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The structure of psychosomatic symptoms.

1. According to our findings, a psychosomatic structure is not an alternative to neurosis. The syndrome of alexithymia appears to be, in our cases, a transitional phase, the dynamics of which can be understood and treated by psychotherapy. In the course of psychotherapeutic treatment, alexithymia always disappears. 2. However, a special psychotherapeutic technique is advisable, one different from that applied in classical neurosis. 3. For this reason the term psychosomatic structure can be used as a way of expressing a variation of neurosis. 4. Modern concepts of psychosomatic disease describe pathological personalities that are different from the classic pseudoneurotic type because of their narcissistic and pregenital structures. These structures can be concealed underneath a facade of genital and psychoneurotic defense. 5. The old relationship between psychosomatosis and psychosis can be better understood on the basis of our findings, which reveal a borderline structure and splitting mechanisms in many psychosomatic patients. 6. Psychosomatic pathology can be better understood today by relating it to the structure of the psychosomatic family. 7. It appears that if, on the one hand, psychosomatic diseases of a more hysterical picture are frequent among preindustrial cultures and in low-income classes, on the other hand psychosomatic syndromes of a narcissistic and borderline type are characteristic for our civilization.

Humans↗

Subliminality, consciousness, and temporal shifts in awareness: implications within and beyond the laboratory.

In his analysis of subliminal perception research, documented two important (but neglected) phenomena: subchance perception and temporal variability in stimulus availability and accessibility. This Commentary addresses three issues raised by Erdelyi's review: (1) the importance of distinguishing "micro" from "macro" temporal shifts; (2) the need to analyze perception without awareness data at the level of the individual as well as the group; and (3) parallels between the dissociations associated with neuroclinical phenomena (e.g., hemispheric isolation) and those observed in patients with certain forms of personality pathology. Continued integration of laboratory findings with in vivo observations of clinical syndromes will yield a more cohesive and heuristic approach to the study of implicit mental states.

Awareness↗

Dialectical Behavior Therapy of borderline patients with and without substance use problems. Implementation and long-term effects.

OBJECTIVE: The aim of this article is to examine whether standard Dialectical Behavior Therapy (DBT) (1) can be successfully implemented in a mixed population of borderline patients with or without comorbid substance abuse (SA), (2) is equally efficacious in reducing borderline symptomatology among those with and those without comorbid SA, and (3) is efficacious in reducing the severity of the substance use problems. METHOD: The implementation of DBT is examined qualitatively. The impact of comorbid SA on its efficacy, as well as on its efficacy in terms of reducing SA, is investigated in a randomized clinical trial comparing DBT with treatment-as-usual (TAU) in 58 female borderline patients with (n = 31) and without (n = 27) SA. RESULTS: Standard DBT can be applied in a group of borderline patients with and without comorbid SA. Major implementation problems did not occur. DBT resulted in greater reductions of severe borderline symptoms than TAU, and this effect was not modified by the presence of comorbid SA. Standard DBT, as it was delivered in our study, however, had no effect on SA problems. CONCLUSIONS: Standard DBT can be effectively applied with borderline patients with comorbid SA problems, as well as those without. Standard DBT, however, is not more efficacious than TAU in reducing substance use problems. We propose that, rather than developing separate treatment programs for dual diagnosis patients, DBT should be "multitargeted." This means that therapists ought to be trained in addressing a range of severe manifestations of personality pathology in the impulse control spectrum, including suicidal and self-damaging behaviors, binge eating, and SA.

Adolescent↗

The prevalence of atypical features across mood, anxiety, and personality disorders.

This study examines and compares the prevalence rates of the atypical features subtype across each of the major mood, anxiety, and personality disorders (PDs). It also evaluates the impact that comorbid anxiety and PDs have on the likelihood that depressed patients will present with atypical symptoms. Eleven hundred thirty psychiatric outpatients were evaluated for the presence of atypical symptoms. All axis I diagnoses were made using the Structured Clinical Interview for DSM-IV (SCID). PDs were assessed in a subset of 530 patients using the Structured Interview for DSM-IV Personality Disorders (SIDP-IV). From a sample of 579 patients diagnosed with a current major depressive disorder, 22.5% met criteria for the atypical subtype. Prevalence rates were similar in bipolar and unipolar patients, although the pattern of symptoms was distinct. Prevalence rates were lower in patients with dysthymic disorder (12.5%), adjustment disorder with depressed mood (9.4%), and depression not otherwise specified (NOS) (7.9%). When major depression existed in the presence of a comorbid anxiety disorder, the likelihood of presenting with atypical features doubled. Nine percent of the patients diagnosed with an anxiety disorder (without a comorbid depressive disorder) met criteria for atypical features. Two of the four atypical symptoms, leaden paralysis and rejection sensitivity, were found to be especially prominent in nondepressed anxiety disorder patients. Of the 10 PDs listed in DSM-IV, only avoidant PD was associated with the atypical features subtype. In large part, this was accounted for by the high rate of rejection sensitivity in these patients. In conclusion, as many as one quarter of depressed patients who present for outpatient psychiatric treatment meet criteria for the atypical features subtype. There appears to be a strong association between anxiety and atypical depression, but the exact nature of this relationship needs to be further elucidated. It is unclear whether personality pathology is independently associated with the atypical features subtype.

