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PubMed2006

A comparison of massage effects on labor pain using the McGill Pain Questionnaire.

The purpose of this study was to describe the characteristics of pain during labor with and without massage. Sixty primiparas in labor were randomly assigned to either a massage or control group and tested using the self-reported Short-Form McGill Pain Questionnaire (SF-MPQ) at 3 phases of cervical dilation: phase 1 dilation (3-4 cm), phase 2 dilation (5-7 cm), and phase 3 dilation (8-10 cm). The massage group received standard nursing care and massage intervention, whereas the control group received standard nursing care only. The results of this study showed: (1) In both groups, as cervical dilation increased, there were significant increases in pain intensity as measured by SF-MPQ; (2) massage lessened pain intensity at phase 1 and phase 2, but there were no significant differences between the groups at phase 3; (3) the most frequently selected five sensory words chosen by both groups were similar at phases 1 and 2- (a) sore, (b) sharp, (c) heavy, (d) throbbing, and (e) cramping, while of the 4 affective classes, "fearful" and "tiring-exhausting" were the most used by participants to describe the affective dimension. The results of this study indicate that, although massage cannot change the characteristics of pain experienced by women in labor, it can effectively decrease labor pain intensity at phase 1 and phase 2 of cervical dilation during labor. Nurses and caregivers could consider using massage to help laboring women through the labor pain.

Adult↗

PubMed1997

Antroduodenal manometry in children with no upper gastrointestinal symptoms.

BACKGROUND: The interpretation of antroduodenal manometry in children with gastrointestinal motility disorder has been limited by a paucity of data from normal children. The purpose of this study was to define antroduodenal manometry findings in children with no upper gastrointestinal symptoms. METHODS: We reviewed 260 consecutive antroduodenal manometries and selected 18 studies from subjects aged 2-12 years with no symptoms referable to a gastrointestinal motility disorder involving the stomach and/or the small bowel. RESULTS: During fasting, phase 3 of the migrating motor complex (MMC) was present in 14 of 18 children, and it was induced by erythromycin in 4 who failed to have a spontaneous phase 3. Phase 3 propagation velocity increased significantly with age. The cycle length between MMCs showed no age-dependent variation. Phase 3 occupied 3%; phase 1, 10%; and phase 2, 87% of the fasting recording time. CONCLUSIONS: Antroduodenal manometry findings in children with no upper gastrointestinal symptoms are similar to those in adults.

Adult↗

PubMed2004

[Processes and strategies for developing public health nurse directed community health projects in municipalities of Japan--focusing on setting agendas and making project alternatives].

PURPOSE: The purpose of this study was to explore processes and strategies for developing community health projects directed by public health nurses (PHNs) in municipalities of Japan. METHOD: Yin's case study design was adopted into the 5-step Policy Making Process Model as the theoretical framework. The first two steps involving agenda setting and project planning were the focus of this study. PHNs who had developed new community health projects in municipalities were interviewed as study participants. In order to maintain the quality of projects at a certain level, only these approved officially by municipalities with a program and budget were selected. RESULTS: Common strategies emerged for developing community health projects in the cases presented by the 5 PHNs. Out of 891 codes, twenty-six sub-categories were identified and integrated into 9 categories. When categories were analyzed in a time series, the following common processes were found: integration of related data, identification of the health problems in the community and recognition of project needs (Phase 1); refining the concept and characteristics of the project plan (Phase 2); and assuring that resources were available for the optimal implementation of the project by consolidating ideas (Phase 3). In Phase 1, PHNs integrated the information about previous experimental cases or social circumstances to identify community health problems needing solution. PHNs' thoughts were given to problems of existing projects and daily practices were grouped to make comprehensive plans for improvement. In Phase 2, PHNs discussed ideas for the project plans and considered resources and strategies that were necessary for putting new projects into place. In Phase 3, PHNs were attentive to the factors reviewed in Phase 2, kept account of necessary resources, and made certain of timing for immediate implementation of plans. The dual roles of PHNs, both as nurses and public servants, helped to clarify and solve the community health problems. CONCLUSION: Common strategies of developing programs were explored; "Identifying the community health problems through analyzing the causes of difficult cases," "Recognizing the necessity of coverall-projects which will improve the existing projects," "Understanding the awareness of those involved and discuss ideas for the project plan." The findings have based solely on the experiences of PHNs, they can provide suggestions that are keys to efficient development of new projects.

