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PubMed2003

Assessment of Acinetobacter baumannii susceptibility to antiseptics and disinfectants.

Disinfection and antisepsis are of primary importance in controlling outbreaks of Acinetobacter baumannii, a nosocomial pathogen that frequently shows multiple antibiotic resistance. In this study we assessed the susceptibility of nine A. baumannii strains isolated during a sustained intensive care unit outbreak, to several antiseptics and disinfectants based on European Standards. While the tested strains showed diverse antibiotic resistance patterns, they were equally sensitive to the biocides assessed in vitro. We observed neither evidence of development of resistance to biocides over time, nor a correlation between resistance to antibiotics and a decreased susceptibility to antiseptics or disinfectants.

Acinetobacter Infections↗
PubMed1996

[Kinetics of in vitro bactericidal activity of the antiseptic biseptine combining 3 active principles].

Biseptine, is an association of chlorhexidine digluconate, benzalkonium chloride and benzylic alcohol. Little is known, in literature, on this antiseptic, used for cutaneous antisepsis. We studied killing kinetic of Biseptine, at different concentrations, on 4 AFNOR bacterial strains. Killing curves were studied at antiseptic concentration of 90 to 0.1% in 10 ml of distilled water. Bacterial counts were determined after neutralization in liquid medium. Synergy of chlorhexidine and benzalkonium chloride in Biseptine, allowed to obtain similar bactericidal activity than Hibitane champ with chlorhexidine concentrations 2 fold less. At 90, 50, 25, 10 and 5% concentrations, bactericidal activity (5 log10 reduction of the initial bacterial count) was effective in one minute. After 5 to 15 minutes, activity persisted at 1 and 0.5% concentrations. The 0.1% solution was inefficacious. This report disclosed an important security margin in antiseptic activity.

Anti-Infective Agents, Local↗
PubMed1989

[Influence of antiseptic measures on the flora of the oral cavity. 2. In vivo examinations].

For prophylactic antisepsis of the oral cavity 12 antiseptic solutions and 4 antiseptically acting tablets were examined in vivo. A total of 720 samples were evaluated after indirect contact sampling and 80 after direct contact sampling. After the evaluation of the in vivo findings the following antiseptic agents can be recommended for prophylactic antisepsis of the oral cavity in stomatological practice: the 0.2% chlorhexidine solution, the 0.1% aqueous solution of Tosyl-chloramid-Sodium, and Sulfachin.

Anti-Infective Agents, Local↗