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PubMed1988

Biometry has to improve the quality of decision making both in biomedical research and in clinical practice.

The leading principles of biometrical design, evaluation and decision making in biomedicine can be summarized as follows: (1) formulation of the problem to be solved and of the specific question(s) to be answered; (2) definition of the population in study, ways of sampling and manoeuvres (treatments); (3) determining the kind and number of variables (time intervals of measurement, investigated biomedical parameters); (4) performing the pilot study if necessary (to arrange randomized blocks, to form hypotheses); (5) formulation of zero (alternative) hypothesis, setting the values of alpha(beta) risk; (6) ordering the sample sizes; (7) testing the type of statistical distribution and the homoscedasticity of the obtained data; (8) calculation of the point and interval (confidence, tolerance) estimates; (9) performing the chosen tests, e.g. on the significance of differences or correlations; and (10) the conclusions for science and practice, with eventual return to point (1) on a higher level of knowledge.

Biometry↗
PubMed1986

[Biometry as a methodologic principle of clinical research in otorhinolaryngology].

The basic biometric theories for different types of clinical studies in Oto-Rhino-Laryngology are presented with a minimum use of formulae. A check-list is sketched with all points to be taken into account in the design of a study. The prerequisites for organisation of work and data processing are outlined. The understanding of this methodological basis can be very helpful in promoting the collaboration of clinicians and statisticians in pursuing successful clinical investigations in the field of Oto-Rhino-Laryngology.

Biometry↗
PubMed1985

[The heart of the Papio Erxleben, 1777: biometry and macroscopic anatomy].

One hundred hearts of baboons were studied (P. hamadryas and P. cynocepahlus). The weight and the volume of the hearts were measured by Scherle method (1970). The other measurements were: oblique diameter right "atrium" - apex cordis", right and left free ventricular thickness and the inner aorta diameter. The hearts were also studied by gross dissection and anatomical sections. The morphology of the heart of the baboon proved to be similar to the human heart morphology. Probably it is a good model to the cardiovascular research and may be surgical applications.

Animals↗