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At least 343 records · Page 19Linked to original sources

Developments in component-based normalization for 3D PET.

Normalization in positron emission tomography (PET) is the process of ensuring that all lines of response joining detectors in coincidence have the same effective sensitivity. In three-dimensional (3D) PET, normalization is complicated by the presence of a large proportion of scattered coincidences, and by the fact that cameras operating in 3D mode encounter a very wide range of count-rates. In this work a component-based normalization model is presented which separates the normalization of true and scattered coincidences and accounts for variations in normalization effects with count-rate. The effects of the individual components in the model on reconstructed images are investigated, and it is shown that only a subset of these components has a significant effect on reconstructed image quality.

Adult↗

EEG data compression techniques.

In this paper, electroencephalograph (EEG) and Holter EEG data compression techniques which allow perfect reconstruction of the recorded waveform from the compressed one are presented and discussed. Data compression permits one to achieve significant reduction in the space required to store signals and in transmission time. The Huffman coding technique in conjunction with derivative computation reaches high compression ratios (on average 49% on Holter and 58% on EEG signals) with low computational complexity. By exploiting this result a simple and fast encoder/decoder scheme capable of real-time performance on a PC was implemented. This simple technique is compared with other predictive transformations, vector quantization, discrete cosine transform (DCT), and repetition count compression methods. Finally, it is shown that the adoption of a collapsed Huffman tree for the encoding/decoding operations allows one to choose the maximum codeword length without significantly affecting the compression ratio. Therefore, low cost commercial microcontrollers and storage devices can be effectively used to store long Holter EEG's in a compressed format.

Algorithms↗

Automatic "pipeline" analysis of 3-D MRI data for clinical trials: application to multiple sclerosis.

The quantitative analysis of magnetic resonance imaging (MRI) data has become increasingly important in both research and clinical studies aiming at human brain development, function, and pathology. Inevitably, the role of quantitative image analysis in the evaluation of drug therapy will increase, driven in part by requirements imposed by regulatory agencies. However, the prohibitive length of time involved and the significant intraand inter-rater variability of the measurements obtained from manual analysis of large MRI databases represent major obstacles to the wider application of quantitative MRI analysis. We have developed a fully automatic "pipeline" image analysis framework and have successfully applied it to a number of large-scale, multicenter studies (more than 1,000 MRI scans). This pipeline system is based on robust image processing algorithms, executed in a parallel, distributed fashion. This paper describes the application of this system to the automatic quantification of multiple sclerosis lesion load in MRI, in the context of a phase III clinical trial. The pipeline results were evaluated through an extensive validation study, revealing that the obtained lesion measurements are statistically indistinguishable from those obtained by trained human observers. Given that intra- and inter-rater measurement variability is eliminated by automatic analysis, this system enhances the ability to detect small treatment effects not readily detectable through conventional analysis techniques. While useful for clinical trial analysis in multiple sclerosis, this system holds widespread potential for applications in other neurological disorders, as well as for the study of neurobiology in general.

Algorithms↗

Blockwise processing applied to brain microvascular network study.

The study of cerebral microvascular networks requires high-resolution images. However, to obtain statistically relevant results, a large area of the brain (several square millimeters) must be analyzed. This leads us to consider huge images, too large to be loaded and processed at once in the memory of a standard computer. To consider a large area, a compact representation of the vessels is required. The medial axis is the preferred tool for this application. To extract it, a dedicated skeletonization algorithm is proposed. Numerous approaches already exist which focus on computational efficiency. However, they all implicitly assume that the image can be completely processed in the computer memory, which is not realistic with the large images considered here. We present in this paper a skeletonization algorithm that processes data locally (in subimages) while preserving global properties (i.e., homotopy). We then show some results obtained on a mosaic of three-dimensional images acquired by confocal microscopy.

Algorithms↗

Uncertainty of data, fuzzy membership functions, and multilayer perceptrons.

Probability that a crisp logical rule applied to imprecise input data is true may be computed using fuzzy membership function (MF). All reasonable assumptions about input uncertainty distributions lead to MFs of sigmoidal shape. Convolution of several inputs with uniform uncertainty leads to bell-shaped Gaussian-like uncertainty functions. Relations between input uncertainties and fuzzy rules are systematically explored and several new types of MFs discovered. Multilayered perceptron (MLP) networks are shown to be a particular implementation of hierarchical sets of fuzzy threshold logic rules based on sigmoidal MFs. They are equivalent to crisp logical networks applied to input data with uncertainty. Leaving fuzziness on the input side makes the networks or the rule systems easier to understand. Practical applications of these ideas are presented for analysis of questionnaire data and gene expression data.

