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At least 325 records · Page 18Linked to original sources
PubMedDate not supplied

[Treatment of iron deficiency in preschool children with a weekly dose of ferrous sulfate].

INTRODUCTION: Iron deficiency is the most frequent haematological disease during the paediatric age and is a health public problem; the iron deficiency has a special interest during early development of human beings; in recent years the group of research recommend intermittent treatment, with ferrous sulphate every week because is more easily adhesion to treatment. OBJECTIVE: To know iron concentration in plasma after treatment, given oral ferrous sulphate daily and single dose every week. METHODS AND MATERIAL: We established two groups A and B, with ten iron deficiency pre-school children each one. RESULTS: Group A: the children received oral ferrous sulphate twice a day during three months; the doses were 3.5 mg of ferric iron per kilogram of weight in children with ages less of three years old, and 2.5 mg/kg/day in children with three to five years old. After the treatment all the patients improved haemoglobin, ferritin an iron concentrations (p = 0.001). Group B: The patient received the some dose per kilogram of weight like that of group A, in a single dose weekly for three months, there was an improvement in haemoglobin not reaching normal levels, half of the patients improved iron and ferritin observing statistical significance; haemoglobin (p = 0.001) iron (p = 0.062) and ferritin (p = 0.01). CONCLUSION: The administration of ferrous sulphate daily provide an positive balance of iron status for the group A. Group B: that they received iron weekly dose showed changes to positive balance of iron status with a statistical significance, it is probably that the half doses of ferrous sulphate also improve the anaemia by iron deficiency.

Age Factors↗
PubMed2002

Prevention of iron deficiency in infants and toddlers.

The prevalence of nutritional iron deficiency anemia in infants and toddlers has declined dramatically since 1960. However, satisfaction with this achievement must be tempered because iron deficiency anemia in infants and toddlers is associated with long-lasting diminished mental, motor, and behavioral functioning. Additionally, the prevalence of iron deficiency anemia in one- to three-year-old children seems to be increasing. The exact relationship between iron deficiency anemia and the developmental effects is not well understood, but these effects do not occur until iron deficiency becomes severe and chronic enough to produce anemia. At that point, treatment with iron can reverse the anemia and restore iron sufficiency, yet the poorer developmental functioning appears to persist. Therefore, intervention should focus on the primary prevention of iron deficiency. In the first year of life, measures to prevent iron deficiency include completely avoiding cow's milk, starting iron supplementation at four to six months of age in breastfed infants, and using iron-fortified formula when not breastfeeding. Low-iron formula should not be used. In the second year of life, iron deficiency can be prevented by use of a diversified diet that is rich in sources of iron and vitamin C, limiting cow's milk consumption to less than 24 oz per day, and providing a daily iron-fortified vitamin. All infants and toddlers who did not receive primary prevention should be screened for iron deficiency. Screening is performed at nine to 12 months, six months later, and at 24 months of age. The hemoglobin/hematocrit level alone detects only patients with enough iron deficiency to be anemic. Screening by erythrocyte protoporphyrin or red-cell distribution width identifies earlier stages of iron deficiency. A positive screening test is an indication for a therapeutic trial of iron, which remains the definitive method of establishing a diagnosis of iron deficiency.

Age Factors↗
PubMedDate not supplied

Anemia: when is it iron deficiency?

Iron deficiency anemia, the most common of childhood anemias, presents many challenges to the practitioner. Careful history taking that includes nutritional assessment may uncover this frequently subtle condition. In keeping with AAP recommendations, screening will aid in diagnosing this condition in populations at risk. Prompt treatment and conscientious follow-up will afford the most optimal outcome.

Adolescent↗
PubMed1992

Iron bioavailability from Spirulina platensis, whole egg and whole wheat.

Bioavailability of iron from Spirulina was assessed in comparison with whole egg, whole wheat and standard ferrous sulphate using haemoglobin depletion repletion assay. Haemoglobin regeneration efficiency of Spirulina and whole egg was similar and significantly higher than that of whole wheat. The absorption of iron from Spirulina was significantly lower than that of ferrous sulphate and whole egg but significantly greater than that from whole wheat.

Absorption↗
PubMed1960

[Sulfhemoglobin].

Explore the source record for details and available documents.

Aniline Compounds↗
PubMed2004

Treatment of anaemia after joint replacement. A double-blind, randomised, controlled trial of ferrous sulphate versus placebo.

After total hip and knee replacement arthroplasty, patients may become anaemic and may be prescribed oral iron. There is, however, no published evidence that this is of benefit when used postoperatively. We treated 72 patients who were anaemic after primary total hip and knee arthroplasty by randomly allocating them to receive six weeks of either oral ferrous sulphate (35 patients) or a placebo (37 patients). Both groups of patients were similar in all aspects except for the treatment given. There was no statistically significant difference in the change of haemoglobin levels between the two groups. We therefore believe that the prescription of iron to all anaemic patients post-operatively should be avoided. The level of serum ferritin should be monitored at preoperative assessment.

Administration, Oral↗
PubMed2005

Management of iron deficiency in pregnancy.

