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At least 325 records · Page 18Linked to original sources
PubMed1976

[Research on hepatic and overall collagen metabolism in irradiated rats (author's transl)].

The authors studied the effect of ionising radiation on hepatic and overall collagen metabolism in rats. Doses of 100 and 250 rads produced a reduction in urinary hydroxyproline while doses of 500 and 700 rads produced an increase. These results may be interpreted in favour of an increase in reticulation in the first case and in the second case, destruction of inter-molecular bonds. The quantity of total and insoluble collagen increases proportionally to the dose 40 days after the radiation. This proportional relationship is not observed during the first few days after radiation. Prolonged radiation with 700 rads produces a marked reduction in all collagen fractions, compared with 4 days after acute radiation. Among the substances studied, "folcisteine" had the best radio-protective effect when administered before radiation with 700 rads.

Adrenalectomy↗
PubMed1975

[Chromosome aberrations in the cells of monkeys that have undergone acute irradiation with the use of chemical protection].

The rate and type of chromosomal aberrations in the bone marrow cells and circulating lymphocytes of the gamma-irradiated monkeys prophylactically treated with cystamine and mexamine 5-10 minutes before the irradiation was studied. The number of chromosomal aberrations 9-10 years after the gamma-irradiation (600-650 r) of the protected monkeys was similar to that in the animals irradiated without protection. Symmetrical chromosomal changes were most freuqent in all the monkeys long after the irradition, including the animals treated with radioprotectors.

5-Methoxytryptamine↗
PubMedDate not supplied

[Study of the cytogenetic activity of radioprotectors in a human lymphocyte culture. II].

Action of certain radioprotectors: 2-mercaptoethylamine HCl (MEA), cysteine HCl, 2-aminoethylsothiouronium (AET), dithiol 2,3-dimercaptopropansulphate Na (unithiol), aminopropylaminoethylthiophosphoric acid (gammaphos), cystaphos and 5-metoxytriptamine (mexamine) was studied as applied to human chromosome aberrations induced with thio-TEPA. It was shown that with an increase in thioTEPA and protectors concentrations their effect grows.

5-Methoxytryptamine↗
PubMedDate not supplied

The effects of acute and long-term irradiation on collagen in rat liver.

The alterations of hepatic collagen were investigated at various periods of time after acute (28 min.) and long-term (11 h) irradiation with 100 R, 250 R, 500 R, 700 R. The amount of total and insoluble collagen increases proportionally with the dose 40 days after irradiation, no such a relationship being apparent in the first days after irradiation. The long-term irradiation with 700 R results in a strong decrease of the amount of each of the collagen fractions, as compared with acute irradiation, tested 4 days after irradiation. The most evident protective effect against irradiation was shown by folcystein, as compared with the other agents administered prior to irradiation with 700 R.

Animals↗
PubMed1975

[Therapy of early symptoms of radiation sickness in dogs using Pyrimetin].

The antiemetic effect of Pyrimetin (V.V.M.I.) in dogs whose whole body had been irradiated with gamma rays with the dose of 500 R, administred per os, intramuscularly, and subcutaneously, immediately before the exposure and after it in the course of the initial symptoms of the radiation sickness was studied. Decreased emesis occurred after per os administration of Pyrimetin immediately before the whole body irradiation of the dogs. After an intramuscular application before the whole body irradiation two dogs vomitted, and in the case of an i.m. administration after the whole body irradiation one dog vomitted. Subcutaneous application of Pyrimetin to dogs before the whole body irradiation and also after it produced only a 30 p.c. therapeutic effect.

Acute Disease↗
PubMed1976

[Radiorestoration by 3 cytokinins contained in yeast RNAs and extracts, of scorzonera tumor tissues exposed to cobalt-60 gamma rays].

The 3 natural cytokinins contained both in the extracts and RNA of yeast and the tumor tissues cultivated in vitro, elicit radiorestorative properties from the crown-gall tissues of Scorsonera submitted to Co60 gamma-rays. However the cytokinins produce no stimulating effect whatsoever on the non irradiated tissues that are nontheless highly stimulated by yeast extract and their RNA.

Cobalt Radioisotopes↗