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Benign cementoblastoma associated with an unerupted third molar.

Benign cementoblastoma is a rare lesion representing less than 1% of all odontogenic tumours. It usually affects young people and is located in the posterior jaw. In almost all cases the tumour tends to be associated with an erupted permanent tooth, most often the first molar: only rarely has an association with an impacted or deciduous tooth been reported. The authors present a case of a cementoblastoma involving an impacted third molar.

Adult↗

A longitudinal study of the growth and development of the dental arch width from childhood to adolescence in Japanese.

The purpose of this study was to evaluate the longitudinal changes in arch width from childhood to adolescence. The subjects were 28 persons (13 males and 15 females) with untreated normal occlusion. Dental casts were taken at bimonthly intervals from childhood to adolescence. These materials were measured; the changes in the dental arch were compared on the basis of the status of the tooth emergence of certain permanent teeth and also on the chronological age from 3 years to 20 years of age. In the maxilla and mandibula, the width between the deciduous canines, the width between the first deciduous molars, and the width between the second deciduous molars were nearly stable or slightly increased until 6 years of age. After that, all of the deciduous tooth widths gradually increased, especially in the width between the deciduous canine at the emergence of the permanent incisors. The width between the canines decreased until 13 years of age in the maxilla and until 15 years of age in the mandibula. After that, the width between the canines were nearly stable. Until 1 year after emergence, the width between the canines decreased, in particular during the transition to the canines, based on dental age observation. The maxillary first premolar width decreased until 6 months after emergence, based on dental age observation. Thereafter, the width between the maxillary first premolars showed no clear change. The width between the mandibular first premolars, the width between the maxillary second premolars, and the width between the mandibular second premolars increased until about 2-3 years after emergence, but they showed no clear changes thereafter. The width between the maxillary first molars gradually increased until 15 years of age; there was no clear change thereafter. The width between the mandibular first molars was nearly stable throughout the observation period. The width between the maxillary second molars decreased until 2 years after emergence; no clear change was observed thereafter. The width between the mandibular second molars was unstable until after about 2-3 years after emergence and then became nearly stable.

Adolescent↗

A supernumerary tooth in a 1.7 million-year-old Australopithecus robustus from Swartkrans, South Africa.

The maxillary dental arch of a partial cranium of an adult specimen of Australopithecus robustus shows the presence of a supernumerary tooth between the right first and second incisors. The fossil specimen, SK 83, is from Swartkrans Member 1 sediments, considered, on the basis of associated fauna, to be approximately 1.7 million yr old. The specimen was analyzed macroscopically, stereomacroscopically and by X-ray computed tomography. The anatomic position and the morphology of the tooth are consistent with a diagnosis of supernumerary lateral incisor rather than a mesiodens or a retained deciduous tooth. This is the first description of a supernumerary tooth found in Plio-Pleistocene hominid fossils from South African cave deposits.

Adult↗

[Morphological and functional properties of odontoclasts on dentine resorption].

Tooth root resorption in tooth movement is the principal unsolved problem in orthodontics. In order to study this mechanism, odontoclasts in bovine deciduous tooth root-resorbing tissues (RRT) were cultured and characterized for their biological properties in comparison with those of osteoclasts. Multinucleated cells isolated from the RRT had tartrate-resistant acid phosphatase activity and responded to calcitonin and also formed the resorption lacunae on the dentine. These results are consistent with the notion that odontoclasts resemble osteoclasts with respect to enzyme-cytochemical and morphological properties. However, odontoclasts cultured on dentine in the presence of 1 alpha,25-dihydroxyvitamin D3 demonstrated a higher activity in forming resorption lacunae than did osteoclasts. Immunohistochemical examinations revealed that interleukin-1 (IL-1) was detected in mononuclear cells and occasionally in odontoclasts that were present adjacent to the site where active root resorption occurred. The IL-1 stimulated the formation of resorption lacunae on dentine to a higher extent in odontoclasts than in osteoclasts, suggesting functional differences between odontoclasts and osteoclasts. In conclusion, the present study demonstrates that 1) odontoclasts present in the RRT possess similar biological properties to those of osteoclasts. However, under certain circumstances odontoclasts may behave differently from osteoclasts; 2) IL-1 produced in the RRT might play a role in controlling the function of odontoclasts in a paracrine and autocrine fashion.