Adolescent↗

[Problem of clinico-pathogenetic analysis and correction of behavior disorders in adolescents].

On the basis of integrated clinical, dynamic, and neurophysiological examinations of 542 children and adolescents with behaviour deviations a high (54.05%) percentage of psychic anomalies (primarily, characterological ones) was discovered. The structure of the delinquent behaviour was found to be the most complicated in children and adolescents taught at special schools for juvenile offenders. In adolescents registered at the Inspection on Minors' Affairs this structure was of a more isolated character. An important role of combinations of constitutional-biological, exogenous-organic, and negative microsocial factors in the genesis of the juvenile delinquency is demonstrated. Clinical and laboratory examinations of "difficult" adolescents with distinct neuropsychic disturbances revealed substantial shifts in their cortical neurodynamics and the functioning of chemoreactive systems. On the basis of the data obtained a complex of differentiated therapeutic and hygienic measures aimed at attaining a regression of the borderline personality pathologies has been developed.

Adolescent↗

The hysterical personality--I. The healthy hysteric.

This paper examines the meaning and validity of 'hysterical personality disorders'. Theories and descriptions of hysterical personalities have been conflicting and often mutually incompatible, leading to a vague and imprecise nosology. No generally accepted specific inclusion criteria or follow-up studies are available; consequently, the diagnosis of 'hysterical personality disorder' has reflected adaptive as well as maladaptive traits. This paper critically examines the healthy dimension of Lazare's continuum of personality pathologies exhibiting hysterical traits. The continuum, in an attempt to reconcile the inconsistencies of this diagnosis, ranges from the relatively healthy (good, genital, true) hysteric, to the sick (bad, oral, 'so-called good') hysteric. But this paper concludes that here, too, evidence for diagnostic legitimacy is lacking. Women at the healthy end of the hysterical personality spectrum are best regarded as healthy and do not meet criteria for the diagnosis of a personality disorder.

Female↗

Predicting psychological mindedness from personality style and attachment security.

The aim of this study was to increase the construct validity of the Psychological Mindedness Scale (PM Scale) by investigating its relationship to well-established measures of personality style (NEO Five-Factor Inventory) and attachment security (Inventory of Parent and Peer Attachment). Personality and attachment variables functioned as differential predictors of psychological mindedness (PM). Openness to Experience emerged as the best predictor of PM, followed by Extraversion, Neuroticism (inversely related to PM), and Attachment to Peers. Neither Attachment to Mother nor Attachment to Father predicted PM. The results of this study indicate that PM is related positively to healthy, rather than pathological, personal and interpersonal constructs.

Adult↗

The blood brain barrier in HIV infection.

The blood brain barrier (BBB) serves as a protective mechanism for the brain. It prevents entry of pernicious substances, whether chemical or cellular, from free access to the CNS. In essence, it is a defense mechanism preserving the internal milieu of the brain. The BBB may be disrupted by a number of pathological processes. CNS infection is a well recognized cause of BBB disruption. Among the CNS infections demonstrated to affect the BBB is human immunodeficiency virus (HIV). HIV infects the brain shortly after its acquisition. Studies of cerebrospinal fluid (CSF) as well as dynamic studies of contrast enhanced magnetic resonance imaging have confirmed abnormalities of the BBB in HIV-infected persons. Pathological studies of the CNS have confirmed the in vivo studies, and in vitro studies have identified a range of pathogenic mechanisms of HIV-associated BBB compromise. This disruption of the BBB may not only contribute to accelerating brain infection by HIV, but may also alter CNS function. Additionally, BBB disruption has implications with respect to antiretroviral therapy. This review will address these issues.

Acquired Immunodeficiency Syndrome↗

[Clinico-psychopathological characteristics of the mental disorders at a neurotic level detected in patients at a general polyclinic].

Examination of patients observed at a general somatic outpatient centre showed that 31.2% of the patients had mental disorders of the borderline level. Most commonly occurring among the psychopathological syndromes were atypical affective conditions with definite somatization of mental disturbances, which was expressed in massive somatic sensations (senestopathies), vegetative irregularities, and somatic pathology of the functional character. Such conditions made up 62.7%. The given syndromologic type is defined as senestopathic-hypochondriac depression which is subdivided into two variants depending on the nature of the symptomatology. The study has shown that the revealed psychopathological syndromes of the borderline level predominantly refer to the endogenic process of low intensity and less frequently to personality pathology at the stage of decompensation.

