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PubMed1983

Ameloblastoma. Light and electron microscopic study.

Light and electron microscopic studies of ameloblastoma were reviewed. The 21 cases of ameloblastoma examined were classified into 12 cases of the plexiform type and nine of the follicular type. The average age of the patients with the plexiform type was 25.3 years, while that of those with the follicular type was 54.4 years. Histologically, in the follicular type, the tumor cells consisted of two cell types, central polyhedral and star-shaped cells resembling the stellate reticulum and peripheral cuboidal and columnar cells similar to the inner enamel epithelium. The resemblance between the tumor follicle and enamel organ was confirmed electron microscopically. In the plexiform type, however the tumor cells did not show two cell types, but resembled squamous epithelium. Electron microscopically, all cells of the tumor strands had relatively numerous bundles of tonofilaments and were joined together by desmosomes. Differentiation of tumor cells to squamous epithelium less evident than in normal surface epithelium. We speculate that these histological differences between plexiform and follicular types represent the differentiation tendency of the remnant of the dental lamina at the time of neoplastic transformation. What decides the histological pattern is unknown but age may be a factor. Central epidermization with keratinization or microcytic changes was frequently seen in the follicular type. Keratinization and microcystic changes rarely occurred in the plexiform type. We do not believe that these changes are a form of involution or result from multipotentiality of the tumor cells.

Adolescent↗
PubMed1988

Adenomatoid odontogenic tumour: co-expression of keratin and vimentin.

Immunohistochemical observations of intermediate sized proteins in five cases of adenomatoid odontogenic tumour (AOT) are described. The immunohistochemical detections of keratins were made with polyclonal antiserum (TK, 41-65 kDa) and three monoclonal keratin antibodies (KL1: 55-57 kDa; PKK1: 40, 45, and 52.5 kDa and nos. 19, 18, 8; K8.12: nos. 16, 13) and vimentin and desmin monoclonal antibodies. Histologically, the tumour epithelia could be divided into two types: type A cells were a spindle or columnar shape and formed solid, ductal, tubular or whorled structures. Type B cells were small and compact cells at the periphery of the A cell-containing focus. Immunohistochemically, the type A cells showed very slight reaction with all antibodies to keratins, whereas the type B cells indicated slight-to-moderate expression of keratin and vimentin, and showed coexpression. Both types of cell showed a negative reaction for desmin. Only one case was associated with cystic lesions, and the cyst-lining was composed of thin squamous epithelium. Keratin expression in this epithelium was strong. In the histogenesis of AOT it was postulated that the tumour cells may have originated from undifferentiated odontogenic epithelium or stratum intermedium cells.

Adolescent↗
PubMed1999

Induction of apoptosis in maxillary sinus cancer cells by 5-fluorouracil, vitamin A and radiation (FAR) therapy.

The triple combination of 5-fluorouracil (5-FU), vitamin A and radiation (FAR therapy) has been used since 1972 to treat malignant tumors of the head and neck at Kyushu University. Using nick end labeling of tumor specimens, cells of human maxillary sinus carcinomas were observed previously to undergo apoptosis in response to FAR therapy. The present study evaluated the in vitro effects of FAR therapy on a human maxillary sinus cancer (IMC-4) cell line. We further compared the effects of FAR therapy on this cell line with those effects seen on tissue samples taken from patients with maxillary sinus cancers. DNA electrophoresis and electron microscopic examination of the IMC-4 cells after treatment with FAR therapy revealed typical apoptotic features. The effects of 50-100 micrograms/ml 5-FU, 10(-4) M all-trans-retinoic acid and radiation to 6 Gy on IMC-4 cells were evaluated by trypan blue dye exclusion and a cell colony formation assay. 5-FU and radiation caused direct cell death, while vitamin A mainly inhibited cell growth. The combination of these treatment as FAR therapy synergistically enhanced cell death and inhibited cell growth. Flow cytometry demonstrated that FAR-treated cells were arrested in the G1 phase of the cell cycle before undergoing apoptosis. To further investigate possible biological parameters influencing a tumor's apoptotic sensitivity, we also examined the expression of p53 in human maxillary sinus cancer cells and analyzed the relationship between p53 expression and apoptosis. However, no relationship was found between these two markers at the time point studied.

Antineoplastic Agents↗
PubMed1999

[Titanium magnets on implants as an aid in rehabilitation after tumor treatment].

After the resection of a tumor, many patients need a reconstruction with hard and soft tissue and also with sufficient dentures. Often, only little space is available for the implantation. Implant length and diameter have to be reduced, and the result is a change in the biomechanics with a possible mechanical overloading of the implant. We examined 52 tumor patients undergoing reconstruction with 189 implants. A new concept involving attachment with the help of magnets is presented, offering a satisfactory solution in these difficult cases after tumor resection and reconstruction.

Bone Transplantation↗
PubMed2000

[Odontogenic tumors].

The clinical symptoms of odontogenic tumors are non-specific. On the roentgenographs one most often sees radiolucencies within the bone, sometimes in combination with scattered or diffuse radioopacities. Root resorptions may be another important feature. After a short historical introduction on the development of today's classification of odontogenic tumors (WHO), each individual type of neoplasm is discussed briefly. Out of this, a therapeutic regime is developed that places each of the 22 entities into one of the following four groups: malignant, locally aggressive, tumors with recurrences, and non-recurrent ones.

Adult↗
PubMed2002

[Implantology in oromaxillofacial surgery].