Cities↗

PubMed1982

A morphometric and biochemical study of the pre-eruptive development of hamster molars in vivo.

Surface area measurements of cross-sections of M1 and M2 at 1-11 days were related to biochemical parameters for cell proliferation ([3H]-thymidine incorporation) and mineralization (45Ca uptake) and with increase in dry weight. The pre-eruptive development of molar tooth germs was divided into 4 phases which partly reflect the life cycle stages of the ameloblast. In phase 1 (proliferation phase, duration in M2 about 5 days) mitotic activity and increase in total area were great; ameloblasts were undifferentiated or in a pre-secretory state. In phase 2 (differentiation phase, duration 2-3 days) the number of secretory ameloblasts increased and 45Ca uptake started and increased rapidly. At the end of phase 2, crown morphogenesis was completed and cell proliferation ([3H]-thymidine incorporation) became less. In phase 3 (secretion phase, duration 0.5-1 days) all ameloblasts throughout the tooth germ had differentiated into secretory ameloblasts and enamel matrix surface area increased about twice as fast as that of dentine. At the end of phase 3, the surface area of the enamel matrix almost attained its final value. In phase 4 (maturation phase, duration in M1 till first eruption about 2-3 days), post-secretory ameloblasts increased in number and, in contrast to the surface area of the enamel matrix, that of the dentine continued to increase. The fast, linearly increasing total uptake of 45Ca during phase 4 which was attributed to the mineralization of both newly formed dentine and existing maturing enamel was the main cause of the rapid increase in dry weight of the whole tooth germ.

Amelogenesis↗

PubMed2004

Differentiation of benign prostatic hyperplasia from prostate cancer using prostate specific antigen dynamic profile after transrectal prostate biopsy.

PURPOSE: Serum prostate specific antigen (PSA) level is increased after needle biopsy (Bx) of the prostate. This study tested the hypothesis that the prostate harboring malignant lesions demonstrates less leakage of PSA after prostate biopsy and this phenomenon can be helpful in discriminating benign from cancer diagnosis. MATERIALS AND METHODS: This prospective study was divided into 3 separate phases. Sextant prostate biopsy was done with transrectal ultrasound guidance, and the change and PSA values after biopsy were evaluated. Phases 1 and 2 had 20 and 41 patients, respectively. PSA dynamic profiles were plotted. We defined the most appropriate timing for blood sampling and the cutoff value of the PSA ratio (post-Bx total PSA-to-pre-Bx total PSA) to be applied for further assessment. Phase 3 recruited 97 cases, of which 66 satisfied the end point criteria in which a diagnosis such as malignancy, or 3 successive benign biopsies or benign transurethral resection of prostate was obtained. RESULTS: From phases 1 and 2 the cutoff value for the PSA ratio was 2.0, and the timing of blood sampling was 60 minutes after the biopsy. In phase 3 of those whose PSA ratio was less than 2.0, 92.6% (25) had cancer. For those whose PSA ratio was greater than 2.0, 82.1% (32) were benign. Of the 4 cases with a PSA ratio less than 2.0 and an initial benign biopsy, 3 (75%) were proven to have cancer later. CONCLUSIONS: Evaluating the 1-hour PSA ratio might be helpful for clinicians to select the high risk patients who might have cancer in the prostate. Repeat biopsy should be suggested for cases with a smaller PSA ratio in spite of initial benign results.

Aged↗

PubMed1997

A crossover comparison of intermittent oral and intravenous administration of calcitriol on the parathyroid hormone concentration in hemodialysis patients.

