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[Acute alveolitis after using a waterproofing aerosol: apropos of 2 cases].

INTRODUCTION: Waterproofing sprays for leather clothing have seldom been involved in severe accidents. In some circumstances, their pulmonary toxicity is marked, as shown by two case reports and a review of the literature. EXEGESIS: Acute alveolitis is described in two young adults without previous respiratory illness, following the use of a waterproofing spray for leather clothing. Clinical features typical of a flu-like reaction (malaise, fever and chills) were associated with dyspnea and with hemoptysis in one patient. X-ray examination evidenced lesional edema which quickly resolved after symptomatic treatment. The toxic mechanism is debated, but experimental data and clinical findings suggest the causative role of recently introduced fluoropolymers. CONCLUSIONS: Waterproofing sprays for leather clothing may induce severe respiratory illness after massive inhalation in confined area. Treatment is supportive.

Acute Disease↗

Genetic variation between Phytophthora cactorum isolates differing in their ability to cause crown rot in strawberry.

Analysis of 44 isolates of Phytophthora cactorum, isolated from strawberry and other hosts, by AFLP showed that the crown rot pathotype is different from leather rot isolates and from P. cactorum isolated from other hosts. 16 of 23 crown rot isolates, including isolates from Europe, Japan, Australia, and New Zealand, were identical in an analysis based on 96 polymorphic bands from seven primer combinations. Leather rot isolates of strawberry could not be distinguished from isolates from other hosts. The pathogenicity test of all 44 isolates on strawberry plants mostly gave unambiguous results, except for three American isolates, which seemed to have reduced aggressiveness compared to the crown rot isolates. These isolates also differed in the AFLP analysis. Comparing information on the origin of the isolates with results from the pathogenicity test, showed that isolates from strawberry fruits or petioles could be either leather rot or crown rot pathotypes. None of the isolates from hosts other than strawberry caused crown rot symptoms in strawberry.

DNA, Fungal↗

Silicate enhanced enzymatic dehairing: a new lime-sulfide-free process for cowhides.

A conventional dehairing process with sodium sulfide and lime is a major source of the pollution from the tanning industry. In other words, conventional dehairing processes degrade the hair to the extent that it cannot be recovered; thus, these processes become a major contributor to wastewater pollution. In this study, an attempt has been made to develop a lime and sulfide-free dehairing process using a commercial enzyme formulation with the activation of a silicate salt. A dip and pile method of application has been standardized. The amount of enzyme and sodium metasilicate has also been optimized based on complete removal of hair. Enhancement of enzyme activity by the addition of silicate has been demonstrated through activity measurements. Hair removal is found to be complete using scanning electron microscope analysis. Strength and bulk properties of the experimental leathers are comparable to that of control leathers. The process enjoys a significant reduction in chemical oxygen demand (COD) and total solids (TS) by 53 and 26%, respectively. More importantly, the application of enzyme for dehairing results in an 8% area increase in the final leather. Also, the process is proven to be techno-economically feasible.

Animals↗

PCP in the blood plasma: current exposure of the population in Germany, based on data obtained in 1998.

The fungicidal substance pentachlorophenol (PCP) had been used commonly for wood protection and leather impregnation in Germany until 1989, when this substance was prohibited by law. Hence, the body burden in the general population in Germany has been steadily declining. The reference values (95th percentiles) in blood plasma decreased from 20 micrograms PCP/l in 1991 to 12 micrograms/l in 1996. In 1998 the current exposure in a large residential population was investigated. 623 persons with an average age of 34.6 years (0-62 years) were investigated. For all of them there was neither evidence of occupational contact with PCP nor of the presence of PCP in the residential indoor environment. The mean PCP concentration in the plasma samples was 2.4 +/- 3.9 micrograms/l, the median 1.7 micrograms/l, and the 95th percentile 6.1 micrograms/l, the maximum value was 59.3 micrograms/l. In children and adolescents higher median and 95th percentiles were obtained than in adults (median 2.5 vs. 1.5 micrograms/l and 95th percentile 7.7 vs. 5.9 micrograms/l). All values above 20 micrograms/l were checked again individually: relationships with the level of PCP in household dust could not be detected. In one family leather clothing containing PCP, however, was found to be the cause of unusually high PCP values in the blood. Our investigations confirm a trend observed in recent years: exposure to PCP in the population in Germany decreases steadily and leads to an actualized reference value of 6.1 micrograms PCP/l plasma. In individual cases, however, greatly increased PCP levels in blood can still occur today, for example due to leather clothing treated with PCP.

