SEARCH · PubMed Health

Results for “Muscle Fatigue”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 343 records · Page 19Linked to original sources

PubMed1994

Electromyographic signal frequency analysis in evaluating muscle fatigue of patients with peripheral arterial disease.

Peripheral arterial disease (PAD) patients are commonly classified on the basis of subjective evaluations of pain and fatigue. Surface electromyography (EMG) is an objective method for studying peripheral muscle fatigue. Fifteen patients with PAD and 15 healthy volunteers matched for age and sex were studied. Surface EMG was recorded over the medial gastrocnemius during 100 seconds at 60% of maximal effort. EMG traces were analyzed off-line to obtain the power spectrum. The median frequency was calculated in the first 30 seconds (T0) and between 70 and 100 seconds (T1). Significantly lower T1 values, compared with T0, were found in both the PAD and the control groups (p < .005; p < .05). T0 values were not different between group, whereas T1 values were significantly lower in PAD patients (p < .01). EMG frequency analysis can be considered an easy, painless method providing objective information on muscular performance and fatigue in PAD patients.

Aged↗

PubMed2006

Effects of exercise-induced arterial hypoxaemia on limb muscle fatigue and performance.

1. Reductions in arterial O(2) saturation (-5% to -10%S(a)o(2) below rest) occur over time during sustained heavy-intensity exercise in a normoxic environment, caused primarily by the effects of acid pH and increased temperature on the position of the HbO(2) dissociation curve. 2. We prevented the desaturation incurred during exercise at approximately 90% VO(2 MAX) via increased fraction of inspired O(2) (F(i)o(2)) (0.23 to 0.29) and showed that exercise time to exhaustion was increased. 3. We used supramaximal magnetic stimulation (1-100 Hz) of the femoral nerve to test for quadriceps fatigue. We used mildly hyperoxic inspirates (F(i)o(2) 0.23 to 0.29) to prevent O(2) desaturation. We then compared the amount of quadriceps fatigue incurred following cycling exercise at S(a)o(2) 91% vs 98% with each trial carried out at identical work rates and for equal durations. 4. Preventing the normal exercise-induced O(2) desaturation prevented about one-half the amount of exercise-induced quadriceps fatigue; plasma lactate and effort perception were also reduced. In a subset of less fit subjects who showed only minimal arterial hypoxaemia during sustained exercise (S(a)o(2) approximately 95%), breathing a mildly hypoxic inspirate (F(i)o(2) 0.17; S(a)o(2) approximately 88%) exacerbated the quadriceps fatigue. 5. We conclude that the normal exercise-induced O(2) desaturation during heavy-intensity endurance exercise contributes significantly to exercise performance limitation in part because of its effect on locomotor muscle fatigue.

Adult↗

PubMed2005

The use of correlation integrals in the study of localized muscle fatigue of elbow flexors during maximal efforts.

Innovative applications of non-linear time series analysis have recently been used to investigate physiological phenomena. In this study, we investigated the feasibility of using the correlation integral to monitor the localized muscle fatigue process in the biceps brachii during sustained maximal efforts. The subjects performed isometric maximum contractions until failure in elbow flexion (90 degrees from neutral). The median and the 70th percentile frequency of the Surface electromyography (SEMG) power spectrum, the integrated SEMG, and the Correlation Integral (CI) were evaluated during the trials. The linear correlation between these variables and the elbow torque production was used to quantify the ability of a parameter to follow the fatiguing process. The CI had the highest linear correlation with torque (0.77 (0.12SD)), while the spectral indices correlations with torque were much lower. The decreasing trend of the torque production was followed by the spectral indices for only the beginning part of the contraction, while the CI increased sharply after the torque production fell to about 0.60 of the MVC. This suggests that the CI is sensitive to different changes of the SEMG signal during fatigue than the spectral variables.

Adult↗

PubMed2003

Evidence of long term muscle fatigue following prolonged intermittent contractions based on mechano- and electromyograms.

