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[Radiological diagnosis of adrenal gland diseases].

Among all the radiological examination techniques, CT is today, besides scintigraphy, the method of choice as far as the detection of functional adrenal lesions is concerned. In primary aldosteronism, CT classification of the syndrome is based on the detection of an adenoma which can be reliably detected in adenoma sizes up to 8-10 mm. Thus, 70 to 80% of Conn's syndromes can be classified. In adrenal Cushing's syndrome, the distinction between adenoma and carcinoma of the adrenal gland is up to CT and can usually be easily made due to the characteristic morphology of each type of lesion. In case of a typical adrenal or juxtaadrenal tumor location, detection of a pheochromocytoma is likewise easy. In ectopic and multiple pheochromocytomas or such as occur as part of a MEN-syndrome, the situation is quite different. If lesions of the adrenal gland are found by accident in examinations otherwise indicated, the question arises whether the process is malignant or benign. In this respect, all the traditional imaging methods, including CT, involve a considerable factor of uncertainty, especially if a malignant tumor is anamnestically known and the question of metastases arises. According to recent information, MR-imaging seems to be advantageous concerning this difficult differential diagnosis.

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[Surgical aspects of the treatment of adrenal gland diseases].

With the greatly enhanced accuracy of current endocrinologic diagnosis assisted by precise diagnostic imaging, together with greatly enhanced preparation of patients with endocrinopathy for safer anesthetic and surgical procedure (e.g. adrenal cortical cancers, cortisol and aldosterone producing adenomas and pheochromocytomas), operative procedures can be planned and conducted more precisely. For the surgeon, the strategy for treatment of functional and neoplastic disorders of the adrenal glands has essentially to consider the anatomy of the suprarenal glands, the deleterious effects of hormone excess before and during operation, the presumed nature of incidentally discovered adrenal mass and the size of the tumor.

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[Computerized tomography and nuclear magnetic resonance tomography in adrenal gland diseases].

Currently, the morphology of the adrenal glands can be demonstrated by different tomographic techniques: CT, MRI and ultrasound (US). The choice of the imaging modality and the examination procedure mainly depend on the suspected disease. In general, CT and MRI are superior to US due to the excellent visualization of the adrenals in nearly all circumstances, whereas sonography is strongly dependent upon the experience of the radiologist. Up to now CT is the procedure of choice in the evaluation of adrenal diseases with only minimal morphological disturbance, for example Conn's syndrome and hyperplasia. MRI and CT are nearly equivalent in the detection of adrenal masses larger than 2 cm in diameter, such as in Cushing's adenoma or pheochromocytoma. MRI has advantages compared with CT in the capability of tissue characterization, multiplanar imaging and in the visualization of blood vessels. For this reason MRI seems to be suitable for the distinction between adenomas and adrenal metastases.

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[Nuclear medicine diagnosis of adrenal gland diseases].

Localization procedures are required in adrenal diseases after biochemical confirmation of hormonal excess. Whereas computed tomography, ultrasound and--in rare cases--also magnetic resonance are needed to image the morphological abnormalities and the anatomy of neighbouring structures, adrenocortical and adrenomedullary scintigraphy is dependent on a functioning adrenal gland. Adrenocortical scintigraphy has the advantage of being able to differentiate between unilateral adenoma and bilateral hyperplasia in patients with primary hyperaldosteronism. It is of minor significance in patients with Cushing's syndrome or hyperandrogenism. In patients with catecholamine-producing tumours scintigraphy with radioiodine-labelled meta-iodobenzylguanidine (MIBG) may detect intra- and extra-adrenal, uni- and bilateral or multilocular, benign and malignant lesions. In patients with malignant but inoperable phaeochromocytoma, therapy with high doses of MIBG may improve clinical symptoms and reduce tumour volume.

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