Adolescent↗

Tympanic temperature and heart rate changes in firefighters during treadmill runs performed with different fireproof jackets.

Six well-trained firefighters performed six treadmill runs at 70% of the velocity at VO2max (Maximal aerobic velocity MAV = 13.2+/-0.3 km h(-1)). A recovery time of 1 week was allowed between trials. The first session was performed by subjects wearing only shorts (i.e. no fire jacket, J0). A similar protocol was applied subsequently to test the physiological effects associated with the wearing of one of five different fire jackets: one leather (J1) and four textile-type jackets: VTN with membrane (J2), VTN without membrane (J3), Vidal with Kermel HTA (Haute Teneur en Aramide i.e. high density in Aramide) (J4); and Rolland with Kermel HTA (J5). All sessions were performed in a randomized order and in laboratory conditions. Exercise with the fireproof jackets resulted in higher tympanic temperature (Tty), heart rate (HR) and body mass loss (BML) changes compared to J0 (p<0.001). The magnitudes of these changes depended on the type of the jacket. Exercise in the leather jacket (J1) resulted in the highest Tty and HR, which differed significantly from values in all other conditions (p<0.001). The exercise-induced increases in Tty wearing jackets J3 and J5 were also significantly (p < 0.05) higher than those observed with jackets J2 and J4. In conclusion, textile jackets induced less HR and Tty stresses than the leather one. The magnitude of the physiological responses induced by textile jackets were correlated to jacket weight. J2 and J4 jackets were more effective in limiting hyperthermia and any potential detrimental effect on the exercise capacity.

Adult↗

Mechanical anisotropy in cobra skin is related to body movement.

The mechanical breaking stress and strain of cobra leather, along with their mechanical anisotropies, were studied in relation to body movement. The mechanical breaking strain in the transverse direction (TD), which was perpendicular to the direction (CCD) from the caudal to the cranial end, was much larger around the dorsum, and slightly larger around the abdomen, than that in the CCD. The mechanical strain is closely related to the expansion of skin. The mechanical anisotropy of cobra leather was relatively large in the dorsum, but smaller in the abdomen. These findings indicate that it was comparatively easy for the cobra body to expand preferentially in the TD around the dorsum and also to expand roughly equally in all directions around the abdomen, whereas expansion of the dorsum in the CCD was restricted by the spinal column. These findings also suggest that the strong mechanical anisotropy in cobra leather is closely related to the motion of the skin around the waist, which accompanies movement of the body.

Animals↗

Occupation and risk of stomach cancer in Poland.

BACKGROUND: In spite of the dramatic decline in the incidence of stomach cancer in the twentieth century, Poland has one of the highest rates in the world. AIMS: To evaluate the risk of stomach cancer by grouped occupations and industries, as well as by some specific occupational exposures. METHODS: Cases (n = 443) were newly diagnosed with stomach adenocarcinomas between 1994 and 1996. Controls (n = 479) were randomly selected from the general population in Warsaw. RESULTS: Only a few occupations and industries were associated with significantly increased risks of stomach cancer. The most suggestive finding was for work in the leather goods industry. Risk was also significantly increased among men working in fabricated metal production and among women ever employed as managers and governmental officials. Men ever employed as teaching professionals and women employed as technical and science professionals had significantly decreased risks of stomach cancer. Among men, a significant positive trend in risk with duration of employment was observed for work in the leather industry and special trade construction. No significantly increased risks were observed for specific exposures assessed by a job-exposure matrix or by self-reports. However among men there were non-significantly increased risks with 10 or more years exposure to asbestos, metal dust, and nitrosamines assessed by a job-exposure matrix. CONCLUSIONS: Employment in the leather goods industry, special trade construction, and metal fabrication was associated with an increased risk of stomach cancer among men. However, there were only weak associations with specific exposures. Occupational exposures do not contribute substantially to the high rates of stomach cancer in Poland.

Adenocarcinoma↗

Mortality of tanners.

The mortality of 833 male tannery workers known to have been employed in the industry in 1939 and who were followed up to the end of 1982 was studied. A total of 573 men had been employed in making leather tanned by vegetable extracts for soles and heels, and 260 men had used chrome tanning to make leather for the upper parts of shoes. No significant excesses of deaths were found for any of the common sites of cancer in either group of workers. One death from nasal cancer (0.21 expected) was reported among the men who worked with sole and heel leather.