Active vitamin D3 is used commonly in hemodialysis patients with severe secondary hyperparathyroidism. Intermittent pulse therapy with active vitamin D3, either orally or intravenously, has been proven to be effective with less hypercalcemic complication than daily oral vitamin D3. We therefore designed a three-phase crossover study to compare the effect of oral and intravenous calcitriol given by intermittent pulse therapy. Thirteen regular hemodialysis patients were enrolled. In phase 1, 1 microgram calcitriol was given orally at bedtime twice a week for 4 months, and then was stopped for 1 month to washout. In phase 2, 1 microgram calcitriol was given intravenously immediately after hemodialysis twice a week for 2 months, and then was stopped for 1 month to washout. Phase 3 repeated phase 1 but lasted for only 2 months. Calcium carbonate was given as the sole phosphate-binding agent if there was no severe hypercalcemia or hyperphosphatemia. Serum parathyroid hormone (PTH) levels decreased dramatically in all three phase therapies. As a result, mid-molecule PTH decreased from 5.71 +/- 2.65 to 3.97 +/- 2.92 ng/ml in phase 1 (p = 0.010), from 4.34 +/- 3.39 to 1.98 +/- 1.76 ng/ml in phase 2 (p = 0.007), and from 2.72 +/- 0.97 to 1.67 +/- 0.71 ng/ml in phase 3 (p = < 0.001). However, there was no difference in the calculation of the PTH declination among the three phases (32, 50 and 42%, respectively). The incidence of hypercalcemia was higher in using calcitriol than without it (23 vs. 6%, p < 0.05), but there was no difference between intravenous and oral calcitriol (35 vs. 19%). The above results suggested that both oral and intravenous calcitriol, with lower doses and intermittent pulse therapy, were equally effective in controlling secondary hyperparathyroidism. The incidences of hypercalcemia were similar in both oral and intravenous calcitriol using 3.5 mEq/1 dialysate calcium concentration and calcium carbonate as the chief phosphate binder.

Administration, Oral↗

PubMed2001

Small group learning in the final year of a medical degree: a quantitative and qualitative evaluation.

The new undergraduate medical curriculum in Manchester uses problem-based learning (PBL) throughout the course. However, the major difference from other PBL schools is that in years 3 & 4 (phase 2) the students can use clinical experience when discussing the paper cases. The process is then developed further in year 5 (phase 3), in which there are no set PBL 'triggers' and students bring their own cases to the groups for discussion. In this study, we have explored what happens in the phase 3 (year 5) group sessions and how the students view them. A questionnaire and focus groups were used to generate data, from which a model was developed of what happens in a 'good' group session. The data suggest that most groups run on a case-presentation and discussion format, most commonly about clinical management and diagnosis. Students want tutors to act as an expert resource and to be flexible in allowing students to direct the discussions. University guidance about the group sessions was not generally used.

Journal Article↗

PubMed1978

Evaluation of the heart rate response to the Valsalva maneuver.

A study has been made of the heart rate (HR) response to the Valsalva maneuver in five different groups of normal white males and two groups of male coronary heart disease (CHD) patients using non-invasive methods. By means of the analysis of variance the effects of age, posture, Valsalva phase and CHD on the HR response were assessed. Both age and CHD were factors that reduce the HR response. Further analysis indicated that the HR change from Phase 3 to Phase 4 in the Valsalva was the preferred discriminator between normals and cardiac patients. We have derived a "Valsalva score" that can be used to identify HR changes that deviate from the expected average normal response for a given age, control HR and Phase 3 HR. HR assessment of the Valsalva maneuver is a simple safe non-invasive test. An abnormal response suggests altered functioning of hemodynamic or autonomic cardiovascular mechanisms governing HR control.

Adult↗

PubMed2001

Enzyme replacement and beyond.