The focus of the present study is the long term element of muscle fatigue provoked by prolonged intermittent contractions at submaximal force levels and analysed by force, surface electromyography (EMG) and mechanomyogram (MMG). It was hypothesized that fatigue related changes in mechanical performance of the biceps muscle are more strongly reflected in low than in high force test contractions, more prominent in the MMG than in the EMG signal and less pronounced following contractions controlled by visual compared to proprioceptive feedback. Further, it was investigated if fatigue induced by 30 min intermittent contractions at 30% as well as 10% of maximal voluntary contraction (MVC) lasted more than 30 min recovery. In six male subjects the EMG and MMG were recorded from the biceps brachii muscle during three sessions with fatiguing exercise at 10% with visual feedback and at 30% MVC with visual and proprioceptive feedback. EMG, MMG, and force were evaluated during isometric test contractions at 5% and 80% MVC before prolonged contraction and after 10 and 30 min of recovery. MVC decreased significantly after the fatiguing exercise in all three sessions and was still decreased even after 30 min of recovery. In the time domain significant increases after the fatiguing exercise were found only in the 5% MVC tests and most pronounced for the MMG. No consistent changes were found for neither EMG nor MMG in the frequency domain and feedback mode did not modify the results. It is concluded that long term fatigue after intermittent contractions at low force levels can be detected even after 30 min of recovery in a low force test contraction. Since the response was most pronounced in the MMG this may be a valuable variable for detection of impairments in the excitation-contraction coupling.

Adult↗

PubMed1994

The effects of muscle fatigue on bone strain.

There is anecdotal evidence that bone strains may increase to the point that bone becomes susceptible to rapid failure when muscles become fatigued. To determine whether neuromuscular response could be a factor in accelerating bone failure, we tested the hypothesis that muscle fatigue causes a significant increase in peak principal and shear strains in bone. Ten adult foxhounds were subjected to rigorous exercise that caused muscular fatigue while myoelectrical activity of the quadriceps and hamstrings and strain on the distal tibia were monitored simultaneously. Ground reaction forces on the dog hindlimbs were measured before and after strain gauges had been applied to the tibia. The data show a significant shift to lower median myoelectrical frequencies in the quadriceps, indicating muscular fatigue, following the 20 min exercise period. In conjunction with this shift, peak principal and shear strains increased on both compressive and tensile cortices of the tibia and shear strain on the tensile cortex increased significantly (P = 0.02). The largest changes were along the anterior and anterolateral surfaces of the tibia, where peak principal strain increased by an average of 26-35% following muscular fatigue. The cross-sectional strain distribution was calculated at the gauge site at peak strain at the beginning of the exercise period and at peak strain after 20 min of exercise. These data show a change in strain distribution when muscle becomes fatigued. Strains on the posterior cortex of the bone showed the greatest change. Correlation analysis demonstrated a significant inverse association between median myoelectrical frequency and bone strain after 20 min of exercise (Spearman r2 = 1.00; P = 0.05). These data show that muscle fatigue may be associated with increased bone strain.

Animals↗

PubMed1989

[Electromyographic study of masticatory muscle fatigue and recovery under voluntary contraction. 2. Comparison between normal subjects and craniomandibular disorder patients].

During fatiguing clenching, power spectrum in the surface electromyogram decrease to the lower frequency. The phenomenon has been expected to indicate the fatiguing condition. However, the underlying mechanism between the muscle fatigue and the power spectrum shift is still unclear. Therefore, it may be difficult to employ the spectrum shift for the diagnostic process. The aim of this paper was to clarify the mechanism in the power spectrum shift and to find a possible parameter for diagnostic process. The shift in the mean power frequency (MPF) was observed during fatiguing clenching and the successive recovery period from a normal group (n = 47) and a craniomandibular disorder patient group (n = 46). The results suggested that the power spectrum shift during the fatiguing clenching might be due to a reflex inhibition at the motoneuron level. From the comparison between the normal group and the dysfunctional group, there was larger difference in normalized absolute MPF values between the right and left muscles. Also the larger variance was seen during the fatiguing process and the recovery process in the dysfunctional group than in the normal group.

Bruxism↗

PubMed2002

Comparison of potentiated and unpotentiated twitches as an index of muscle fatigue.

