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At least 325 records · Page 18Linked to original sources
PubMed1999

Early childhood cirrhoses (ECC) in Germany between 1982 and 1994 with special consideration of copper etiology.

In a multicentric retrospective clinical study with 16 pediatric centres we identified 103 cases of histologically confirmed early childhood cirrhosis (ECC) in Germany for the years 1984-1994. The most prominent diagnoses were congenital bile duct anomalies (47.5%), inborn metabolic disorders (17.5%) and unclear etiologies (17.5%). Chronic and excessive intake of copper might be discussed as an etiological factor in 8 other cases. 5 of these were proven to have coincided with very high hepatic copper contents and copper plumbing/acid well water. Their connection with copper exposure must be considered as probable, whereas 3 others were only suspected copper cases, mainly due to reliable exclusion of other etiologies. High corrosivity (base capacity) values and copper levels in the water for infants formula of 9-26.4 mg/L were determined in those probable cases for which exposure conditions could be exactly reproduced. Additional reports on copper associated ECC, either Indian Childhood Cirrhosis (ICC) from outside India or so-called Idiopathic Copper Toxicosis ( ICT ), originate from Austria, Australia, Germany, Ireland, USA.

Child, Preschool↗
PubMed1990

[The pregnancy outcome and changes in the blood volume in relation to the time of the appearance of late toxicosis symptoms].

The author studied plasma volume and mass plasma proteins on pregnant women with late toxicosis, occurring before and after 37 weeks' gestation, as well as respective groups of healthy pregnant women--113 in all. In comparison with control groups of healthy pregnant women, the women with late toxicosis, occurred before 37 weeks' gestation, had a considerable reduction in plasma volume and in the mass plasma proteins and an increase in hematocrit, but women with symptoms of late toxicosis, occurred after 37 weeks' gestation, had an increase in plasma volume and mass plasma proteins and a reduction in the hematocrit. Delivery occurred on the average during 38.6 weeks' gestation and the newborns had weight lower with 10.8% than the respective children in the country at the same period in the group of women with toxicosis, occurred early. In women with symptoms of late toxicosis the delivery occurred during 40.4 weeks' gestation larger children than normal were born and the pregnant women gained weight considerably more. The results from the study give foundation to assume that there is no late toxicosis when the symptoms of late toxicosis occur after 37 weeks' gestation, because of which the time of occurrence of the disease should be taken into consideration in establishing the diagnosis of late toxicosis of pregnancy.

Birth Weight↗