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Body surface Laplacian mapping of bioelectrical activity.

A method is described to process and interpret multi-channel bioelectrical signals. The bioelectrical signals were recorded noninvasively over the body surface of human subjects at 120 sites. The body surface Laplacian maps were then constructed from the multi-channel bioelectrical potential measurement. The method was evaluated by means of computer simulations, and applied to imaging cardiac electrical activity. The present investigation suggests body surface Laplacian mapping provides an important means in interpreting bioelectrical signals.

Body Surface Potential Mapping↗

Computer analysis of multichannel ECG.

Multichannel electrocardiography (MECG) is an extension of the conventional electrocardiography that is aimed at refining the non-invasive characterisation of cardiac activity. Body surface mapping is a graphical presentation of cardiac activity as measured from the body surface. Body surface maps can show the distribution of the potential at a selected moment in time or over a specified time interval. A new family of maps, based on the characteristics derived from the complete analysed beat, is described. Some new computer supported methods, which are able to calculate automatically different temporal maps, are proposed. MECG measurements can be seen in this context as a powerful research and clinical tool for improving the resolution of cardiac measurements.

Body Surface Potential Mapping↗

Body surface Laplacian ECG mapping.

A new noninvasive approach has been developed to resolve spatially distributed cardiac electrical activity by measuring the surface Laplacian of the body surface potential. Computer simulations demonstrate the ability of the Laplacian map compared with the potential map to image spatially distributed dipole sources embedded in a semi-infinite volume conductor. Body surface Laplacian mapping has been implemented in human subjects utilizing dry bipolar Laplacian electrodes and compared with potential maps obtained using the central terminal of each bipolar Laplacian electrode. The body surface Laplacian ECG distribution was found to provide better spatial resolution than the body surface potential distribution. The body surface Laplacian map appears to resolve depolarization and repolarization of different regions of the heart. Further improvements of the body surface Laplacian mapping may permit noninvasive mapping of spatially distributed intracardiac events.

Body Surface Area↗

The state of body surface mapping in Japan.

In Japan, body surface mapping (BSM) started in 1974. A huge amount of data has been accumulated regarding basic researches and clinical applications. Recent work on BSM in Japan is summarized here, with the goals of establishing a normal database and diagnostic criteria by using the standardized mapping system. The standard systems used in Japan are the HPM-7100 and the VCM-3000, manufactured by Fukuda-Denshi (Tokyo, Japan) under the supervision of a committee of the Japanese Circulation Society. The number of leads in this system is 87 (59 on front, 28 on back). As a basic study, a computer simulation was carried out on bundle branch block with myocardial infarction (MI), on late potentials in MI, and finally, on the solution of the inverse problem. The database of 606 normal subjects was established regarding age and sex, and a "departure index" (the grade of deviation from normal: the difference between a patient's data the normal mean divided by the normal SD) was proposed. Using the departure index, diagnostic criteria were proposed for the ischemic site, MI site, hypertrophic site of the ventricle, etc. The origin of the ventricular premature contractions was determined by the site of minima and maxima of the QRS and QRST isointegral maps. The site of accessory pathways was determined by the site of minimum less than -0.15 mV on the BSM. For the prediction of patients prone to ventricular tachycardia (VT), several approaches were tried such as multipolar patterns of QRST isointegral maps, Wigner distribution, late potentials with relation to endo- or epicardial delayed potentials, body surface distribution of specific frequency band (25-50 Hz) obtained from fast Fourier transform analysis, and nondipolarity of the QRST isointegral map. To improve the ablation procedure of VT, the author developed a technique to determine the precise location of the VT focus in pace mapping using a correlation matrix between VT and pace maps. To ensure the longevity of the BSM, a reduction of the number of leads has been proposed. The usefulness of BSM has been confirmed and the technique accepted in Japan for daily clinical diagnosis.

