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At least 37 records · Page 2Linked to original sources
PubMed1984

Squamous cell carcinoma arising in acne conglobata.

A squamous cell carcinoma was found on the back of a man who had had acne conglobata for more than forty years. Squamous cell carcinomas called Marjolin's ulcers may arise in the sites of chronic inflammation and scarring such as thermal burn scars, discoid lupus erythematosus, leg ulcerations, and foci of osteomyelitis. Squamous cell carcinoma has also been reported in all three diseases included in the so-called "follicular occlusion triad": acne conglobata, dissecting cellulitis of the scalp, and hidradenitis suppurativa.

Acne Vulgaris↗
PubMed1977

On cell-mediated immunity in acne conglobata.

In 25 of 35 cases of acne conglobata, a reduction in or lack of delayed reactivity was found by intracutaneous tests with a battery of antigens. On the basis of these findings as well as of normal T-cell function in lymphocyte culture and of negative Kveim-tests (in three cases), the possible immunological mechanisms are discussed.

Acne Vulgaris↗
PubMed1975

The surgical treatment of acne conglobata of the face.

Successful treatment of Acne conglobata is only possible by surgical excision. Two procedures are most favoured. Gross excision and fine trimming by dermabrasion with subsequent secondary reepithelization gives excellent results without scars: If a radical excision is preferred or if cartilage is exposed, a full thickness skin graft has to be applied. The results are good although slight difference in colour between facial skin and skin graft must be noted. For each of these two procedures a case is presented and treatment and results are discussed.

Acne Vulgaris↗
PubMed1979

Neutrophil functions in acne conglobata.

Chemotaxis, random migration, phagocytosis, spontaneous and stimulated NBT reduction were evaluated in neutrophils from the peripheral blood of 8 patients with acne conglobata and were found to be normal. Only 2 patients had an increased spontaneous NBT reduction, and another exhibited a defect in neutrophil adhesiveness. On this basis, intrinsic defects of the major neutrophil functions, as evaluated in vitro, can be excluded in acne conglobata.

Acne Vulgaris↗
PubMed2002

[ANCA-positive vasculitis of the skin and kidneys associated with acne conglobata].

A 19 year old man with severe acne conglobata and ulcerated pyoderma gangraenosum-like skin lesions on the face was first treated with isotretinoin (Roaccutan((R))), then immunosuppressively with prednisolone, diaminodiphenylsulfone (Dapson-Fatol((R))) and mycophenolate mofetil (Cellcept((R))). Under a daily maintenance dose of immunosuppressive treatment with 2.5 mg prednisolone and 1 g mycophenolate mofetil, weakness, muscle and joint aches appeared. Due to proteinuria, haematuria and an elevated antineutrophil cytoplasmic antibody (cANCA) and the histological detection of a leukocytoclastic vasculitis, the diagnosis of cANCA positive vasculitis of the skin and kidneys was established. Therapy with cyclophosphamide (Endoxan((R))) along with prednisolone was effective. An exact classification of this disease process was not possible.

Acne Vulgaris↗
PubMedDate not supplied

Immunological studies of the arthritis of acne conglobata and hidradenitis suppurativa.

The etiology and pathogenesis of acne arthritis and the arthritis of hidradenitis suppurativa remain unknown. Some patients have an asymmetrical pauciarticular arthritis compatible with the 'reactive' peripheral and central forms of Reiter's syndrome, whereas others have a symmetrical polyarthritis/polyarthralgias syndrome. The cutaneous disease is clinically manifest as acne conglobata or hidradenitis of axilla or groin. We determined human leukocyte antigens (HLA), levels of immunoglobulins, C3, C4 and circulating immune complexes from six patients with acne arthritis. Four of six patients had HLA antigens of B7 Creg group (B7, BW22, B27, BW40, BW42) and all six possessed DRW4. Isolated elevations of immunoglobulins, C3 and C4 were observed. Immune complexes were elevated uniformly. These observations suggest that immunogenetic mechanisms may play a role in the systemic manifestations of these skin diseases.

Acne Vulgaris↗
PubMed1989

[Surgical therapy of severe acne conglobata].

Thirty-six patients were treated for severe acne conglobata. Wide and deep excision of the affected area should be followed by wound closure, primary or secondary, depending on the body region involved.

Acne Vulgaris↗
PubMed1989

Ankylosing spondylarthritis associated with acne conglobata.

We report a case of a rare association between acne conglobata and ankylosing spondylarthritis B27 negative which occurred in a young man. The pathogenetic relationship of the association is not certain, although some researches suggest that the onset of ankylosing spondylarthritis can result from cutaneous disease. Despite the long evolution of ankylosing spondylitis, it is not severe. Thus, the presence of B35 CREG antigens confirm that locus B antigens different from B27 could be associated with a more favourable prognosis of the disease.

Acne Vulgaris↗
PubMed1986

[Osteonecrosis in acne conglobata].

We report on a 17-year-old man suffering from acne conglobata, who developed osteomyelitis with osteonecrosis of the left clavicula after a rash of acne fulminans. The infection spread from a cystic nodule into the adjacent bone.

Acne Vulgaris↗
PubMed1977

Delayed hypersensitivity and febrile acne conglobata.