Adult↗

Microscopic anatomy of the equine skin with special reference to the dermis.

We have observed and re-evaluated the histology of the skin of the horse, using samples from four Thoroughbreds. The skin was composed of the usual three components: epidermis, dermis and subcutis. In particular, the dermis was found to have three fibrous components: a papillary layer, a reticular layer and a cordovan-leather tissue layer. The cordovan-leather tissue layer was subdivided into a superficial main layer and a deeper accessory layer. The superficial main layer was thick, and present in all of the skin samples. The deeper accessory layer was found in the dorsal and dorso-lateral parts of the neck and trunk and in the extremities. Hair bulbs and sudoriferous glands did not extend into the cordovan-leather tissue layer and subcutis.

Animals↗

Issues of environmental compliance in developing countries.

Environmental laws define the scarcity of environmental resources as they affect the factor endowment of a country and therefore its position in the international division of labour. There is now also a general agreement that applying the "polluter pays" principle should solve environmental problems. As the burden of abatement increases, as measured by the ratio of abatement expenditure to sales, there is definitely an incentive for firms to either invest in cleaner technology or more efficient abatement technology. There is also evidence that taxes and charges, designed to internalise externalities, can actually affect trade. It is interesting to know if the developing countries face particular market access problems in the face of stringent environmental standards and regulations. While it is true that stringent measures impose market access restrictions and cause limitations on competitiveness, this is much more widely felt by the developing countries because of lack of infrastructure and monitoring facilities, limited technology choices, inadequate access to environment-friendly raw materials, lack of complete information, presence of small-scale exporters and emergence of environmental standards in sectors of export interest to developing countries. The small and medium enterprises often divert sales either to the domestic market or to external markets where environmental requirements are less stringent, in order to save on their costs. In developing countries, 80% of the tanning industry is comprised of small and medium enterprises (SMEs) processing raw to semi-finished leather, usually less than 2 tons per day. In Europe and other developed countries the SMEs in the leather sector have vanished due to strict environmental legislation and this will likely occur in developing countries also. The environmental legislation has not always been practical, either because the laws are too ambitious or unrealistic in certain parameters, or because they have lacked effective instrumentation and institutional support. Some environmental regulations have not succeeded as they do not match the technical requirements and economic reality of the country or region, or because they do not take the institutional capabilities of the society that has to implement them into consideration. For the survival and sustenance of the SMEs in the leather industry, it may be a viable alternative to carry out the tanning process in a decentralized fashion such that the raw to semi-finished process is carried out in the large scale sector while the semi-finished to finished process could either be reserved or open to competition as per the countries' requirements. But the issue of concern is whether it is fair that the raw to semi-finished tanning process, containing 70% of the pollution discharge should be undertaken by developing countries alone, especially if it is at the cost of their survival! However, the game analysed in the paper reveals that tanning units in developing countries would prefer to comply with the regulations and stay in the industry, the alternatives being to collude or to compete!

Commerce↗

[Epithelial naso-sinusal cancer incidence and the role of work in 100 cases diagnosed in the Province of Brescia (northern Italy), in the period 1978-2002].

BACKGROUND: Naso-sinusal cancers (NSC) cover a group of rare tumours in Italy for which the role of occupational risk has been established. The systematic survey of NSC in the province of Brescia made it possible to analyse the jobs of the cases occurring in the area. OBJECTIVES: The aims of the research were: estimation of epithelial NSC incidence both in the general population and among wood and leather workers, description of the frequency and type of occupational exposure to substances or manufacturing processes. METHODS: The epithelial type cases were obtained from the Naso-sinusal Cancer Register (population-based) operating in the Province of Brescia since 1994. Work histories were obtained via a standardized questionnaire. RESULTS: The annual incidence ofepithelial NSC (for 100,000) in the entire population (1,090,000 inhabitants, ISTAT census 1991) from 1993 to 1997 and from 1998 to 2002 was nearly the same, 0.82 and 0.90 for men, 0.37 and 0.37 for women, respectively. The nasal cavity was the most affected anatomic site (45%) and squamous cell carcinoma was the most frequent histotype (44%) among the first 100 cases whose case histories were appropriate; in the ethmoidal sinus adenocarcinoma represented 62% of the cases; 25% of all cases were exposed to occupational carcinogens (list A) and particularly to wood dust (17%), even if only of softwood species (30%), and leather dusts (7%) especially in the shoe repair. The average latency period was 47 years (SD 7.4) and 44 years (SD 5.6) respectively; 71% of these epithelial NSC cases involved the ethmoid and 85% were adenocarcinomas. Only 1% of the cases was exposed to chromium and nickel and occurred in galvanization processes. Among the exposures to occupational risks with limited epidemiological evidence (list B) there was one case exposed to formaldehyde and 42 cases occurring in the building, agricultural, metallurgic and textile sectors. Thus all the exposures to occupational risks, both certain and probable (lists A and B) reached 84% among men and 17% among women. Epithelial NSC annual incidence rates (for 100,000) estimated among the wood and leather workers for the period 1985-2002 were 13 and 6.5 respectively. CONCLUSION: The results confirm the meaning of sentinel event for these tumours in occupational health and justify maintaining an active surveillance programme for the cases occurring in the area.