Action Potentials↗

Estimation of inter-electrode distance for body surface mapping: application of Fourier analysis to potential distribution due to the epicardial breakthrough.

For the purpose of determining an appropriate distance of lead points for constructing body surface maps, Fourier analysis was performed on potential distribution reflecting the epicardial breakthrough, and inter-electrode distance necessary for sampling of harmonics contributing to the body surface potential distribution was determined by application of sampling theorem. Potential distribution was simultaneously recorded with an interval of 4 mm for 250 msec along the vertical (head to foot) and horizontal (right to left) line crossing a second-minimum appearing on the chest surface of a healthy adult, and the data obtained from 9.6 cm along the respective lines underwent Fourier transform. Relative contribution of the second harmonics to the original wave forms increased with time lapse after QRS initiation, in accordance with reductions of the first harmonics component, and attained the maximum (32.5% of total power spectrum without d-c component) at the instant of occurrence of the second-minimum. A similar tendency was observed among higher harmonics, but their contribution was comparatively low (within 10%). Inter-electrode distance determined by sampling theorem was 4.8 cm for the first harmonics and 2.4 cm for the second harmonics. In conclusion it is proposed that placement of electrodes with an inter-electrode distance of 2.4 cm is necessary for acquiring clinically important data on the epicardial breakthrough.

Electrocardiography↗

Correlation of the endocardial fragmented electrogram with body surface signal-averaged electrocardiographic mapping.

We compared signal-averaged electrocardiography (SAE), SAE mapping, and left ventricular catheter mapping in 60 patients with ischemic heart disease. Using the data obtained in patients with no fragmented electrograms (FE) in the left ventricle, the late potential was defined by SAE as a filtered QRS duration > 131 msec or a root mean square voltage < 16 microV for the last 40 msec of the QRS complex. SAE mapping was performed by recording the signal-averaged electrocardiogram at 48 sites on the body surface. With SAE mapping, the filtered QRS duration and the area in the last 20 msec of the QRS complex were significantly different between the patients with and without FEs. The late potential was defined by SAE mapping as a filtered QRS duration > 136 msec or an area < 28 microV.msec for the last 20 msec of the QRS complex. The sensitivity and specificity of detecting FEs were 46% and 88%, respectively, by the SAE filtered QRS criterion, while they were 66% and 88% by the root mean square criterion. In contrast, SAE mapping gave values of 66% and 92% by the filtered QRS criterion, as well as values of 100% and 92% by the area criterion. Thus, SAE mapping provided better detection of the FE and was more closely correlated with the results of catheter mapping, suggesting its potential for clinical application.

Action Potentials↗

Quantitative assessment of myocardial ischemia by electrocardiographic and scintigraphic imaging.

We calculated distributions of epicardial potentials from body-surface electrocardiograms (ECGs) recorded during controlled myocardial ischemia and compared them with scintigraphic estimates of ischemia's extent/severity. The study population consisted of patients suffering from single-vessel coronary artery disease, referred for elective percutaneous transluminal coronary angioplasty of either the left anterior descending (n=7), the right coronary (n=9), or the left circumflex (n=2) artery. After the target vessel had been dilated, a 1960s "study" inflation was performed with a non-perfusion-type balloon catheter; at its commencement, technetium-99m sestamibi was injected via a femoral-vein catheter, and ECGs were recorded throughout the inflation from 120 leads. Single photon emission computed tomographic imaging was performed one hour after the injection of radionuclide to obtain an "occlusion image", and again one hour after a repeat injection 24 hours later to obtain a "control image"; the latter image was subtracted from the former, to derive a scintigraphic difference map (Delta map). The ECGs were signal-averaged over a 10-s window at preinflation and peak-inflation states, the preinflation averaged complexes were subtracted from the peak-inflation ones to produce body-surface Delta maps, and the corresponding Delta maps of epicardial potentials were calculated by applying the electrocardiographic inverse solution; this procedure is referred to as electrocardiographic imaging. The ECG-derived epicardial Delta maps related spatially to the scintigraphic Delta maps in all patients. The percent areas and surface integrals of positive values in ECG-derived Delta maps were found to be very good single-variable predictors of the extent (r=0.73; p=0.0006) and severity (r=0.72; p=0.0008) of the scintigraphically-estimated perfusion defect; a regression equation using two ECG-derived predictors further improved the agreement with scintigraphic estimates (r=0.81; p=0.0004 for estimates of severity). These findings suggest that noninvasive electrocardiographic imaging might provide quantitative estimates of the extent/severity of myocardial ischemia that agree closely with those provided by scintigraphic techniques.