During the last decade, enzyme replacement therapy for lysosomal storage diseases became a reality with the demonstration of its safety and effectiveness in type 1 Gaucher disease. Currently, enzyme replacement and several other potential therapeutic strategies are being developed for selected lysosomal storage diseases, including Fabry disease due to the deficient activity of alpha-galactosidase A (alpha-Gal A). The development and clinical evaluation of these new therapies require a stepwise process, each step being rigorously reviewed and approved by national or international regulatory agencies. For lethal disorders that affect small populations, such as many inherited metabolic diseases, this process can be accelerated by 'orphan drug' and 'fast track' regulations. As an example of the drug development process, the development of recombinant human alpha-Gal A (r-halphaGal A) replacement for Fabry disease is presented, including the preclinical studies in the 'Fabry mouse' model, and the clinical phase 1/2, phase 3, and phase 3 extension studies, which demonstrate the safety and efficacy of this new therapy.

Animals↗

PubMed2002

Analysis of exhaled nitric oxide by the helium bolus method.

STUDY OBJECTIVES: The precise anatomic sites contributing to exhaled nitric oxide (eNO) are still unknown. The present study was designed to analyze profiles of eNO by referring to the He exhalation curve and examining the effects of breath-holding and expiratory flow rates on eNO. PARTICIPANTS: Healthy volunteers and patients with stable asthma. MEASUREMENTS AND RESULTS We used the He bolus method of the closing volume, and simultaneously analyzed the concentrations of exhaled He and nitric oxide (NO). By referring to the He exhalation curve, the expired gas was divided into three parts: airway dead space (phase 1), a mixture of airway and alveolar gas (phase 2), and alveolar gas (phase 3 and phase 4). The eNO profiles showed a peak in phase 2 (peak eNO) and decreased gradually to a plateau in the latter half of phase 3 (plateau eNO). The levels of peak eNO were higher than those of plateau eNO in both normal subjects and asthmatic patients. Breath-holding increased levels of peak eNO 2.5-fold in both normal subjects and asthmatic patients, but it did not affect the levels of plateau eNO. The levels of peak eNO increased as the expiratory flow rate decreased, and the levels of plateau eNO showed a similar flow dependency. CONCLUSION: A peak value of eNO concentration profiles may directly express the production of NO in the airway.

Adult↗

PubMed1998

Effect of over-the-counter dosages of naproxen sodium and acetaminophen on plasma lithium concentrations in normal volunteers.

Prescription doses of nonsteroidal antiinflammatory agents have been shown to decrease clearance and increase plasma concentrations of lithium. This study was designed to evaluate whether over-the-counter (OTC) doses of naproxen sodium or acetaminophen have the same potential to affect lithium concentration. This was a prospective, crossover, 3-phase study conducted at the Clinical Pharmacology Studies Unit of the Albany Medical Center Hospital during July and August of 1995. The 3-phase study comprised the following: phase 1, lithium carbonate (300 mg every 12 hours) alone for 7 days; phase 2, lithium and either naproxen sodium (220 mg every 8 hours) or acetaminophen (650 mg every 6 hours) for 5 days; and phase 3, a 2-day washout period followed by a crossover to lithium with the alternate drug (acetaminophen or naproxen sodium) for 5 days. Twelve healthy male volunteers were recruited, nine of whom completed the study and were included in the statistical analysis. Mean (+/-SD) plasma lithium concentrations for subjects in treatment group 1 (lithium in phase 1, lithium and naproxen sodium in phase 2, lithium and acetaminophen in phase 3) were 0.38 (+/-0.11), 0.40 (+/-0.07), and 0.36 (+/-0.11) mEq/L, respectively. Mean plasma lithium concentrations for subjects in treatment group 2 (lithium in phase 1, lithium and acetaminophen in phase 2, lithium and naproxen sodium in phase 3) were 0.43 (+/-0.05), 0.48 (+/-0.10), and 0.48 (+/-0.05) mEq/L, respectively. One-way repeated-measures analysis of variance and paired t-test showed no statistically significant differences (p>0.05) in plasma lithium concentrations during any phase of the study. The results of this study demonstrated that OTC doses of naproxen sodium and acetaminophen did not increase plasma lithium concentrations in these volunteers when taken for short periods of time.

