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PubMedDate not supplied

The effect of social learning on a conditioned avoidance response of rats treated prenatally with aluminum lactate.

Aluminum (Al) has been proven to be a behavioral teratogenic agent in a number of experimental studies. Prenatal exposures to Al lactate have been shown to cause cognitive deficits in a variety of species. The present experiment was carried out on SPRD rat pups treated prenatally with Al lactate to determine whether observational conditioning (social learning) would reverse the impairment in learning described previously following such treatment. A conditioned avoidance response was used as an observational learning task. The results provide evidence that Al-treated pups are capable of social learning (i.e., the performance of the avoidance response improved as a result that Al-treated learning); however, the response latency of the avoidance response was not different in these animals from those that were not exposed to such facilitation, suggesting that additional factors are involved in the effects of prenatal aluminum intoxication on cognitive processes.

Aluminum Compounds↗
PubMed2005

The search for social safety and comfort in families raising children with complex chronic conditions.

Social consequences of raising children who were medically fragile and developmentally delayed (MF/DD) were explored in an ethnographic study of 20 families with school-age children. The overarching theme was the families' search for safety and comfort in social situations. Major categories comprising this theme included the need to anticipate and plan for the child's care; overcoming environmental, child-related, and attitudinal barriers; and finding social activities that were comfortable for all members of the family. When this search was successful, families could relax, and all members could participate in a variety of social encounters and activities; but when safety and comfort could not be achieved, families were likely to limit social activities or split the family so that the child who was MF/DD could be cared for while other family members participated in social events.

Adaptation, Psychological↗
PubMed2006

Social environment and depression among pregnant women in urban areas of Pakistan: importance of social relations.

Aspects of the social environment, including social conditions (socio-economic status, household situations, chronic illnesses) and social relations (attitude and behaviors of relations) are major determinants of depression among women. This study evaluates the relative power of social relations and social conditions in predicting depression among pregnant women in Pakistan. In the qualitative phase of the study, social environmental determinants were identified through literature search, and experts' opinions from psychologists, psychiatrists, gynecologists, sociologists and researchers. Along with this, 79 in-depth interviews were conducted with pregnant women drawn from six hospitals (public and private) and two communities in Karachi, Pakistan. Identified determinants of depression were grouped into themes of social conditions and social relations and pregnancy-related concerns. In the study's quantitative phase, the relative power of the identified themes and categories, based on their scores for predicting depression (determined by the Center for Epidemiological Studies-Depression Scale (CES-D scale)), was determined through multivariate linear regression. Social environmental determinants of pregnant women were described under the themes and categories of (1) social relations: involving husband, in-laws and children; (2) social conditions: involving the economy, illness, life events, household work, environmental circumstances and social problems; and (3) pregnancy-related concerns i.e. symptoms of pregnancy, changes during pregnancy, dependency and concern for unborn baby. Multivariate analysis found that among these themes, social relations and pregnancy-related concerns were significantly associated with total CES-D scores. Among the categories besides increasing age and less education, husband, in-laws, household work and pregnancy symptoms were significantly associated with total CES-D scores. The study highlights the importance of social relations compared to social conditions for determining depression in pregnant women.

Adult↗
PubMed1982

National social data series: a compendium of brief descriptions.

This is a compilation of brief descriptions of 101 data bases that together are a large portion of the national body of data as of December 31, 1981, for the study of U.S. social conditions and social change. Most of these data bases were generated by national samples, have substantial social content, and contain observations for more than one time period. The descriptions include information on sponsors, sampling procedures, cycles of data collection, magnetic tapes or other forms of output, and substantive content. Linkages to other data bases are often indicated. Topical and chronological indexes are provided, and key words are supplied for each description. An address and telephone number are provided for persons seeking further information.

Directories as Topic↗
PubMed1994

Effect of corticotropin releasing hormone on the pituitary-adrenocortical activity under basal and social stress conditions.

