Release of vasoactive intestinal polypeptide in mast cells by histamine liberators.
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It was demonstrated in rat experiments that a positive direct correlation exists between the decrease in the amount of histamine in rat peritoneal must cells after intravenous infusion of radiopaque agents (ROA) in a dose of 2 ml/kg and the amount of these penetrating from the blood into the peritoneal cavity. The degree of penetration is determined by the chemical structure and/or physiochemical properties of the ROA.
A relapse of bronchial obstruction during women's menstrual cycle in often observed. Incubating blood and rising rates of estrogens produce an increase of histamine-release induced by allergens. As estrogens alter the membranous potentialities of cells, they may increase their sensibility and produce a degranulation.
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