Acetaminophen↗

PubMed1984

3-Aminobenzamide is lethal to MMS-damaged human fibroblasts primarily during S phase.

3-Aminobenzamide (3-AB) interferes with DNA repair and enhances lethality in growing MMS (methyl methane sulfonate)-treated human fibroblasts. This sensitivity to 3-AB disappears slowly; MMS-treated cells are sensitive to 3-AB for up to 36 hours (Boorstein and Pardee, 1984). Evidence is now presented that 3-AB potentiates the effects of MMS primarily during S phase. When cells were synchronized at the G1/S boundary, released, and then treated with MMS, 3-AB caused very substantial lethality in only 4 hours, and a 12-hour treatment gave maximum lethality. These cells also lost sensitivity to 3-AB within 12 hours of growth minus 3-AB. In contrast, MMS-treated quiescent (G0) cells did not lose sensitivity to 3-AB nor did 3-AB cause lethality during G0. Enhanced lethality occurred when damaged G0-arrested cells were subsequently allowed to proceed through S phase in the presence of 3-AB; this 3-AB sensitivity was removed only during growth in the absence of 3-AB. The lethality of 3-AB to a population of asynchronously cycling cells treated with MMS is thus the summation of effects on the cells as they traverse S phase. Aphidicolin prevented lethality of 3-AB to cells released from G1/S and treated with MMS. It also inhibited the loss of sensitivity to added 3-AB later. Correlation with the inhibition of DNA synthesis by this drug suggests that DNA synthesis is essential for the lethality enhancement by 3-AB. Cells treated first with MMS and then with 3-AB accumulated in G2. This G2 arrest depended on S-phase events and correlated with cell lethality. Cells treated with a nonlethal dose of MMS at the G1/S boundary were delayed briefly (3 hours) in their passage through S and G2. These cells, when also exposed to 3-AB, were delayed 6-9 hours in S and they became arrested in G2. There was no G2 arrest when 3-AB was added only after these cells had reached G2. Treatment with 3-AB during S phase thus resulted in both enhanced lethality and G2 arrest. 3-AB inhibited repair of DNA single-strand damage, shown by alkaline elution analysis, in both S-phase and quiescent cells. Aphidicolin inhibited disappearance of breaks and eliminated the difference between 3-AB-treated and untreated cells. Lethality did not correlate well with the measured single-strand damage.(ABSTRACT TRUNCATED AT 400 WORDS)

Aphidicolin↗

PubMed1979

Histopathologic sequence of events in adult mice undergoing lethal graft-versus-host reaction developed across H-2 and/or non-H-2 histocompatibility barriers.

The sequence of histologic events in graft-versus-host reaction (GVHR) caused by major and/or minor histoincompatibilities was studied. It was discovered that GVHR may manifest itself in the form of two distinct multiphasic disease entities, depending on whether the donor cells are incompatible with the host for both major and minor histocompatibility antigens ("major GVHR") or for minor histocompatibility antigens alone ("minor GVHR"). The acute or major GVHR has four phases: 1) a transient phase of aplasia, 2) a repopulation phase, 3) a proliferative phase involving lymphoid, presumably immunocompetent, cells, and 4) a phase of acute organ rejection (terminal). The chronic or minor GVHR is characterized by six phases, namely: 1) a transient phase of aplasia, 2) a repopulation phase, 3) a phase of proliferation and tissue infiltration by lymphoid, presumably immunocompetent cells, 4) a phase of major immunologic injuries, 5) a phase of repair, and 6)a terminal phase with advanced sclerosis and proliferative glomerulonephritis. In acute or major GVHR the disease was manifested by the tissue reactions characteristic of acute organ rejection. Lesions were seen in the kidney, liver, bone marrow, lymph nodes, spleen, thymus, intestine, and skin. In the chronic or minor GVHR, tissue injuries were more widespread, affecting the collagen, vessel walls, adipose tissue, renal glomeruli, heart muscle, fascias of skeletal muscles, lymph nodes, spleen, thymus, bone marrow, intestine, skin, esophageal mucosa, and urinary tract. A pronounced plasma cell proliferation was a striking feature in the minor GVHR. Its evolution coincided with advanced thymic epithelial atrophy. It is suggested that the destruction of thymic epithelium resulted in depletion of suppressor T cells and, consequently, in an unopposed proliferation of plasma cells.