Adult↗

Distribution map of collagen fiber orientation in a whole calf skin.

It is important to obtain information about the collagen fiber orientation in biological fibrous tissues such as human and animal skins because the collagen fiber orientation in the skins may closely relate to the motional functions of the body. However, no reports are yet available on the distribution of collagen fiber orientation in a whole skin. The microwave method recently developed by the author was applied for giving the distribution of collagen fiber orientation. A map representing the distribution of collagen fiber orientation was obtained for a leather sheet prepared from the entire skin of a calf. It was found that the direction of collagen fiber orientation was, on an average, parallel to the calf's spinal column and limbs, corresponding to the direction perpendicular to that of skin motions due to eating and walking, and that the degree of orientation was large in the parts where the skin motions were marked. These findings suggest that the distribution map of fiber orientation in calf leather significantly affects the motional functions of its different parts and also hopefully gives useful information for performing an appropriate transplant of skins.

Animals↗

Occupations and breast cancer risk among Chinese women in urban Shanghai.

BACKGROUND: Although, an elevated risk of breast cancer has been suggested for a number of occupations, many earlier studies were limited by selection biases, the incomplete assessment of job histories, and the inability to control for confounding. METHODS: We examined the relationship between occupational history and breast cancer risk using data from a population-based case-control study of 1,458 cases and 1,556 age-matched controls (90% response rate) conducted in Shanghai, China. Unconditional logistic regression models were used to derive odds ratios (ORs) and 95% confidence intervals (95% CIs) of breast cancer risk associated with occupations and duration of employment adjusting for non-occupational risk factors. RESULTS: The following occupations were found to be associated with an increased risk of breast cancer: laboratory technicians (OR 9.94, 95% CI 1.20-82.37), telephone and telegraph operators (OR 4.63, 95% CI 1.85-11.59), leather and fur processors (OR 3.25, 95% CI 1.11-9.53), and glass-manufacturing workers (OR 2.08, 95% CI 1.14-3.82). A dose-response pattern for years of employment was observed for leather and fur processors (P = 0.02) and glass-manufacturing workers (P = 0.01). Stratified analyses also revealed dose-response relationships between the risk of breast cancer and years of employment as inspector and product analysts among pre-menopausal women (P = 0.02), and as farmers among post-menopausal women (P = 0.04). CONCLUSIONS: This study found that several occupations are associated with an increased risk of breast cancer among women. Studies examining various occupational exposures in these high-risk occupations are warranted to identify carcinogens that may play a role in the increased breast cancer risk.

Adult↗

Occupation and bladder cancer in Utah.

The relationships between bladder cancer and occupation, industries, and occupational exposures in Utah were examined in a population-based, case-control study conducted between 1977 and 1983. Life-long occupational histories were obtained for 417 cases (332 men and 85 women) and 877 controls (685 men and 192 women). Although few positive findings emerged in this study, increased risks were detected among men for employment in the leather and textile industries which increased with duration of employment. The effects were most marked for employment beginning 45 or more years prior to interview (odds ratio [OR] for textiles = 1.92, confidence interval [CI] = 0.89-4.46; for leather OR = 2.95, CI = 0.63-13.76). Among men and women, increased risk was detected among clerical workers employed for less than 10 years (OR = 1.59, CI = 1.16-2.17) although the risk decreased with increased duration of employment (OR = 0.88, CI = 0.55-1.40 for greater than or equal to 10 years). A protective effect was seen among men and women for 10 or more years employment in professional, managerial, and technical occupations (OR = 0.68, CI = 0.50-0.92). Employment as a carpenter resulted in increased risk which increased with duration. Increased risk for bladder cancer was detected among carpenters who smoked but not among carpenters who never smoked. We used an occupation-exposure linkage system to identify workers exposed to aromatic amino compounds; such workers did not have increased risk of bladder cancer, although interaction between long-term exposure to aromatic amino compounds and smoking was detected. Interactions between smoking and other industrial or occupational exposures were not demonstrated, and for the most part, smoking did not confound the estimates of the bladder cancer-occupation relationships.