Algorithms↗

Sensitivity to noise in bidirectional associative memory (BAM).

Original Hebbian encoding scheme of bidirectional associative memory (BAM) provides a poor pattern capacity and recall performance. Based on Rosenblatt's perceptron learning algorithm, the pattern capacity of BAM is enlarged, and perfect recall of all training pattern pairs is guaranteed. However, these methods put their emphases on pattern capacity, rather than error correction capability which is another critical point of BAM. This paper analyzes the sensitivity to noise in BAM and obtains an interesting idea to improve noise immunity of BAM. Some researchers have found that the noise sensitivity of BAM relates to the minimum absolute value of net inputs (MAV). However, in this paper, the analysis on failure association shows that it is related not only to MAV but also to the variance of weights associated with synapse connections. In fact, it is a positive monotone increasing function of the quotient of MAV divided by the variance of weights. This idea provides an useful principle of improving error correction capability of BAM. Some revised encoding schemes, such as small variance learning for BAM (SVBAM), evolutionary pseudorelaxation learning for BAM (EPRLAB) and evolutionary bidirectional learning (EBL), have been introduced to illustrate the performance of this principle. All these methods perform better than their original versions in noise immunity. Moreover, these methods have no negative effect on the pattern capacity of BAM. The convergence of these methods is also discussed in this paper. If there exist solutions, EPRLAB and EBL always converge to a global optimal solution in the senses of both pattern capacity and noise immunity. However, the convergence of SVBAM may be affected by a preset function.

Algorithms↗

A delayed neural network for solving linear projection equations and its analysis.

In this paper, we present a delayed neural network approach to solve linear projection equations. The Lyapunov-Krasovskii theory for functional differential equations and the linear matrix inequality (LMI) approach are employed to analyze the global asymptotic stability and global exponential stability of the delayed neural network. Compared with the existing linear projection neural network, theoretical results and illustrative examples show that the delayed neural network can effectively solve a class of linear projection equations and some quadratic programming problems.

Algorithms↗

Study of a fast discriminative training algorithm for pattern recognition.

Discriminative training refers to an approach to pattern recognition based on direct minimization of a cost function commensurate with the performance of the recognition system. This is in contrast to the procedure of probability distribution estimation as conventionally required in Bayes' formulation of the statistical pattern recognition problem. Currently, most discriminative training algorithms for nonlinear classifier designs are based on gradient-descent (GD) methods for cost minimization. These algorithms are easy to derive and effective in practice, but are slow in training speed and have difficulty selecting the learning rates. To address the problem, we present our study on a fast discriminative training algorithm. The algorithm initializes the parameters by the expectation-maximization (EM) algorithm, and then uses a set of closed-form formulas derived in this paper to further optimize a proposed objective of minimizing error rate. Experiments in speech applications show that the algorithm provides better recognition accuracy in a fewer iterations than the EM algorithm and a neural network trained by hundreds of GD iterations. Although some convergent properties need further research, the proposed objective and derived formulas can benefit further study of the problem.

Algorithms↗

A neural network approach to dynamic task assignment of multirobots.

In this paper, a neural network approach to task assignment, based on a self-organizing map (SOM), is proposed for a multirobot system in dynamic environments subject to uncertainties. It is capable of dynamically controlling a group of mobile robots to achieve multiple tasks at different locations, so that the desired number of robots will arrive at every target location from arbitrary initial locations. In the proposed approach, the robot motion planning is integrated with the task assignment, thus the robots start to move once the overall task is given. The robot navigation can be dynamically adjusted to guarantee that each target location has the desired number of robots, even under uncertainties such as when some robots break down. The proposed approach is capable of dealing with changing environments. The effectiveness and efficiency of the proposed approach are demonstrated by simulation studies.

Algorithms↗

Monitoring the formation of kernel-based topographic maps in a hybrid SOM-kMER model.

A new lattice disentangling monitoring algorithm for a hybrid self-organizing map-kernel-based maximum entropy learning rule (SOM-kMER) model is proposed. It aims to overcome topological defects owing to a rapid decrease of the neighborhood range over the finite running time in topographic map formation. The empirical results demonstrate that the proposed approach is able to accelerate the formation of a topographic map and, at the same time, to simplify the monitoring procedure.

Algorithms↗

The virtual cell.

