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Magnetic resonance imaging of the musculoskeletal system. Part 8. The spine, section 1.

Magnetic resonance has assumed a preeminent role in the imaging evaluation of the spine. Owing to its multiplanar capability and superior soft tissue contrast, magnetic resonance imaging is the procedure of choice for a host of spinal disorders including degenerative disc disease, tumor evaluation, trauma, and spinal deformities. It represents the most accurate means of distinguishing between recurrent disc herniation and epidural fibrosis, and it excels at the assessment of many postoperative abnormalities such as infection, adjacent segment disc degeneration, and arachnoiditis. Magnetic resonance imaging is also helpful in the evaluation of numerous diagnostic challenges that are less well resolved by other means. This includes the distinction between disc herniation and epidural hematoma, synovial cyst from nonspecific fibrous thickening of a facet capsule, and the evaluation of numerous other soft tissue abnormalities. Computed tomography, computed tomography myelography, and scintigraphy continue to be useful for numerous specific disorders and in those patients with metal hardware or contraindications to magnetic resonance scanning. Overall, however, magnetic resonance is the imaging procedure preferred for many spinal disorders. This article is the first installment of a 3-part series discussing the role of magnetic resonance imaging of spinal disorders. Section 1 will describe the varying imaging modalities available and their relative advantages and disadvantages. A consideration of magnetic resonance imaging techniques will follow, followed by a discussion of the imaging manifestations of early degenerative disc disease. Section 2 will be devoted to an in depth discussion of specific pathologic processes encountered in patients with degenerative disc disease. Section 3 will end the series with a consideration of postoperative imaging followed by a discussion of spinal deformities, trauma, and neoplasms.

Bone Marrow↗

Magnetic resonance imaging of the musculoskeletal system. Part 8. The spine, section 2.

Magnetic resonance imaging has revolutionized the noninvasive evaluation of degenerative disc disease and its complications. Compared with computed tomography and computed tomographic myelography, magnetic resonance allows specific determination of the nature of disc protrusions and other degenerative related soft tissues about the spine. Magnetic resonance offers the most complete evaluation of specific degenerative disorders including degenerative facet disease, spondylolysis, spondylolisthesis, spontaneous lumbar epidural hematomas, and juvenile discogenic disease.

Hematoma, Epidural, Cranial↗

Magnetic resonance imaging of the musculoskeletal system. Part 9. Primary Tumors.

Magnetic resonance imaging, because of its exquisite soft tissue contrast, has dramatically improved the ability to preoperatively stage primary osseous and soft tissue neoplasms. This technique also has allowed the monitoring of the effects of chemotherapy and the screening for recurrence of neoplasms. The role of magnetic resonance imaging in the preoperative evaluation of the patient with a suspected primary osseous or soft tissue neoplasm is outlined, instances where magnetic resonance imaging potentially may make a specific diagnosis are outlined, the importance of gadolinium enhancement as an adjunct to native magnetic resonance imaging is stressed, and an algorithm for followup of patients after chemotherapy or definitive surgical treatment is presented. In all cases, the magnetic resonance images should be correlated with the plain film, which is still an important aspect of the diagnosis of osseous lesions.

Biopsy↗

Variable gearing during locomotion in the human musculoskeletal system.

Human feet and toes provide a mechanism for changing the gear ratio of the ankle extensor muscles during a running step. A variable gear ratio could enhance muscle performance during constant-speed running by applying a more effective prestretch during landing, while maintaining the muscles near the high-efficiency or high-power portion of the force-velocity curve during takeoff. Furthermore, during acceleration, variable gearing may allow muscle contractile properties to remain optimized despite rapid changes in running speed. Forceplate and kinematic analyses of running steps show low gear ratios at touchdown that increase throughout the contact phase.

Acceleration↗

Effect of acupuncture on disorders of musculoskeletal system in Nigerians.

Acupuncture was offered to patients with lesions affecting the locomotor system. These patients had received conventional physiotherapy treatment with limited success. The lesions treated by acupuncture were hemiplegia, low back pain, frozen shoulder, dropped foot, Sciatica, and arthritis of the knee and hip. Response to acupuncture was excellent in the more acute conditions of low back pain and frozen shoulder, where six treatment sessions were required for complete recovery. The more chronic conditions required many more treatment sessions and the improvement recorded was significant, though not complete. It was concluded that acupuncture has a valuable role to play in a physiotherapy department.

Acupuncture Therapy↗

Infections of the musculoskeletal system: high-field-strength MR imaging.

Twenty-two patients with clinical findings consistent with osteomyelitis, soft-tissue infection, or both were studied with magnetic resonance (MR) imaging at 1.5 T. Another 15 patients with joint effusion but no clinical or laboratory signs of infection served as controls. Soft-tissue abscesses, osteomyelitis, joint and tendon sheath effusion, and cellulitis were well depicted on MR imaging, allowing the correct diagnosis of presence and extent of infection in all but two cases. MR imaging was as sensitive as technetium-99m methylene diphosphonate bone scintigraphy in demonstrating osteomyelitis and was more specific and more sensitive than other scintigraphic techniques in demonstrating soft-tissue infections, primarily because of its superior spatial resolution. Computed tomography, performed in seven cases, was as accurate as MR imaging in demonstrating bone and soft-tissue infections. Infected and noninfected synovial effusions had the same signal intensity, but associated findings such as soft-tissue fluid collections or osteomyelitis made the distinction possible.