UNLABELLED: This article reviews a study, published in Clinical and Laboratory Haematology (2003), which looked at using iron-rich spa water (Spatone) as a prophylaxis against iron deficiency in pregnancy. Anaemia is a significant problem in pregnant women that can have a detrimental effect on the baby and mother. The problems of non-compliance with oral iron supplements in this population are well-documented. This was a prospective, randomised, double-blind, placebo-controlled trial, and 102 patients were recruited into the study. Inclusion criteria included singleton pregnancy, booking haemoglobin >10.4g/dl and gestational age confirmed by ultrasound at 20 weeks. Primary outcome measures were compliance with treatments during the trial period, ferritin levels at 22 and 28 weeks and dyspepsia scores at 22 and 26 weeks. RESULTS: Mean ferritin levels fell by 24% in the Spatone group compared with a mean fall of 51% in ferritin levels in the control group, p = 0.016. In the Spatone group, 31% of patients raised their ferritin levels during the trial period compared with 11% in the control group. The authors concluded that Spatone is effective in maintaining iron stores in non-anaemic patients and is well-tolerated. The study delivers a clear message to midwives--namely that Spatone has a place in the management of iron-deficient pregnant women, because it is well-tolerated and provides iron in a highly bioavailable form.

Adult↗
PubMedDate not supplied

The challenges of using serum ferritin to guide i.v. iron treatment practices in patients on hemodialysis with anemia.

Expert guidelines recommend routine administration of intravenous iron therapy and frequent monitoring of iron status for patients on hemodialysis who are being treated for anemia with erythropoiesis-stimulating agents. However, monitoring iron status using conventional markers, such as serum ferritin, may be complicated by acute and chronic inflammation and malnutrition, which are common in this patient population. Therefore, nephrology nurses must be knowledgeable of the limitations of using serum ferritin to assess iron status and how to interpret high serum ferritin values to effectively treat patients on hemodialysis with anemia.

Anemia, Iron-Deficiency↗
PubMed1990

[Iron resorption and the effects of iron supplementation in blood donors].

Topical values for some haematological factors such as Hb and Ery as well as transferrin and ferritin were determined in 7 female blood donors and 8 male blood donors during the years of their work as blood donors. Subsequently, an iron resorption test was carried out which unexpectedly resulted in low rates of resorption ranging from 5.6% in men to 3.7% in women. After supplementing with vitaferro for 3 months the ferritin values which initially lay around the lower limiting value of 20 or 10 mg/l in men or women had doubled.

Blood Donors↗
PubMed1991

[The use of drinking water as a vehicle of nutrients: experimental studies with iron].

This investigation is part of a large project, the objective of which is to study the possibility of utilizing drinking water as a carrier of nutrients, such as iron. Various iron salts and in different concentrations, were added to water and tested for their effect on color and turbidity. The bioavailability of various forms of iron salts added to drinking water was tested using the rat bioassay technique. The results of this study indicated that ferric ammonium citrate changed very little the color and turbidity of the water solutions. It was considered the best suitable form of iron to be added to drinking chloride water. Ferric ammonium citrate, ferrous sulfate and ferrous gluconate were all found effective in preventing rat anemia when added to their drinking water.

Anemia, Hypochromic↗
PubMedDate not supplied

[Iron deficiency in children: which is the correct therapy?].

Iron is essential for human metabolism. Under normal circumstances its homeostasis is strictly kept by absorption and excretion through genitourinary, gastrointestinal tracts and skin losses. In several systemic disorders, dietary iron is insufficient to keep such a dynamic balance: development of iron deficiency may be due to increased requirements, decreased intestinal absorption, inadequate dietary uptake. Low birth weight newborns, children and adolescents are at increased risk for developing iron deficiency. Although clinical aspects may vary, hematochemical findings show a three-step gradual progression. In a first step iron deficiency is diagnosed by serum ferritin level which will be under 10-20/micrograms/ml showing a depletion of total body iron stores. In a second step progressing iron deficiency will be assessed by lowered serum iron and increased unsaturated serum transferrin, serum iron bound to transferrin and erythrocyte protoporphyrin IX. Scanty clinical signs are still available. In a third step while clinical findings show a complete features of iron deficiency anemia (weakness, fatigue, palpitations, etc.), laboratory findings show morphologic alterations in red cells (hypochromia and microcytemia), together with the aforementioned disorders in ferrokinetics. Iron deficiency anemia responds very effectively to treatment due a correct etiological diagnosis, crucial to a through therapy tending to first eliminating the causes of it. Prophylaxis against iron deficiency anemia is required in prematurely born and low birth weight infants because of doubled iron requirements. After the second month of life diet is supplemented with 2-4 mg/kg/die of ferrous iron orally along the first year of life.

Adolescent↗
PubMed1991

[Study of screening criteria for anemia among school children in China].

A study of 10,378 school children of 6-17 years old from six southern and northern provinces of china, where there was no hookworm disease or thalassemia was made. All the children selected were healthy, with normal development and well nourished. Abnormal children and national minorities were excluded. After taking vermifuge before experiment, the subjects were given FeSO4 tablet 100 mg/day for 60 days, at same time they were given dietary instructions. Hb was measured before taking FeSO4 and two weeks after stop taking the drug. Based on the results of Hb values of children with supplemented iron, deriving percentile curves, according to percentile 5 and the reference suggestions used at home and abroad, the following (criteria) for screening anemia of Chinese children are suggested: [table: see text]

Adolescent↗
PubMed1990

Prevention of iron deficiency in preterm neonates during infancy.

The preterm infant inevitably develops iron deficiency unless supplementary iron is given. Oral iron supplementation is preferred in ideal social circumstances but, where compliance with such therapy is uncertain, intramuscular iron dextran may be a more effective treatment. A study was conducted to compare the effectiveness of two methods of preventing iron deficiency of prematurity. One group of healthy premature infants was given oral iron 2 mg/kg/d until the age of 6 months. The second similar group was given 100 mg as intramuscular iron dextran (Imferon; Fisons) between the ages of 6 and 8 weeks. Both kinds of supplementary iron appeared to have benefited the majority of infants in this trial.

Anemia, Hypochromic↗