Adult↗

Silent myocardial ischemia in Kawasaki disease: evaluation of percutaneous transluminal coronary angioplasty by dobutamine stress testing.

BACKGROUND: Myocardial ischemia and myocardial infarction are the most serious complications of coronary artery lesions in children with Kawasaki disease (KD). Therefore, early detection and treatment of myocardial ischemia in patients with KD is essential. We studied the effectiveness of percutaneous transluminal coronary angioplasty (PTCA) in patients with silent myocardial ischemia detected by dobutamine stress 99mTc myocardial scintigraphy (TMS), body surface mapping (BMS), and signal-averaged ECG late potentials (ELP). METHODS AND RESULTS: Eight of 76 asymptomatic patients with a coronary stenosis >25% and a positive dobutamine stress test were considered to have silent myocardial ischemia. All eight patients had >95% stenoses demonstrated by coronary angiography (CAG) just before PTCA. After PTCA, CAG showed that all of the coronary artery stenoses had been reduced to <50%. Additionally, intravascular ultrasonography (IVUS) performed in five patients before and after PTCA demonstrated adequate dilation of the coronary stenosis after PTCA. All eight patients underwent dobutamine stress TMS, BMS, and ELP 2 to 3 months after PTCA, which demonstrated no regions of myocardial ischemia. Approximately 6 months later, CAG was performed in all eight patients, and only one patient had developed restenosis. CONCLUSIONS: PTCA effectively dilates stenotic coronary arteries in children with KD. Moreover, dobutamine stress TMS, BMS, and ELP are useful for detecting silent myocardial ischemia and estimating the effectiveness of PTCA. Furthermore, IVUS is useful for evaluating the severity of coronary artery lesions before and after PTCA in patients with KD.

Adolescent↗

Natural history of ST-segment potential distribution determined by body surface mapping in patients with acute inferior infarction.

The authors studied the natural history of the electrocardiographic ST-segment using body surface mapping in 123 patients with acute inferior infarction who were not treated with thrombolytic agents. In 91 patients they compared body surface ST-segment maps recorded at 7.9 +/- 5.4 hours after the onset of acute myocardial infarction with maps recorded at 32.6 +/- 21.6 hours after infarction. In 46% of the patients the ST-segment distribution map pattern was unchanged. Twenty-eight percent of the patients moved to a ST-segment distribution associated with low mortality, and 7% correlated with a normal ST-segment distribution. Patients who started in a group dominated by marked anterior ST-segment depression or who developed this pattern at the time of the late map had a 45% morbidity, compared to 13% for patients who never developed this pattern (p less than 0.005). In a second group of 61 patients they compared maps recorded at 15.0 +/- 15.8 hours after infarction and repeat maps 19.6 +/- 13.0 recorded months later. At follow-up mapping, 44% of the patients correlated with a normal ST-segment distribution, 38% of patients had a low-risk pattern map and in 7% the map pattern was dominated by anterior ST-segment potential depression. The latter patients had a higher morbidity than patients in the other groups, but this did not reach statistical significance. Four of seven patients in this last group had significant angina at the time of follow-up mapping, compared to 2 of 54 patients in the other two groups (p less than 0.001).

Aged↗

Cardiac mapping.

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Arrhythmias, Cardiac↗