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At least 343 records · Page 19Linked to original sources

Impairment of central motor conduction to the diaphragm in stroke.

Respiratory complications are common in patients with stroke, but the involvement of the diaphragm in this setting is not completely understood. The purpose of this study was to assess corticodiaphragmatic pathways in patients with vascular hemiplegia. Fifteen patients were studied, nine with a capsular type of hemiplegia. Seven age-matched subjects served as the control group, and eight healthy young volunteers were studied to validate the methods by comparison with the literature. Diaphragm electromyogram was recorded bilaterally, using surface electrodes. Abductor pollicis brevis electromyogram was also recorded. After having checked the integrity of peripheral conduction, corticofugal pathways were studied using cortical magnetic stimulation, a reproducible and patient-independent stimulus. Left and right conduction times to the diaphragm were symmetrical in the control subjects, the young volunteers, and the six patients with hemiplegia but without capsular lesion (16.5 to 20.1 ms). Conversely, they were markedly asymmetrical in patients with capsular hemiplegia, diaphragm response on the plegic side being abolished or markedly delayed. Although the clinical impact of these findings remains to be determined, this study confirms that "central diaphragm paralysis" can be present in stroke. It also indicates that there is no bilateral motor representation of each hemidiaphragm.

Adult↗

Partial rupture of the flexor hallucis longus tendon in a tennis player: a case report.

A 39-year-old woman sustained a forced dorsiflexion injury to the left great toe while pivoting to the right during tennis activity. Posteromedial ankle pain was reproduced with active plantarflexion and passive dorsiflexion of the great toe and, to a smaller extent, the lesser toes. Symptoms persisted for 9 months despite nonoperative treatment. Magnetic resonance imaging 5 months after injury revealed evidence of fluid surrounding the flexor hallucis longus (FHL) tendon. Operative findings 9 months after injury included scar tissue and tenosynovitis of the FHL and flexor digitorum longus tendon sheaths, with impingement of distal FHL muscle fibers and a longitudinal split tear (partial rupture) of the FHL tendon. Tenolysis, tenosynovectomy, excision of the distal muscle fibers, and repair of the partial tendon rupture were performed, resulting in resolution of symptoms. Partial rupture of the FHL tendon as a single-impact injury, or in activity other than ballet, has not been documented previously.

Adult↗

Effect of dl-3-n-butylphthalide on brain edema in rats subjected to focal cerebral ischemia.

The present study evaluated the effect of dl-3-n-butylphthalide(NBP), a novel brain protective agent, on brain edema in rats following focal ischemia. Edema was induced by occluding the right middle cerebral artery (MCAO), producing permanent focal ischemia in the right cerebral hemisphere, which developed ipsilateral brain edema reproducibly. Edema was assessed 24 h after MCA occlusion by determining the brain water content from wet and dry weight measurements, and the sodium, potassium concentrations with ion-selective electrodes. In this model, NBP at the dose of 80, 160 and 240 mg/kg p.o. 15 min after MCAO prevented from brain edema in a dose-dependent manner. A significant reduction of sodium content and an increase in potassium level were observed in all drug-treated groups. It showed that NBP strongly attenuated brain water entry, sodium accumulation and potassium loss. Nimodipine treatment (5 mg/kg s.c.) also reduced brain edema (P < 0.05). The results suggest that a strong anti-edema activity of NBP may play an important role to contribute to the treatment of ischemic damage.

Animals↗

Idiopathic left ventricular aneurysm associated with pleomorphic ventricular tachycardia: a case report.

A 39-year-old Japanese woman presented with an idiopathic left ventricular aneurysm manifesting as recurrent episodes of palpitation. She was referred to our hospital for evaluation of sustained ventricular tachycardia. Echocardiography disclosed a dyskinetic well-defined wall bulge during both systole and diastole at the basal region of the interventricular septum, and reduced left ventricular wall thickness and severe hypokinesis at the anterolateral to posterolateral region. These appearances were confirmed by the angiographic findings. The sustained ventricular tachycardia was reproducibly induced by a single extrastimulus from the right ventricular apex. Subsequently, 4-type ventricular tachycardias were induced during the electrophysiological study and the mechanism of these ventricular tachycardias was considered reentry. Radiofrequency catheter ablation failed due to the changing QRS morphologies during the entrainment study. The patient was treated with cibenzoline 300 mg a day, and there has been no recurrence of tachycardia during the 18-month follow-up period.