Ambulatory Care↗

[Comparative multidimensional analysis of the personality traits of patients with different forms of gynecologic pathology].

The personality characteristics of gynecological patients with hormonal dysfunction versus hormone dependent pathology were compared, using a factorial analysis of answers to 377 questions of the Russian modified variant of MMPI and a cluster analysis of intergroup subdivisions. A group of patients with uterine myoma (UM) differed considerably from all the others in relation to six "varimax" factors. A new factor scale was elaborated which makes it possible to differentiate a group of patients with UM from both healthy women and other gynecological patients. The results obtained are discussed in the light of the hypothesis about the psychosomatic nature of UM. The factor scale presented may be utilized for detecting a group of high risk for UM development.

Adrenal Cortex Diseases↗

Personality disorders and associated features in cocaine-dependent inpatients.

Previous research has shown a high prevalence of comorbid personality disorders among individuals seeking treatment for cocaine dependence. We studied axis II disorders (using the Structured Clinical Interview for DSM-III-R Personality Disorders [SCID-II]) in 50 patients admitted for inpatient rehabilitation. All patients met lifetime criteria for cocaine dependence and reported cocaine use during the month before admission. Seventy percent of patients met criteria for at least one axis II diagnosis; the mean number of axis II diagnoses among these patients was 2.54 (range, one to six). The most common axis II diagnosis was borderline (34% of all patients), followed by antisocial and narcissistic (each 28%), avoidant and paranoid (each 22%), obsessive-compulsive (16%), and dependent (10%). To evaluate the relationship between comorbid personality pathology, substance abuse, and other psychiatric symptomatology, patients were divided into two groups based on whether they received an axis II disorder diagnosis. The groups did not differ on substance abuse variables. However, there were significant group differences on a measure of psychosis proneness and in the number of comorbid depressive and anxiety disorder diagnoses. These results are consistent with other studies of personality disorders in substance abuse patients, and suggest that it may be clinically useful to characterize cocaine-dependent patients with respect to comorbid axis II disorders.

Adult↗

Reliability and validity of DSM-IV axis V.

OBJECTIVE: The authors investigated the reliability and convergent and discriminant validity of the DSM-IV Global Assessment of Functioning Scale and two experimental DSM-IV axis V global rating scales, the Global Assessment of Relational Functioning Scale and the Social and Occupational Functioning Assessment Scale. METHOD: Forty-four patients admitted to a university-based outpatient community clinic were rated by trained clinicians on the three DSM-IV axis V scales. Patients also completed self-report measures of DSM-IV symptoms as well as measures of relational, social, and occupational functioning. RESULTS: The Global Assessment of Functioning Scale, Global Assessment of Relational Functioning Scale, and Social and Occupational Functioning Assessment Scale all exhibited very high levels of interrater reliability. Factor analysis revealed that the Global Assessment of Relational Functioning Scale and the Social and Occupational Functioning Assessment Scale are each more related to the Global Assessment of Functioning Scale individually than they are to each other. The Global Assessment of Functioning Scale was significantly related to concurrent patient responses on the SCL-90-R global severity index. The Social and Occupational Functioning Assessment Scale was significantly related to concurrent patient responses on the SCL-90-R global severity index and to a greater degree with both the Social Adjustment Scale global score and the Inventory of Interpersonal Problems total score. Although the Global Assessment of Relational Functioning Scale was not significantly related to any of the three self-report measures, it was related to the presence of clinician-rated axis II pathology. CONCLUSIONS: The three axis V scales can be scored reliably. The Global Assessment of Relational Functioning Scale and the Social and Occupational Functioning Assessment Scale evaluate different constructs. These findings support the validity of the Global Assessment of Functioning Scale as a scale of global psychopathology; the Social and Occupational Functioning Assessment Scale as a measure of problems in social, occupational, and interpersonal functioning; and the Global Assessment of Relational Functioning Scale as an index of personality pathology. The authors discuss further refinement and use of the three axis V measures in treatment research.

Adult↗

[Neurological and mental disorders in combatants].

Four hundred and twenty patients admitted to the veteran's hospital with neuro- and psychopathology have been examined. Along with clinical, neurological, psychiatric and psychological methods, electroencephalography, computed tomography, electrocardiography, ultrasonic and X-ray methods for nervous system investigation as well as biochemical and immunological blood examination were used. The following disorders were singled out: (1) mental disorders--neurosis, personality pathology, post-traumatic stress disorder and different types of addictions (alcoholism, drug dependence): (2) consequences of craniocerebral and other injuries; (3) psychosomatic pathology. The prevalence, clinical manifestations and dynamics of each group of disorders are studied and their patho- and sanogenesis in terms of theory of functional systems are regarded.

