in the area of the forearm of the growing skeleton].

Growth phenomena after paediatric forearm fractures are described. The capacity for spontaneous remodelling of malunions should be primarily considered in the treatment of fractures of the growing skeleton. Thus, unnecessary reductions, anaesthesia and posttraumatic deformities can be prevented. Generally speaking, a high remodelling capacity can be expected in cases of enough remaining growth, proximity to a physis with high activity, and if the main deformity lies in the plane of motion of the nearest joint. It is widely accepted that distal radius and/or ulna fractures are fully remodelled up to the age of 11 to 12 years. However, the remodelling capacity of fractures of the proximal and middle third of the shaft is smaller and less well known. Stimulating growth disturbances at the upper extremities are clinically of minor importance. Growth arrests are rare. Their fateful occurrence is not predictable and not closely related to fracture pattern or amount of dislocation.

Bone Remodeling↗
PubMed2002

Auxological computer based network for early detection of disorders of growth and weight attainment.

INTRODUCTION: For several years practising pediatricians and pediatric endocrinologists in Leipzig have been collaborating closely to achieve early detection of growth disorders. As a result of this collaboration a data-bank was established in September 1998 into which height and weight measurements were entered and related to age and gender. This well established network of pediatricians in practice, pediatric endocrinologists and the auxological data-bank functions well. METHODS: All data are anonymized and continually monitored. By September 2000, the data for 60,984 children had been assessed. The data were evaluated using the German Synthethic Norm Curve for body height and German normal data for BMI. Pathology of growth dynamics was assumed when change in height SDS was greater than 0.5 height SDS/year. RESULTS: Analysis showed that 2,216 children (3.6%) had a height greater than the 97th percentile and 2,775 children (4.5%) had a height less than the 3rd percentile of the normative reference. BMI above the 97th percentile was found in 7,687 children (12.6%) and below the 3rd percentile in 2,678 children (4.4%). When assessing growth development (n = 5,665), 194 (3.4%) showed acceleration and 155 (2.7%) showed deceleration of growth. CONCLUSION: The computer-based monitoring system is useful to document short-term and long-term changes of growth and weight attainment in the general population. The presence of growth disorders and/or disturbed weight gain can be detected early in the individual child.

Body Height↗