Recent data suggest that the potentiated twitch is a more sensitive index of contractile fatigue than is the unpotentiated twitch. We hypothesized that after a potentially fatiguing load, the fall in twitch amplitude of the potentiated twitch would be significantly greater than that of an unpotentiated twitch. We compared the response of the potentiated and unpotentiated twitches to a series of potentially fatiguing loads using magnetic stimulation of the femoral nerve in 10 healthy subjects. The baseline unpotentiated quadriceps twitch force (TwQu), potentiated quadriceps twitch force (TwQp), and maximal voluntary contraction (MVC) were 129 plus minus 6 N, 198 plus minus 6 N, and 622 plus minus 25 N, respectively. During a fatigue protocol that was designed to induce a spectrum of fatigue from mild to marked, the percent fall in quadriceps twitch force was significantly greater for the potentiated method than for the unpotentiated method at all levels of fatigue (P <.005). The within-subject within-day coefficient of variation was 7.5 plus minus 0.5% for TwQu and 5.6 plus minus 0.9% for TwQp. Thus, TwQp is reproducible and is superior to TwQu for detecting early muscle fatigue.

Electric Stimulation↗

PubMed2006

Anticipation mechanism in body sway control and effect of muscle fatigue.

The aim of this work is to quantify the occurrence of an anticipatory mechanism in the control of quiet standing by measuring the lag between the myoelectric activity of the lateral gastrocnemius muscle and the stabilometric signal, as well as to determine the influence of the muscle fatigue on this process. Stabilometric and electromyographic (EMG) signals were synchronously collected from 22 subjects. Gastrocnemius fatigue was induced by a sustained plantar flexed posture until muscle failure. The data acquisition lasted for 120 s before and after the induced fatigue. After mean removal, the root mean square values of the EMG (RMS-EMG) were calculated for each 20 ms period. The normalized cross-correlation function was estimated to find the time delay between RMS-EMG and stabilometric signals. Anticipation values up to 1.62 s were found both before and after fatigue conditions (p<0.05), indicating that this mechanism plays an important role in body sway control. The fatigue caused a significant increase in the latency between the myoelectric activity of the gastrocnemius muscle and the movements of the center of pressure (p<0.05).

Adult↗

PubMed2003

Sternohyoid muscle fatigue properties of dy/dy dystrophic mice, an animal model of merosin-deficient congenital muscular dystrophy.

Humans with merosin-deficient congenital muscular dystrophy have both sucking problems during infancy and sleep-disordered breathing during childhood. We hypothesized that merosin-deficient pharyngeal muscles fatigue faster than normal muscles. This was tested in vitro using sternohyoid muscle from an animal model of this disease, the dy/dy dystrophic mouse. Isometric twitch contraction and half-relaxation times were similar for dy/dy and normal sternohyoid. However, rate of force loss during repetitive 25-Hz train stimulation was markedly diminished in dystrophic compared with normal sternohyoid muscle. Furthermore, force potentiation, which occurred during the early portion of the fatigue-inducing stimulation, had a longer duration in dystrophic compared with normal muscle (approximately 60 versus 20 s). As a result of these two processes, at the end of 2 min of stimulation, force of dystrophic muscle had decreased by 8 +/- 5% and that of normal muscle by 69 +/- 4% (p < 0.0001). The potassium-channel blocker, 3,4-diaminopyridine, increased force of dy/dy sternohyoid muscle during twitch and 25-Hz contractions by 148 +/- 20% (p < 0.00001) and 109 +/- 18% (p < 0.00002), respectively. During repetitive 25-Hz stimulation, force of 3,4-diaminopyridine-treated dystrophic muscle remained significantly higher than that of untreated muscle, despite the early force potentiation being eliminated and fatigue being accelerated. Thus, merosin deficiency reduces fatigue and prolongs the duration of force potentiation. The latter alterations may partially preserve the integrity of upper airway muscle function, without which the severity of pharyngeal complications (feeding problems, sleep-related respiratory dysfunction) might be even more pronounced in the human merosin-deficient congenital muscular dystrophies.