Adult↗

Efficacy of pharmacotherapy in depressed patients with and without personality disorders: a systematic review and meta-analysis.

BACKGROUND: During the past decades personality pathology was considered to have a negative influence on the outcome of pharmacotherapy of depressive disorders. Recently, there has been a shift towards a less negative opinion. Still, the evidence in the literature remains inconclusive. This may be explained by methodological differences between published studies. OBJECTIVE: To present a meta-analysis of the results of Randomised Controlled Trials with pharmacotherapy in the treatment of depression with comorbid personality disorders. METHOD: Systematic literature search for RCTs in adult ambulatory patients with major depressive disorder and comorbid PDs; pooling of data and meta-analysis according to strict methodological criteria. RESULTS: The difference in remission rates between the groups with and without personality disorders in high quality studies was 3%; this difference was neither statistically significant nor clinically relevant. LIMITATIONS: Due to the specific and sensitive methods of the search only six studies could be included in the meta-analysis. Due to lack of data, analyses of drop-out rates could not be made. CONCLUSION: When only data from high quality RCTs are included, comorbidity of personality disorder and major depression does not have a negative effect on the treatment outcome of pharmacotherapy for major depression.

Comorbidity↗

Generalizability of antidepressant efficacy trials: differences between depressed psychiatric outpatients who would or would not qualify for an efficacy trial.

OBJECTIVE: In recent years the generalizability of antidepressant efficacy trials has been questioned. Central to the question of generalizability is whether there are differences in clinical, demographic, and psychosocial characteristics between patients who would qualify for an antidepressant efficacy trial and those who would not qualify. METHOD: The authors compared three groups: 123 depressed patients who would qualify for an antidepressant efficacy trial, 289 whose symptom severity was too mild to qualify for an antidepressant efficacy trial, and 187 who would be excluded because they were suicidal or had a comorbid anxiety or substance use disorder. RESULTS: Compared with patients who would qualify for an antidepressant efficacy trial, patients who would be excluded because of comorbidity or suicidality were a more chronically ill group with more previous episodes, greater psychosocial impairment, and more personality pathology. CONCLUSIONS: These findings support further caution in generalizing the results from antidepressant efficacy trials to clinical populations.

Adult↗

Personality profiles in patients referred for chest pain. Investigation with emphasis on panic disorder patients.

Patients (N = 199) referred to cardiac outpatient investigation because of chest pain were assessed with the Personality Diagnostic Questionnaire (PDQ-4). Thirty-nine percent scored positive for any personality disorder. Borderline and avoidant personality disorders were found significantly more often in patients with panic disorder (PD) (n = 72) than in patients without PD (12.5% vs. 2.5%, 23.7% vs. 7.7%, respectively). In PD patients, the presence of any personality disorder was significantly associated with higher scores of self-reported anxiety-agoraphobia symptoms, neuroticism, and the presence of suicidal thoughts. These results suggest that personality pathology is important in a subgroup of patients presenting with chest pain and that these patients may require more extensive treatment.

Adolescent↗

Personality subtypes in eating disorders: validation of a classification in a naturalistic sample.

BACKGROUND: Research has identified three personality subtypes in patients with eating disorders: emotionally dysregulated, constricted and high-functioning/perfectionistic. AIMS: To see whether the subtypes are distinguished in ways indicative of valid classification, notably in patterns of adaptive functioning, comorbidity, treatment response and therapeutic interventions. METHOD: A random sample of experienced clinicians provided data on 145 patients with bulimic symptoms, including data on eating disorder symptoms, DSM-IV comorbidity, personality pathology, treatment response and treatment interventions. RESULTS: Patients categorised as dysregulated had the poorest functioning, most comorbidity and worst outcome, followed by patients in the constricted and high-functioning groups. The three subtypes elicited different therapeutic interventions and accounted for substantial incremental variance in outcome, holding constant the severity of eating disorder symptoms and presence of other Axis I disorders. CONCLUSIONS: The data provide accumulating evidence for the validity of three personality subtypes in patients with eating disorders.

Adolescent↗

[The effect of aminazine therapy on the functional state of the brain in children with behavioral disorders].

The study deals with the influence of therapy with chlorpromazine on EEG in children aged 9 to 15 with psychopath-like affective-excitable behavior of residual-organic origin (21 patients, and with pathologic personality development of affective-excitable type (15 patients). Baseline indices of the brain electric activity were compared with those during chlorpromazine treatment. Histographic analysis was applied to EEG. The rate of extinction of various components of orienting response to sound (activation response, vertex-potential, galvanic skin response) were also recorded, as was the reproduction of the rhythm of light flashed at different rates. The results pointed to the increase in pathological signs in the patients' EEG during the prolonged chlorpromazine course that suggested its more careful use in children with psychopath-like affective-excitable behavior.

Adolescent↗