Abscess↗

Experimental infections of the musculoskeletal system: evaluation with MR imaging and Tc-99m MDP and Ga-67 scintigraphy.

Acute osteomyelitis, soft-tissue infection, or both were experimentally produced in 38 New Zealand white rabbits, and three-phase technetium-99m methylene diphosphonate, gallium-67, and magnetic resonance (MR) images were obtained 7 or 14 days after infection. There was no significant difference between radionuclide studies and MR images in the detection of osteomyelitis, but MR imaging was significantly more sensitive (100% vs. 69%; P less than .01) in the detection of soft-tissue infection. In addition, cellulitis could not be distinguished from soft-tissue abscess on radionuclide studies, whereas MR imaging was 92% accurate in depicting soft-tissue abscesses. Further research is necessary to determine how to relate these findings to true human clinical situations.

Abscess↗

Epaxial muscle function during locomotion in a lizard (Varanus salvator) and the proposal of a key innovation in the vertebrate axial musculoskeletal system

The pattern of electromyographic activity in the epaxial muscles of walking and running lizards (water monitors, Varanus salvator) was quantified with high-speed video and synchronized electromyography. Muscle denervation experiments were performed and ground reaction forces were recorded to evaluate hypotheses of muscle function. Water monitors exhibit unilateral, uniphasic activation of the epaxial muscles ipsilateral to rear limb support. The iliocostalis and longissimus dorsi muscles are active throughout the support phase of the rear limb, while the transversospinalis is active only during the second half of the support phase. The timing of muscle activity does not support the presumed locomotor function of the epaxial muscles of lizards (lateral bending of the trunk). Bilateral denervation of the two most lateral epaxial muscles (iliocostalis and longissimus dorsi) caused no significant change in the amplitude of lateral trunk bending. These two epaxial muscles do not appear to be necessary for lateral bending of the trunk, nor do they appear to be involved in resisting lateral bending of the trunk. On the basis of the data reported in this study, as well as a re-evaluation of previously existing data, it is proposed that the locomotor function of the epaxial muscles of lizards is to stabilize the trunk against the vertical component of the ground reaction forces; i.e. the epaxial muscles function in a postural role during locomotion in lizards, as they do in other amniotes. This proposed postural role of the epaxial muscles may represent a key innovation of amniotes, made possible by the loss of an aquatic larval stage in their common ancestor.

Journal Article↗

Hindquarter amputation for tumours of the musculoskeletal system.

We reviewed 34 hindquarter amputations performed for malignant tumours around the hip from 1971 to 1988, classifying them as palliative or curative according to the resection margins or the presence of disseminated disease at the time of surgery. There were three peri-operative deaths, 12 palliative and 19 curative procedures. Ten patients died of disseminated disease within a year of surgery, eight of whom had had a palliative operation. Three patients died between one and five years after palliative surgery. One died of unrelated disease at nine years. Seventeen patients are disease free an average of 31 months from surgery, 16 after curative procedures. The median survival after palliative amputations was six months and the 5-year survival rate for curative cases was 83%.

Adolescent↗

Percutaneous biopsy of the musculoskeletal system: a review of 77 cases.

OBJECTIVE: To analyze the accuracy of percutaneous bone and soft-tissue biopsies. METHODS: A total of 77 percutaneous biopsies performed under computed tomographic or fluoroscopic guidance over a 24-month period were reviewed. The biopsies were performed in 74 patients, 32 male and 42 female, with a mean age of 60.3 years. RESULTS: Sixty-three bone and 14 soft-tissue biopsies were performed. No follow-up information was available for 8 patients, and 1 patient died before an accurate diagnosis could be made. There were 44 true-positive, 17 true-negative, 8 false-negative and no false-positive results. The correct diagnosis was obtained in 57 of 68 cases (83.8%). For bone biopsies, the accurate diagnosis was obtained in 47 of 55 cases (85.5%). For soft-tissue biopsies, the correct diagnosis was obtained in 10 of the 13 cases (76.9%). Diagnostic accuracy was slightly better for osteolytic than for osteosclerotic lesions. Accuracy also varied with lesion site and needle type. Cytology and pathology specimens were almost equally useful in contributing to the correct diagnosis. CONCLUSION: The accuracy of percutaneous biopsy achieved in this series is similar to that found in other series. Although diagnostic accuracy varied, accuracy is improved if both cytologic and pathologic specimens are analyzed.

Adolescent↗

[Therapy of degenerative diseases of the musculoskeletal system with South African devil's claw (Harpagophytum procumbens DC)].

Extracts of the secondary tubers of Devil's Claw (Harpagophytum procumbens) are recommended for the supportive treatment of degenerative painful rheumatism. There was observed an improvement of motility and a reduction of pain sensation in several clinical studies. Pharmacological experiments have shown analgesic, antiphlogistic and antiinflammatory actions. Most important constituents are iridoid glycosides, which are supposed to contribute mainly to the observed effects. However, the entire extract has to be considered as active ingredient.

Analgesics↗