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PubMed1995

Assessment of patients with menorrhagia: how valid is a structured clinical history as a measure of health status?

A patient-administered questionnaire for menorrhagia based on the type of questions asked when taking a gynaecological history was developed and tested using the following steps: literature reviews, devising the questions, testing responses for internal consistency and test-retest reliability and validating the questionnaire by comparing patient's scores with their responses to the SF-36 general health measure, and with family practitioner perceptions of severity. The main sample consisted of 351 women with menorrhagia, 246 referred to gynaecology ambulatory clinics and 105 from four large training practices in North-east Scotland. Following testing, two questions were discarded from the questionnaire. The final questionnaire demonstrated a good level of reliability and the resulting patient scores correlated significantly with their scores on the scales making up the general health measure. The questions asked in taking a clinical history from a woman with menorrhagia can be used to construct a valid and reliable measure of health status. This clinical measure may be a useful guide in selection for treatment and in the assessment of patient outcome following treatment.

Adolescent↗
PubMed2000

On the reliability, validity, and cognitive structure of the Thurstone Word Fluency Test.

The Thurstone Word Fluency Test (TWFT) is a widely used neuropsychological instrument. However, data regarding its psychometric properties are lacking. The results of the present study suggest that the TWFT possesses excellent test-retest and inter-rater reliability, in addition to good construct validity. However, its criterion validity is limited by its lack of specificity and sensitivity. The present study also suggests that the TWFT is a complex cognitive task, and that successful TWFT performance depends upon a constellation of cognitive abilities, including attention/concentration, psychomotor speed, and memory. Finally, the relationship between verbal IQ and TWFT letter association value was examined. While the TWFT appears to be useful in detecting the presence of cerebral dysfunction, it is of less value in localizing such dysfunction. It is argued that the TWFT should not be used as a neuropsychological screening instrument, but rather, is best used within the context of a thorough neuropsychological examination.

Journal Article↗
PubMed1998

Assembling genes from predicted exons in linear time with dynamic programming.

In a number of programs for gene structure prediction in higher eukaryotic genomic sequences, exon prediction is decoupled from gene assembly: a large pool of candidate exons is predicted and scored from features located in the query DNA sequence, and candidate genes are assembled from such a pool as sequences of nonoverlapping frame-compatible exons. Genes are scored as a function of the scores of the assembled exons, and the highest scoring candidate gene is assumed to be the most likely gene encoded by the query DNA sequence. Considering additive gene scoring functions, currently available algorithms to determine such a highest scoring candidate gene run in time proportional to the square of the number of predicted exons. Here, we present an algorithm whose running time grows only linearly with the size of the set of predicted exons. Polynomial algorithms rely on the fact that, while scanning the set of predicted exons, the highest scoring gene ending in a given exon can be obtained by appending the exon to the highest scoring among the highest scoring genes ending at each compatible preceding exon. The algorithm here relies on the simple fact that such highest scoring gene can be stored and updated. This requires scanning the set of predicted exons simultaneously by increasing acceptor and donor position. On the other hand, the algorithm described here does not assume an underlying gene structure model. Indeed, the definition of valid gene structures is externally defined in the so-called Gene Model. The Gene Model specifies simply which gene features are allowed immediately upstream which other gene features in valid gene structures. This allows for great flexibility in formulating the gene identification problem. In particular it allows for multiple-gene two-strand predictions and for considering gene features other than coding exons (such as promoter elements) in valid gene structures.

Algorithms↗
PubMed1990

Reliability and validity of the structured interview for personality disorders in adolescents.