Animals↗

Tooth ankylosis in deciduous teeth of children with cleft lip and/or palate.

The present study aimed at evaluating the prevalence of tooth ankylosis in deciduous molars of Caucasian children with cleft lip and/or palate aged 5 to 12 years, of both genders. A total of 330 patients seen at the Hospital for Rehabilitation of Craniofacial Anomalies of the University of São Paulo for routine treatment were clinically evaluated. The prevalence of ankylosis was analyzed in relation to gender, age range (5-7, 8-10, 11-12 years), type of cleft, affected tooth and arch. The total group showed a prevalence of 18%, with no statistical difference between genders and among types of cleft; ankylosis was more often in the mandibular arch, lower first molars and among children in the age ranges 8-10 and 11-12 years. The results agreed with those observed in the related literature for patients without clefts, pointing out the absence of influence of the cleft on the prevalence of ankylosis. This reinforces the importance of early diagnosis of this anomaly and of the treatment of choice, which are similar in patients with or without clefts.

Age Factors↗

A review of 47 cases of unerupted maxillary incisors.

OBJECTIVES: To study the prevalence of aetiological factors associated with unerupted maxillary incisors and to follow the outcome of treatment in a study of 47 cases. DESIGN: A retrospective study. SETTING: The Dental Department, St Luke's Hospital, Malta, the School Dental Clinic of Malta and the private practices of two orthodontists in Malta. SAMPLE AND METHODS: Forty-seven patients with a total of 53 unerupted maxillary incisors were classified according to the aetiological factors causing non-eruption. The relative prevalence of the various aetiologies were ascertained, and the outcome after treatment was recorded to assess the efficacy of the treatment methods being used. RESULTS: The most common cause of lack of eruption was the presence of supernumerary teeth (47% of patients). The other 53% of cases were distributed more or less equally between the remaining aetiological factors, which were odontomes (9%), dilacerations (9%), tooth germ malposition (12%), crowding (4%), one case of a calcifying odontogenic cyst (2%) and one case of trauma to the preceding deciduous tooth (2%). The aetiology of 15% of cases could not be ascertained. Once supernumerary teeth were removed, maxillary incisors usually erupted successfully with the help of conventional treatment methods such as surgical exposure and orthodontics. A relatively large number of incisors that failed to erupt due to other aetiological factors had to be extracted. CONCLUSIONS: Maxillary incisors that fail to erupt due to the presence of supernumerary teeth have a better prognosis than unerupted incisors with less common aetiologies.

Adolescent↗

Effect of calcium phosphate ceramic particle insertion on tooth eruption.

The effects of calcium phosphate ceramic implants on tooth eruption were investigated radiographically and histologically in 20 3-month-old dogs. Four kinds of ceramic particles were used: dense and porous hydroxyapatite particles, and dense and porous tricalcium phosphate particles. These particles were implanted in the sockets after deciduous tooth extraction. The four types of calcium phosphate ceramic particles produced similar radiographic and histologic findings. There was no delay of tooth eruption, no dysplasia, and no resorption of dental hard tissue.

Animals↗

[Frequency of transposition and its treatment at the Department of Pedodontics and Orthodontics of Semmelweis University in the last five years].

Tooth transposition is a rare but severe disturbance of tooth eruption. The maxillary canine and the premolar are the most commonly transposed teeth. The occurrence of transposition in the mandible is very rare. The transposition may occur in combination with other anomalies, like aplasia (40%), peg-shaped lateral incisor (25%), deciduous tooth retention (50%). The adjacent teeth exchange positions in the dental arch for genetic or traumatic reasons. In the last five years orthopantomograms of 2736 patients were analysed at the Department of Pedodontics and Orthodontics of Semmelweis University. Twelve transposition cases (0.43%) were found: 10 in the upper and 2 in the lower dental arch. Only one case was bilateral transposition. Nine patients were treated with fixed appliance. In one of these cases the transposed tooth was extracted and two patients are being observed. The methods of treatment are in accordance with the international guide-lines.

