PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Organomercury Compounds”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 325 records · Page 18Linked to original sources
PubMed2005

Simultaneous separation of organomercury species by nonaqueous capillary electrophoresis using methanol containing acetic acid and imidazole.

A simple and rapid nonaqueous capillary electrophoresis method for simultaneous separation of four kinds of mercury species, namely inorganic mercury, methylmercury, ethylmercury, and phenylmercury, is reported. The effective mobilities of organomercury in aqueous and nonaqueous electrolytes were compared. Imidazole was confirmed not only as a co-ion for the separation but also as an online complexing reagent for mercury species. The optimum conditions for separation were achieved by using methanol solvent containing 0.15 M acetic acid and 15 mM imidazole as electrolyte. The sensitive detection of mercury species was accomplished at 191 nm.

Acetic Acid↗
PubMed1986

Glutathione: a protective agent in Salmonella typhimurium and Escherichia coli as measured by mutagenicity and by growth delay assays.

Cultures of some aerobically grown strains of Salmonella typhimurium and Escherichia coli contain up to 24 microM extracellular glutathione (GSH) [Owens RO, Hartman PE (1985): Environ Mutagen 7(Suppl 3): 47] in addition to having intracellular GSH concentrations in the millimolar range. The addition of 26 microM GSH to cultures of Salmonella typhimurium strain TA1534 partially protected the bacteria from the toxic effects causing growth delay by 54 microM N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). When MNNG was preincubated with equimolar GSH, the mutagenicity of the MNNG was neutralized. The addition of micromolar GSH to cultures of an Escherichia coli GSH- strain protected the cells from growth inhibition by micromolar concentrations of mercuric chloride, methyl mercuric chloride, silver nitrate, cisplatin, cadmium chloride, cadmium sulfate, and iodoacetamide. In the cases of mercuric chloride, cisplatin, MNNG, silver nitrate, and iodoacetamide, reaction products with GSH were detected by paper chromatography. In contrast to reduced GSH, micromolar concentrations of oxidized glutathione (GSSG) provided little or no protection and formed no detectable reaction products. Export of GSH by enteric bacteria may provide an important defense mechanism against exogenous toxic agents otherwise active in the micromolar range.

Cadmium↗
PubMed1983

Tissue origin of MDH isozymes in blood serum of rats exposed to alkylmercurials.

Wistar rats were dosed with Hg at 2.5 mg kg-1 intragastrically as methylmercuric chloride (MeHg) or ethylmercuric chloride (EtHg) on alternate days for 6 weeks. Activities of the mitochondrial (m-MDH) and cytosol (c-MDH) isozymes of malate dehydrogenase (MDH: E.C. 1.1.1.37) were studied in the serum, liver and kidneys of rats at 2-week intervals using agar gel electrophoresis. In order to determine the tissue of origin of the MDH isozymes in rat serum, studies were also made on changes in their activities after poisoning the animals with a hepatotoxic (CCl4) or nephrotoxic (HgCl2) agent. The results indicate that the kidneys are responsible for the increase of the c-MDH activity in the serum of rats poisoned with EtHg, while in the case of MeHg this increase results from damage initially to the liver and then also to the kidneys.

Animals↗
PubMed1984

Hair mercury levels of Japanese women during the period 1881 to 1968.

The hair samples of Japanese females during the period from 1881 to 1968 were obtained from various localities of the central area of Japan. Inorganic mercury levels were elevated in unwashed hair samples from prewar periods, especially during 1920s , while elevation of organic mercury levels was conspicuous during 1960s. The increase of inorganic mercury levels in samples from the 1920s is suspected to be due to mercury contamination of hair cosmetics, and increased organic mercury levels in the hair from the 1960s can be explained by active fish consumption.

Adolescent↗
PubMed1985

Receptors for insulin and epidermal growth factor: interaction with organomercurial agarose.

The receptor for both insulin and epidermal growth factor (EGF) from human placental membranes, after crosslink labeling with 125I-labeled insulin and EGF, can be absorbed to an organomercurial-agarose derivative (Affi-Gel 501) and can be recovered from the gel by elution with dithiothreitol (DTT). Pretreatment of crosslink-labeled membranes with N-ethylmaleimide (NEM) blocks the ability of the receptor to react with the organomercurial column. NEM also abolishes the protein kinase activity of both receptors. Under appropriate conditions, insulin can promote the reaction of the insulin receptor with the organomercurial-agarose derivative. For both the insulin and EGF receptors, our results provide an avenue for the isolation of the sulfhydryl-containing receptor domains that may play a role in the control of receptor function.

Chromatography, Affinity↗