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Results for “GINGIVAL HYPERPLASIA”

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At least 343 records · Page 19Linked to original sources
PubMed1997

[Factors involved in gingival hyperplasia caused by diphenyl hydantoin].

BACKGROUND: The objective of this clinical study is to evaluate the relationship between the degree of the phenytoin-induced gingival overgrowth (GO) and factors like bacterial plaque, the "individual predisposition" to develop GO and multiple drug based therapy. MATERIALS AND METHODS: During a one year period we examined 20 epileptic patients taking phenytoin alone or in association with other drugs; they underwent initial therapy and in some cases periodontal surgery. RESULTS: The long-term control showed that a better oral hygiene and an association of drugs may reduce the gingival overgrowth but not eliminate it. CONCLUSION: A determining factor in developing GO seems to be the "individual predisposition" probably due to the presence of a fibroblast subpopulation sensitive to phenytoin.

Gingival Hyperplasia↗
PubMed1994

[Gingival hyperplasia of drug origin. A review of the literature].

The frequency of gingival overgrowth is increasing, due to the more and more frequent use of cyclosporin and calcium antagonists. Such lesions are the same as those known to occur in patients treated with phenytoin. They appear after a few months of treatment and are favoured by inflammation. Marginal gingiva starts to grow in excess, especially in the anterior region, and might end up covering the teeth entirely, with major occlusal problems. The hyperplasia occurs in about 50% of the phenytoin treated patients and in about 20% of those treated with cyclosporin or calcium antagonists. A genetic predisposition has been thought to be present in such susceptible people. However, no precise pathogenic pathway, possibly common for the three types of drugs, has been clearly proposed. As for therapy, the most severe lesions are treated by surgery but, in general, the dentist can be very helpful by simply stressing gingival hygiene.

Gingiva↗