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At least 343 records · Page 19Linked to original sources
PubMed1986

[Anatomical types of the conduction system in congenital heart defects].

A correlation is demonstrated between the fully formed conduction system and the anatomical type of the so-called normal and abnormal heart. Changes in the anatomy of the conduction system in congenital heart diseases are interpreted as a consequence of respective changes in the anatomy of the heart. New principles are formulated for the classification of congenital heart diseases on the basis of the anatomical types of the conduction system. They permit simultaneous systematization of types of ventricular septal defects and complex congenital heart diseases with ventricular septal defects.

Heart Conduction System↗
PubMed1994

Distribution of calcitonin gene-related peptide-like immunoreactivity in the bovine conduction system: correlation with substance P.

The role of calcitonin gene-related peptide (CGRP) in the heart conduction system is unclear. In the present study, the distribution of CGRP in relation to that of substance P (SP) was examined in the bovine conduction system using immunohistochemical methods. Varicose nerve fibres showing CGRP-like immunoreactivity (LI) were frequently observed in the nerve fascicles, some of these fibres often also showing SP-LI. A few fibres exhibiting CGRP-LI were also observed in the intrinsic ganglia. In blood vessel walls and particularly in the conduction tissue, i.e., in association with the nodal cells and the Purkinje fibres, there were only a few varicose fibres showing both CGRP- and SP-LI, whilst there was a large number of varicose fibres showing only SP-LI. The observations show that the main morphologic correlate for the occurrence of CGRP-effects in the bovine conduction system is varicose nerve fibres located in the nerve fascicles. The observations also suggest that CGRP has effects at the intrinsic ganglia and that SP predominates over CGRP in the innervation of blood vessel walls and the conduction tissue.

Animals↗
PubMed1992

The conduction system in transplanted hearts.

This is a serial section examination of the conduction system (CS) in six patients who died seven months, 11 months, two years four months, four years two months, 11 years, and 16 years eight months following cardiac transplantation. The heart was hypertrophied and enlarged in all. There was myocarditis of varying degree in all cases with arteriosclerosis and arteriolosclerosis. These findings were more dominant in the atria than in the ventricles. In the CS, myocarditis with fibrosis was found in all in the approaches to the sinoatrial (SA) node, the SA node, the atria, the atrioventricular (AV) node, and the bundle and bundle branches, to a varying degree. When compared with the endomyocardial biopsy findings, the autopsied cases revealed more myocarditis and fibrosis than those estimated to be present in the biopsy specimen. In summary, this study demonstrates that there are fibrotic changes in the CS with the persistence of inflammatory phenomena of the myocardium and the CS to a varying degree in transplanted hearts. This is accompanied by the ubiquitous coronary artery disease affecting not only the large coronaries but also the small vessels. The pathologic changes in and around the CS may be responsible for arrhythmias and sudden death in some cases of cardiac transplantation.

Adolescent↗
PubMed1982

Histopathological study of the conduction system of the heart in Duchenne progressive muscular dystrophy.

The cardiac conduction systems including sinoatrial (SA) node, atrioventricular (AV) node, atrioventricular(His) bundle, and peripheral conduction system (left and right bundle branch, and Purkinje fiber) of 23 patients with Duchenne progressive muscular dystrophy(DMD) were studied with light microscope. Infiltration of fat tissue and mild fibrosis were occasional findings in SA and AV nodes. Degeneration of the conduction muscle fiber was hardly noted in SA node, AV node, and His bundle. Only the peripheral conduction system (Purkinje fiber) showed significant degenerations such as eosinophilic, necrotic and vacuolar changes with fibrosis. These necrobiotic changes resembled hyaline and vacuolar skeletal and cardiac muscular degenerations in DMD and were assumed to have occurred on the basis of the structural and constitutional characteristics of the peripheral conduction fiber as a striated muscle fiber. The vascular changes and amyloid deposit suggesting precocious aging in the conduction systems were not observed.

Adolescent↗
PubMed1980

Perfusion-fixation of the heart and its conduction system for ultrastructural studies.

Nine hearts from children who died from noncardiac causes were perfused within 3 h of death with 2.5% glutaraldehyde, 0.1 M sodium cacodylate, pH 7.2, at 4 degrees C. Each heart was perfused continuously for 4 h using a perfusion pressure of 110 mm Hg. The ultrastructural characteristics of the perfused atrial and ventricular myocardium and conduction system, including sinoatrial, atrioventricular node and Purkinje fibers, were studied. These observations were compared with standard published observations on similar tissues. The results demonstrate that the present method yields comparable results and hence provides a simple, yet effective, means for studying ultrastructural aspects of the heart and its conduction system in children. In addition, this method permits satisfactory gross morphologic examination of the organ.

Adolescent↗