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At least 343 records · Page 19Linked to original sources
PubMed1990

Is the syntax development of dysphasic children deviant and why? New findings to an old question.

The present study addresses three main issues: First, it considers whether the syntax development of dysphasic preschoolers is adequately described as being a purely quantitative retardation or whether there are qualitative differences as well. Second, the suggestion put forward by Grimm (1987) that the syntactic deficits of dysphasic children result from deficient language processing strategies is further explored. Third, it asks whether the language deficits are related to specific structural and interactional aspects of the language input. We examined two groups of children with comparable levels of language development: 8 dysphasic children, ages 3:9 to 4:8 years, and 8 control children, ages 2:1 to 2:11 years, who showed normal language development. The empirical evidence suggested that the dysphasic children's syntax development was not only delayed but also deviant, and that the children's deviant syntax structures were the result of insufficient language processing and could not be traced back to structural characteristics of the sentences used by their mothers.

Age Factors↗
PubMed2003

Computerized tomography screening for lung cancer: new findings and diagnostic work-up.

On computerized tomography (CT) screening for lung cancer within the Early Lung Cancer Action Project, both at baseline and repeat screening, we found not only solid but also subsolid nodules, which unlike solid ones do not completely obscure the lung parenchyma. We established that subsolid nodules represent approximately 20% of the nodules shown on screening and that they have a higher frequency of malignancy than solid nodules. Although we found growth of solid nodules to be a reliable indicator of malignancy, growth of subsolid nodules was more difficult to assess. On review of our results to date in screening, we have continued to refine our definition of a positive result of screening from that given in our initial publication on screening. We have also provided an updated screening regimen. It starts with the initial, low-dose CT test and for all those with positive results on this initial test, the regimen continues by specifying the work-up needed to rule-in a diagnosis of malignancy. In this regimen, we found growth assessed by high-resolution CT to be a useful indicator of malignancy and have developed image-processing tools to help in this assessment. Once growth is ascertained, we recommend fine-needle aspiration for confirmation of malignancy. It may be that once criteria for definitive growth are established and validated, fine-needle aspiration may become optional. However, in the meantime, in the context of screening, a more cautious approach is warranted.

Humans↗
PubMed1988

[New findings in Oguchi disease].

The authors report on clinical and electrophysiological studies of a patient with Type I Oguchi's disease. Numerous small pigmentations of the retinal pigment epithelium (RPE) causing focal disruption of the Oguchi reflex were observed, a phenomenon which has not previously been reported. Consistent with reports of pathologic changes in the RPE, an abnormal electro-oculogram (EOG) was recorded in this patient. On the basis of this information, the pigmentations were interpreted as dysplastic changes.

Adolescent↗