Adult↗

[Measurement by Doppler echocardiography of the ratio of pulmonary/systemic flow rates in atrial septal defects. Apropos of 15 cases].

Fifteen patients with an ostium secundum type atrial septal defect, aged between 5 and 68 (mean = 31) underwent Doppler-echocardiographic evaluation of the ratio of pulmonary and systemic flow rates. Systemic flow was evaluated at the aortic orifice, as well as at the mitral ring and at the extremities of the mitral cusps, based upon the measurement of valve diameters by 2D or TM echocardiography, pulsed Doppler velocity curve and hear rate. Pulmonary flow was measured by the same technique at the site of insertion of the pulmonary cusps. The values obtained were compared with cardiac catheterisation findings, the reference method being an oxymetric measurement of the shunt ratio. Feasibility of the Doppler investigation was 100 per cent. Correlation between the two techniques was r = 0.85 when the Doppler measurement was at the aorta, r = 0.81 for the mitral ring and r = 0.71 at the extremity of the mitral cusps. Doppler-echocardiography thus appears to be a reliable and reproducible method for the evaluation of left-right shunts, confirming data from the literature.

Adolescent↗

Fractures of the femoral neck: a review and personal statement.

EPIDEMIOLOGY: The number of hip fractures will increase enormously in the decades to come as will the cost of treatment of these patients do. In the USA the annual cost has estimated to be nearly $10 billion. Hip fractures, therefore, represent an enormous socio-economic and medical problem and challenge (orthopaedic) surgeons an anaesthetists to find the cheapest and most effective way to treat them. At the same time the search for preventive measures should be continued. Biphosphonates and hip protectors seem to be able to decrease the risk of suffering a hip fracture with 50%. CLASSIFICATION: The first classification of femoral neck fractures, proposed by Abraham Colles, in displaced and non-displaced (impacted) fractures appears to be still the most useful one. The Pauwels classification cannot be applied to the preoperative x-ray, because the fractured leg is always in external rotation. The Garden classification is not reproducible and does not lead us to the right treatment. TREATMENT: Stability and healing chances of impacted fractures depend especially on age and general condition. In patients under 70 years of age without co-morbidity, the secondary instability rate after non-operative treatment is very low: 5%. In elderly people with multiple co-morbidity secondary instability can go up to 80%. These patients are better served with primary operative treatment. Although the majority of surgeons feel good with a strategy of prophylactic internal fixation in all patients, this author pleads for non-operative (early mobilization) treatment of all patients, who are healthy or have only one serious comorbidity. There is consensus about the treatment of displaced fractures in patients under 65 years of age: closed reduction and internal fixation. The best treatment for patients over 80 years of age is prosthetic replacement. In the (large) group of patients between 65 and 80 years of age calendar age is not a reliable guide to the right treatment. There is a growing conviction that the choice between internal fixation and prosthetic replacement in these patients should be made on the basis of the biological age (ASA-score, habitat, the activity level, the need for walking aids and cognitive function). Bone density does not seem to play an important role. If internal fixation is the preferred treatment, the choice of implant is controversial. It is the author's experience that fractures with a steep fracture line (Pauwels 3) should be anatomically reduced and stabilized with a sliding hip screw. The less steep fractures (Pauwels 1 and 2) can be slightly over-reduced in valgus and anteversion, which provides a bony support against shearing forces, and fixed with parallel screws according to the 3-point-fixation principle. The timing of surgery continues to be a controversial subject. From a recent study in our own institution we concluded that no significant association could be found between delay to surgery and the clinical outcomes.However, considering the trends towards less complications and shorter length of hospital stay, early surgery (within 1 day from admission) is likely to be beneficial for hip fracture patients who are able to undergo operation. There is agreement about the use of the cemented arthroplasty. If a hemiarthroplasty is chosen, the bipolar type is to be preferred to the unipolar type. The difference in price between both prostheses is negligible because the overall cost of the treatment have gone up so immensely. Furthermore, a basic advantage of the bipolar system is the relatively small operation, needed for conversion to a total hip replacement, because the stem can stay in place. As to the question hemiarthroplasty or total hip replacement, the discussion has not yet been closed. We studied the natural history of the cemented bipolar hemiarthroplasty by evaluating 307 patients, operated between 1975 and 1989 in our institution. Only 3 patients, who not have been revised, were alive at the end of the observation period (2004). A striking difference was found in the occurrence of late mechanical complications (aseptic loosening and acetabular wear) between patients under 75 years of age (22%) and the older group of patients (6%). As to the patient's overall satisfaction 56% suffered no impairment from their sustained fracture, 36% were slightly impaired. We concluded that the use of the cemented bipolar prosthesis is justified in patients over 75 years of age. Patients between 65 and 75 years of age should either be treated with internal fixation or with a total hip replacement. NONUNION OF THE FEMORAL NECK: Nowadays in cases of nonunions of the femoral neck the surgeon is tempted to perform prosthetic replacement of the hip, the more so if there is also evidence of a disturbed vascularisation of the head. This will provide rapid pain relief and mobilization. However, long-term results of hip arthroplasties, especially in younger people and in presence of bone atrophy, are not always as expected and a less radical approach is worth considering. The intertrochanteric valgization osteotomy, described by Pauwels is an excellent alternative for patients up to 65 years of age with a non-union of the femoral neck. A union rate of 80-90% is described by most authors. Leg length, rotational and angular deformities can be corrected at the same time. Between 65 and 80 years a total hip replacement is probably the best option for fit patients. For elderly patients a cemented bipolar hemiarthroplasty is an adequate treatment.