Animals↗

PubMed1990

Lack of triggered automaticity despite repolarization abnormalities due to bepridil and lidoflazine.

Bepridil and lidoflazine are calcium channel antagonists that also prolong action potential duration, produce QT interval prolongation on the surface ECG, and have been associated with the distinctive form of ventricular tachycardia, torsade de pointes. It has been demonstrated that quinidine, which also prolongs QT interval and induces torsade de pointes, produces early afterdepolarizations and triggered activity in canine Purkinje fibers driven at slow rates. The effects of bepridil (1-10 microM) and of lidoflazine (5-15 microM) on the transmembrane action potential from canine Purkinje fibers were therefore studied. At long cycle lengths, unlike with quinidine, triggered activity arising during phase 3 was rare; phase 3 secondary plateaus (early afterdepolarizations) were, however, common. Arrest of transmembrane potential between -50 and -60 mV during stimulation at long cycle lengths was also frequently observed (7/20 of bepridil and 3/15 of lidoflazine-treated fibers). In preparations with prominent phase 3 secondary plateaus, addition of epinephrine resulted in triggered activity; similarly, epinephrine caused automaticity from a depolarized membrane potential in 8/9 fibers quiescent at -50 to -60 mV. Thus, the calcium channel blocking drugs bepridil and lidoflazine produced striking repolarization changes at slow stimulation rates, but unlike quinidine, triggered activity was rare. The effect of epinephrine on these drug-treated fibers suggests that the slow inward calcium current plays a role in the generation of triggered activity in the presence of prolonged repolarization.

Action Potentials↗

PubMed1991

Sequential transformations of human sperm nucleus in human egg.

In-vitro insemination of human zona-free oocytes prepared from oocytes that failed to fertilize in an in-vitro fertilization programme was used as an experimental model to study the time course and morphological events during the development of sperm nuclei into male pronuclei. At 30 min after insemination, 22 eggs were cultured in a CO2 incubator for further 3.5 h and 17 eggs were placed individually between a slide and coverslip for randomly repeated microscopical observations in a controlled environment for at least 3.5 h. Simultaneous arrest of maternal meiosis and sperm nuclear development occurred in 36.4% (8/22) eggs cultured in the CO2 incubator and 47.1% (8/17) of those cultured between a slide and coverslip. Sequential transformation of the human sperm nucleus in human eggs was studied in 6 eggs that showed continuous development of sperm nuclei into male pronuclei during at least 3.5 h after insemination. The early sperm nuclear development in human egg ooplasm can be divided into three phases: the sperm nucleus first decondenses (phase 1) then partly recondenses (phase 2) before expanding again to form an early male pronucleus (phase 3). The prepronuclear stages (phases 1 and 2) took about 60 min each and the pronuclear formation (phase 3) began between 120 and 170 min after insemination. Early pronuclear formation was associated with the occurrence of dense outline material, probably a precursor of the future pronuclear membrane, around the recondensed nucleus in re-expansion (phase 3). Between 30 and 60 min after the beginning of phase 3, numerous (greater than 20) dense grains, considered as nucleolar precursors, were clearly visible inside the growing male pronucleus. Moreover, we have examined sperm nuclear changes in some eggs in which the progression of late meiosis was abnormal. Meiotic arrest of maternal chromatin was always associated with arrest of sperm head development. In 75% (6/8) of the eggs arrested in the metaphase II stages and in 87.5% (7/8) of the eggs arrested in late anaphase II, sperm nuclear development was stopped at the decondensed and recondensed stages, respectively. We have always observed male pronuclei when a maternal pronucleus was present in the egg. These observations suggested that maternal chromatin and sperm nuclear development are probably regulated by common factor(s).