This paper describes a computational framework for cell biological modeling and simulation that is based on the mapping of experimental biochemical and electrophysiological data onto experimental images. The framework is designed to enable the construction of complex general models that encompass the general class of problems coupling reaction and diffusion.

Cell Physiological Phenomena↗

[The results and outlook for the use of mathematical methods and computer technology in dentistry].

Development and introduction into wide practice of various mathematical methods (systemic, regression, and factor analyses, etc.) and modern computation devices (personal computers, local computer network, etc.) is shown. These devices extended the potentialities of differential diagnosis and pathogenetic (including laser) therapy of the major oral diseases (dental carries, pulpitis, periodontitis, periodontal diseases and buccal mucosa, odontogenic inflammations, tumors, etc.).

Computing Methodologies↗

Implementing cognitive learning strategies in computer-based educational technology: a proposed system.

Switching the development focus of computer-based instruction from the concerns of delivery technology to the fundamentals of instructional methodology, is a notion that has received increased attention among educational theorists and instructional designers over the last several years. Building upon this precept, a proposed methodology and computer support system is presented for distilling educational objectives into concept maps using strategies derived from cognitive theory. Our system design allows for a flexible and extensible architecture in which an educator can create instructional modules that encapsulate their teaching strategies, and mimics the adaptive behavior used by experienced instructors in teaching complex educational objectives.

Cognition↗

Transitions: noninvasive coronary angiography using electron beam computed tomography: technique, clinical application, future prospective.

Electron beam computed tomography has been available clinically for 20 years. It is the only computed tomography scanner specifically developed for cardiac imaging. Over the past decade, with improvements in methodology and computer software, electron beam computed tomography has been shown to provide an excellent method to perform noninvasive coronary angiography. This article looks at the historical aspects of electron beam computed tomography and comments on how to perform and interpret electron beam angiography studies. The expanding development of noninvasive coronary and peripheral angiography methods using computed tomography will have a significant influence on cardiovascular specialists and their practices.

Coronary Angiography↗

Computers in a human perspective: an alternative way of teaching informatics to health professionals.

An alternative way of teaching informatics, especially health informatics, to health professionals of different categories has been developed and practiced. The essentials of human competence and skill in handling and processing information are presented parallel with the essentials of computer-assisted methodologies and technologies of formal language-based informatics. Requirements on how eventually useful computer-based tools will have to be designed in order to be well adapted to genuine human skill and competence in handling tools in various work contexts are established. On the basis of such a balanced knowledge methods for work analysis are introduced. These include how the existing problems at a workplace can be identified and analyzed in relation to the goals to be achieved. Special emphasis is given to new ways of information analysis, i.e. methods which even allow the comprehension and documentation of those parts of the actually practiced 'human' information handling and processing which are normally overlooked, as e.g. non-verbal communication processes and so-called 'tacit knowledge' based information handling and processing activities. Different ways of problem solving are discussed involving in an integrated human perspective--alternative staffing, enhancement of the competence of the staff, optimal planning of premises as well as organizational and technical means. The main result of this alternative way of education has been a considerably improved user competence which in turn has led to very different designs of computer assistance and man-computer interfaces. It is the purpose of this paper to give a brief outline of the teaching material and a short presentation of the above mentioned results.(ABSTRACT TRUNCATED AT 250 WORDS)

Attitude to Computers↗

Efficiency of parallel direct optimization.

Tremendous progress has been made at the level of sequential computation in phylogenetics. However, little attention has been paid to parallel computation. Parallel computing is particularly suited to phylogenetics because of the many ways large computational problems can be broken into parts that can be analyzed concurrently. In this paper, we investigate the scaling factors and efficiency of random addition and tree refinement strategies using the direct optimization software, POY, on a small (10 slave processors) and a large (256 slave processors) cluster of networked PCs running LINUX. These algorithms were tested on several data sets composed of DNA and morphology ranging from 40 to 500 taxa. Various algorithms in POY show fundamentally different properties within and between clusters. All algorithms are efficient on the small cluster for the 40-taxon data set. On the large cluster, multibuilding exhibits excellent parallel efficiency, whereas parallel building is inefficient. These results are independent of data set size. Branch swapping in parallel shows excellent speed-up for 16 slave processors on the large cluster. However, there is no appreciable speed-up for branch swapping with the further addition of slave processors (>16). This result is independent of data set size. Ratcheting in parallel is efficient with the addition of up to 32 processors in the large cluster. This result is independent of data set size.

Algorithms↗