4-Aminopyridine↗

PubMed2000

Changes in muscle afferents, motoneurons and motor drive during muscle fatigue.

Fatigue is a reduction of maximal muscle force or power that occurs with exercise. It is accompanied by changes at multiple levels in the motor pathway and also by changes in the discharge patterns of muscle afferents. Changes in afferent firing can lead to altered perceptions and can also act on the efferent pathway. Changes in the motor pathway include slowing of motor unit firing rates during sustained maximal voluntary contractions (MVCs). Muscle responses to stimulation at different levels of the motor pathway also change. Transcranial magnetic stimulation of the motor cortex and stimulation of descending tracts in the spinal cord in human subjects show an increase in the response of the cortex and a decrease in response of the motoneuron pool during sustained MVCs. In addition, the silent period following magnetic stimulation is prolonged. During relaxation after fatiguing exercise, muscle responses to stimulation of the motor cortex are initially facilitated and are then depressed for many minutes, whereas responses to descending tract stimulation are initially depressed but recover over about 2 min. Although some of the loss of force of fatigue does occur through inadequate drive to the muscle, it is not clear which, if any, of the changes described in the cortex or the motoneurons are responsible for loss of maximal voluntary force and thus contribute to fatigue. Changes may be associated with muscle fatigue without causing it.

Animals↗

PubMed2005

Comparison of brain activation after sustained non-fatiguing and fatiguing muscle contraction: a positron emission tomography study.

The concept of fatigue refers to a class of acute effects that can impair motor performance, and not to a single mechanism. A great deal is known about the peripheral mechanisms underlying the process of fatigue, but our knowledge of the roles of the central structures in that process is still very limited. During fatigue, it has been shown that peripheral apparatus is capable of generating adequate force while central structures become insufficient/sub-optimal in driving them. This is known as central fatigue, and it can vary between muscles and different tasks. Fatigue induced by submaximal isometric contraction may have a greater central component than fatigue induced by prolonged maximal efforts. We studied the changes in regional cerebral blood flow (rCBF) of brain structures after sustained isometric muscle contractions of different submaximal force levels and of different durations, and compared them with the conditions observed when the sustained muscle contraction becomes fatiguing. Changes in cortical activity, as indicated by changes in rCBF, were measured using positron emission tomography (PET). Twelve subjects were studied under four conditions: (1) rest condition; (2) contraction of the m. biceps brachii at 30% of MVC, sustained for 60 s; (3) contraction at 30% of MVC, sustained for 120 s, and; (4) contraction at 50% of MVC, sustained for 120 s. The level of rCBF in the activated cortical areas gradually increased with the level and duration of muscle contraction. The fatiguing condition was associated with predominantly contralateral activation of the primary motor (MI) and the primary and secondary somatosensory areas (SI and SII), the somatosensory association area (SAA), and the temporal areas AA and AI. The supplementary motor area (SMA) and the cingula were activated bilaterally. The results show increased cortical activation, confirming that increased effort aimed at maintaining force in muscle fatigue is associated with increased activation of cortical neurons. At the same time, the activation spread to several cortical areas and probably reflects changes in both excitatory and inhibitory cortical circuits. It is suggested that further studies aimed at controlling afferent input from the muscle during fatigue may allow a more precise examination of the roles of each particular region involved in the processing of muscle fatigue.

Adult↗

PubMed1993

The effect of opioids on inspiratory muscle fatigue during inspiratory resistive loading.

