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At least 343 records · Page 19Linked to original sources
PubMed2005

Autoantibodies and hepatitis C virus genotypes in chronic hepatitis C patients in Estonia.

AIM: To determine the prevalence of several autoantibodies in chronic hepatitis C patients, and to find out whether the pattern of autoantibodies was associated with hepatitis C virus (HCV) genotypes. METHODS: Sera from 90 consecutive patients with chronic hepatitis C were investigated on the presence of anti-nuclear (ANA), anti-mitochondrial (AMA), anti-smooth muscle (SMA), anti-liver-kidney microsomal type 1 (LKMA1), anti-parietal cell (PCA), anti-thyroid microsomal (TMA), and anti-reticulin (ARA) autoantibodies. The autoantibodies were identified by indirect immunofluorescence. HCV genotypes were determined by a restriction fragment length polymorphism analysis of the amplified 5' noncoding genome region. RESULTS: Forty-six (51.1%) patients were positive for at least one autoantibody. Various antibodies were presented as follows: ANA in 13 (14.4%) patients, SMA in 39 (43.3%), TMA in 2 (2.2%), and ARA in 1 (1.1%) patients. In 9 cases, sera were positive for two autoantibodies (ANA and SMA). AMA, PCA and LKMA1 were not detected in the observed sera. HCV genotypes were distributed as follows: 1b in 66 (73.3%) patients, 3a in 18 (20.0%), and 2a in 6 (6.7%) patients. CONCLUSION: A high prevalence of ANA and SMA can be found in chronic hepatitis C patients. Autoantibodies are present at low titre (1:10) in most of the cases. Distribution of the autoantibodies show no differences in the sex groups and between patients infected with different HCV genotypes.

Autoantibodies↗
PubMedDate not supplied

A new start in Estonia.

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Education, Nursing, Baccalaureate↗
PubMedDate not supplied

[The epidemiological aspects of viral hepatitides in Estonia].

The etiological structure of viral hepatitides among the adult population of Tallinn and the occurrence of markers of hepatitis B and hepatitis C virus infections in medical workers, addict introducing drugs intravenously and hemodialysis patients were studied. Changes in the etiological structure of viral hepatitides were established: they took the form of a decrease in the level of hepatitis A morbidity and the considerable growth of the role of hepatitides B and C, as well as the newly detected circulation hepatitis D virus. About one-third in the structure of morbidity in viral hepatitides were hepatitis cases without markers of hepatitis A, B or C viruses (non-A, non-B, non-C). The highest rates of hepatitis B virus infection (78.9%) and hepatitis C virus infection (82.5%) were detected among drug addicts. Their level of HBsAg was 8.8%. In the group of medical workers, 25% of the examinees, i.e. every fourth person, had markers of hepatitis B virus, while antibodies to hepatitis C virus were detected in 5% of cases. Among hemodialysis patients these rates were 21.4% and 10.7% respectively.

Adolescent↗
PubMed1998

Mixed respiratory viral infections in Estonia: a long-term laboratory study.

During the period of 1981-1997, a total of 13,110 patients with acute respiratory viral infections were tested simultaneously for influenza virus A and B, parainfluenza, adenovirus and respiratory syncytial virus (RSV) infections. Of 3,800 laboratory-confirmed cases mixed infections were established in average in 27%. The incidence varied in dependence on the season between 12% and 36%. All infections were involved in mixed infections, yet their participation greatly varied in different seasons. During a season when the incidence of two respiratory viral infections increased, the case number of their mixed infections also increased. We assume that respiratory viruses widely co-circulating among human population also simultaneously infected the same persons. Therefore a proportion of respiratory viral diseases may represent in fact mixed infections which, in turn, may lead to the emergence of mixtures of different viruses and their spread in humans.

Estonia↗