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PubMed1989

[Cerebellar side effects in treatment with antidepressive agents].

Nine patients are reported with marked cerebellar side-effects under antidepressant treatment, mostly in combination with other psychopharmacological agents. The main symptoms were dysmetria, ataxia, intentional tremor, dysarthria and rarely myocloni. In nearly all cases symptomatology disappeared by slight dosis reduction of the antidepressant. Pathophysiology could be best explained by influence on nonadrenergic afferences of cerebellar cortex.

Adult↗
PubMed1991

[Intoxication with tricyclic antidepressive agents in therapeutic doses. Benefits of routine blood level measurements].

Measurement of the level of tricyclic antidepressants in the blood is useful in the treatment of affective disorders. We describe four patients, all of whom became intoxicated by the recommended therapeutic doses of tricyclic antidepressants. The only obvious sign of such gradual intoxication may be worsening of the depressive syndrome. Therefore, to enable administration of high enough doses without intoxication we recommend routine blood level measurements. We present therapeutic ranges and intoxication levels, based on the international literature.

Adult↗