The effect of opioids on inspiratory muscle function under high mechanical load is still unknown. Even less clear is the extent to which opioids influence the shift of the electromyographic power spectrum of the inspiratory muscles to lower frequencies during ventilatory stress. We studied seven healthy subjects breathing against high inspiratory threshold loads until exhaustion while keeping the minute ventilation constantly high. We compared runs with and without administration of 0.2 mg kg-1 of morphine sulphate intramuscularly; two subjects were given 30 mg morphine sulphate so that we could study the effect of higher opioid concentration. The endurance time (Tlim), the diaphragmatic electromyogram (EMG), the transdiaphragmatic pressures (Pdi) and the ventilatory effort sensation were analysed. Morphine did not have any effect on Tlim or on the effort sensation elicited by the inspiratory resistance in both concentrations. Analysing the spectral shifts of the diaphragmatic EMG, we did not find any significant difference in the decrease of the centroid frequency between drug and control runs. Furthermore, the activation pattern of the diaphragm and the intercostal muscles, evaluated from the percentage contribution of oesophageal and gastric pressures on the transdiaphragmatic pressure swings, did not change following the administration of morphine. Our study shows that morphine does not change the function of the inspiratory muscles during high-resistive breathing. Morphine does not affect the electromyographic power spectrum of the diaphragm during those resistive breathing runs, either. This points out that during stressful ventilatory situations, the shift of the electromyographic power spectrum is attributed to a peripheral (muscular) event consequent to muscle fatigue and not to the elaboration of endogenous opioids.

Adult↗

PubMed1986

Grip strength, muscle fatigue, and body composition in nomadic Turkana pastoralists.

Tests of hand grip strength and hand grip muscle fatigue were conducted on Ngisonyoka Turkana pastoralists of northwest Kenya to explore some of the functional relationships between activity and body composition. The test of maximal voluntary contraction (MVC) of hand grip flexors was conducted on 151 Turkana and 38 U.S. men and women. The fatigue test was conducted on the same number of subjects who were instructed to attempt to maintain 80% of the MVC for 90 seconds. The results of these tests, combined with arm measurements of size and body composition, were used to evaluate muscle size and strength relationships and to estimate muscle fiber type distribution in the forearm. MVC values of Turkana men were low by U.S. and European standards. The low values resulted from smaller Turkana muscle areas. MVC values of Turkana women were comparable to those of U.S. and European women, reflecting comparable muscle areas. The fatigue curves of Turkana and U.S. men and women suggest that slow-twitch aerobic muscle fibers predominate for the hand grip flexors of the Turkana pastoralists.

Adult↗

PubMed2002

Vibratory facilitation of strength in fatigued muscle.

OBJECTIVE: To assess the effects of tendon vibration on isometric torque and electromyographic activity of fatigued muscles. DESIGN: Subjects performed a 30-trial isometric (2-s maximal effort contractions alternating with 6-s rest periods) elbow extensor fatigue series. Three additional trials with the same work-to-rest ratio were then performed in which the triceps extensor tendon was subjected to a 60-Hz, 1-mm vibration during the rest intervals. SETTING: A biomechanics research laboratory. PARTICIPANTS: Thirteen healthy women without history of upper-extremity injury or neurologic disorder. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Elbow extension torque was measured with a load cell. Triceps and biceps brachii muscle activity was measured with surface electromyography electrodes. RESULTS: Elbow extension torque increased 10% (2 Nm) during the stimulation trials relative to the control trials (P<.05). The associated increase in mean peak-to-peak electromyographic amplitude was 47 % (103 microV) for the triceps brachii and 38% (33 microV) for the biceps brachii (all P<.05). The electromyographic frequency measures failed to reach the.05 probability level of significance. CONCLUSIONS: Elbow extension torque and triceps electromyographic activity were facilitated by tendon vibration of fatigued triceps in healthy subjects. This finding supports the use of proprioceptive feedback to facilitate voluntary muscle contractions.

Adult↗

PubMed1996

Respiratory muscle fatigue after an ultra-marathon measured as inspiratory task failure.

Controversial literature exists concerning the occurrence of inspiratory muscle fatigue during efforts performed outside a laboratory. The purpose of this study was to assess inspiratory muscle strength and endurance time measured as Tlim, the length of time a subject can endure a task before the onset of fatigue, in ultra-marathon runners by simple non-invasive techniques before and after an ultra-marathon (87 km). Ten runners, (8 males and 2 females), who had normal clinical evaluation and lung function underwent inspiratory muscle assessment by measurement of maximal inspiratory mouth pressures and sustained inspiratory mouth pressures at a given target pressure and a given duty cycle. The measurements were performed prior to the race and 3 days after the race. No significant difference was observed in the inspiratory muscle strength 3 days after the race (p > 0.37), but the inspiratory muscle endurance time as measured by Tlim, was significantly lower (p < 0.002), with an overall decrease of 26.5%. Inspiratory muscle strength was normal 3 days after the race, however the inspiratory muscle endurance time as measured by sustained inspiratory pressure was still impaired 3 days after the race.