Delayed hypersensitivity reactions were investigated in 5 patients with febrile acne conglobata. Each of them had febrile periods, large abscesses and leukocytosis. They reacted negatively to tuberculin 10 TU/ml, to Schick toxin, to oidiomycin, to trichophytin as well as to 25 common contact allergens. DNCB did not induce sensitization in those 4 patients in whom it was carried out. However, the transforamtion of lymphocytes by phytohaemagglutinin (PHA) was normal. Five of 7 control patients with cystic or ordinary acne had positive tuberculin test reactions and 3 of them were sensitized to DNCB.

Acne Vulgaris↗
PubMed1954

Acne conglobata; use of cortisone and corticotropin in therapy.

Six patients with acne conglobata were treated with cortisone and adrenocorticotropic hormone. Definite immediate improvement was observed in all of them. In three cases control of the disease was maintained on relatively low doses of steroid. In one case there was response to superficial x-ray therapy after the acute phase of the disease had subsided in response to steroids. Resistance to steroid therapy apparently developed in one patient after approximately 18 months of treatment. One patient responded to treatment and then remained well (for two months when last observed) although steroids and all other treatment were discontinued. The combined use of antibiotics and steroids in the patients treated gave the best results.

Acne Vulgaris↗
PubMed1991

End-stage renal disease in a patient with amyloidosis secondary to acne conglobata.

The clinical profile of a patient with a 15 years' evolution of acne conglobata developing systemic amyloidosis with severe renal involvement is described, and the possible influence of suppurative skin foci surgical excision on the rapid progression to terminal renal failure is discussed. This etiological cause of secondary amyloidosis has rarely been reported as a cause of end-stage renal disease.

Acne Vulgaris↗
PubMed1990

[Rheumatism and acne conglobata . Apropos of a new case, in a 13-year-old boy].

With reference to a new case of acne conglobata-associated rheumatic disease in a thirteen-year-old boy, we recall the characteristics of the main joint and/or bone manifestations that may occur during severe flares of acne conglobata, but also acne fulminans or pustulosis of the palms and soles. Joint manifestations mainly involve the large proximal joints of the limbs and consist in pain rather than in signs of inflammation. Although recurrences may develop, joint disease responds to treatment of the acne combined with a non-steroidal antiinflammatory drug. Bone involvement consists in true rheumatic osteitis with hyperostosis responsible for densification and thickening of bone, mainly in the anterior chest wall and spine. The pathogenesis and nosologic place of these bone and joint manifestations remain controversial: they do not seem to represent true reactive arthritis and, although the B27 antigen is usually lacking, they have been likened to the group of spondylarthropathies, especially in those cases with sacroiliac involvement and enthesopathy . Oddly enough, they are reminiscent of some of the side effects of etretinate, an agent prescribed in these severe forms of acne. After a national survey carried out in 1986, the acronym SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis) was suggested to designate the range of skin, bone and joint manifestations observed.

Acne Vulgaris↗
PubMed1990

A case of pyoderma vegetans associated with acne conglobata.

A 41-year-old man visited our clinic because of vegetating plaques resembling pemphigus vegetans on his sacral and perianal areas. He had also suffered from acne conglobata since adolescence. A biopsy specimen taken from the perianal area showed marked acanthosis, exocytosis, and inflammatory infiltrates in the dermis, but no acantholysis. Direct and indirect immunofluorescent tests were negative for anti-intercellular antibodies. Bacterial cultures from the lesions showed many different types of organisms. We diagnosed the case as pyoderma vegetans and discussed the relationship between pyoderma vegetans and other pyoderma.

Acne Vulgaris↗
PubMed1983

[Oral treatment of acne conglobata using 13-cis-retinoic acid. Results of the German multicentric study following 24 weeks of treatment].

Results of the isotretinoin (13-cis-retinoic acid, Ro 4-3780) German Cooperative Study Group, with 198 acne conglobata patients being treated in 19 departments are reported. For the first 12 weeks (phase I) there was an open assignment to 0.2, 0.5 or 1.0 mg/kilogram bodyweight (kg bw). This was followed by further 12 weeks (phase II). If there was at least a two-third improvement of lesions, the 0.2 mg/kg bw was continued, and the 0.5 mg/kg bw dose lowered to 0.2 mg/kg bw. If there was no such improvement, the dose was elevated to 0.5 and 1.0 mg/kg bw respectively. The initial high dose group of 1.0 mg/kg bw was divided after twelve weeks into 0.2 mg/kg bw maintenance therapy, or no therapy at all. Non-inflammatory and inflammatory acne lesions from the entire body were counted. Seborrhea was graded on a four scale (0 to 3+). Subjective side effects were registered. Laboratory data included hematological profile with differential counts, creatinin, SGOT, SGPT, alkaline phosphatase, total bilirubin, serum cholesterol and serum triglycerides, and urine analysis. For statistical analysis 171 patients were available, 27 dropped out of the study, mostly for reasons unrelated to the drug. At least 75 per cent improvement was seen, in the 0.2 mg/kg bw group in 73.7 and 59.5 per cent respectively; in the 0.5 mg/kg bw group in 72.5 and 61.2 per cent respectively; and in the 1.0 mg/kg bw group in 85.4 and 92 per cent respectively (phase I t12 and phase II t24 values, respectively). Sebum suppression was dose-related. Subjective side effects were fairly well dose-related, particularly those of skin and mucous membranes. Myalgia was rare. There was a dose-related elevation of triglycerides and cholesterol, but not significant for the means of each group. Single patients did show significant elevation of blood lipids. All other laboratory parameters did not change significantly. Isotretinoin is presently the most effective drug to control severe forms of acne, leading to long lasting remissions.

Acne Vulgaris↗