The Structured Interview for the DSM-III Personality Disorders was administered to 23 currently affectively ill adolescents and their parents. Interviews were videotaped and rerated; interrater agreement was moderate (weighted K = 0.49; unweighted K = 0.59). Moreover, there was evidence of convergent validity for Cluster II traits and disorders (borderline, histrionic, narcissistic), insofar as these diagnoses were associated with higher scores on the novelty-seeking subscale of the Tridimensional Personality Questionnaire as predicted. Cluster II patients tended to have higher rates of attention deficit disorder and bipolar disorder, and higher rates of suicidal gestures among second-degree relatives. Some difficulty was encountered differentiating symptoms of affective illness from those of personality disorder and in deciding when personality traits were impairing enough to call them disorders. Reliability may be improved by: (1) interviewing patients when out of affective episode; and (2) using standardized functional impairment criteria for differentiating personality style from disorder. Additional work is advocated to learn if personality disorders are precursors, epiphenomena, or the consequences of affective disorder.

Adjustment Disorders↗
PubMed1997

The Youth Client Satisfaction Questionnaire: development, construct validation, and factor structure.

Developed and pilot-tested a measure of satisfaction with mental health services for young clients. One hundred fifty youth from 11 to 17 years of age who had completed services received the measure as a telephone interview. Fourteen of 17 candidate items met criteria for test-retest reliability, part-whole correlation, and correlation with a validation item, and they were retained in the instrument. Total score test-retest reliability and internal consistency were highly satisfactory. Principal components analysis revealed two factors, labeled Relationship With Therapist and Benefits of Therapy. Unexpectedly, satisfaction scores were not related to change in youth self-reported behavior problems. However, convergent validity was indicated by significant relationships with change in parent-reported behavior problems, parent satisfaction, parent ratings of treatment progress, therapist ratings of progress, and Global Assessment of Functioning change scores. These results indicate that the Youth Client Satisfaction Questionnaire is a reliable and valid measure of consumer evaluations of their treatment.

Adolescent↗
PubMed1983

Factor structure and discriminant validity of the SCL-90 in a veteran psychiatric population.

This study tested whether the symptom dimension subscales derived for the Symptom Checklist-90 (SCL-90) by factor analysis could be replicated in a new sample. It was administered to 442 veterans undergoing psychiatric treatment at a VA psychiatric outpatient clinic. Factor analysis using the principal-components method yielded a factor structure different from those previously reported for other populations. The first factor extracted, Depression, explained 37% of the variance of the entire instrument, or more than eight times the variance explained by the second factor. Only five of the nine reported SCL-90 symptom subscales emerged in this study; the Anxiety and Psychoticism subscales disappeared, and the Paranoia and Interpersonal Sensitivity subscales merged. In this population the instrument seems to measure a single global distress factor instead of nine independent symptom subscales as reported previously. This finding was corroborated by the fact that depressed, anxious, and schizophrenic patients showed no differences in SCL-90 symptom profile shapes, although they did differ in overall symptom intensity.

Adult↗
PubMed2004

Factor structure and concurrent validity of the Drug Use Screening Inventory in a community adolescent sample.

A variety of screening instruments for adolescent alcohol and drug abuse have been designed to be used within a clinical setting. This study adapted one of these instruments, the Drug Use Screening Inventory (DUSI), to be used within behavioral genetic or other epidemiological research on nonclinical samples. A primary goal of this study was to obtain a factor structure and set of subscales that might predict experimental and regular use of alcohol and drugs in a community sample. A secondary goal was to define subscales in a way that facilitated our interpretation and understanding of pathways to substance use and abuse. We investigated the underlying factor structure of items from four of the DUSI domains using a principal components analysis of the responses from 1266 adolescents from the Colorado Adolescent Twin Study. The resulting set of six subscales shows adequate internal consistency and provides an easily interpretable research tool for investigating etiological relationships between substance use problems and other risk behaviors.

Adolescent↗
PubMed2006

The Type A-Type B classification in a community sample of problem drinkers: structural and predictive validity.