The effect of social crowding stress on the CRH-induced hypothalamic-pituitary-adrenocortical (HPA) responsiveness was assessed in rats crowded for 3 days, when the HPA response to neurotransmitter receptors stimulation was powerfully reduced. CRH given systemically dose-dependently increased the secretion of corticosterone. The increase was not affected by pretreatment with prazosin or propranolol, an alpha 1- or beta-adrenergic receptor antagonist, indicating the lack of involvement of adrenergic receptors in that stimulation. In the corticosterone response to CRH administered icv, a moderate involvement of hypothalamic alpha 1-adrenergic receptors and neuronal noradrenaline seems possible. The corticosterone responses to CRH given by either route to rats exposed to social crowding stress were identical with the responses of unstressed controls. Our results for the first have time shown that social crowding stress does not impair the HPA responsiveness to CRH stimulation.

Animals↗
PubMedDate not supplied

[Fact-finding investigation of the social health conditions of the elderly].

PURPOSE: The intent of the present contribution is that to verify the social health conditions of the elderly present on national territory. MATERIALS AND METHODS: The Authors have thought up an anonymous questionnaire, made up of 63 questions, concerning the life-style, the social conditions and health of the elderly over 65 years old, and consequently by now on pension. Two thousand questionnaires have been distributed to medical officers, present in north as well as in the centre and in the south of the Country; of these we have then received 1386 questionnaires for statistical processing. RESULTS: The results have been about the same for both sexes as well as for geographical distribution. The greatest part of the elderly are self-sufficient from an economical point of view, in spite of a certain economical dissatisfaction present among the males in the north. The women appear to be more active, inclined to travel. The voluptuary habits, of which smoking and drinking are almost absent in all the national territory and in both sexes. As far as prevention in concerned, consequently submitting oneself to medical check-ups, is more accepted in the south by both males and females and in the north and centre only by women. CONCLUSIONS: Our fact-finding study has given good results, and a good conformity in the portion of people interviewed. There could be a greater impulse given to the prevention of pathologies, perhaps with the assistance of free prevention campaigns revolted toward the elderly, and still dedicating more time to our "grandparents" that must not be considered a burden, but rather as a resource.

Aged↗
PubMedDate not supplied

[Children's health under the conditions of social differentiation].

Results of social-and-hygienic research of the health condition of children belonging to different social-and-economic population categories are under discussion. The material family status is shown to directly affect the child's life quality, i.e. family life mode, psychological climate, scope and variety of food-stuffs, the possibility to have a regular and valuable recreation, educational regime, and the possibility to satisfy the spiritual demands of a child etc. The morbidity goes up among children as the family income decreases. The social-and-economic conditions are the uttermost and often decisive risk factor that provokes the development of deviations in children's health. The material stratification of society conditions, for children, differing degrees of access to public benefits that are involved in shaping the children's health, thus, entailing the disequilibrium in their health. A realistic pattern of children's health is needed as a data base to define an objective necessity of children in medical care of different types as well as their necessity in medical drugs and equipment.

Adolescent↗
PubMed1984

[An objective of the education of mankind: delegated destructiveness. Mass murder of psychiatric patients in Hitler Germany].

The extermination of 100,000 inpatients of mental hospitals and 5,000 mentally retarded children in NAZI-Germany under the Hitler régime between 1939 and 1941 is reported. The ideological precursors of these actions are traced. The ethological and anthropological aspects of inner-species destruction in the phylogenesis of mankind are traced. Psychological and social conditions of social destructiveness under "normal" and exceptional conditions are discussed and the consequences for education drawn.

Germany↗
PubMed2000

Effect of social housing condition on heat shock protein (HSP) expression in the Shionogi mouse mammary carcinoma (SC115).

