PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “BLOOD ALKALINE PHOSPHATASE”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 343 records · Page 19Linked to original sources
PubMed1989

[Metabolism of calcium and phosphorus in Cushing syndrome with osteoporosis].

52 patients with Cushing syndrome were studied. According to the appearance of X-ray film of bones, they were divided into three groups: (I) Without osteoporosis, 12 cases (23.1%), (II) Mild osteoporosis, 17 cases (32.7%), (III) Severe osteoporosis with fractured ribs and/or wedge-shaped vertebrae, 23 cases (44.2%). It was found that the mean level of serum calcium in the patients was significantly lower than that in 94 normal subjects (mean +/- S 2.3 +/- 0.2 versus 2.4 +/- 0.1 mmol/L P less than 0.001). The mean concentrations of blood alkaline phosphatase and parathyroid hormone in the patients were much higher than those in normal subjects (65.0 +/- 27.6 versus 42.6 +/- 15.6 IU/L P less than 0.001, 44.6 +/- 22.4 versus 20.6 +/- 8.0 pg/ml P less than 0.001 respectively). The mean level of serum 25 (OH)-D in the patients was significantly lower than that in controls (10.9 +/- 5.6 versus 16.2 +/- 4.6 ng/ml P less than 0.001). Urinary calcium excretion increased in the patients as compared with that in controls (P less than 0.01). The urinary calcium excretion correlated well with the blood total cortisol and urinary free cortisol. It is suggested that hypercalciuria might cause decrease of serum calcium. Thus the parathyroid glands were stimulated and the parathyroid hormone (PTH) secretion was increased. Excess of PTH stimulates bone resorption. All of these factors are involved in the pathogenesis of osteopenia in Cushing's syndrome.

Adolescent↗
PubMed1989

Short-term effect of exposure to intense magnetic fields on hematologic indices of bone metabolism.

Magnetic resonance imaging (MRI) is a useful tool in the diagnosis and management of orthopedic disease. Previous reports indicate that magnetic fields of MRI intensity stimulate bone growth in vivo. We investigated the question of whether exposure to intense magnetic fields modified ionic and enzymatic constituents of the circulatory system. Mice were exposed to a static (direct current) magnetic field (1 Tesla) for 30 minutes on each of ten consecutive days. No significant difference in blood alkaline phosphatase, acid phosphatase, calcium ion concentration, and phosphate ion concentration was detected between control, sham-exposed, and magnetic field-exposed mice. These results suggest that exposure to intense magnetic fields does not alter physiological mechanisms of bone mineralization.

Animals↗