Arthroplasty, Replacement, Hip↗

Transient evoked otoacoustic emissions in infants: effects of gender, ear asymmetry and activity status.

This study examined the effects of gender, ear asymmetry and activity status of infants on various measures of transient evoked otoacoustic emission (TEOAE), including signal-to-noise ratio (SNR) and reproducibility of emissions, using TEOAE as a mass screening procedure in a community health setting. Five hundred and sixty-eight infants were screened for hearing at two months of age, before immunization. The ILO88 Otodynamic Analyzer Quickscreen program was used for all testing with pass/fail criteria similar to those used in the Rhode Island hearing assessment project. The results indicated a significant difference in SNR across sex, with females showing a higher mean SNR. The right ear was found to have higher values in 'reproducibility' and 'response level' than the left ear. A significant difference in SNR across activity states was also evident. Implications from these findings, as applied to community-based screening programs, are discussed.

Acoustic Stimulation↗

Influence of perfusion on hepatic MR diffusion measurement.

Percutaneous liver biopsy is the current gold standard for the diagnosis and assessment of hepatic fibrosis: it is an uncomfortable procedure with associated risks of infection and internal bleeding. Diffusion-weighted MRI may be important as a non-invasive measure of the grade of hepatic fibrosis, owing to the morphological and physiological changes in hepatic tissues as fibrosis develops. The factors that influence hepatic diffusion measurements are complex and are thought to include hepatic perfusion. This study assesses whether hepatic diffusion measurements are influenced by hepatic perfusion changes as this could be an important variable when investigating the relationship between diffusion measurements and grade of hepatic fibrosis. Hepatic apparent diffusion coefficients (ADCs) were measured in 10 healthy volunteers after an 8-h fast and 1-h after a standard meal (which increases portal vein flow and hepatic sinusoidal perfusion) using a breath-hold technique at b-values of 750, 500 and 200 s/mm(2). ADC measurements using b = 750 and 500 s/mm(2) in the posterior right lobe were unaffected by the perfusion changes (P = 0.15 and 0.14, respectively) whereas the results from the anterior right lobe significantly increased post-prandially (P = 0.03 and 0.008, respectively): inter-subject variability was low ( approximately 5%) for these b-values. Portal perfusion had a significant effect in both the posterior and anterior segments of the right lobe when using a b-value of 200 s/mm(2) (P = 0.01 and 0.00001 respectively): inter-subject variability was found to be high ( approximately 25%). The most reproducible measurements of the ADC can be made in the posterior right lobe and the effect of perfusion is minimised at the higher b-values (b = 500 and 750 s/mm(2)).

Adult↗

Acoustic rhinometry: effects of decongestants and posture on nasal patency.