OBJECTIVE: The Type A-Type B multidimensional classification model has been useful for identifying a subgroup of alcohol dependent drinkers with more severe psychosocial problems and a poor prognosis. Evidence suggests its dimensions may be useful for identifying problem drinkers in the general population at risk for developing alcohol dependence. To date, the model has not yet been investigated for this purpose. The present study investigated the Type A/Type B distinction in a community sample of problem drinkers as well as its predictive validity among problem drinkers with no history of alcohol dependence. METHOD: Households from a geographically delimited area in the United States were designated via random digit dialing and randomly designated members were screened for eligibility. A total of 876 participants met eligibility criteria and completed a structured interview (AUDADIS) on alcohol and other health related behaviors at baseline and at 1-year follow-up. A k-means cluster analysis was performed to identify subgroups of problem drinkers. RESULTS: A two-cluster solution adequately fit the data and identified two main subgroups of problem drinkers consistent with a Type A-Type B distinction. The group differences held among those with and without a history of alcohol dependence and the subset of Type B drinkers with no history of alcohol dependence were approximately five times (beta = 1.56, p< or =0.01) more likely to have an initial onset of dependence than Type A drinkers at 1-year follow-up. In contrast, a DSM-IV alcohol abuse diagnosis at baseline did not predict 1-year onset of dependence. CONCLUSIONS: The Type A-Type B model is useful for identifying untreated problem drinkers at risk for developing alcohol dependence. This model may facilitate the development of more targeted prevention efforts.

Adolescent↗
PubMed2000

Validation and factorial structure of a standardized neurological examination assessing neurological soft signs in schizophrenia.

Although neurological soft signs (NSS) have been consistently reported in patients with schizophrenia, their clinical relevance, the actual impact of treatment or their evolution during the disease are not well clarified, possibly because of methodological limitations of the available tools. We have developed a new standardized examination integrating the assessment of 23 NSS selected from the literature and the rating of well-validated scales for assessment of extra-pyramidal symptoms. We examined 161 subjects (controls, n=48; patients with schizophrenia, n=95; or recurrent mood disorder, n=18). Half of the patients were neuroleptic-free. Schizophrenic patients had significantly higher total score (14. 6+/-8) than mood disorder patients (12.0+/-7) and controls (5.0+/-2). Internal consistency (Cronbach's alpha=0.85) and inter-rater reliability were good. Principal component analysis found five consistent factors ('motor coordination', 'motor integrative function', 'sensory integration', 'involuntary movements or posture', 'quality of lateralization'). This scale thus confirmed a factorial structure in agreement with the conceptual areas of interest explored by NSS and should be a useful tool for assessment of the different dimensions of neurological dysfunction in schizophrenia.

Adult↗
PubMed2001

Reliability, validity, and factor structure of the Arabic version of the 12-item General Health Questionnaire.

The aim was to examine the psychometric properties of the Arabic 12-item General Health Questionnaire in a sample of university students. A sample of 157 university students was screened using this questionnaire and the Hopkins Symptom Checklist-90. A standardized clinical interview using SCID was conducted on a subset of screened students. Reliability, validity, and factor analysis of the questionnaire were evaluated. Using factor score discrimination between cases and noncases was also evaluated. The Arabic version of the GHQ-12 proved to be reliable as indicated by Cronbach alpha of .86. The best balance between sensitivity and specificity was found at the General Health Questionnaire cut-off point of 15/16: at this threshold, sensitivity was .88 and was paired with a specificity of .84. Principal component analysis with varimax rotation identified three factors, namely, Factor A (general dysphoria), Factor B (lack of enjoyment), and Factor C (social dysfunction). Factors A and C discriminated between clinically distressed and clinically nondistressed subjects. The General Health Questionnaire-12 as a whole is a reliable and valid screening tool in university settings.

Arabs↗
PubMed2003

The Infant-Toddler Social and Emotional Assessment (ITSEA): factor structure, reliability, and validity.