Our previous studies have shown that social housing conditions can significantly alter the growth rate of the Shionogi mouse mammary carcinoma (SC115). The present study extended our investigations to the molecular level by examining stressor effects on the expression of a group of stress-responsive proteins, the heat shock proteins (HSPs). We hypothesized that HSP expression in SC115 cells may be altered by (a) different social housing conditions in vivo and (b) steroid hormone and growth factor exposure in vitro. Mice were reared in groups (G) or as individuals (I). Immediately following tumor cell injection, mice were rehoused from group to individual (GI), from individual to group (IG), or they remained in groups (GG). Tumor tissue was resected at 0.8 g or 3.0 g, as evidence suggests that tumor size affects HSP expression, which in turn affects proliferation. The data demonstrate that expression of HSP25, 70, and 90 was increased in tumors from mice in the IG compared to GG and GI mice, at both tumor weights examined. In addition, in IG mice, HSP90 expression was greater in 0.8 g compared to 3.0 g tumors. Under controlled culture conditions, hormones known to stimulate SC115 growth both in vivo and in vitro altered HSP expression. Physiological levels of dihydrotestosterone (DHT) and pharmacological levels of hydrocortisone (HC) upregulated expression of HSP25, whereas physiological levels of beta-estradiol (E2) upregulated expression of HSP90. These data are the first to demonstrate that a psychosocial stressor, a change in social housing condition, can induce differential HSP expression. Further, these data show that hormones that regulate SC115 tumor growth, also alter HSP expression.

Animals↗
PubMedDate not supplied

[A comparison of the effects of dopamine agonists on self-stimulation of the hypothalamus with destruction of the mesolimbic brain structures in rats raised under conditions of social isolation].

In rats bred in groups or under conditions of social isolation, amphetamine administration did not change significantly the basic rate of hypothalamic self-stimulation. The unilateral lesions of ventral tegmental area and medial prefrontal cortex in the early ontogeny (on the 17th day after birth) increased the sensitivity to amphetamine only in isolated rats. Apomorphine, the dopamine receptor agonist, in the dose which mainly affected the presynaptic receptors (0.05 mg/kg) inhibited self-stimulation by 21-23% both in grouped and socially isolated rats. Destruction of the ventral tegmental area did not change, but that of the medial prefrontal cortex doubled the sensitivity of isolated rats to apomorphine. It is suggested that the hypersensitivity of presynaptic dopamine receptors in the mesocorticolimbic system develops as a result of partial sensory and full intraspecies isolation in rats.

Amphetamine↗
PubMed2005

Anger and social appraisal: a "spicy" sex difference?

The central objective of this study was to investigate the role of social appraisal in sex differences in anger expression. Anger expression was inferred from the amount of hot sauce given to the person who induced anger. Participants were randomly assigned to a social condition, in which they expected to meet this person, or to a nonsocial condition, in which they had no such expectation. Men and women differed in their anger expressions, despite the fact that they did not differ in anger experience. Women expressed anger to a lesser extent than men, but only in the social condition. Social appraisal partly mediated the relation between sex and anger expression. The role of social appraisal in emotion and appraisal theory is discussed.

Adult↗
PubMed1997

Effects of social housing condition on the response of the Shionogi mouse mammary carcinoma (SC115) to chemotherapy.

In the present study, we demonstrate that social housing conditions significantly alter the response of the transplantable androgen-responsive Shionogi mouse mammary tumor (SC115) to chemotherapy. Mice were reared either in groups (G) or as individuals (I). Immediately following tumor cell or vehicle injection, mice were rehoused from group to individual (GI) or from individual to group (IG) conditions. A combination of Adriamycin (4 mg/kg) and cyclophosphamide (61.5 mg/kg), in a series of three i.p. injections 7 days apart, was initiated when mean tumor weights of mice within a housing condition (GI or IG) reached 1 g. Survival probability was significantly greater in mice in the IG housing condition compared to those in the GI housing condition (47% versus 19%, respectively). Additionally, the median survival time following the initiation of chemotherapy was greater for mice in the IG than for mice in the GI condition (24.5 days versus 15.0 days, respectively). These findings suggest that a psychosocial stressor, social housing condition, can significantly influence chemotherapeutic efficacy.

Androgens↗