To determine whether acoustic rhinometry can be used to detect changes in nasal patency caused by decongestants or posture, we studied 10 healthy volunteers. Maps of the effective cross-sectional area of the nasal cavity as a function of distance into the respiratory system were generated, and an index of nasal cavity volume was calculated in the right and left nostril of each subject. The volume index was reproducible in subjects. The mean of the intrasubject coefficients of variation was 7.9%. After administration of phenylephrine in the form of a nasal spray, the volume index increased in the right nostril from 29.8 +/- 3.6 to 40.9 +/- 4.4 cm3 (mean +/- SEM) (p less than 0.001) and in the left nostril from 26.3 +/- 2.1 to 38.0 +/- 3.0 cm3 (p less than 0.001). On another occasion in the same subjects, the volume index was determined before and 90 minutes after oral administration of 60 mg pseudoephedrine. The volume index for the sum of both nostrils increased from 56.7 +/- 4.7 to 65.1 +/- 5.2 cm3 (p less than 0.5). In another group of subjects, turning from the supine position to the right side caused right nasal volume to decrease from 29.3 +/- 4.4 to 19.5 +/- 3.6 cm3 (p less than 0.003) and the left nasal volume to increase from 20.9 +/- 2.8 to 25.5 +/- 3.2 cm3 (p less than 0.05). We conclude that acoustic rhinometry can provide a sensitive index of changes in nasal geometry.

Ephedrine↗

Primary and secondary antibody responses to sheep erythrocytes of allogeneic bone marrow chimeras histocompatible at the left or right one-half of the H-2 complex.

Employing a new and reproducible method for allogeneic bone marrow transplantation, two kinds of irradiation chimeras were prepared. A/J mice treated with C3H/He marrow cells, which were designated [C3H leads to A/J], where donor and recipient were matched at left one-half of the H-2 complex showed significant numbers of plaque forming cells (PFC) following primary immunization with SRBC, a T-dependent antigen. In contrast [BALB/c leads to A/J] chimeras where donor and recipient were matched at right one-half of the H-2 were unresponsive to SRBC. These results are quite concordant with our previous observations in which B10 H-2 recombinant mice and AKR were used as bone marrow donor and recipient respectively. The vigorous antibody responses after the second stimulation with SRBC, however, were seen in either [C3H leads to A/J] or [BALB/c leads to A/J] chimeras. Direct PFC responses in [BALB/c leads to A/J] chimeras were slightly higher than those of [C3H leads to A/J] chimeras or normal control mice, while indirect PFC responses in [BALB/c leads to A/J] chimeras were low compared to those of the latter groups of mice. These findings suggest that there might be a delay in initiating the response and switching from IgM to IgG production in the chimeras where donor and recipient differed at the left one-half of the H-2.

Animals↗

Validation of a new intraoperative technique to evaluate load-independent indices of right ventricular performance in patients undergoing cardiac operations.

BACKGROUND: Assessment of right ventricular performance in the perioperative period is difficult because there is no generally accepted method of measuring right ventricular volume. We set out to determine whether conductance technology could provide a valuable technique for the investigation of intraoperative right ventricular function. METHODS AND RESULTS: Three validating studies were performed in 25 patients undergoing routine coronary revascularization. Study 1: The influence of conductance catheter position in the right ventricle was examined in 10 patients. Insertion of the conductance catheter through the outflow tract was associated with a larger gain constant and a smaller parallel conductance compared with insertion through the tricuspid valve. Study 2: The reproducibility of contractility measurements with the use of a conductance catheter was examined in 7 additional patients. Removal and reinsertion of the conductance catheter was not associated with any significant difference in right ventricular volume or contractile function. Study 3: Right ventricular performance before and after cardiopulmonary bypass was compared in 8 additional patients. There was a fall in the slope of the right ventricular preload recruitable stroke work from 15.6 (3.8) to 11.0 (5.1) mm Hg (P=.01) and an increase in the slope of the end-diastolic pressure-volume relations from 0.05 (0.02) to 0.11 (0.05) mm Hg/mL (P=.001). CONCLUSIONS: The conductance technique can be used to study perioperative changes in right ventricular performance. Insertion of the conductance catheter through the outflow tract provides stable and reproducible data. There is significant impairment of right ventricular contractility in the early postoperative period.

Cardiac Catheterization↗

Three-dimensional visual guidance improves the accuracy of calculating right ventricular volume with two-dimensional echocardiography.

Three-dimensional guidance programs have been shown to increase the reproducibility of 2-dimensional (2D) left ventricular volume calculations, but these systems have not been tested in 2D measurements of the right ventricle. Using magnetic fields to identify the probe location, we developed a new 3-dimensional guidance system that displays the line of intersection, the plane of intersection, and the numeric angle of intersection between the current image plane and previously saved scout views. When used by both an experienced and an inexperienced sonographer, this guidance system increases the accuracy of the 2D right ventricular volume measurements using a monoplane pyramidal model. Furthermore, a reconstruction of the right ventricle, with a computed volume similar to the calculated 2D volume, can be displayed quickly by tracing a few anatomic structures on 2D scans.