Since the last 30 years endosseous implants are a well established treatment technique in maxillofacial surgery. Implants are used in the rehabilitation of patients having lost parts of maxilla or mandible due to tumor surgery, or which due to radiotherapy have problems tolerating mucosa-borne dentures. The implant borne prosthesis will aid to regain live quality to those patients. Improvement of live quality is also the result when epithetic reconstructions of soft tissue defects in the face are stabilized by extraoral implants. Aim of the paper is to give an overview on important implant related pathophysiological osseous healing patterns, discuss methods to influence these processes, to show correction possibilities for the bony bed and highlight their indications as well as to inform about clinical experiences with endosseous implants.

Dental Implantation, Endosseous↗
PubMed2001

[Neoplasms of the temporomandibular joint (TMJ). Diagnosis, differential diagnosis and intervention].

PURPOSE: To evaluate the effectiveness of diagnostic and interventional radiological techniques for neoplastic lesions of the temporomandibular joint (TMJ). MATERIAL AND METHODS: Modern diagnosis of the TMJ is based on the clinical use of conventional X-ray techniques, computed tomography (CT), magnetic resonance imaging (MRI) and interventional techniques like biopsies, vascular occlusion and ablation. RESULTS: Conventional X-ray still forms the basic diagnostic procedure applied in open and closed mouth position. CT improves the diagnostic information and serves as the standard diagnostical instrument for cartaliganeous or osseous neoplastic lesions. MRI evaluates soft tissue infiltration in multiplanar techniques and high spatial resolution. Interventional vascular and ablative techniques improve the treatment of neoplastic disorders. CONCLUSION: Radiological diagnostic procedures are essentials for the diagnosis and intervention of neoplastic lesions of the temporomandibular joint.

Biopsy↗
PubMed2001

Pulmonary metastasectomy in the treatment of recurrent ameloblastoma of the maxilla and mandible: a case report.

Ameloblastoma is an aggressive benign tumor with frequent local recurrences. Although histologically benign, it occasionally metastasizes to many organs, most commonly to the lungs. The metastasis develops after multiple recurrences and many unsuccessful attempts at removal of the tumor. When distant metastasis occurs, the prognosis is poor and there is no effective treatment. A case of metastatic ameloblastoma of the mandible and maxilla is reported which was treated with pulmonary metastasectomy. The treatment options are discussed in relation to the literature.

Adult↗
PubMed1975

American Burkitt's lymphoma: a clinicopathologic study of 30 cases. II. Pathologic correlations.

Thirty cases of malignant lymphoma, undifferentiated, Burkitt's type are reviewed. An older median age and a predominance of presentation in abdominal and pelvic sites rather than in the jaw distinguishes this series of American patients from those reported from endemic regions in Africa. Bone marrow involvement invariably consisted of massive infiltration recognizable in smear, clot and biopsy preparations. Involvement of the central nervous system or bone marrow was always associated with short survival. In all eight long-term survivors lymphoma was apparently confined to a single site at presentation. At autopsy, the most consistent finding was widespread multiorgan involvement without predilection for lymphoreticular structures. The histologic appearance of the tumor changed after chemotherapy, varying from diffuse necrosis within 48 hours of initial therapy to extreme pleomorphism of tumor cells after 9 months of therapy. In one patient, there was almost complete absence of lymphoma at autopsy in an organ site shown clinically to have been extensively involved by tumor prior to treatment. The diagnostic and therapeutic implications of these findings are discussed.

Abdomen↗
PubMed1976

Advanced and recurrent squamous carcinoma of the lower lip.

The results of aggressive surgical treatment of primary lip cancer and advanced and recurrent carcinoma of the lip are illustrated and discussed. Early detection of involved lymph nodes before capsular penetration occurs and careful and complete dissection of the submental and submandibular regions are advocated as possible ways to prevent persistent upper neck disease, the main killer of these patients.

Carcinoma, Squamous Cell↗
PubMed1981

Fibroosseous tumors of the facial skeleton in association with primary hyperparathyroidism: an endocrine syndrome or coincidence?

In a retrospective study of 350 cases of primary hyperparathyroidism at the University of Toronto, 5 patients had associated benign fibroosseous lesions of the facial skeleton which did not regress after successful parathyroidectomy and restoration of normocalcemia. Two of these patients were siblings and an offspring of one of these patients was recently shown to have hyperparathyroidism, suggesting that this group of patients does represent a syndrome with familial and genetic implications. At present bone disease in patients with hyperparathyroidism should be viewed with some consideration of unrelated process, and appropriate biopsy and treatment should be undertaken after its recognition.

Adenoma↗
PubMed1977

Jaw lymphoma in Middle East children.

Six cases of jaw lymphoma occurring in Middle East children between 1971-1976 are reported. While the histological and radiological appearances of the tumours were suggestive of a diagnosis of Burkitt's tumour, the Middle East tumour failed to respond clinically to treatment which is effective against Burkitt's lymphoma. It is believed that these tumours may constitute a separate clinical entity. The identification of the initiating agent should be a matter of urgency, for treatment at present is invariably unsuccessful.

Child↗
PubMed1977

Clinical statistics of odontogenic cysts in West Malaysia.

A study was made of the clinical statistics of odontogenic cysts treated at two hospitals in West Malaysia over a 6-year period. The general incidence of the individual cyst-types is similar to that reported in previous studies. A marked difference in the age distribution of radicular cysts emerged and 80% of the residual cysts in the survey occurred amongst the Chinese population. Reasons for the distribution variation are discussed.

Adolescent↗
PubMed1980

Gigantiform cementoma: review of the literature and a case report.

Gigantiform cementoma is a very rare lesion in the jaw. A 64-year-old caucasian female who presented with this condition is reported and the relevant literature reviewed. The difficulty of making a definitive diagnosis on histological grounds is discussed. An attempt has been made to analyse the lesion biochemically in order to confirm its cemental origin.

Cementoma↗