In this paper the refinement and psychometric properties of the Infant-Toddler Social and Emotional Assessment (ITSEA) are described. Results from a sociodemographically diverse birth cohort sample of 1,235 parents of children between the ages of 12 and 36 months are presented. Confirmatory factor analyses supported the hypothesized Internalizing, Externalizing, Regulatory, and Competence domains as well as the 17 individual scales that comprise the ITSEA. Findings for 3 additional indices useful in identifying significant psychopathology are presented. Subgroup analyses revealed structural invariance and expected mean level differences across both child sex and 6-month age bands. Child sex differences emerged for some problem and most competence scales, with boys rated as higher on Activity/Impulsivity and girls rated higher on Anxiety and most Competence scales. All competence scores increased across age groups. Problem behaviors showed a more mixed developmental pattern. Test-retest and interrater reliability were acceptable. Associations between the ITSEA and independent evaluator ratings and parental ratings of child behavior problems, temperament, and parental distress support the validity of the instrument.

Affect↗
PubMed1991

A comparison of cognitive measures in low back pain: statistical structure and clinical validity at initial assessment.

Four cognitive measures--MHLC, PLC, CSQ and PRSS/PRCS--were directly compared in 120 U.K. patients with chronic low back pain. 80% of the individual items in the PLC and 86% in the CSQ had satisfactory test-retest reliability, as had most of the scales of the CSQ and the PLC PC scale. The items and the scales of the MHLC and the PRSS/PRCS had lower reliability. The factor structures of the PLC and the PRSS/PRCS bore close similarity to the original descriptions. The CSQ structure was similar to the original but further investigation of its psychometric properties is required. The structure of the MHLC was not replicated. Considerable communality was found between the cognitive measures. The strongest relationship found in this study was between the CSQ and PRSS catastrophising scales and depressive symptoms. There was also a relationship among cognitive measures and both disability and work loss which persisted even after controlling for severity of pain and depressive symptoms. The present results suggest that the concept of catastrophising has greatest potential for understanding current low back symptoms and that the CSQ may be the most useful measure of this. Other work, however, suggests that the PLC may also be of value in following change and predicting response to treatment.

Adaptation, Psychological↗
PubMed2005

Cross-cultural validity of the structured clinical interview for panic-agoraphobic spectrum.

BACKGROUND: We sought to develop a series of assessment measures of psychiatric spectrum conditions associated with major DSM-IV mood and anxiety disorders that might capture the true phenotypes underlying these disorders. The specific objective of this report was to describe the methods we employed to create instruments that could cross linguistic and national boundaries and to evaluate the comparability of results obtained when one of these instruments, the Structured Clinical Interview for Panic-Agoraphobic Spectrum (SCI-PAS), was administered in the United States and in Italy. METHOD: After developing, in parallel, the English and the Italian versions of the SCI-PAS, identical protocols were conducted in patients and control samples at the University of Pittsburgh and the University of Pisa to examine the reliability and validity of the interview. RESULTS: Total and domain scores on the SCI-PAS were strikingly similar in the US and Italian patient groups and in controls. In addition, similarly high levels of inter-rater and test-retest reliability were found at the two sites. Finally, virtually identical patterns of relationships were found between the domains of the SCI-PAS and established measures of the same constructs. CONCLUSIONS: The SCI-PAS displays similar reliability and validity properties in the two versions. This suggests that the instrument taps a phenotype that is consistent in American and Italian patient and control populations.

Adult↗
PubMed2006

The development of the Toronto Structured Interview for Alexithymia: item selection, factor structure, reliability and concurrent validity.

BACKGROUND: Assessments of personality constructs increasingly use self-report and structured interview instruments, which allow for a multimethod measurement approach and decrease specific measurement method bias. The aim of this study was to develop a valid and reliable structured interview for assessing the alexithymia construct. METHODS: Sixty interview questions were written initially, each with a set of scoring criteria and prompts and probes to elicit information assisting in the scoring of the respondents' answers. RESULTS: After pilot testing, the number of questions was reduced to 43, which were administered to 136 community participants and 97 psychiatric outpatients. A series of item and scale analyses further reduced the item pool to 24 items. Principal component analysis and confirmatory factor analysis of these 24 items revealed preliminary evidence of a hierarchical, four-factor structure, with four lower factors nested within two higher-order latent factors. This structural configuration resulted in the Toronto Structured Interview for Alexithymia (TSIA) with two domain scales and four facet scales. The TSIA and its six scales demonstrated acceptable levels of interrater, internal, and retest reliability. The TSIA and its scales correlated modestly but significantly with the 20-item Toronto Alexithymia Scale and its three factor scales, providing some support for the concurrent validity of this interview. CONCLUSION: The TSIA appears to be a promising structured interview for assessing alexithymia.