Adult↗

[Diagnosis of right heart stress with one- and two-dimensional echocardiography--sensible normal values, problems and limitations].

Unidimensional and two-dimensional echocardiography is considered to be an established method of examination in cardiology alongside Doppler sonography and the transoesophageal method. It is planned to propagate the use of unidimensional and two-dimensional echocardiography in internistic pneumological diagnostics. To achieve this it is imperative to know the standard values of the right heart and to know how they are to be assessed. The standard values stated so far have proved to be too low in practice, resulting in many false positive findings, and are often also too complicated to obtain. 53 healthy probands were selected at random and six different measurements of the right heart and the efferent major vessels were performed. Only the diameter of the right ventricle and right atrium, as well as the wall thickness of the right ventricular wall were found to be suitable parameters for confirming right ventricular strain. The measured values were tested for reproducibility in patients suffering from diseases of the lung and of the airways. Compared with pressure values of pulmonary circulation obtained by invasive methods, maximum values obtained in patients with pulmonary hypertension can serve to recommend unidimensional and two-dimensional echocardiography as screening method in cases of suspected cor pulmonale.

Adult↗

An unusual mechanism of initiation of circus movement tachycardia in a patient with concealed Wolff-Parkinson-White syndrome.

Infranodal conduction delay is an uncommon mechanism of initiation of circus movement tachycardia in the Wolff-Parkinson-White syndrome. A patient with a concealed left free wall atrioventricular accessory pathway who underwent electrophysiological study is presented. During atrial extrastimulus testing, a pattern of alternating bundle branch block was observed and was most marked after the administration of intravenous procainamide. Conversion from right bundle branch block to left bundle branch block was reproducibly associated with the initiation of circus movement tachycardia utilizing the normal conducting system antegradely and the accessory pathway retrogradely. Initiation of tachycardia was critically related to the increase in the HV interval associated with left bundle branch block. Of interest, conduction in the right bundle branch became progressively slower as the prematurity of the atrial extrastimulus increased, whereas conduction time through the left bundle branch remained fixed prior to block. Implications of these findings are discussed. To our knowledge, this is the first report of alternating bundle branch block during atrial extrastimulus testing as a mode of initiation of circus movement tachycardia in the Wolff-Parkinson-White syndrome.

Adult↗

A statistical study of optical rotation for synthetic d,l-copolypeptide solutions.

The right-handed helical fraction H(L) in a D,L-copolypeptide chain is evaluated by a simple probability theory for each L-fraction, p. The curves of optical rotation at a single wavelength against p for poly(gamma-benzyl-D,L-glutamate) and D,L-copolyleucine of a series of different D:L ratios in several positive helix-solvents are calculated with a modified semi-empirical Moffitt equation. From the comparison between the rotations calculated by us and observed by Downie et al., it is shown that to reproduce the observed rotations, the minimum number of right-handed helical nuclei or sequences of L-residues appropriate to the Moffitt equation are eight and four for degrees of polymerization 320 and 1860, respectively.

Journal Article↗

Individual functional anatomy of verb generation.

Examination of the individual functional anatomy of language is of particular interest in clinical neurology to explain the variability of aphasic symptoms after focal lesions and to avoid damage of language-related brain areas by surgery. For a silent verb generation task, we examined whether activation PET with 3D data acquisition, multiple replication of conditions, and coregistration with MRI provides results that are consistent and reproducible enough to be useful clinically. Visual analysis was performed on PET-MRI fusion images, including renderings of the brain surface. Quantitative analysis was based on volumes of interest. In seven right-handed normals, activation of the triangular part of the left inferior frontal cortex [Brodman area (BA) 45] was the most significant finding that was present in each subject. Two subjects showed minor anatomical variants of the ascending or horizontal ramus of the sylvian fissure that were associated with the least activation of BA 45. In the left hemisphere the other frontal gyri, the superior temporal and posterior part of the middle temporal gyrus, and the paracingulate gyrus were also significantly activated. There was significant bilateral cerebellar activation, but it was significantly more intense on the right than on the left side. The consistency and high interindividual reproducibility of these findings suggest that this technique may be useful for clinical assessment of language-related areas.

Acoustic Stimulation↗