Adolescent↗

Age and sequence of permanent-tooth emergence among Khasis.

The times and emergence of permanent teeth were ascertained by examining 1,263 Khasi children (615 males and 648 females), aged 5 to 15 years. Gingival emergence of the first 28 permanent teeth was recorded and the data were subjected to probit analysis to compute the mean (and standard deviation) emergence time of each individual tooth. Tooth emergence in females was markedly earlier than in males, and canines were most advanced in this respect. Females acquired all their teeth in shorter time span (5.5 years) than males (6.5 years). There were no decisive sex differences in the sequence of tooth emergence. The differences in emergence times between antimeres were statistically nonsignificant. The length of hiatus between two active emergence dental stages was shorter for the maxilla than for the mandible. It occurred between lateral incisor and first premolar in the maxilla of both the sexes, while in case of the mandible, it was spaced between lateral incisor and canine. The Khasis showed early emergence when compared to other populations. The findings support the earlier reports that the controls of deciduous-tooth emergence continue to play some part in emergence of the permanent dentition, especially the first permanent teeth that emerge.

Adolescent↗

Enamel hypoplasias and physiological stress in the Sima de los Huesos Middle Pleistocene hominins.

This study presents an analysis of linear enamel hypoplasias (LEH) and plane-form defects (PFD) in the hominine dental sample from the Sima de los Huesos (SH) Middle Pleistocene site in Atapuerca (Spain). The SH sample comprises 475 teeth, 467 permanent and 8 deciduous, belonging to a minimum of 28 individuals. The method for recording PFD and LEH is discussed, as well as the definition of LEH. The prevalence of LEH and PFD in SH permanent dentition (unilateral total count) is 4.6% (13/280). Only one deciduous tooth (lower dc) showed an enamel disruption. Prevalence by individual ranges from 18.7-30%. The most likely explanation for the relatively low LEH and PFD prevalence in the SH sample suggests that the SH population exhibited a low level of developmental stress. The age at occurrence of LEH and PFD was determined by counting the number of perikymata between each lesion and the cervix of the tooth. Assuming a periodicity of nine days for the incremental lines, the majority of LEH in the SH sample occurred during the third year of life and may be related to the metabolic stress associated with weaning.

Aging↗

Changing occlusal variation in Pima Amerinds.

Occlusal variables and arch measurements have been recorded on 341 Pima Amerinds pertaining to two samples, one of older individuals raised on traditional diets, the other of younger individuals raised on refined commercial foods that are typical of modern urbanized people. Permanent dental occlusion is significantly more variable from defined ideals in the younger sample, despite their fewer deformities resulting from progressive aging. The youths had relatively narrower palates, correlating with a general trend among industrialized populations and also among experimental animals fed soft diets. Relative rate of deciduous tooth loss and replacement did not correlate with any occlusal variable.

Adult↗

Enamel hypoplasia in the middle pleistocene hominids from Atapuerca (Spain).

The prevalence and chronology of enamel hypoplasias were studied in a hominid dental sample from the Sima de los Huesos (SH) Middle Pleistocene site at the Sierra de Atapuerca (Burgos, northern Spain). A total of 89 permanent maxillary teeth, 143 permanent mandibular teeth, and one deciduous lower canine, belonging to a minimum of 29 individuals, were examined. Excluding the antimeres (16 maxillary and 37 mandibular cases) from the sample, the prevalence of hypoplasias in the permanent dentition is 12.8% (23/179), whereas the deciduous tooth also showed an enamel defect. No statistically significant differences were found between both arcades and between the anterior and postcanine teeth for the prevalence of hypoplasias. In both the maxilla and the mandible the highest frequency of enamel hypoplasias was recorded in the canines. Only one tooth (a permanent upper canine) showed two different enamel defects, and most of the hypoplasias were expressed as faint linear horizontal defects. Taking into account the limitations that the incompleteness of virtually all permanent dentitions imposes, we have estimated that the frequency by individual in the SH hominid sample was not greater than 40%. Most of the hypoplasias occurred between birth and 7 years (N = 18, X = 3.5, SD = 1.3). Both the prevalence and severity of the hypoplasias of the SH hominid sample are significantly less than those of a large Neandertal sample. Furthermore, prehistoric hunter-gatherers and historic agricultural and industrial populations exhibit a prevalence of hypoplasias generally higher than that of the SH hominids. Implications for the survival strategies and life quality of the SH hominids are also discussed.

