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PubMed1984

Bacillus subtilis spores as a natural pro-host oral agent. Preliminary data in children.

The commercial preparation of Bacillus subtilis spores may be considered within the classification of biological response modifiers (BRM's) and included among exogenous natural substances. Recently we decided to study the effect of a long-term B. subtilis spores oral treatment in children suffering from recurrent infectious diseases of the respiratory tract. Fifty-three children 5-9 years old have been studied. The clinical valuative parameter was the number of days of absence from school during a 4-month period. In another group of 12 diseased children, mean age 5.5 yrs we recently initiated a laboratory immunological evaluation of peripheral lymphomonocytes in relation to an oral treatment with B. subtilis spores for at least 2 months. Our results show that B. subtilis spore therapy significantly reduced the frequency of respiratory tract infections in the group of treated children. In addition, preliminary immunological laboratory evaluation demonstrated a complete return to the normal lymphomonocyte status after at least 2 months of treatment with B. subtilis spores.

Adjuvants, Immunologic↗
PubMed1993

[Epidemiological data on children hospitalized with malaria from 1983 to 1992].

Authors record the manifestations on the child of the severe malaria epidemic that raged in Antananarivo. Using the hospitalisation registers of the Debré room, Pediatric Service "A", at the Hospital of Befelatanana as source documents, they underline some points: Concerning morbidity, the epidemic started in 1984, reached its highest point in 1988 (26.7%, of in patients) and began to fade away in 1992. Boys and girls were equally affected, with a majority among children of 5 years old and more (51 to 58% of cases). All patients came from the center of Antananarivo (33.5%) or mainly from the surroundings (66.5%). At the highest point of the epidemic, about half of the children were suffering from severe malaria (48.9%). Plasmodium falciparum was the parasite responsible for 93.3% of cases. It seems that mortality is not influenced by sex, age or home but two factors are especially observed: nutrition disorders and delay of hospitalisation. The quinine based treatment has stemmed mortality by neuropaludism since two years.

Age Factors↗