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At least 343 records · Page 19Linked to original sources
PubMed1975

[Pyrazolic sulfanilamides. XIV. Hydroxyderivatives of 1-phenyl-5-sulfanilamidopyrazole and of 1-phenyl-3-methyl-5-sulfanilamidopyrazole].

A report is given of the variations in bacteriostatic activity on introduction of a hydrophilic group, the hydroxyl group (-OH), at positions 2',3' and 4' of the phenyl group linked to the heterocyclic nitrogen os 1-phenyl-5-sulfanilamidopyrazole (I: R = -H) and of 1-phenyl-3-methyl-5-sulfanilamidopyrazole (II: R = -H). The substances prepared for this purpose: 1-(hydroxyphenyl)-5-sulfanilamidopyrazoles (Ia)(Ib))(Ic)(-OH at 2', 3',4') and 1-(hydroxyphenyl)-3-methyl-5-sulfanilamidopyrazoles (IIa)(IIb)(IIc)(-OH at 2',3'4') in vitro tests of bacteriostatic activity against strains of S. aureus and E. coli gave the following results: See journal for results.

Escherichia coli↗
PubMed1991

[Liver function in diabetics with secondary sulfanilamide resistance (based on the data from dynamic hepatobiliary scintigraphy)].

Dynamic hepato-bilio-scintigraphy was performed in 43 patients with diabetes mellitus. An analysis of results showed that characteristic of patients with diabetes mellitus is a reduction of the detoxicating and bile excretory function of the liver which was most pronounced in patients with insulin-dependent type in the condition of secondary sulfanylamide resistance. Typical of diabetes mellitus disorder of the gallbladder function was its hypotonia and dyskinesia.

Biliary Tract↗