Age Distribution↗

Pre- and postnatal lead exposure and behavior problems in school-aged children.

The association between early lead exposure and later problem behaviors was evaluated prospectively in a cohort of 8-year-old children born during a 12-month period at one hospital. Lead levels in umbilical cord blood (means = 6.8 micrograms/dl, SD = 3.1) and the dentin of a shed deciduous tooth (means = 3.4 micrograms/g, SD = 2.4) provided measures of prenatal and postnatal exposure, respectively. Ratings on the Teacher Report Form of the Child Behavior Profile provided information about children's problem behaviors. Cord blood lead level was not associated with the overall prevalence or nature of problem behaviors. In both crude and adjusted analyses, tooth lead level was significantly associated with total problem behavior scores (approximately 2 points in T score per log unit increase in tooth lead). Significant tooth lead-associated increases in both internalizing and externalizing scores were also observed (approximately 1.5 points in T score per log unit increase). Weaker associations were noted between tooth lead level and the prevalence of "extreme" problem behavior scores. The extent to which these associations reflect residual confounding is uncertain. These data suggest, however, that social and emotional dysfunctions are correlates and may be expressions of increased lead exposure.

Child↗

Measurements of manganese with respect to calcium in histological enamel cross sections: toward a new manganese biomarker.

Airborne Mn may become an important route of exposure if the use of Mn-containing gasoline additives becomes more widespread. We report on the measurement of manganese and calcium in histological cross sections of shed deciduous tooth enamel of three human subjects. The goal of this research was to measure Mn in tooth enamel for use as a biomarker in assessing manganese exposure in cross-sectional and longitudinal studies. The histological locations can be time-specific (analogous to examining growth rings in trees). This technique, which may identify critical windows of exposure, can be important for evaluating potential vulnerability of the fetus and neonate to inhaled or ingested Mn.

Air Pollutants↗

Enamel lead biomarker for prenatal exposure assessment.

The development of the enamel biomarker for heavy metal exposure assessment is designed to improve studies of dose-effect relationships to embryonic anomalies, particularly neurotoxic dysfunction. This report documents initial demonstrations of ambient lead (Pb) relative to calcium (Ca) in histological cross sections of deciduous tooth enamel of three human subjects, by use of ion mass spectrometry. The goal of this research was to measure Pb and Ca in tooth enamel for use as a temporal biomarker in assessing prenatal and postnatal exposure. This involves measurement of these heavy metals in enamel at high spatial resolution along histological transects following the temporal pattern of enamel growth. The technique may be applied when completely developed to cross-sectional and longitudinal research.

Biomarkers↗

The secretory ameloblast of the mini-pig foetus: Morphology, and effect on morphology of various aldehydes and of delayed fixation.

Electron microscopic investigations of secretory ameloblasts from deciduous tooth germs of mini-pig foetuses and investigations of the ability of various fixatives to preserve these cells in tooth germs immersion-fixed in to 5 min, 10 min, 15 min, 20 min and 40 min after death of the mother gave the following results: 1. The ameloblasts exhibit ultrastructural characteristics typical of exocrine secretory cells of merocrine type. 2. The localization of organelles is as in rodent secretory ameloblasts, but differs from the location in the human analogues. 3. Fixation with 4% formaldehyde invariably gives unacceptable ameloblast preservation. 4. Fixation with 2.5% glutaraldehyde gives fair preservation of the ameloblasts when the germs are fixed within 10 min of the death of the mother. 5. Fixation with a fixative mixture 2% formaldehyde-1.25% glutaraldehyde gives good preservation when the ameloblasts are fixed within 15 min of the death of the mother. 6. Fixation with a fixative mixture 2% formaldehyde-1% glutaraldehyde-1% acrolein gives good ameloblast preservation when the germs are fixed within 15 min of the death of the mother.

Acrolein↗