Adult↗
PubMed2006

Validating the theoretical structure of the Treatment Self-Regulation Questionnaire (TSRQ) across three different health behaviors.

Nearly 40% of mortality in the United States is linked to social and behavioral factors such as smoking, diet and sedentary lifestyle. Autonomous self-regulation of health-related behaviors is thus an important aspect of human behavior to assess. In 1997, the Behavior Change Consortium (BCC) was formed. Within the BCC, seven health behaviors, 18 theoretical models, five intervention settings and 26 mediating variables were studied across diverse populations. One of the measures included across settings and health behaviors was the Treatment Self-Regulation Questionnaire (TSRQ). The purpose of the present study was to examine the validity of the TSRQ across settings and health behaviors (tobacco, diet and exercise). The TSRQ is composed of subscales assessing different forms of motivation: amotivation, external, introjection, identification and integration. Data were obtained from four different sites and a total of 2731 participants completed the TSRQ. Invariance analyses support the validity of the TSRQ across all four sites and all three health behaviors. Overall, the internal consistency of each subscale was acceptable (most alpha values >0.73). The present study provides further evidence of the validity of the TSRQ and its usefulness as an assessment tool across various settings and for different health behaviors.

Adolescent↗
PubMed1995

The reliability and validity of a structured interview for the assessment of infectious illness symptoms.

Respiratory infections are the leading cause of morbidity in community populations. We developed a structured interview based on the Health Review (Rose et al., Psychosom. Med. 40: 142-165, 1978) to provide a simple method for periodic assessment of infectious illness, particularly upper respiratory infections. Congruence between interview data and physician diagnoses demonstrated excellent agreement regarding the presence or absence of an infection. Subjects who showed a clinically significant increase in antibody titers to an influenza virus vaccine reported fewer than half as many respiratory infections in the subsequent year as subjects who did not show a significant response. Interrater and test-retest reliabilities were satisfactory. These data support the reliability and validity of this method of assessing infectious illnesses.

Aged↗
PubMed2004

Diagnosis of migrainous vertigo: validity of a structured interview.

BACKGROUND: Migraine and vestibular symptoms are co-morbid. Migraine is increasingly recognized as a cause of benign, recurrent vertigo. Although the International Headache Society does not currently include the diagnosis of migrainous vertigo, specific criteria have been proposed and utilized in clinical trials. MATERIAL/METHODS: Seventeen adult migraineurs were separately screened for the diagnosis of migrainous vertigo using a standardized structured interview for migrainous vertigo (SIM-V) and a clinical evaluation by an experienced neurotologist. The SIM-V was administered by a nurse who read and recorded subject responses, obtaining no additional information for the diagnosis of migrainous vertigo. Comparison of diagnoses between clinician and SIM-V was made using Cohen's kappa reliability testing. Subjects were asked to return for a second interview by the same nurse using the SIM-V, at least 2 weeks after the initial assessment. Testing stability was evaluated by comparing diagnoses obtained with each SIM-V administration. RESULTS: Cohen's kappa demonstrated excellent test validity (kappa=0.75). Fourteen subjects returned for repeat testing, with excellent retest stability (kappa=0.85). The additional three subjects could not be relocated or were not interested in attending a retest appointment. CONCLUSIONS: The SIM-V is an easy-to-administer screening tool for the diagnosis of migrainous vertigo. Diagnostic comparison to a standard clinical assessment shows good test validity. Retest stability was also demonstrated. The SIM-V may be a useful screening tool for migraineurs with an additional complaint of dizziness.

Adult↗