Adult↗

PubMed1998

Skeletal muscle fatigue and physical endurance of young and old mice.

In order to evaluate the role played by muscular and extramuscular factors in the development of fatigue in old age, the time course of fatigue in isolated skeletal muscles and spontaneous motor activity and endurance of whole animals were monitored using young (3-6 months) and old (34-36 months) CF57BL/6J mice. The isolated extensor digitorum longus (EDL) and soleus muscles from old mice had smaller (P < 0.05) mass and developed lower (P < 0.02) maximal tetanic tension at 100-Hz stimulation than the muscles of young mice. During stimulation at 30 Hz every 2.5 s, a 50% decline in original tetanic tension occurred by 109 s in young EDL and 129 s in old EDL, but by 482 s in young soleus and 1134 s (projected) in old soleus, indicating more (P < 0.05) resistance to fatigue in old than young soleus. However, the old mice showed significantly fewer (P < 0.002) spontaneous ambulatory movements than the young mice. On a treadmill with a belt speed of 10 m/min at an inclination of 0 degrees, the old mice could only run for 22 min compared to 39 min ran by young mice (P < 0.02). They took more rest periods (P< 0.02) than the young mice. In a quantitative swimming monitor, the old mice swam for a shorter (P < 0.05) time than young mice (20.4 min compared to 28.6 min). Integrated swimming activity at 20 min was smaller (P < 0.05) in old mice than in young mice (413 g/s compared to 628 g/s). Hence increased fatigue in old age is not caused by impairment of processes within the muscles, but by impairment of central or extramuscular processes.

Aging↗

PubMed1994

The effect of posture and seat suspension design on discomfort and back muscle fatigue during simulated truck driving.

Several studies have shown a relationship between low-back problems and exposure to seated whole-body vibration. The amount of vibration transmitted to the operator is influenced by the posture of the subject in the vehicle. The aim of this study was to determine whether a truck seat with a gas spring in its suspension is superior to the standard spring seat in slowing the onset of muscle fatigue and reducing the level of discomfort experienced during road vibrations while maintaining typical driving postures. The experiment used a 2 x 3 (2 seats x 3 postures) repeated measures design. It was conducted on six males free from low-back pain. Subject comfort was rated before and directly after exposure to typical vibrations. Muscle fatigue using centre frequency was determined during vibration exposure, and the magnitude and phase of acceleration transfer were calculated from the base plate to the seat pan and from the seat pan to the bite bar. None of comfort, fatigue rate or fatigue average were affected by seat type or seat suspension design in the short term, 10 min vibration exposure. Fatigue and comfort measures could continue to be used to detect postural defects, but the more sensitive measures of seat/driver interactions remain mechanical ones using motion-measuring techniques such as accelerometry and correcting for the heavily damped nature of the system. Until more sophisticated manikins are available the characteristics of vibration-attenuating seats should be confirmed using live humans.

Journal Article↗

PubMed1983

The acquisition and validation of the surface electromyogram signal for evaluating muscle fatigue.

The advent of new USAF aircraft control concepts necessitates the investigation of muscle fatigue in complex dynamic environments. The Acceleration Effects Branch of the Aerospace Medical Research Laboratory at Wright-Patterson Air Force Base had undertaken such a study for evaluation of fatigue in lateral G environments. Investigation of the literature indicates that the Fast Fourier Transform (FFT) of the electromyogram (EMG) signal samples could be used to determine fatigue by analysis of the center frequencies and amplitudes of the sampled power spectra. Reproducibility of data, especially in a dynamic environment, proved to be a challenge. However, acquisition and processing of the EMG signal have been optimized to give consistently reproducible and useable data. The method of sampling data and its processing are discussed.

Acceleration↗