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Results for “ADRENAL CORTEX HORMONES/effects”

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PubMed1957

The activity of different steroids in producing thymic involution.

The assay method for corticotrophin, in which the involution of the thymus of the nestling rat is measured, can be applied successfully as a quick and simple screening test for biologically active corticosteroids. The sensitivity of the test is such that injection of a standard dose of cortisone acetate produces different results when made up in different media, or injected by different routes. A standard procedure for dispensing and injecting the steroids has therefore been adopted. Of the steroids investigated, it is noticeable that those possessing marked thymolytic activity are also steroids with therapeutic properties.

Adrenal Cortex Hormones↗
PubMed1959

The effect of adrenal steroids and corticotrophin on the growth of a sarcoma of human origin in small laboratory animals.

9alphaFluorohydrocortisone, prednisolone, and hydrocortisone promoted the growth of the human tumour (H.S.l) in weanling rats, but deoxycortone acetate was ineffective even when injected in very high dosage; Cortrophin ZN, a long-acting corticotrophin preparation, was just as effective as cortisone. This effect of corticotrophin on tumour growth was mediated by the adrenal cortex, and was related to the enhanced secretion of adrenocorticoids; some correlation existed between tumour size and adrenal hypertrophy in the corticotrophin-treated rats. The action of adrenal steroids and of corticotrophin in promoting the growth of the tumour is discussed.

Adrenal Cortex↗