Environmental Exposure↗

A crossover trial of custom-made and commercially available wrist splints in adults with inflammatory arthritis.

OBJECTIVE: To compare the effect of 3 wrist splints (2 prefabricated commercial splints and 1 custom made) on perceived wrist pain, hand function, and perceived upper extremity function in adults with inflammatory arthritis. METHODS: Subjects (n = 45, mean age 49 years, mean disease duration 8.6 years) were randomly assigned to treatment order in a 3-phase crossover trial. Splints were worn for 4 weeks, separated by 1-week washouts. Outcomes were assessed at baseline, after each splint phase and washout period, and at 6 months' followup using a pain visual analog scale (VAS), the Arthritis Hand Function Test, and McMaster-Toronto Arthritis Patient Function Preference questionnaire. Data were analyzed with multivariate analyses of variance (MANOVAs), t-tests, and chi-square tests. RESULTS: There did not appear to be order or carryover effects. MANOVA indicated that wrist splints significantly reduced pain (P = 0.007). The custom leather splint was most effective in reducing pain, from 4.1 cm to 2.8 cm on the VAS (P = 0.001). All splints improved hand strength, and the commercial Rolyan splint provided significantly stronger grip than the Anatech commercial splint (P = 0.04). In contrast to previous studies, splints did not compromise dexterity. There were several significant differences among splints, depending on the outcome measure. Improvements were maintained at 6 months. CONCLUSION: After 4 weeks' use, wrist splints reduce pain, improve strength, and do not compromise dexterity. Similar improvements were achieved with the custom leather splint and Rolyan commercial splint, which were superior to the Anatech commercial splint.

Adult↗

Water quality analysis of mixtures obtained from tannery waste effluents.

In this study, the mixing of waste solution obtained from chrome tanning process and waste solution derived from liming of bovine leather was investigated. The liming process of bovine leather was performed using calcium carbonate and sodium sulfide, and the tanning process was performed using alkaline chromium sulfate. The analyses of waste solutions and sediments formed during the mixing process include pH values, the concentration of sulfides, the concentration of chromium(III) oxide, and parameters such as chemical oxygen demand and biochemical oxygen demand. All measurements were carried out before and after the mixing process. Results indicate that the mixing of the corresponding waste solutions yields the mixture effluents that are ecologically acceptable.

Animals↗

The use of tannin from chestnut (Castanea vesca).

After mimosa and quebracho extracts, chestnut extract is the third most important vegetable tannin used for leather production. It is produced only in Europe on the northern side of the Mediterranean sea. The extract is prepared by hot water extraction of the bark and timber, followed by spray-drying of the solution. Analysis shows that there are insignificant variations in extract quality between batches, so the extract can be used with modern automated leather production systems. The extract contains approximately 75 percent active tanning substances. The primary component is castalagin, along with smaller amounts of vescalagin, castalin, and vescalin. A castalagin-based pharmaceutical product is currently in use for prevention and treatment of diarrhea in pigs and cattle that is caused by changes in diet. The beneficial effect is due to prevention of water losses through mucous membranes. The castalagin may also form chelates with iron, which influences the reabsorption of the metal in the animal digestive tract.

Animals↗

High bladder cancer mortality in rural New England (United States): an etiologic study.

An interview study of next-of-kin of 325 persons who died of bladder cancer and 673 individuals who died of other causes in Vermont and New Hampshire (United States) was conducted to assess reasons for the persistent pattern of elevated bladder cancer mortality for both genders in rural New England. There are some evidence of elevated risks for both leather and textile workers that rose to over twofold for workers who also lived near these industries and for persons with French-Canadian ancestry. Occupational exposures in the textile and leather industry may explain at least a portion of the excess bladder cancer risk in rural New England.

Case-Control Studies↗