Cell Nucleus↗

PubMedDate not supplied

Evaluation of the oral antihyperglycemic drug metformin in normal and diabetic cats.

Metformin is an oral antidiabetic drug that improves control of glycemia primarily by inhibiting hepatic gluconeogenesis and glycogenolysis. This study evaluated the usefulness of metformin for the treatment of diabetes mellitus in cats. The study consisted of 3 phases. Phase I was a dose-finding study performed in healthy cats that were randomly administered varying doses of metformin to determine the approximate dose that would yield plasma concentrations known to be effective in humans. Phase 2 was a 3-week safety study performed in healthy cats to determine if cats could tolerate the daily oral dose and administration protocol identified during phase 1. Phase 3 was a clinical trial evaluating the clinical response of diabetic cats to oral metformin treatment. Five cats with newly diagnosed, naturally acquired diabetes mellitus were enrolled in phase 3. Plasma metformin concentrations in the therapeutic range of 0.5-2 microg/mL were achieved with doses of 50 mg/cat PO q12h without dramatic drug accumulation. Intermittent lethargy, inappetence, vomiting, and weight loss were identified, and the results of the CBC, serum biochemical analysis, plasma lactate concentration, and urinalysis remained within the reference range during phase 2 of the study. During phase 3, control of glycemia was achieved in 1 of 5 diabetic cats after 8 weeks of metformin treatment; 3 cats failed to respond to metformin, and treatment with insulin was initiated after 7-8 weeks of metformin treatment; 1 cat died unexpectedly 11 days after starting metformin treatment. The cause of death was not determined. The serum insulin concentration was within or greater than the reference range in the responder diabetic cat and was undetectable or at the low end of the reference range in the nonresponder diabetic cats. The results of this study suggest that metformin is beneficial only in those diabetic cats with detectable concentrations of insulin at the time metformin treatment is initiated.

Administration, Oral↗

PubMed1999

Sex differences in late behavioral response to subcutaneous formalin injection in mice.

We investigated sex- or gender-dependent differences in nociception using the formalin test in mice. In addition to typical biphasic responses, a new, late phase (Phase 3) was observed. A local anesthetic QX-314 injected at the end of Phase 2 blocked Phase 3. Phase 3 in female mice was significantly greater than that in male mice regardless the stage of the estrus cycle.

Animals↗

PubMed1989

[24 hours of intestinal motility].

The normal pattern of fasting motility in the small intestine shows migrating bursts of intense electrical activity associated with smooth muscle contractions. The migrating motor complex (MMC) is a recurring pattern of contractions of the human small bowel which is inhibited in the fed state. At any given site the entire MMC cycle comprises three phases numbered 1, 2 and 3. Phase 3 activity, the most prominent feature of the MMC, consists of a burst of intense contractions which generally start in the stomach or in the duodenum and migrate distally. In humans, phase 3 recurs every 110 minutes and clears the small bowel of cellular debris and residual food. During phase 2, several other patterns of motility have been identified in man. The migrating action potential complex (MAPC) or its manometric equivalent (peristaltic rush) is an infrequent event in normal subjects, occurring only once every 160 minutes. Minute rhythms are defined as rhythmic bursts of phasic contractions of shorter duration than phase 3 and occurring with a much greater periodicity. They never occur in fed state. At night, the periodicity of phase 3 is more regular and its propagation velocity is slower than during daytime. In normal subjects the MMC pattern shows important inter- and intra-individual variations which need to be known to study patients with disorders of small bowel motility.

Animals↗